I-TASSER results

I-TASSER results for job id Rv2820c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (302 residues)
MNSRLFRFDFDRTHFGDHGLESSTISCPADTLYSALCVEALRMGGQQLLGELVACSTLRL
TDLLPYVGPDYLVPKPLHSVRSDGSSMQKKLAKKIGFLPAAQLGSFLDGTADLKELAARQ
TKIGVHAVSAKAAIHNGKKDADPYRVGYFRFELDAGLWLLATGSESELGLLTRLLKGISA
LGGERTSGFGAFNLTESEAPAALTPTVDAASLMTLTTSLPTDDELEAALAGATYRLVKRS
GFVASSTYADMPLRKRDIYKFAAGSVFSRPFQGGILDVSLGGNHPVYSYARPLFLALPES
AA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MNSRLFRFDFDRTHFGDHGLESSTISCPADTLYSALCVEALRMGGQQLLGELVACSTLRLTDLLPYVGPDYLVPKPLHSVRSDGSSMQKKLAKKIGFLPAAQLGSFLDGTADLKELAARQTKIGVHAVSAKAAIHNGKKDADPYRVGYFRFELDAGLWLLATGSESELGLLTRLLKGISALGGERTSGFGAFNLTESEAPAALTPTVDAASLMTLTTSLPTDDELEAALAGATYRLVKRSGFVASSTYADMPLRKRDIYKFAAGSVFSRPFQGGILDVSLGGNHPVYSYARPLFLALPESAA
Prediction	CCEEEEEEHCCEEEHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEHCCCCCCCEEHCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHCCCCCCEEEEEEEEEEHCCCCCCCCEEEEEEEHCCCEEEEEEEHCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEHCCCCCCCCCCCCCEEEEEHCCCCCCHHHHHHHHHCCEEEEEEEEEHCCCCCCCCCCCCCCEEEEHCCEHCCCCCCCEEEHCCCCCCCEEEEHCEEEEHCCCCCCC
Conf.Score	97899999767578768887655677776579999999999987958999999769979985566558767657887777666546777777655457999999999877665555554666545677766787678898876799999987995799999778589999999998756888876655557999864554545666888859998657998568899887574789999767667776777776665788757755578877779985789985578755567875788889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MNSRLFRFDFDRTHFGDHGLESSTISCPADTLYSALCVEALRMGGQQLLGELVACSTLRLTDLLPYVGPDYLVPKPLHSVRSDGSSMQKKLAKKIGFLPAAQLGSFLDGTADLKELAARQTKIGVHAVSAKAAIHNGKKDADPYRVGYFRFELDAGLWLLATGSESELGLLTRLLKGISALGGERTSGFGAFNLTESEAPAALTPTVDAASLMTLTTSLPTDDELEAALAGATYRLVKRSGFVASSTYADMPLRKRDIYKFAAGSVFSRPFQGGILDVSLGGNHPVYSYARPLFLALPESAA
Prediction	65320030404201013331540442130100000000000423446303501754301000000226441000110231654554543132231520316204400533352651465465123531323020334464231121030314650000000225662142035004323412342120203031443624451452752410000001104563144116502030222112021442464422232010010101044614020110337561300100200003146628
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCEEEEEEHCCEEEHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEHCCCCCCCEEHCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHCCCCCCEEEEEEEEEEHCCCCCCCCEEEEEEEHCCCEEEEEEEHCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEHCCCCCCCCCCCCCEEEEEHCCCCCCHHHHHHHHHCCEEEEEEEEEHCCCCCCCCCCCCCCEEEEHCCEHCCCCCCCEEEHCCCCCCCEEEEHCEEEEHCCCCCCC
MNSRLFRFDFDRTHFGDHGLESSTISCPADTLYSALCVEALRMGGQQLLGELVACSTLRLTDLLPYVGPDYLVPKPLHSVRSDGSSMQKKLAKKIGFLPAAQLGSFLDGTADLKELAARQTKIGVHAVSAKAAIHNGKKDADPYRVGYFRFELDAGLWLLATGSESELGLLTRLLKGISALGGERTSGFGAFNLTESEAPAALTPTVDAASLMTLTTSLPTDDELEAALAGATYRLVKRSGFVASSTYADMPLRKRDIYKFAAGSVFSRPFQGGILDVSLGGNHPVYSYARPLFLALPESAA

