I-TASSER results

I-TASSER results for job id Rv2819c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (375 residues)
MNTYLKPFELTLRCLGPVFIGSGEKRTSKEYHVEGDRVYFPDMELLYADIPAHKRKSFEA
FVMNTDGAQATAPLKEWVEPNAVKLDPAKHRGYEVKIGSIEPRRASRGRGGRMTRKKLTL
NEIHAFIKDPLGRPYVPGSTVKGMLRSIYLQSLVHKRTAQPVRVPGHQTREHRQYGERFE
RKELRKSGRPNTRPQDAVNDLFQAIRVTDSPALRTSDLLICQKMDMNVHGKPDGLPLFRE
CLAPGTSISHRVVVDTSPTARGGWREGERFLETLAETAASVNQARYAEYRAMYPGVNAIV
GPIVYLGGGAGYRSKTFVTDQDDMAKVLDAQFGKVVKHVDKTRELRVSPLVLKRTKIDNI
CYEMGQCELSIRRAE

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MNTYLKPFELTLRCLGPVFIGSGEKRTSKEYHVEGDRVYFPDMELLYADIPAHKRKSFEAFVMNTDGAQATAPLKEWVEPNAVKLDPAKHRGYEVKIGSIEPRRASRGRGGRMTRKKLTLNEIHAFIKDPLGRPYVPGSTVKGMLRSIYLQSLVHKRTAQPVRVPGHQTREHRQYGERFERKELRKSGRPNTRPQDAVNDLFQAIRVTDSPALRTSDLLICQKMDMNVHGKPDGLPLFRECLAPGTSISHRVVVDTSPTARGGWREGERFLETLAETAASVNQARYAEYRAMYPGVNAIVGPIVYLGGGAGYRSKTFVTDQDDMAKVLDAQFGKVVKHVDKTRELRVSPLVLKRTKIDNICYEMGQCELSIRRAE
Prediction	CCCCEEEEEEEEEEEEEEEHCCCCCCCCCEEEEHCCEEEEHCHHHHHHHHHHHCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCEEEHCCCCCCCCCEEEEEEEEEHCCCCCCCCCEEEEEHCCCEEEEEEEEHCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHCCCCCCCEHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEHCCEEEEEEEEEEEEEHCC
Conf.Score	987657899999997556658976457655899899999968999999999975899999999757776578999999987887765665455555444455544444444455666665544454447999865787568999999999999997557776666555555666778889988766555465566544574455566467778887668999888757888777756899987996999999985478766556779999999999999999999999999987664567766897568875443556665456889999999876555556777788857999998896776558999999879
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MNTYLKPFELTLRCLGPVFIGSGEKRTSKEYHVEGDRVYFPDMELLYADIPAHKRKSFEAFVMNTDGAQATAPLKEWVEPNAVKLDPAKHRGYEVKIGSIEPRRASRGRGGRMTRKKLTLNEIHAFIKDPLGRPYVPGSTVKGMLRSIYLQSLVHKRTAQPVRVPGHQTREHRQYGERFERKELRKSGRPNTRPQDAVNDLFQAIRVTDSPALRTSDLLICQKMDMNVHGKPDGLPLFRECLAPGTSISHRVVVDTSPTARGGWREGERFLETLAETAASVNQARYAEYRAMYPGVNAIVGPIVYLGGGAGYRSKTFVTDQDDMAKVLDAQFGKVVKHVDKTRELRVSPLVLKRTKIDNICYEMGQCELSIRRAE
Prediction	855315405030100000000216404422001365201001242005203753263034103535555425302400563525154352441304254244454345444444555542440341043254200000012010100000110045335533434554544355235513453145445654446412301030010011431565302004224043554553121000003363504030303451265331640340053035104401551154036305724654301010011000100000223552450145204521452444473521221020032554111001020205528
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCEEEEEEEEEEEEEEEHCCCCCCCCCEEEEHCCEEEEHCHHHHHHHHHHHCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCEEEHCCCCCCCCCEEEEEEEEEHCCCCCCCCCEEEEEHCCCEEEEEEEEHCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHCCCCCCCEHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEHCCEEEEEEEEEEEEEHCC
MNTYLKPFELTLRCLGPVFIGSGEKRTSKEYHVEGDRVYFPDMELLYADIPAHKRKSFEAFVMNTDGAQATAPLKEWVEPNAVKLDPAKHRGYEVKIGSIEPRRASRGRGGRMTRKKLTLNEIHAFIKDPLGRPYVPGSTVKGMLRSIYLQSLVHKRTAQPVRVPGHQTREHRQYGERFERKELRKSGRPNTRPQDAVNDLFQAIRVTDSPALRTSDLLICQKMDMNVHGKPDGLPLFRECLAPGTSISHRVVVDTSPTARGGWREGERFLETLAETAASVNQARYAEYRAMYPGVNAIVGPIVYLGGGAGYRSKTFVTDQDDMAKVLDAQFGKVVKHVDKTRELRVSPLVLKRTKIDNICYEMGQCELSIRRAE

