I-TASSER results

I-TASSER results for job id Rv2823c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (809 residues)
MNPQLIEAIIGCLLHDIGKPVQRAALGYPGRHSAIGRAFMKKVWLRDSRNPSQFTDEVDE
ADIGVSDRRILDAISYHHSSALRTAAENGRLAADAPAYIAYNIAAGTDRRKADSDDGHGA
STWDPDTPLYSMFNRFGSGTANLAFAPEMLDDRKPINIPSPRRIEFDKDRYAAIVNKLKA
ILVDLERSDTYLASLLNVLEATLSFVPSSTDASEVVDVSLFDHLKLTGALGACIWHYLQA
TGQSDFKSALFDKQDTFYNEKAFLLTTFDVSGIQDFIYTIHSSGAAKMLRARSFYLEMLT
EHLIDELLARVGLSRANLNYSGGGHAYLLLPNTESARKSVEQFEREANDWLLENFATRLF
IATGSVPLAANDLMRRPNESASQASNRALRYSGLYRELSEQLSAKKLARYSADQLRELNS
RDHDGQKGDRECSVCHTVNRTVSADDEPKCSLCQALTAASSQIQSESRRFLLISDGATKG
LPLPFGATLTFCSRADADKALQQPQTRRRYAKNKFFAGECLGTGLWVGDYVAQMEFGDYV
KRASGIARLGVLRLDVDNLGQAFTHGFMEQGNGKFNTISRTAAFSRMLSLFFRQHINYVL
ARPKLRPITGDDPARPREATIIYSGGDDVFVVGAWDDVIEFGIELRERFHEFTQGKLTVS
AGIGMFPDKYPISVMAREVGDLEDAAKSLPGKNGVALFDREFTFGWDELLSKVIEEKYRH
IADYFSGNEERGMAFIYKLLELLAERDDRITKARWVYFLTRMRNPTGDTAPFQQFANRLH
QWFQDPTDAKQLKTALHLYIYRTRKEESE