4qtsA

0.21

0.19

0.90

2.16

MUSTER

MKMVVLKPKINKFHFK---------IFHSNSLFSAIVNNYIKLYGREDLEKNIEKKNIRLSSLLYKIKNIYLIPKPEH------PEFYPKDIKKIQFFSIKAYKELLDNELDIEEIKRIFGKHAKISLISKHLEQKVADKGQLYNIEFIKLNENVEFYFLIDYDKEFIKKLEASIKLIEGLGGAGFFEKVEIVDDFNEILDENSKYNNLEYKMLLGVGIPNKDDIKNI---EYYKLIEIGGYIYSLECLT--KPKRNILALTEGSIVKNDFIGDVKDV--------YTHGKPILLPFNP---

4qtsA

0.20

0.18

0.90

4.27

dPPAS

MKMVVLKPKINKFHFK---------IFHSNSLFSAIVNNYIKLYGREDLEKNIEKKNIRLSSLLYKIKNIYLIPKPEH------PEFYPKDIKKIQFFSIKAYKELLDNELDIFGIKAEKLKHAKISLISKHLEQKVADKGQLYNIEFIKLNENVEFYFLIDYNNEDKEFIKKLEASIKGLGGAGFFEKVEIVDLPEDILDENSKYNNLEYKMLLGVGIPNKDDIKNI---EYYKLIEIGGYIYSLEC--LTKPKRNILALTEGSIVKNDFIGDVKDVY--------THGKPILLPFNP---

4qtsA

0.21

0.19

0.89

5.56

wdPPAS

MKMVVLKPKINKFHFK---------IFHSNSLFSAIVNNYIKLYGREDLEKNIEKKNIRLSSLLYKIKNIYLIPKPEH------PEFYPKDIKKIQFFSIKAYKELLDNELDIFGIKAEKLKHAKISLISKHLEQKVADKGQLYNIEFIKLNENVEFYFLIDYNNKKLEASIKLIEDE-GLGGAGFFEKVEIVDLPEDFNDENSKYNNLEYKMLLGVGIPNKDDIKNI---EYYKLIEIGGYIYSLE--CLTKPKRNILALTEGSIVKNDFIGDVKDV--------YTHGKPILLPFNP---

4qtsA

0.21

0.19

0.89

2.52

wMUSTER

-KMVVLKPKISKFHFK---------IFHSNSLFSAIVNNYIKLYGREDLEKNIEKKNIRLSSLLYKIKNIYLIPKPEH------PEFYPKDIKKIQFFSIKAYKELLDNELDIEEIKRIFGKHAKISLISKHLEQKVADKGQLYNIEFIKLNENVEFYFLIDYDKEFIKKLEASIKLIEGLGGAGFFEKVEIVDLPEEILDENSKYNNLEYKMLLGVGIPNKDDIKNI---EYYKLIEIGGYIYSLECLT--KPKRNILALTEGSIVKNDFIGDVKDV--------YTHGKPILLPFNP---

4qtsA

0.21

0.19

0.89

4.91

wPPAS

MKMVVLKPKINKFHFK---------IFHSNSLFSAIVNNYIKLYGREDLEKNIEKKNIRLSSLLYKIKNIYLIPKPEH------PEFYPKDIKKIQFFSIKAYKELLDNELDIFGIKAEKLKHAKISLISKHLEQKVADKGQLYNIEFIKLNENVEFYFLIDYNNKKLEASIKLIEDE-GLGGAGFFEKVEIVDLPEDFNDENSKYNNLEYKMLLGVGIPNKDDIKNI---EYYKLIEIGGYIYSLE--CLTKPKRNILALTEGSIVKNDFIGDVKD--------VYTHGKPILLPFNP---

4qtsA

0.20

0.18

0.90

17.15

dPPAS2

MKMVVLKPKINKFHFK---------IFHSNSLFSAIVNNYIKLYGREDLEKNIEKKNIRLSSLLYKIKNIYLIPKPEH------PEFYPKDIKKIQFFSIKAYKELLDNELDIFGIKAEKLKHAKISLISKHLEQKVADKGQLYNIEFIKLNENVEFYFLIDYNNEDKEFIKKLEASIKGLGGAGFFEKVEIVDLPEDILDENSKYNNLEYKMLLGVGIPNKDDIKNI---EYYKLIEIGGYIYSLEC--LTKPKRNILALTEGSIVKNDFIGDVKDVY--------THGKPILLPFNP---

4qtsA

0.21

0.19

0.90

3.89

PPAS

MKMVVLKPKINKFHFK---------IFHSNSLFSAIVNNYIKLYGREDLEKNIEKKNIRLSSLLYKIKNIYLIPKPEH------PEFYPKDIKKIQFFSIKAYKELLDNELDIFGIKAEKLKHAKISLISKHLEQKVADKGQLYNIEFIKLNENVEFYFLIDYNNEFIKKLEASIKLIEGLGGAGFFEKVEIVDDFNEILDENSKYNNLEYKMLLGVGIPNKDDIKNI---EYYKLIEIGGYIYSLE--CLTKPKRNILALTEGSIVKNDFIGDVKDV--------YTHGKPILLPFNP---

