I-TASSER results

I-TASSER results for job id Rv2824c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (314 residues)
MAARRGGIRRTDLLRRSGQPRGRHRASAAESGLTWISPTLILVGFSHRGDRRMTEHLSRL
TLTLEVDAPLERARVATLGPHLHGVLMESIPADYVQTLHTVPVNPYSQYALARSTTSLEW
KISTLTNEARQQIVGPINDAAFAGFRLRASGIATQVTSRSLEQNPLSQFARIFYARPETR
KFRVEFLTPTAFKQSGEYVFWPDPRLVFQSLAQKYGAIVDGEEPDPGLIAEFGQSVRLSA
FRVASAPFAVGAARVPGFTGSATFTVRGVDTFASYIAALLWFGEFSGCGIKASMGMGAIR
VQPLAPREKCVPKP

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MAARRGGIRRTDLLRRSGQPRGRHRASAAESGLTWISPTLILVGFSHRGDRRMTEHLSRLTLTLEVDAPLERARVATLGPHLHGVLMESIPADYVQTLHTVPVNPYSQYALARSTTSLEWKISTLTNEARQQIVGPINDAAFAGFRLRASGIATQVTSRSLEQNPLSQFARIFYARPETRKFRVEFLTPTAFKQSGEYVFWPDPRLVFQSLAQKYGAIVDGEEPDPGLIAEFGQSVRLSAFRVASAPFAVGAARVPGFTGSATFTVRGVDTFASYIAALLWFGEFSGCGIKASMGMGAIRVQPLAPREKCVPKP
Prediction	CCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEHCCCCCCCCCCHHHCCEEEEEEEEHCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEEEHCCCEEEEEEEHCCHHHHHHHHHHHHHCCCCEEEEEHCCEEEEEEEEEHCCCCHHHHHHHHHCCCCCCEEEEEEHCCEEEEHCCEEEHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCEEEEEEEEEEEEEHCCEEEEEEEEEEEEEEHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHCCCCCCCCCCC
Conf.Score	98766776467877665888876677788888776788654456667776545544458999999858888788875789999999998999999999857999858888885895899999986868999999999976876699986466999999997468999999998578888679999978768988998886899999999999999998588878879999998755677765589999979978877899999999689999999999999999869876566668858999757888888999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MAARRGGIRRTDLLRRSGQPRGRHRASAAESGLTWISPTLILVGFSHRGDRRMTEHLSRLTLTLEVDAPLERARVATLGPHLHGVLMESIPADYVQTLHTVPVNPYSQYALARSTTSLEWKISTLTNEARQQIVGPINDAAFAGFRLRASGIATQVTSRSLEQNPLSQFARIFYARPETRKFRVEFLTPTAFKQSGEYVFWPDPRLVFQSLAQKYGAIVDGEEPDPGLIAEFGQSVRLSAFRVASAPFAVGAARVPGFTGSATFTVRGVDTFASYIAALLWFGEFSGCGIKASMGMGAIRVQPLAPREKCVPKP
Prediction	74454440432411342353564644653643141244223011234443540353032010202051647442222101100000022026600530173633100001034774301000001356004300410363434403044371404124242452314301530365653330303020001023643110102032003100410241074615355004200620303414030230417743020010201020445640140031003003102012310200010204325376644768
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEHCCCCCCCCCCHHHCCEEEEEEEEHCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEEEHCCCEEEEEEEHCCHHHHHHHHHHHHHCCCCEEEEEHCCEEEEEEEEEHCCCCHHHHHHHHHCCCCCCEEEEEEHCCEEEEHCCEEEHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCEEEEEEEEEEEEEHCCEEEEEEEEEEEEEEHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHCCCCCCCCCCC
MAARRGGIRRTDLLRRSGQPRGRHRASAAESGLTWISPTLILVGFSHRGDRRMTEHLSRLTLTLEVDAPLERARVATLGPHLHGVLMESIPADYVQTLHTVPVNPYSQYALARSTTSLEWKISTLTNEARQQIVGPINDAAFAGFRLRASGIATQVTSRSLEQNPLSQFARIFYARPETRKFRVEFLTPTAFKQSGEYVFWPDPRLVFQSLAQKYGAIVDGEEPDPGLIAEFGQSVRLSAFRVASAPFAVGAARVPGFTGSATFTVRGVDTFASYIAALLWFGEFSGCGIKASMGMGAIRVQPLAPREKCVPKP