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MNPQLIEAIIGCLLHDIGKPVQRAALGYPGRHSAIGRAFMKKVWLRDSRNPSQFTDEVDEADIGVSDRRILDAISYHHSSALRTAAENGRLAADAPAYIAYNIAAGTDRRKADSDDGHGASTWDPDTPLYSMFNRFGSGTANLAFAPEMLDDRKPINIPSPRRIEFDKDRYAAIVNKLKAILVDLERSDTYLASLLNVLEATLSFVPSSTDASEVVDVSLFDHLKLTGALGACIWHYLQATGQSDFKSALFDKQDTFYNEKAFLLTTFDVSGIQDFIYTIHSSGAAKMLRARSFYLEMLTEHLIDELLARVGLSRANLNYSGGGHAYLLLPNTESARKSVEQFEREANDWLLENFATRLFIATGSVPLAANDLMRRPNESASQASNRALRYSGLYRELSEQLSAKKLARYSADQLRELNSRDHDGQKGDRECSVCHTVNRTVSADDEPKCSLCQALTAASSQIQSESRRFLLISDGATKGLPLPFGATLTFCSRADADKALQQPQTRRRYAKNKFFAGECLGTGLWVGDYVAQMEFGDYVKRASGIARLGVLRLDVDNLGQAFTHGFMEQGNGKFNTISRTAAFSRMLSLFFRQHINYVLARPKLRPITGDDPARPREATIIYSGGDDVFVVGAWDDVIEFGIELRERFHEFTQGKLTVSAGIGMFPDKYPISVMAREVGDLEDAAKSLPGKNGVALFDREFTFGWDELLSKVIEEKYRHIADYFSGNEERGMAFIYKLLELLAERDDRITKARWVYFLTRMRNPTGDTAPFQQFANRLHQWFQDPTDAKQLKTALHLYIYRTRKEESE
Prediction	CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEEHCCHHHHEEHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHCCCEEEEEHCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEHCCCCCCCCHCCCCCEEEEHCCCCHHHHHHCCHHHHHHHHCCCCCCCHHHCCCCCCCCCCHHCHHHHHHHCCCCCEEEEEEEHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCC
Conf.Score	96789999999988776555443899887756788899988765555556789999998765677789999999998575556777766546788999999877654444555566666666666665456677647887766667545776777788886655555899999999999999985765679999999999998758888888889887799999999999999999998567656889988665456677758999998565444445546755788899999999999999999999998998654787679959999768789999999999999999999986647888876666788987655444555555566799999999999999998757677888876566777777655544687666666776557799999999998887655546775677766644566756887646655666655546677765555555444446556656545458999987578767999999566589999997556666666889999999999999999999999998655554444455667779999778759998738999999999999999998999679999999779877999999999999999866898779996776576478888888999999999999875665478999999999997556678999999999755555579999999999999868677899999999999998675559
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MNPQLIEAIIGCLLHDIGKPVQRAALGYPGRHSAIGRAFMKKVWLRDSRNPSQFTDEVDEADIGVSDRRILDAISYHHSSALRTAAENGRLAADAPAYIAYNIAAGTDRRKADSDDGHGASTWDPDTPLYSMFNRFGSGTANLAFAPEMLDDRKPINIPSPRRIEFDKDRYAAIVNKLKAILVDLERSDTYLASLLNVLEATLSFVPSSTDASEVVDVSLFDHLKLTGALGACIWHYLQATGQSDFKSALFDKQDTFYNEKAFLLTTFDVSGIQDFIYTIHSSGAAKMLRARSFYLEMLTEHLIDELLARVGLSRANLNYSGGGHAYLLLPNTESARKSVEQFEREANDWLLENFATRLFIATGSVPLAANDLMRRPNESASQASNRALRYSGLYRELSEQLSAKKLARYSADQLRELNSRDHDGQKGDRECSVCHTVNRTVSADDEPKCSLCQALTAASSQIQSESRRFLLISDGATKGLPLPFGATLTFCSRADADKALQQPQTRRRYAKNKFFAGECLGTGLWVGDYVAQMEFGDYVKRASGIARLGVLRLDVDNLGQAFTHGFMEQGNGKFNTISRTAAFSRMLSLFFRQHINYVLARPKLRPITGDDPARPREATIIYSGGDDVFVVGAWDDVIEFGIELRERFHEFTQGKLTVSAGIGMFPDKYPISVMAREVGDLEDAAKSLPGKNGVALFDREFTFGWDELLSKVIEEKYRHIADYFSGNEERGMAFIYKLLELLAERDDRITKARWVYFLTRMRNPTGDTAPFQQFANRLHQWFQDPTDAKQLKTALHLYIYRTRKEESE
Prediction	65442120000000001000000043535550342034004422443322122013202444453434202400330034425534444412442022102302222434544555544443344422021002304474442312244044545141145643623462034005303630561544541041001000000000000134462200000000000000000001002444353134412444453343210000003122014101314444003201000000000021003200641702310000110100000002164035205401530241015313110100001130305202444444244334333302400430053035402430436324402432454444523031033344435456541151042024025303534330112343444301001222011134343452254641331123243323431243021343243340441054344220000000000200310240044644542210420230041013002410330054343443445443453100000001000000000320030033005103611464000000000011110012005203500540173641100000135230303302441145004202510465462121001101300341463131010000013035455545204401520251044463233011001000022155568
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560                 580                 600                 620                 640                 660                 680                 700                 720                 740                 760                 780                 800

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Sec.Str
Seq

CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEEHCCHHHHEEHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHCCCEEEEEHCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEHCCCCCCCCHCCCCCEEEEHCCCCHHHHHHCCHHHHHHHHCCCCCCCHHHCCCCCCCCCCHHCHHHHHHHCCCCCEEEEEEEHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCC
MNPQLIEAIIGCLLHDIGKPVQRAALGYPGRHSAIGRAFMKKVWLRDSRNPSQFTDEVDEADIGVSDRRILDAISYHHSSALRTAAENGRLAADAPAYIAYNIAAGTDRRKADSDDGHGASTWDPDTPLYSMFNRFGSGTANLAFAPEMLDDRKPINIPSPRRIEFDKDRYAAIVNKLKAILVDLERSDTYLASLLNVLEATLSFVPSSTDASEVVDVSLFDHLKLTGALGACIWHYLQATGQSDFKSALFDKQDTFYNEKAFLLTTFDVSGIQDFIYTIHSSGAAKMLRARSFYLEMLTEHLIDELLARVGLSRANLNYSGGGHAYLLLPNTESARKSVEQFEREANDWLLENFATRLFIATGSVPLAANDLMRRPNESASQASNRALRYSGLYRELSEQLSAKKLARYSADQLRELNSRDHDGQKGDRECSVCHTVNRTVSADDEPKCSLCQALTAASSQIQSESRRFLLISDGATKGLPLPFGATLTFCSRADADKALQQPQTRRRYAKNKFFAGECLGTGLWVGDYVAQMEFGDYVKRASGIARLGVLRLDVDNLGQAFTHGFMEQGNGKFNTISRTAAFSRMLSLFFRQHINYVLARPKLRPITGDDPARPREATIIYSGGDDVFVVGAWDDVIEFGIELRERFHEFTQGKLTVSAGIGMFPDKYPISVMAREVGDLEDAAKSLPGKNGVALFDREFTFGWDELLSKVIEEKYRHIADYFSGNEERGMAFIYKLLELLAERDDRITKARWVYFLTRMRNPTGDTAPFQQFANRLHQWFQDPTDAKQLKTALHLYIYRTRKEESE