4qtsA

0.21

0.19

0.90

4.72

Env-PPAS

MKMVVLKPKINKFHFK---------IFHSNSLFSAIVNNYIKLYGREDLEKNIEKKNIRLSSLLYKIKNIYLIPKPEH------PEFYPKDIKKIQFFSIKAYKELLDNELDIEEIKRIKLKHAKISLISKHLEQKVADKGQLYNIEFIKLNENVEFYFLIDYNNEFIKKLEASIKLIEGLGGAGFFEKVEIVDDFNEILDENSKYNNLEYKMLLGVGIPNKDDIKNI---EYYKLIEIGGYIYSLEC--LTKPKRNILALTEGSIVKNDFIGDVKDV--------YTHGKPILLPFNP---

3w2vB

0.13

0.11

0.84

0.90

MUSTER

----MIEVTFTPY------------IPLPQTVAGAIRTLLFYKGLKNCVGVGEEEPEFTLVGIAIGTEKGRIYPLPFNIIKSEKFYKVVNPGRKSGYVTESILEKYLKGELK--EVEENKVIRIEKEKRITVEFLRIE-----------------KIYAWIEDPGCG-------IKDILS-SYEFLTLSRVAFVEVDDKTPDIFNREGSTKKALFYFSTPKVGEIVQELEKRLNAKIDDYLLVSSRPTAHEKKPKGTKFAIPPGSVLEFKEEVEVPPYIKLGKLKKLGYGLALGGIWE----

4w8vA

0.09

0.06

0.65

1.15

dPPAS

LHAITGKFKTQRLVVGLGDESYGVPYIPGSAIKGVTRHLTYYVLAEFINNDFYKRAKTVQDAFMKGDPKEILSNAKVPERCSRLCKEFLRIFGEKKVPEIIDELIRIFGTQKKEAEEIADKPILELDIMGEKNVPPPGDWYDPIPIFFLTVPKDVPFLVAVGGRDEKAFSLVKLALRDLGVGAKTSLGYGRLVEYV----------------------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 3 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.94

Estimated TM-score = 0.84±0.08

Estimated RMSD = 4.3±2.9Å

Download Model 2

C-score=0.38

Download Model 3

C-score=-0.23

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4qtsA	0.851	1.73	0.206	0.901
2	3w2vB	0.588	4.53	0.149	0.788
3	3qjjA	0.476	3.73	0.082	0.606
4	3i4hX	0.463	3.84	0.061	0.593
5	4illA	0.430	5.18	0.082	0.626
6	4mjkA	0.425	5.03	0.059	0.619
7	4c8yA	0.406	4.38	0.101	0.553
8	3x1lC	0.405	4.14	0.076	0.517
9	4tvxH	0.404	4.85	0.052	0.553
10	4c98A	0.388	4.46	0.142	0.530

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.15	8	2w72A	XE	Rep, Mult	32,33,36,58
2	0.10	5	3dasA	CA	Rep, Mult	224,234
3	0.04	2	4jcbT	BCL	Rep, Mult	36,40
4	0.04	2	2ckjB	FES	Rep, Mult	217,218,219,220,273,290,292
5	0.02	1	1s5lk	CLA	Rep, Mult	76,80
6	0.02	1	3lw51	CLA	Rep, Mult	90,93
7	0.02	1	1fiqA	FES	Rep, Mult	103,104,107,109,112
8	0.02	1	1i6qA	CO3	Rep, Mult	185,186
9	0.02	1	1bcpL	ATP	Rep, Mult	241,245
10	0.02	1	1gzmA	C8E	Rep, Mult	38,41
11	0.02	1	3eubS	FES	Rep, Mult	235,236,261,262,263,264,266
12	0.02	1	2x8oA	OIN	Rep, Mult	140,144,165
13	0.02	1	3qjlA	NUC	Rep, Mult	1,64,65,129,160,200,201,213,215,232,234,265,295,297,298