3x1lH

0.12

0.08

0.66

1.73

wdPPAS

---------VVVK---PVNLS--NKM--TPFVKRRSESYKSSLSAVKEIF--KNVDDFQNFLNSVLRR-SLDEYRVFFENYERLFNSFSSKIFSMRTK----------SRLVVGLGDESVYETSIRLHRNYGVPYIPGSALKGVAKHYAFSILARENGDEILRIYESVKEDLKEDYYLTAAVIQELFEKKFDELGAIRNDIVK-VIFFDAFPTPEQ--------LKDKPNLELDIMIFFLTVPAGVEFTFAVASRD--LDDLAEKAEKLLKEALKKF----------------------------VGAGYGRFD-------------------------------------------------------------

4n0lA

0.17

0.11

0.69

1.69

wPPAS

IGG-TITLVGEIRLRTGTRIGTSE---------EEIEIGGLD---------------------------------------------------------------------------------NPVIRDPSGYPYVPGSSLKGRARALFELAWMKSREIEPDVFFGAHHNERHECGFVRREVYEEAKEYLREDGDGIGFSDPGRLEDERRGLGYDPYTTYTVNDVFERAGEPTEVKHSMERVPKGSRFGLEVVYRVE-----DGEELESDLKYLMSSLKLVEDQG--------------------IGHSTGYCARSTGWYLDPGAGEGFPEEEDKDEAADEVTYSDLEAERYEIVIREDRAYLR-WVRLDVGELP

3x1lH

0.12

0.09

0.70

1.02

wMUSTER

VNSELANYKFWKKELAIYNLS--NKM--TPFVKRRSESYKSSLSAVKEIF--KNVDDFQNFLNSVL-RRSLDEYRVFFENYERLFNSFSSKIFSMRTKS------------VVGLGDESVYETSIRLHRNYGVPYIPGSALKGVAKHYAFSILARENGDEILRIYESVKEDLKEDYYLTAAVIQELFEKKFDELGAIRNTRVEIISVGDIVKIEEGSVIFFDAFPTDKPNLELDIMIFFLTVPAGVEFTFAVASRDL-------DLAEKAEKLLKEALKKF------------------------VGAGYGRFD-------------------------------------------------------------

4n0lA

0.10

0.08

0.80

1.27

PPAS

IGG-TITLVGEIRLRTGTRIGTSEEIGGLD-VIRDSGYPYVPGSSLKGRARALFELAWMKSREIE--------PDVFFGAHHNE------------------------RHECGFVRREVYEEAKEYLREDPPWLENGTCRIFGS-------AGDGIGFSDPGRLEDERRGLGYDPYGRYRDPNDAQELSGVVDVKKEAR-----VAFRDAHPTT-----YTVNDVFERAGEPTEVKHSMERVPKGSRFGLEVVYRVE-----DGEELESDLKYLMSSLKLVEDQG--------------------IGHSTGYCARSTGWYLDPGAGEGFPEEEDKDEAADEVTYSDLEAERYEIVIRARDLEDRAYLRPEVERLD

3x1lH

0.12

0.08

0.67

1.91

wPPAS

VNSELANYKFWKKELAIYNLS--NKM--TPFVKRRSESYKSSLSAVKEIF--KNVDDFQNFLNSVL-RRSLDEYRVFFENYERLFNSFSSKIFSMRTKS---------------LGDESVYETSIRLHRNYGVPYIPGSALKGVAKHYAFSILARENGDEILRIYESVKEDLKEDYYLTAAVIQELFEKKFDELGAIRNDIVK-VIFFDAFPTPEQL---------DKPNLELDIMIFFLTVPAGVEFTFAVASRD--LDDLAEKAEKLLKEALKKF----------------------------VGAG-GRFD-------------------------------------------------------------