4uw2A

0.27

0.22

0.82

2.60

MUSTER

IDE---LTALGGLLHDIGKPVQRAGL-YSGDHSTQGARFLRDLAENTGRAEYELLSLFSEFNDELIR-----------RIKELSGLTEDVLNALWIVYEADNLASGQPQ---------------ASRPLYSVFN------PGKAYPWAELDFEKELPVPG-DVFSIRSQDYRELVKRLWEELSKAKLR---SDRLLPVLEKYLTFVSSVTS--EGNIISLYDHR--TSAIALALRAG----------------CTAERKEKRFLLIEGDFSGIQDFIYRVSGKGTLKYLRARSAYLELIGWDVVLEILSRLGLTRANVVFNAGGHFIIAQ-NTPDAVKELEEIRAKAVEWLYREFESDLYLAIEWEPVSGREFGREGGK---------NLFAEARKRLKHKLTVRKLKNLPKLLGFGRTAKNDAGVLVEGPFSGFVPYP---------------------------VGEQILVKNTLNPGEIPESAQFVPYFVAD----------------------------YFKKDPKGGVATFEELSA-STGTRR-LGVKGDVDRLGEFFSSDS-----------PSKLATASRFDYFFKGYIGAIIEGKFGYIIGLRDWPEEPDIVVVYAGGDDFFIVGAWDQIFELAFRVRRAFNAYTGGKLTLSVGLGYFDERTPIYR-ADVVSERLDTAKDE-GRNRVFVVGRKLSYEWNHYEELWRTYAPRIYAGRLKGKLESKKGLLWKLLEIRELYVRDPNDVRWAYLTAYLLGRHGLSDLFPEVGIDTKAVERKEPQPVYWVDGVLKIVLAVRR----

4uw2A

0.26

0.22

0.83

3.00

dPPAS

-AEIDELTALGGLLHDIGKPVQRAGL-YSGDHSTQGARFLRDLAENTGRAEYELLSLFSEFNDELIR-----------RIKELSGLTEDVLNALWIVYEADNLASGQPQASRPL---------------------YSVFNPGKAYPWAELDFEKELPVPG-DVFSIRSQDYRELVKRLWEELSKAKLR---SDRLLPVLEKYLTFVSSVTS--EGNIISLYDHR--TSAIALALRAGCT----------------AERKEKRFLLIEGDFSGIQDFIYRVSGKGTLKYLRARSAYLELIGWDVVLEILSRLGLTRANVVFNAGGHFIIAQ-NTPDAVKELEEIRAKAVEWLYREFESDLYLAIEWEPVSGREFGREGGK---------NLFAEARKRLKHKLTVRKLKNLPKLLGFGRTAKNDAGVLVEGPFSGFVPYPVGE----------------------------QILVKNTLNPGEIPESAQFVPYFVAD---------------------------YFKKDPKGGVATFEELSASTGTRR--LGVKGDVDRLGEFFS----------SDSPSKLATASRFDYFFKGYIGAIIEGYIIGDVPSLRDWPEEPDIVVVYAGGDDFFIVGAWDQIFELAFRVRRAFNAYTGGKLTLSVGLGYFDERTPIYR-ADVVSERLDTAKDE-GRNRVFVVGRKLSYEWNHYEELWRTYAPRIYAGRLKGKLESKKGLLWKLLEIRELYVRDPNDVRWAYLTAYLLGRHGSDLFPELVGIDTKAVERKEPQPVYWVDGVLKIVLAVRR----