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1jrpB	0.343	6.88	0.067	0.636	1.17.1.4	NA
2	0.060	1qo8D	0.354	6.76	0.030	0.632	1.3.99.1	NA
3	0.060	2ckjA	0.306	6.94	0.032	0.566	1.17.1.4,1.17.3.2	NA
4	0.060	1ac5A	0.351	5.59	0.025	0.543	3.4.16.6	NA
5	0.060	1tt0A	0.361	6.46	0.045	0.623	1.1.3.10	NA
6	0.060	1kqfA	0.354	6.57	0.019	0.599	1.2.1.2	NA
7	0.060	1ti2A	0.382	6.94	0.043	0.699	1.97.1.2	NA
8	0.060	1yrqI	0.348	6.36	0.052	0.580	1.12.2.1	214,229
9	0.060	1jroB	0.360	6.42	0.062	0.626	1.1.1.204	NA
10	0.060	1fo4A	0.369	6.77	0.040	0.659	1.17.1.4	NA
11	0.060	1q16A	0.381	6.50	0.043	0.652	1.7.99.4	NA
12	0.060	1dgjA	0.362	6.77	0.034	0.652	1.2.-.-	NA
13	0.060	3b9jJ	0.252	6.51	0.051	0.437	1.17.1.4,1.17.3.2	63
14	0.060	1knpA	0.343	6.46	0.038	0.589	1.4.3.16	215
15	0.060	1fdiA	0.351	6.18	0.032	0.566	1.2.1.2	NA
16	0.060	1chuA	0.322	6.92	0.051	0.583	1.4.3.16	NA
17	0.060	1kdgB	0.376	6.29	0.070	0.629	1.1.99.18,	NA
18	0.060	3b9jC	0.278	6.89	0.040	0.510	1.17.3.2,1.17.1.4	NA
19	0.060	1e39A	0.360	6.06	0.037	0.586	1.3.99.1	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.32	0.851	1.73	0.21	0.90	4qtsA	GO:0051607
1	0.07	0.628	4.73	0.15	0.85	3x1lB	GO:0000166 GO:0003723 GO:0005737 GO:0051607
2	0.07	0.588	4.53	0.15	0.79	3w2vB	GO:0000166 GO:0003723 GO:0005737 GO:0051607
3	0.07	0.475	3.87	0.08	0.61	3ufcX	GO:0003723 GO:0016788
4	0.07	0.476	3.73	0.08	0.61	3qjjA	GO:0003723 GO:0016788
5	0.07	0.453	3.80	0.06	0.58	3pkmX	GO:0003723 GO:0004518 GO:0004519 GO:0016787 GO:0016788 GO:0043571 GO:0090305
6	0.06	0.431	5.11	0.09	0.62	4ilmJ	GO:0004518 GO:0004519 GO:0016787 GO:0016788 GO:0051607 GO:0090305
7	0.06	0.425	5.03	0.06	0.62	4mjkA	GO:0043571
8	0.06	0.426	4.46	0.15	0.58	4c9dA	GO:0016788
9	0.06	0.406	4.38	0.10	0.55	4c8yA	GO:0016788
10	0.06	0.406	4.77	0.07	0.57	3zfvD	GO:0004518 GO:0004519 GO:0016787 GO:0016788 GO:0051607 GO:0090305
11	0.06	0.388	4.46	0.14	0.53	4c98A	GO:0016788
12	0.06	0.365	3.43	0.10	0.45	4w8vA	GO:0003723 GO:0005737 GO:0051607
13	0.06	0.329	3.77	0.07	0.41	4qtsC	GO:0051607
14	0.06	0.306	7.11	0.04	0.57	3nc6B	GO:0004497 GO:0005506 GO:0005886 GO:0016125 GO:0016491 GO:0016705 GO:0016713 GO:0020037 GO:0046148 GO:0046872 GO:0055114
15	0.06	0.305	6.61	0.03	0.53	1x0xA	GO:0004367 GO:0004368 GO:0005737 GO:0005739 GO:0005829 GO:0005975 GO:0006072 GO:0006094 GO:0006116 GO:0006127 GO:0006654 GO:0006734 GO:0009331 GO:0016491 GO:0016616 GO:0019432 GO:0042803 GO:0045821 GO:0046168 GO:0046486 GO:0051287 GO:0055114 GO:0070062 GO:0071320 GO:0071356
16	0.06	0.284	6.61	0.04	0.47	2i7vA	GO:0000398 GO:0003723 GO:0004518 GO:0004519 GO:0004521 GO:0005634 GO:0005654 GO:0005847 GO:0006369 GO:0006378 GO:0006379 GO:0006397 GO:0006398 GO:0006406 GO:0008409 GO:0016787 GO:0030529 GO:0031124 GO:0046872 GO:0090305 GO:0090502
17	0.06	0.248	6.55	0.02	0.43	4d2iA	GO:0000166 GO:0004386 GO:0005524 GO:0006281 GO:0006974 GO:0016787
18	0.06	0.269	5.65	0.05	0.42	4kgkD	GO:0000166 GO:0000287 GO:0005524 GO:0005525 GO:0006400 GO:0008193 GO:0046872

Consensus prediction of GO terms

Molecular Function	GO:0003676
GO-Score	0.49
Biological Processes	GO:0051607
GO-Score	0.42
Cellular Component	GO:0005737
GO-Score	0.14

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.