4n0lA

0.16

0.11

0.68

1.32

wdPPAS

IGG-TITLVGEIRLRTGTRIGTS--------------------------------------------------------------EEIEIGGLDN-----------------------------PVIRDPSGYPYVPGSSLKGRARALFELAWMKSREIEPDVFFGAHHNERHECGFVRREVYEEAKEYLREDGDGIGFSDPGRLEDERRGLGYDPYTTYTVNDVFERAGEPTEVKHSMERVPKGSRFGLEVVYRV-----EDGEELESDLKYLMSSLKLVEDQG--------------------IGHSTGYCARSTGWYLDPGAGEGFPEEEDKDEAADEVTYSDLEAERYEIVIREDRAYLR-WVE-VVGELP

3x1lH

0.12

0.07

0.64

2.86

dPPAS2

-------------------------------------VVVKELANYAEKFWKKEKSSLSAVKEIFKNVDDFQNFLNSVLRRSLDEYRVFFENYEFNSFSSKIFSMRTKSRLVVGLGDESVYETSIRLHRNYGVPYIPGSALKGVAKHYAFSILARENGDEILRIYESVKEDLKEDYYLTAAVIQELFEKKFDELGAIRNTRVEIISVGDEGSVIFFDAFPTPEQLKDKPNLELDIMIFFLTVPAGVEFTFAVASRD--LDDLAEKAEKLLKEALKKFTSL-----------------------------------------------------------------------------------------------

4n0lA

0.16

0.10

0.65

1.61

dPPAS2

-------------------------------------------------------------------------------------------GIGGTITLVGEIRLRTGTRIGTSEEEIEIGGLNPVIRDPVGYPYVPGSSLKGRARALFELAWMKSREIEPDVFFGAHHNERHECGFVRREVYEEAKEYLREDPPWLENDPNDAQELSGVVDVKKEARVAFRDAHPTTYGEPTEVKHSMERVPKGSRFGLEVVYRDGEELESDLKYLMSSLKLVEDQTGWYLEEDKDEAADEVTYLSDLEAERYEIVEDRAYLR----------PEEWVERLDEVVGELPWGR--------------------------------

3x1lH

0.11

0.08

0.70

1.44

PPAS

VNSELANYKFWKKELAIYNLS--NKMTP--FVKRRSESYKSSLSAVKEIF--KNVDDFQNFLNSVL-RRSLDEYRVFFENYERLFNSFSSKIFSMRTKS---------------LGDESVYETSIRLHRNYGVPYIPGSALKGVAKHYAFSILARENGDEILRIYESVKEDLKEDYYLTAAVIQELFEKKFDELGAIRNTVGDIVKIFGTQKEEGSDAFPTPEQLKDKPNLELDIMIFFLTVPAGVEFTFAVASRDL----------DDLAEKAEKLLKEALKKF--------------------VGAKTGRFD-------------------------------------------------------------

3x1lC

0.13

0.09

0.69

1.06

PPAS

-----KAVVFGLYSITPVHAGSGAELSVID---------------------------------------------------------------------------------------------LPIQRERHGFPVIWGQSLKGVLRSRFRQLELDEKIEVSQKWKWKEKTKEVLKEKADEFIKKVEERKRDPPATDGASEHAGAVSVGDAKILAKGVFAFVTKEDFELVSVELSNNETIAILNGE-DIVLKVKSDSNVIENLVEVLKTLFGDNFFGKPIESIKE--DDVFKSFTRFSTEIVARVRIDAEKGTVARTLLIAVGSPKKENLPKEVDNTQKIVNVLKVTFNNAFLQI----------GFVKVRA----