4uw2A

0.27

0.22

0.82

5.37

wdPPAS

-AEIDELTALGGLLHDIGKPVQRAGL-YSGDHSTQGARFLRDLAENT----------------GRAEYELLSLFSEFNDELIRSGLTEDVLNALWIVYEADNLASGQPQA---------------SRPLYSVF------NPGKAYPWAELDFEKELPVPGDV-FSIRSQDYRELVKRLWEELSKAKLR---SDRLLPVLEKYLTFVSSVTS--EGNIISLYDHRTSAIALALRAG------------------CTAERKEKRFLLIEGDFSGIQDFIYRVSGKGTLKYLRARSAYLELIGWDVVLEILSRLGLTRANVVFNAGGHFIIAQN-TPDAVKELEEIRAKAVEWLYREFESDLYLAIEWEPVSGREFGREGGK---------NLFAEARKRLKHKLTVRKLKNLP--------KLLGFGRTAKNDAGVLVEGPFSGFVPYP-------------------VGEQILVKNTLNPGEIPESAQFVPYFVA----------------------------DYFKKDPKGGVATFEELSASTGTR--RLGVKGDVDRLGEFFSS----------DSPSKLATASRFDYFFKGYIGAIIEGYIIGDVPSLRDWPEEPDIVVVYAGGDDFFIVGAWDQIFELAFRVRRAFNAYTGGKLTLSVGLGYFDERTPIYR-ADVVSERLDTAKDE-GRNRVFVVGRSRSYEWNHYEELWRTYAPRIYAGRLKGKLESKKGLLWKLLEIRELYVRDPNDVRWAYLTAYLLGRHGSDLFPELVGIDTKAVERKEPQPVYWVDGVLKIVLAVRR----

4uw2A

0.28

0.23

0.82

3.03

wMUSTER

IDE---LTALGGLLHDIGKPVQRAGL-YSGDHSTQGARFLRDLAEN----------------TGRAEYELLSLFSEFNDELIRRIKEEDVLNALWIVYEADNLASGQPQAS---------------RPLYSVFN------PGKAYPWAELDFEKELPVPG-DVFSIRSQDYRELVKRLWEELSKAKLR---SDRLLPVLEKYLTFVSSVTS--EGNIISLYDHRTSAIALALRAG------------------CTAERKEKRFLLIEGDFSGIQDFIYRVSGKGTLKYLRARSAYLELIGWDVVLEILSRLGLTRANVVFNAGGHFIIAQN-TPDAVKELEEIRAKAVEWLYREFESDLYLAIEWEPVSGREFGREGGK---------NLFAEARKRLKHKLTVRKLKNLPK--LLGFGRTAKNDAGVLVEGPFSGFVPYPVGE-------------------------QILVKNTLNPGEIPESAQFVPYFVADYFKK----------------------------DPKGGVATFEELSA-STGTRR-LGVKGDVDRLGEFFSSDS-----------PSKLATASRFDYFFKGYIGAIIEGKFGYIIGLRDWPEEPDIVVVYAGGDDFFIVGAWDQIFELAFRVRRAFNAYTGGKLTLSVGLGYFDERTPIYR-ADVVSERLDTAKDE-GRNRVFVVGRKLSYEWNHYEELWRTYAPRIYAGRLKGKLESKKGLLWKLLEIRELYVRDPNDVRWAYLTAYLLGRHGLSDLFPEVGIDTKAVERKEPQPVYWVDGVLKIVLAVRR----

4uw2A

0.27

0.22

0.82

6.23

wPPAS

IDE---LTALGGLLHDIGKPVQRAGL-YSGDHSTQGARFLRDLAENT----------------GRAEYELLSLFSEFNDELIRSGLTEDVLNALWIVYEADNLASGQPQAS---------------RPLYSVFN------PGKAYPWAELDFEKELPVPGDV-FSIRSQDYRELVKRLWEELSKAKLR---SDRLLPVLEKYLTFVSSVTS--EGNIISLYDHRTSAIALALRAGC------------------TAERKEKRFLLIEGDFSGIQDFIYRVSGKGTLKYLRARSAYLELIGWDVVLEILSRLGLTRANVVFNAGGHFIIAQN-TPDAVKELEEIRAKAVEWLYREFESDLYLAIEWEPVSGREFGREGGK---------NLFAEARKRLKHKLTVRKLKNLP--------KLLGFGRTAKNDAGVLVEGPFSGFVPYP-------------------VGEQILVKNTLNPGEIPESAQFVPYFVA----------------------------DYFKKDPKGGVATFEELSA-STGTRR-LGVKGDVDRLGEFFSSDS-----------PSKLATASRFDYFFKGYIGAIIEGKFGYIIGLRDWPEEPDIVVVYAGGDDFFIVGAWDQIFELAFRVRRAFNAYTGGKLTLSVGLGYFDERTPIYR-ADVVSERLDTAKD-EGRNRVFVVGRSRSYEWNHYEELWRTYAPRIYAGRLKGKLESKKGLLWKLLEIRELYVRDPNDVRWAYLTAYLLGRHGSDLFPELVGIDTKAVERKEPQPVYWVDGVLKIVLAVRR----