4c8yA

0.19

0.14

0.75

1.91

MUSTER

--------------------------------------------------------MVLAALVLVLEGEGLPE-----PLGLRGFFYGLL-REVAPEVHDQGENPFALGFGGREGA-AWARVSLLVEGLYARLAPRLYALEGEEVRLG-PPFRVRAVLQEGHPWAGVSTYPRLFQGPPSRDLALRFASPTFFRRKGVHYPVPEPRLVLESLLRRLEAFGPLKAP-EGVREALLERTTVRSLEGRTLPARTEVD-TAGFVGRVVYHLPRTEEEALWLSALGRFAFYSGVGAKTSLGYGRARAES-----------

4c8yA

0.19

0.14

0.75

3.47

dPPAS

--------------------------------------------------------MVLAALVLVLEGEGLPE-----PLGLRGFFYGLL-REVAPEVHDQGENPFALGFGG-REGAAWARVSLLVEGLYARLAPRLYALEGEEVRLG-PPFRVRAVLQEGHPWAGVSTYPRLFQGPPSRDLALRFASPTFFRRKGVHYPVPEPRLVLESLLRRLEAFGPLKAP-EGVREALLERTTVRSLEGRTLPAR-TEVDTAGFVGRVVYHLPRTEEEALWLSALGRFAFYSGVGAKTSLGYGRARAES-----------

4c8yA

0.20

0.15

0.75

4.79

wdPPAS

--------------------------------------------------------MVLAALVLVLEGEGLPE-----PLGLRGFFYGLL-REVAPEVHDQGENPFALGFGG-REGAAWARVSLLVEGLYARLAPRLYALEGEEVRL---GPPFRVRAVLQEGHPWAGVYPRLFQGPPSRDLALRFASPTFFRRKGVHYPVPEPRLVLESLLRRLEAFGPLKAP-EGVREALLERTTVRSLEGRTLPAR-TEVDTAGFVGRVVYHLPRTEEEALWLSALGRFAFYSGVGAKTSLGYGRARAES-----------

4c8yA

0.21

0.16

0.75

2.40

wMUSTER

----------------------------------------------------------MVLAALVLVLEGEGLPE---PLGLRGFFYGLL-REVAPEVHDQGENPFALGFGGREGA-AWARVSLLVEGLYARLAPRLYALEGEEVRL---GPPFRVRAVLQEGHPWAGVYPRLFQGPPSRDLALRFASPTFFRRKGVHYPVPEPRLVLESLLRRLEAFGPLKAP-EGVREALLERTTVRSLEGRTLPARTEV-DTAGFVGRVVYHLPRTEEEALWLSALGRFAFYSGVGAKTSLGYGRARAES-----------

4c8yA

0.20

0.15

0.75

4.24

wPPAS

--------------------------------------------------------MVLAALVLVLEGEGLPE-----PLGLRGFFYGLL-REVAPEVHDQGENPFALGFGG-REGAAWARVSLLVEGLYARLAPRLYALEGEEVRL---GPPFRVRAVLQEGHPWAGVYPRLFQGPPSRDLALRFASPTFFRRKGVHYPVPEPRLVLESLLRRLEAFGPLKAP-EGVREALLERTTVRSLEGRTLPAR-TEVDTAGFVGRVVYHLPRTEEEALWLSALGRFAFYSGVGAKTSLGYGRARAES-----------

4c8yA

0.19

0.14

0.75

6.23

dPPAS2

--------------------------------------------------------MVLAALVLVLEGEGLPE-----PLGLRGFFYGLL-REVAPEVHDQGENPFALGFGG-REGAAWARVSLLVEGLYARLAPRLYALEGEEVRLG-PPFRVRAVLQEGHPWAGVSTYPRLFQGPPSRDLALRFASPTFFRRKGVHYPVPEPRLVLESLLRRLEAFGPLKAP-EGVREALLERTTVRSLEGRTLPAR-TEVDTAGFVGRVVYHLPRTEEEALWLSALGRFAFYSGVGAKTSLGYGRARAES-----------

4c8yA

0.19

0.14

0.75

3.51

PPAS

--------------------------------------------------------MVLAALVLVLEGEGLPE-----PLGLRGFFYGLL-REVAPEVHDQGENPFALGFGG-REGAAWARVSLLVEGLYARLAPRLYALEGEEVRLG-PPFRVRAVLQEGHPWAGVSTYPRLFQGPPSRDLALRFASPTFFRRKGVHYPVPEPRLVLESLLRRLEAFGPLKAP-EGVREALLERTTVRSLEGRTLPAR-TEVDTAGFVGRVVYHLPRTEEEALWLSALGRFAFYSGVGAKTSLGYGRARAES-----------

4c8yA

0.19

0.14

0.75

4.21

Env-PPAS

--------------------------------------------------------MVLAALVLVLEGEG-----LPEPLGLRGFFYGLL-REVAPEVHDQGENPFALGFGG-REGAAWARVSLLVEGLYARLAPRLYALEGEEVRLG-PPFRVRAVLQEGHPWAGVSTYPRLFQGPPSRDLALRFASPTFFRRKGVHYPVPEPRLVLESLLRRLEAFGPLKAP-EGVREALLERTTVRSLEGRTLPARTEV-DTAGFVGRVVYHLPRAEEEALWLSALGRFAFYSGVGAKTSLGYGRARAES-----------