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.41

Estimated TM-score = 0.34±0.11

Estimated RMSD = 15.1±3.5Å

Download Model 2

C-score=-4.04

Download Model 3

C-score=-3.59

Download Model 4

C-score=-4.24

Download Model 5

C-score=-2.66

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3x1lH	0.626	2.71	0.101	0.683
2	5awhA	0.392	6.17	0.060	0.608
3	4ka7A	0.390	6.60	0.043	0.637
4	4n0lA	0.389	5.24	0.110	0.528
5	3ikmD	0.386	6.45	0.051	0.605
6	2o36A	0.382	6.41	0.062	0.616
7	5l43A	0.380	6.71	0.053	0.632
8	3w37A	0.380	7.06	0.033	0.653
9	4w8vA	0.380	3.47	0.119	0.443
10	1iduA	0.377	6.91	0.058	0.632

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.16	7	3g6wD	GTP	Rep, Mult	139,142,146
2	0.11	5	3nxqB	UUU	Rep, Mult	136,137,138,141,274
3	0.07	3	4ro2B	GLY	Rep, Mult	145,148
4	0.02	1	3x1lH	NUC	Rep, Mult	40,237
5	0.02	1	3bb4A	MG	Rep, Mult	314,343
6	0.02	1	3h36A	CA	Rep, Mult	142,177,180
7	0.02	1	1np6A	SO4	Rep, Mult	309,311,315,316
8	0.02	1	3x1lH	NUC	Rep, Mult	114,115,116,117,139,140,142,143,144,146,147,188,305,306
9	0.02	1	1kj4B	III	Rep, Mult	17,18
10	0.02	1	1gp7B	CA	Rep, Mult	305,307,309,329