4uw2A

0.27

0.22

0.83

9.13

dPPAS2

-AEIDELTALGGLLHDIGKPVQRAGL-YSGDHSTQGARFLRDLAENTGRAEYELLSLFSEFNDELIR-----------RIKELSGLTEDVLNALWIVYEADNLASGQPQ---------------ASRPLYSVF------NPGKAYPWAELDFEKELPVPG-DVFSIRSQDYRELVKRLWEELSKAKLR---SDRLLPVLEKYLTFVSSVTS--EGNIISLYDHR--TSAIALALRAGCT----------------AERKEKRFLLIEGDFSGIQDFIYRVSGKGTLKYLRARSAYLELIGWDVVLEILSRLGLTRANVVFNAGGHFIIAQ-NTPDAVKELEEIRAKAVEWLYREFESDLYLAIEWEPVSGREFGREGGK---------NLFAEARKRLKHKLTVRKLKNLP--------KLLGFGRTAKNDAGVLVEGPFSGFVPYP-------------------VGEQILVKNTLNPGEIPESAQFVPYFVADY----------------------------FKKDPKGGVATFEELSA-STGTRR-LGVKGDVDRLGEFFS----------SDSPSKLATASRFDYFFKGYIGAIIEGYIIGDVPSLRDWPEEPDIVVVYAGGDDFFIVGAWDQIFELAFRVRRAFNAYTGGKLTLSVGLGYFDERTPIYR-ADVVSERLDTAKDE-GRNRVFVVGRKLSYEWNHYEELWRTYAPRIYAGRLKGKLESKKGLLWKLLEIRELYVRDPNDVRWAYLTAYLLGRHGSDLFPELVGIDTKAVERKEPQPVYWVDGVLKIVLAVRR----

4uw2A

0.27

0.22

0.82

4.93

PPAS

IDE---LTALGGLLHDIGKPVQRAGLY-SGDHSTQGARFLRDLAEN----------------TGRAEYELLSLFSEFNDELIRSGLTEDVLNALWIVYEADNLASGQPQAS---------------RPLYSVFN------PGKAYPWAELDFEKELPVPG-DVFSIRSQDYRELVKRLWEELSKAKLR---SDRLLPVLEKYLTFVSSVTS--EGNIISLYDH--RTSAIALALRAGCT----------------AERKEKRFLLIEGDFSGIQDFIYRVSGKGTLKYLRARSAYLELIGWDVVLEILSRLGLTRANVVFNAGGHFIIAQN-TPDAVKELEEIRAKAVEWLYREFESDLYLAIEWEPVSGREFGREGGK---------NLFAEARKRLKHKLTVRKLKNLP--------KLLGFGRTAKNDAGVLVEGPFSGFVPYP-------------------VGEQILVKNTLNPGEIPESAQFVPYFVA----------------------------DYFKKDPKGGVATFEELSA-STGTRR-LGVKGDVDRLGEFFSSDS-----------PSKLATASRFDYFFKGYIGAIIEGKFGYIIGLRDWPEEPDIVVVYAGGDDFFIVGAWDQIFELAFRVRRAFNAYTGGKLTLSVGLGYFDERTPIYR-ADVVSERLDTAKD-EGRNRVFVVGRKLSYEWNHYEELWRTYAPRAGNGRLKGKLESKKGLLWKLLEIRELYVRDPNDVRWAYLTAYLLGRHGSDLFPELVGIDTKAVERKEPQPVYWVDGVLKIVLAVRR----