4c98A

0.24

0.18

0.74

1.79

MUSTER

------------------------------------------------GAASM---PQAVVLELVGE-----KPPLYPARYAHGLFFALLSPELAQKLHEAPRKPFTLAPLP---GTLRLRLTTLDDGLFAPFLRALSSYRLARVLATREGHPL------AGATSWEELKEA----PKREKATFRFLTPTVFATSTRYTPLPDPRLIAGSLLDKWQAHSPFPYNEAALRELFELDLVAGFRNLRFHRVQAGKGFFPGFTGEATLRLWSSLEAQEALGRLHALAFFSGVGAKTPYGMGLAVPL------------

4c98A

0.23

0.17

0.75

3.32

dPPAS

------------------------------------------------GAASM-----PQAVVLELVGEKPPLYPARYAHGLFFALLSRVSPELAQKLHEAPRKPFTLAPLP---GTLRLRLTTLDDGLFAPFLRALSSYRLARVLATREG----------HPLAGATSWEELKEAPKREKATFRFLTPTVFATKTRYTPLPDPRLIAGSLLDKWQAHSPFPYNPKEEAALRELFEVAGFRNLRFHRVQAGKGFFPGFTGEATLRLWSSLEAQEALGRLHALAFFSGVGAKTPYGMGLAVPL------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.43

Estimated TM-score = 0.54±0.15

Estimated RMSD = 9.5±4.6Å

Download Model 2

C-score=-2.28

Download Model 3

C-score=-2.24

Download Model 4

C-score=-3.16

Download Model 5

C-score=-2.93

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2wx7A	0.390	6.09	0.072	0.605
2	1hbnB	0.389	6.15	0.055	0.643
3	1jroB	0.382	5.98	0.076	0.618
4	2sliA	0.367	7.12	0.053	0.672
5	1kekA	0.366	6.40	0.047	0.615
6	1ahvA	0.362	5.56	0.027	0.557
7	1ka4A	0.354	6.42	0.037	0.583
8	2iidA	0.354	6.23	0.054	0.570
9	2e9bA	0.354	6.27	0.051	0.583
10	2exrA	0.354	6.19	0.049	0.580

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.12	6	1hbnB	TP7	Rep, Mult	89,90,95,105,106
2	0.08	4	3qjjA	NUC	Rep, Mult	59,76,77,78,110,111,112,113,114,121,185,197,198,199,244,245,246,247,254,256,259,260,261,284,300,301
3	0.08	3	4c9dB	NUC	Rep, Mult	83,99,101,102,104,192,193,194,195,196,197,198,205,206,210,213,247,252,253,255,256,289,290,291,293,294
4	0.06	3	2c3oA	SF4	Rep, Mult	185,203,207,208,209,288,289,290,298,299
5	0.04	2	3qjlA	NUC	Rep, Mult	59,112,113,114,121,163,175,176,185,187,203,241,242,243,261,300,302,303
6	0.03	1	4c8yA	NUC	Rep, Mult	80,81,83,84,85,87,91,96,99,100,101,102,103,104,146,148,192,193,205,206,209,210,213,289,290,291,293
7	0.02	1	3qjlA	NUC	Rep, Mult	76,77,78,110,111,197,198,199,244,245,246,247,254,256
8	0.02	1	2zozA	ET	Rep, Mult	98,99
9	0.02	1	1hbnB	UUU	Rep, Mult	214,218,219,220
10	0.02	1	1bjyA	CTC	Rep, Mult	82,86
11	0.02	1	2fuqA	ZN	Rep, Mult	56,67,99
12	0.02	1	1mroB	COM	Rep, Mult	282,286,288