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1rm6A	0.286	6.72	0.019	0.467	1.3.99.20	NA
2	0.060	1i1iP	0.383	6.32	0.047	0.608	3.4.24.16	305
3	0.060	2pdaA	0.351	6.57	0.049	0.557	1.2.7.1	143
4	0.060	1dgjA	0.352	6.89	0.048	0.597	1.2.-.-	146
5	0.060	1vncA	0.379	7.00	0.070	0.632	1.11.1.10	NA
6	0.060	1y791	0.356	6.99	0.040	0.603	3.4.15.5	NA
7	0.060	1h16A	0.347	7.51	0.027	0.640	2.3.1.54	NA
8	0.060	2rnpC	0.356	6.87	0.019	0.589	2.7.7.6	NA
9	0.060	1kitA	0.355	6.80	0.036	0.595	3.2.1.18	NA
10	0.060	2ow6A	0.361	6.87	0.032	0.608	3.2.1.114	NA
11	0.060	2eabA	0.370	6.55	0.057	0.597	3.2.1.63	168
12	0.060	3b9jJ	0.254	7.03	0.053	0.437	1.17.1.4,1.17.3.2	282
13	0.060	1s76D	0.285	7.03	0.069	0.493	2.7.7.6	NA
14	0.060	2j5wA	0.360	6.78	0.035	0.605	1.16.3.1	NA
15	0.060	2ckjA	0.304	7.07	0.049	0.531	1.17.1.4,1.17.3.2	NA
16	0.060	1s4bP	0.381	6.37	0.063	0.616	3.4.24.15	NA
17	0.060	1uwkA	0.375	6.63	0.033	0.627	4.2.1.49	144
18	0.060	1ofdA	0.314	7.53	0.040	0.573	1.4.7.1	NA
19	0.060	3b9jI	0.207	5.66	0.105	0.307	1.17.1.4,1.17.3.2	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.06	0.389	5.24	0.11	0.53	4n0lA	GO:0046872
1	0.06	0.382	6.46	0.06	0.61	3ahmA	GO:0006508 GO:0008233 GO:0008237 GO:0016787 GO:0046872
2	0.06	0.383	6.32	0.05	0.61	1i1iP	GO:0004222 GO:0005737 GO:0005739 GO:0005758 GO:0005829 GO:0006508 GO:0006518 GO:0008233 GO:0008237 GO:0016787 GO:0046872 GO:0070012
3	0.06	0.356	6.99	0.04	0.60	1y791	GO:0004180 GO:0004222 GO:0005737 GO:0005829 GO:0006508 GO:0006518 GO:0008233 GO:0008237 GO:0016787 GO:0030288 GO:0046872
4	0.06	0.372	6.50	0.05	0.59	3sksA	GO:0006508 GO:0008233 GO:0008237 GO:0016787 GO:0046872
5	0.06	0.380	3.47	0.12	0.44	4w8vA	GO:0003723 GO:0005737 GO:0051607
6	0.06	0.390	6.60	0.04	0.64	4ka7A	GO:0004222 GO:0005739 GO:0005759 GO:0005829 GO:0006508 GO:0006518 GO:0008233 GO:0008237 GO:0009507 GO:0009536 GO:0009570 GO:0016787 GO:0046872
7	0.06	0.243	7.27	0.09	0.45	1ixsB	GO:0000166 GO:0003677 GO:0004386 GO:0005524 GO:0006281 GO:0006310 GO:0006974 GO:0009378 GO:0009432 GO:0016787 GO:0032508
8	0.06	0.280	7.50	0.03	0.51	1nyqB	GO:0000166 GO:0004812 GO:0004829 GO:0005524 GO:0005737 GO:0006412 GO:0006418 GO:0006435 GO:0016874 GO:0016876 GO:0043039 GO:0046872
9	0.06	0.382	6.41	0.06	0.62	2o36A	GO:0004222 GO:0005737 GO:0005758 GO:0006508 GO:0006518 GO:0008233 GO:0008237 GO:0016787 GO:0042277 GO:0046872
10	0.06	0.285	6.77	0.03	0.47	2fncA	GO:0004175 GO:0005363 GO:0006511 GO:0015768 GO:0019773
11	0.06	0.232	7.20	0.03	0.41	3efmA	GO:0004872 GO:0005506 GO:0006810 GO:0009279 GO:0015891 GO:0016020
12	0.06	0.234	6.94	0.04	0.38	3nl1A	GO:0046872 GO:0051213 GO:0055114
13	0.06	0.242	7.00	0.03	0.41	4jc0A	GO:0003824 GO:0005506 GO:0005737 GO:0005829 GO:0009451 GO:0016740 GO:0018339 GO:0035599 GO:0035600 GO:0043412 GO:0046872 GO:0051536 GO:0051539
14	0.06	0.220	6.13	0.04	0.35	3cs3A	GO:0003677 GO:0003700 GO:0006351 GO:0006355
15	0.06	0.221	5.61	0.03	0.33	3hbdA	GO:0004568 GO:0005975 GO:0006032 GO:0008061 GO:0008152 GO:0016787 GO:0016798 GO:0016998
16	0.06	0.212	6.20	0.02	0.34	4uxdA	GO:0003824 GO:0005975 GO:0006007 GO:0008152 GO:0008674 GO:0008675 GO:0016829 GO:0016832 GO:0061677
17	0.06	0.189	5.57	0.04	0.27	1lxlA	GO:0000910 GO:0001541 GO:0001701 GO:0001836 GO:0005622 GO:0005634 GO:0005737 GO:0005739 GO:0005741 GO:0005743 GO:0005759 GO:0005813 GO:0005815 GO:0005829 GO:0005856 GO:0006897 GO:0006915 GO:0007093 GO:0007281 GO:0007283 GO:0008283 GO:0008284 GO:0008584 GO:0008630 GO:0008637 GO:0009314 GO:0009566 GO:0009615 GO:0010507 GO:0016020 GO:0016021 GO:0019050 GO:0019901 GO:0030054 GO:0030672 GO:0031410 GO:0031965 GO:0031966 GO:0034097 GO:0040007 GO:0042802 GO:0042803 GO:0042981 GO:0043065 GO:0043066 GO:0043524 GO:0045202 GO:0046898 GO:0046902 GO:0046982 GO:0051402 GO:0051434 GO:0051881 GO:0060154 GO:0070584 GO:0071230 GO:0071312 GO:0071480 GO:0071839 GO:0090005 GO:0090201 GO:0097136 GO:0097192 GO:0097284 GO:1900118 GO:1902230 GO:2000811 GO:2001240 GO:2001243 GO:2001244
18	0.06	0.200	5.97	0.06	0.31	4c8yA	GO:0016788

Consensus prediction of GO terms

Molecular Function	GO:0043169	GO:0070011
GO-Score	0.57	0.47
Biological Processes	GO:0019538
GO-Score	0.47
Cellular Component	GO:0005829	GO:0005758	GO:0030288
GO-Score	0.12	0.06	0.06

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.