4uw2A

0.27

0.22

0.82

9.20

Env-PPAS

-AEIDELTALGGLLHDIGKPVQRAGLYS-GDHSTQGARFLRDLAEN----------------TGRAEYELLSLFSEFNDELIRRIKTEDVLNALWIVYEADNLASGQPQASR---------------PLYSVFNPG------KAYPWAELDFEKELPVPGDV-FSIRSQDYRELVKRLWEELSKAKL---RSDRLLPVLEKYLTFVSSVTS--EGNIISLYDH--RTSAIALALRAGCT----------------AERKEKRFLLIEGDFSGIQDFIYRVSGKGTLKYLRARSAYLELIGWDVVLEILSRLGLTRANVVFNAGGHFIIAQN-TPDAVKELEEIRAKAVEWLYREFESDLYLAIEWEPVSGREFGREGGK---------NLFAEARKRLKHKLTVRKLKNLPKLLGFGRTAKNDAGVLVEGPFSGFVPYPVGE---------------------------QILVKNTLNPGEIPESAQFVPYFVADY----------------------------FKKDPKGGVATFEELSA-STGTRR-LGVKGDVDRLGEFFSSDS-----------PSKLATASRFDYFFKGYIGAIIEGKFGYIISLRDWPEEPDIVVVYAGGDDFFIVGAWDQIFELAFRVRRAFNAYTGGKLTLSVGLGYFDERTPIYR-ADVVSERLDTAKDE-GRNRVFVVGRSRSYEWNHYEELWRTYAPRIYAGRLKGKLESKKGLLWKLLEIRELYVRDPNDVRWAYLTAYLLGRHGSDLFPELVGIDTKAVERKEPQPVYWVDGVLKIVLAVRR----

4w8yA

0.15

0.14

0.89

1.97

MUSTER

MVN--IKEKLFVYLHDPDKAL------KIENHEERSKKILSSGNIQDKVKQADALSSKTQRFIIREPV----------IDFLGRFHVGYPVFIHPISTEIKRYETLEKYIDLGRSNRGERFVNEFLERVSKLEGDV----------LKEVFEDASNKF-KGEESKQWAYIWQFYPVKLKEGVKEFAKSEKLKEEEAEKFAEEFVNLPADT---RFPDHAIWTHLDLTSALS----------------------------VKDPTLLRIKIVPVQPFIANSRK---QLDLWASSHLLSMLMYKALEVIVDKFGIGDEILVANLPNKALAIVSG-KEAEKIEEEIKKRIRDFLLQLYREYFTVSITWVSLSIYQVTENAGLSDEDVKKWLKFAEKKEERIAIYPLLVKILDSLGERKVTEERFEKSEQLKGWKCHVCGENLAIFGDMYEPLCPMCLIKRYYPVWIRSKTGQKI-RFESVVDVALLYKNWRKIFDEKYGKDLVSKAREVSEDFVKDNMLVDSSTWESGLSIDEEKVKEVVDFLNAANPPKYYAILVMDGDDMGKVISGEVLGPEAKYYSTPQVHVAISQALANFSIREVRSVVK---------------DEGLLIYAGGDDVLAILPVDKALEVAYKIRKEFGKSFENGWKLSAGILIVHYKHPLYDALEKARDLLNNKKNVPGKDTLAIGLLKRSGSYYISL--VGWELIRVFYNS-ELRKKLLERFIYHVLREVDTWP---IDEMLKFEVIRHI-KEETKELREKIYGEIKDLLEHGNNEVEKVRGLFTFLKIITDAEVF

4w8yA

0.14

0.13

0.90

2.17

dPPAS

--MVNIKEKLFVYLHD-----PPDKALKIENHEERSKKILSSGNIQDKVKQADALSSKTQRFIIREPVIDFLGRFH--VGYPVFIHPISTEIKRYETLEKYIDLGRSNRGERFVNEFLERVSKLEGDVLKEVFEDASNKFKGE----------------ESKQWAYIWQFYPVKLKEGVKEFAKSELK--LKEEEAEKFAEEFVNLPADT---RFPDHAIWTHLDLTSALS----------------------------VKDPTLLRIKIVPVQPFIANSRK---QLDLWASSHLLSMLMYKALEVIVDKFGIGDEILVANLPNKALAIVSGK-EAEKIEEEIKKRIRDFLLQLYREYFTVSITWVSLSIYQVTENAGLSDEDVKKWLKFAEKKENRIAIYPLLVKILDSLGERKVTEERFEKSEQLKGWKCHVCGENLAIFGDMYDHDNLKSLWLDEPMCLIKRYYPVWIRSKTGQKIRFESVVDVALLYKNWRKIFDEKYGKDLVSKAREVSEDFYSSTWESGLSIDEEKVKEVVDFLNAANPPKYYAILVMDGDDMGKVISGEVLGPEAKYYSTPQVHVAISQALANFSIREVRSVVK---------------DEGLLIYAGGDDVLAILPVDKALEVAYKIRKEFGKSFLPGWKLSAGILIVHYKHPLYDALEKARDLLNNKKNVPGKDTLAIGLLKRSGSYYISLVGWELIRVFYNSELRKK---LLERFIYHVLREVDTWPIDEMLKFEVIRHIKEETKELREKIYGEIKDLLEHVRGN--NEVEKVRGLFTFLKIITDAEVF