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1sllA	0.368	7.02	0.061	0.666	4.2.2.15	NA
2	0.060	1hbmB	0.391	6.28	0.064	0.650	2.8.4.1	NA
3	0.060	2e9bA	0.354	6.27	0.051	0.583	3.2.1.41	NA
4	0.060	1f1hL	0.353	6.07	0.029	0.560	6.3.1.2	NA
5	0.060	2j5nB	0.350	6.54	0.034	0.602	1.5.1.12	214
6	0.060	1st8A	0.346	7.18	0.044	0.634	3.2.1.80	NA
7	0.060	1lgrA	0.341	6.28	0.030	0.557	6.3.1.2	NA
8	0.060	2e8yA	0.362	6.03	0.041	0.580	3.2.1.41	NA
9	0.060	1sliA	0.364	7.09	0.053	0.666	4.2.2.15,3.2.1.18	NA
10	0.060	1djnA	0.351	6.79	0.054	0.637	1.5.8.2,1.5.99.7	NA
11	0.060	1s76D	0.296	6.99	0.054	0.535	2.7.7.6	NA
12	0.060	2pdaA	0.368	6.44	0.047	0.618	1.2.7.1	200
13	0.060	1o01C	0.347	6.78	0.054	0.615	1.2.1.3	121
14	0.060	2wvhA	0.351	6.99	0.036	0.634	4.1.1.1	234
15	0.060	1htoA	0.347	6.41	0.040	0.576	6.3.1.2	NA
16	0.060	1l2aE	0.343	6.44	0.040	0.573	3.2.1.4	NA
17	0.060	1aroP	0.336	6.38	0.041	0.564	2.7.7.6	NA
18	0.060	1b0pA	0.368	6.57	0.038	0.621	1.2.7.1	NA
19	0.060	1xc6A	0.325	6.69	0.040	0.567	3.2.1.23	65,84

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.14	0.391	6.26	0.03	0.65	3sqgB	GO:0015948 GO:0016740 GO:0050524
1	0.11	0.396	6.37	0.06	0.66	1e6vB	GO:0015948 GO:0050524
2	0.10	0.403	6.01	0.05	0.65	1e6yE	GO:0015948 GO:0016740 GO:0050524
3	0.06	0.400	6.03	0.07	0.62	4g2cB	GO:0004601 GO:0005576 GO:0016491 GO:0016689 GO:0020037 GO:0030145 GO:0046872 GO:0052750 GO:0055114 GO:0098869
4	0.06	0.419	6.15	0.07	0.66	5c2iA	GO:0004601 GO:0020037 GO:0055114 GO:0098869
5	0.06	0.387	5.89	0.06	0.61	4gs1B	GO:0004601 GO:0020037 GO:0046872 GO:0055114 GO:0098869
6	0.06	0.386	6.04	0.07	0.62	4gt2A	GO:0004601 GO:0005623 GO:0015684 GO:0020037 GO:0033212 GO:0046872 GO:0055114 GO:0098869
7	0.06	0.382	6.08	0.08	0.61	5fw4A	GO:0004096 GO:0004601 GO:0005576 GO:0016491 GO:0020037 GO:0046872 GO:0055114 GO:0098869
8	0.06	0.396	6.06	0.03	0.65	3fahA	GO:0009055 GO:0016491 GO:0033727 GO:0046872 GO:0051536 GO:0051537 GO:0055114
9	0.06	0.375	6.40	0.05	0.62	4grcA	GO:0004601 GO:0005623 GO:0015684 GO:0020037 GO:0033212 GO:0046872 GO:0055114 GO:0098869
10	0.06	0.398	6.33	0.06	0.64	2y4eA	GO:0004601 GO:0006974 GO:0015684 GO:0016491 GO:0016675 GO:0020037 GO:0033212 GO:0042597 GO:0046872 GO:0055114 GO:0098869
11	0.06	0.393	6.19	0.06	0.65	5a0yB	GO:0015948 GO:0016740 GO:0050524
12	0.06	0.375	6.35	0.07	0.60	3qnsA	GO:0004601 GO:0020037 GO:0046872 GO:0055114 GO:0098869
13	0.06	0.382	5.98	0.08	0.62	1jroB	GO:0016491 GO:0030151 GO:0046872 GO:0055114
14	0.06	0.339	7.17	0.03	0.63	1ffuB	GO:0005507 GO:0016491 GO:0018492 GO:0030151 GO:0046872 GO:0055114
15	0.06	0.339	6.77	0.05	0.60	1fo4A	GO:0003824 GO:0004854 GO:0004855 GO:0005506 GO:0005576 GO:0005615 GO:0005737 GO:0005777 GO:0005829 GO:0009055 GO:0009115 GO:0016491 GO:0016614 GO:0016903 GO:0043546 GO:0046872 GO:0050660 GO:0051536 GO:0051537 GO:0055114
16	0.06	0.361	5.99	0.08	0.57	4au9A	GO:0004601 GO:0016491 GO:0020037 GO:0046872 GO:0055114 GO:0098869
17	0.06	0.359	5.97	0.04	0.56	3afvA	GO:0004601 GO:0020037 GO:0046872 GO:0055114 GO:0098869
18	0.06	0.370	6.30	0.05	0.58	4gu7A	GO:0004601 GO:0020037 GO:0046872 GO:0055114 GO:0098869

Consensus prediction of GO terms

Molecular Function	GO:0050524
GO-Score	0.31
Biological Processes	GO:0015948
GO-Score	0.31
Cellular Component	GO:0005576
GO-Score	0.07

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.