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.21

Estimated TM-score = 0.69±0.12

Estimated RMSD = 8.9±4.6Å

Download Model 2

C-score=-1.54

Download Model 3

C-score=-2.88

Download Model 4

C-score=-1.65

Download Model 5

C-score=-1.59

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4uw2A	0.793	1.81	0.279	0.816
2	4w8yA	0.601	5.08	0.132	0.712
3	3ungC	0.417	3.84	0.173	0.467
4	5dkxA	0.358	8.45	0.050	0.569
5	3tonA	0.357	8.14	0.041	0.548
6	3l4uA	0.354	8.38	0.033	0.557
7	4kmqA	0.353	8.86	0.050	0.577
8	3lpoA	0.352	8.32	0.039	0.554
9	5f0eA	0.345	8.53	0.053	0.550
10	1llwA	0.343	8.63	0.045	0.554

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.12	7	3ur3C	CA	Rep, Mult	555,627,628
2	0.10	6	4h54B	MG	Rep, Mult	555,556,557,627,687
3	0.08	5	4h4kC	ATP	Rep, Mult	273,274,277,293,296,297,322,324,623,628
4	0.07	4	1ea0A	F3S	Rep, Mult	643,644,645,646,648,659
5	0.03	2	1n38A	CH1	Rep, Mult	536,537,549,550,551,552
6	0.02	1	3w2wA	ATP	Rep, Mult	325,555,556,557,558,559,560,563,581,588,687,692
7	0.02	1	1ofdB	F3S	Rep, Mult	307,313,314,315,316,319,329
8	0.02	1	1llwA	F3S	Rep, Mult	552,660,661,662,663,683
9	0.02	1	1n1hA	MN	Rep, Mult	269,270,271,403
10	0.02	1	1lm1A	F3S	Rep, Mult	631,632,633,634,635,636,663,664
11	0.02	1	3ungC	ZN	Rep, Mult	432,435,450,453

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3b9jJ	0.170	7.26	0.032	0.248	1.17.1.4,1.17.3.2	264
2	0.060	3iayA	0.311	8.64	0.040	0.499	2.7.7.7	NA
3	0.060	3ecqB	0.313	8.91	0.039	0.514	3.2.1.97	NA
4	0.060	2gbcA	0.294	8.41	0.038	0.466	3.4.14.5,3.4.15.5	636,637
5	0.060	2qtcB	0.300	7.94	0.048	0.456	1.2.4.1	104
6	0.060	2fhbA	0.335	8.29	0.058	0.514	3.2.1.41	NA
7	0.060	1z0hB	0.187	7.42	0.022	0.274	3.4.24.69	NA
8	0.060	1l8aA	0.295	8.42	0.030	0.464	1.2.4.1	NA
9	0.060	2g3mF	0.303	8.02	0.050	0.465	3.2.1.20	NA
10	0.060	2zxqA	0.335	8.49	0.049	0.528	3.2.1.97	NA
11	0.060	1orvA	0.286	8.76	0.039	0.472	3.4.14.5	NA
12	0.060	3b9jI	0.100	5.64	0.078	0.127	1.17.1.4,1.17.3.2	322,326
13	0.060	2hpiA	0.299	8.29	0.056	0.461	2.7.7.7	581,651
14	0.060	3hkzJ	0.297	8.75	0.047	0.483	2.7.7.6	583
15	0.060	1ea0A	0.335	8.45	0.045	0.534	1.4.1.13	NA
16	0.060	2ckjA	0.290	8.90	0.034	0.478	1.17.1.4,1.17.3.2	NA
17	0.060	2vuaA	0.181	7.09	0.071	0.258	3.4.24.69	460
18	0.060	1n1hA	0.337	8.83	0.030	0.549	2.7.7.48	436
19	0.060	2g25A	0.315	7.95	0.048	0.477	1.2.4.1	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.18	0.435	3.73	0.18	0.48	4dozA	GO:0000166 GO:0003723 GO:0005737 GO:0046872 GO:0051607
1	0.13	0.413	4.81	0.15	0.48	3x1lA	GO:0000166 GO:0003723 GO:0005737 GO:0046872 GO:0051607
2	0.12	0.452	4.16	0.17	0.51	3w2wA	GO:0000166 GO:0003723 GO:0005737 GO:0046872 GO:0051607
3	0.07	0.601	5.08	0.13	0.71	4w8yA	GO:0000166 GO:0003723 GO:0005737 GO:0046872 GO:0051607
4	0.06	0.213	7.08	0.05	0.30	3wfoB	GO:0000166 GO:0003723 GO:0005524 GO:0006396 GO:0016740 GO:0016779
5	0.06	0.192	7.32	0.03	0.27	1e3dB	GO:0008901 GO:0016151 GO:0016491 GO:0046872 GO:0055114
6	0.06	0.201	7.19	0.06	0.29	4xeaA	GO:0003824 GO:0046872
7	0.06	0.146	6.93	0.04	0.20	2ol2A	GO:0001972 GO:0002020 GO:0002080 GO:0004867 GO:0005539 GO:0005576 GO:0005615 GO:0006810 GO:0006869 GO:0007283 GO:0007338 GO:0007342 GO:0007596 GO:0008201 GO:0009897 GO:0010466 GO:0010951 GO:0016020 GO:0030414 GO:0031091 GO:0031094 GO:0031210 GO:0032190 GO:0036024 GO:0036025 GO:0036026 GO:0036027 GO:0036028 GO:0036029 GO:0036030 GO:0043234 GO:0045861 GO:0051346 GO:0070062 GO:0097181 GO:0097182 GO:0097183
8	0.06	0.159	7.12	0.04	0.23	3eu7A	GO:0000724 GO:0000731 GO:0000732 GO:0001701 GO:0001756 GO:0001833 GO:0003677 GO:0005634 GO:0005654 GO:0006281 GO:0006310 GO:0006974 GO:0007498 GO:0009887 GO:0031052 GO:0035264 GO:0036342 GO:0043066 GO:0048568
9	0.06	0.141	6.30	0.04	0.19	2dplA	GO:0000166 GO:0003922 GO:0005524 GO:0006164 GO:0006177 GO:0016462 GO:0016874
10	0.06	0.167	6.94	0.03	0.23	3izq0	GO:0004518 GO:0004519 GO:0004521 GO:0005737 GO:0006412 GO:0006417 GO:0007049 GO:0007067 GO:0016787 GO:0032790 GO:0043022 GO:0045727 GO:0046872 GO:0051301 GO:0051321 GO:0070481 GO:0070651 GO:0070966 GO:0071025 GO:0090305 GO:0090502 GO:1990533
11	0.06	0.150	6.38	0.03	0.20	3rbyA	GO:0005634 GO:0005737 GO:0005789 GO:0006613
12	0.06	0.147	7.13	0.07	0.21	1yyaA	GO:0003824 GO:0004807 GO:0005737 GO:0006094 GO:0006096 GO:0006098 GO:0008152 GO:0016853
13	0.06	0.114	5.83	0.03	0.15	1uj3B
14	0.06	0.133	6.27	0.04	0.18	3no3A	GO:0006629 GO:0008081 GO:0008889 GO:0046872
15	0.06	0.118	5.18	0.01	0.14	2ojzH
16	0.06	0.114	6.09	0.04	0.15	2q3sA	GO:0003676 GO:0005634 GO:0005737 GO:0005773 GO:0005774 GO:0006139 GO:0008408 GO:0090305
17	0.06	0.099	5.62	0.06	0.13	3etiA	GO:0000166 GO:0001172 GO:0003723 GO:0003968 GO:0004197 GO:0004386 GO:0004518 GO:0004519 GO:0004527 GO:0005524 GO:0006351 GO:0006508 GO:0008168 GO:0008233 GO:0008234 GO:0008242 GO:0008270 GO:0016020 GO:0016021 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0016896 GO:0019079 GO:0019082 GO:0030430 GO:0030683 GO:0032259 GO:0033644 GO:0036459 GO:0039503 GO:0039520 GO:0039548 GO:0039648 GO:0044172 GO:0044220 GO:0046872 GO:0090305 GO:0090503
18	0.06	0.128	4.65	0.08	0.15	1i1gA	GO:0003677 GO:0003700 GO:0005622 GO:0006351 GO:0006355 GO:0043565

Consensus prediction of GO terms

Molecular Function	GO:0003723	GO:0000166	GO:0046872
GO-Score	0.45	0.45	0.41
Biological Processes	GO:0051607
GO-Score	0.41
Cellular Component	GO:0005737
GO-Score	0.41

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.