I-TASSER results

I-TASSER results for job id Rv2818c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (382 residues)
MLFLSAEIAAFENADRRYSAAITRLAPETDVRIVTYTNPSVHRFDLFVPVFRNHLVELSA
EFPDRTILLNTSSGTPAMQAALVAINVFGIPRTTAVQVSTPARALSKPGDRESPDAYDLE
LMWDANDDNQPGAPNRCFEATSAALGALLERANLKQLIVSYDYSAAVTIAADSRLPDQVS
NLIRGAMHRSRLEHLVAPKFFKDTAFTYDPANKVAEYISALALLAKREQWAEFARSATPA
ITIVLRAAVAKHLPEDRYLDDMGRVDRRKLEREPEIRCALKHPPKSPNAEWYLYTKDWLA
LLRQFAPDRVGALEVLGRFESRVRNTAAHEIVSISEDRITKDGGLLPEQLLKILARETGA
DLTLYDRLNDEIIRQIDMAPLG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MLFLSAEIAAFENADRRYSAAITRLAPETDVRIVTYTNPSVHRFDLFVPVFRNHLVELSAEFPDRTILLNTSSGTPAMQAALVAINVFGIPRTTAVQVSTPARALSKPGDRESPDAYDLELMWDANDDNQPGAPNRCFEATSAALGALLERANLKQLIVSYDYSAAVTIAADSRLPDQVSNLIRGAMHRSRLEHLVAPKFFKDTAFTYDPANKVAEYISALALLAKREQWAEFARSATPAITIVLRAAVAKHLPEDRYLDDMGRVDRRKLEREPEIRCALKHPPKSPNAEWYLYTKDWLALLRQFAPDRVGALEVLGRFESRVRNTAAHEIVSISEDRITKDGGLLPEQLLKILARETGADLTLYDRLNDEIIRQIDMAPLG
Prediction	CEEHCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHCCCCHHHHHHHHHHHHHCCCCEEEEEHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC
Conf.Score	6677899999987899999999998778856799858887556789999999999999997899689999678859999999999998798858999589987778777778887555899999866677776677545568999999999999999999869999999998698789999999999999868588999999868887589999999999999999885999999999999999999999858875445555554588887758888888765566676666554999999998568899999999999999857887657678999999997887999999999998546557999999999999866789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MLFLSAEIAAFENADRRYSAAITRLAPETDVRIVTYTNPSVHRFDLFVPVFRNHLVELSAEFPDRTILLNTSSGTPAMQAALVAINVFGIPRTTAVQVSTPARALSKPGDRESPDAYDLELMWDANDDNQPGAPNRCFEATSAALGALLERANLKQLIVSYDYSAAVTIAADSRLPDQVSNLIRGAMHRSRLEHLVAPKFFKDTAFTYDPANKVAEYISALALLAKREQWAEFARSATPAITIVLRAAVAKHLPEDRYLDDMGRVDRRKLEREPEIRCALKHPPKSPNAEWYLYTKDWLALLRQFAPDRVGALEVLGRFESRVRNTAAHEIVSISEDRITKDGGLLPEQLLKILARETGADLTLYDRLNDEIIRQIDMAPLG
Prediction	4000054026246424102200540177151523426373023023016203500550376265220001011112000000000012452403001031145542563545454333034116314534752651133350441343123520350065120510141057361374033004004114404344045205634163552420120011010224353002001101100130022003540544420543441334315526403521554354443422010210020035236513510530350055200400040440547404731421043004102513753151034005202610743648
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CEEHCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHCCCCHHHHHHHHHHHHHCCCCEEEEEHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC
MLFLSAEIAAFENADRRYSAAITRLAPETDVRIVTYTNPSVHRFDLFVPVFRNHLVELSAEFPDRTILLNTSSGTPAMQAALVAINVFGIPRTTAVQVSTPARALSKPGDRESPDAYDLELMWDANDDNQPGAPNRCFEATSAALGALLERANLKQLIVSYDYSAAVTIAADSRLPDQVSNLIRGAMHRSRLEHLVAPKFFKDTAFTYDPANKVAEYISALALLAKREQWAEFARSATPAITIVLRAAVAKHLPEDRYLDDMGRVDRRKLEREPEIRCALKHPPKSPNAEWYLYTKDWLALLRQFAPDRVGALEVLGRFESRVRNTAAHEIVSISEDRITKDGGLLPEQLLKILARETGADLTLYDRLNDEIIRQIDMAPLG

4rgpA

0.18

0.10

0.60

1.10

MUSTER

--------------------------------------------------------------------------------------------------------------------------------------------------NATEQETLTILLDVYAYYQAYQIVKASQFSDDIIFLLELLKERRELNVDFLFQNQVHLQLDNAYEEELLANYIDLEAKLRNDHIIDFVRSVSPILYRLLR--LQSQVADNDYIYDAKQYDTWKFDKHDSANPFVQNFVAK-GRDSKITSRSLADFIQLLPQAIKDNILLLRDFEKSVRNPLAHLIKPFDEEELHRTTGFSSQTFLEKIIQLAVNDKFYFDKVNELIKRIYQ-----

5fshA

0.20

0.16

0.84

1.30

wdPPAS

YVLHT------PESARFLPRLRQDTGKDLYPVEIGKSD---------VEAIYREVKRLLEKHPEVPVALDLTSGTKAMSAGLAAAGFF-YPKVRVVYVDNEDYELRRP---------------------RAGTEKLRILPNPHEALAEVDALFAKELYGKGEFGQAAAYFRG-QAYALYALLAEMYRAWRALDFGEALKAGRKLLALKEGVYGLARTLLHLAQEAKEEAAVLAALYAYRALELLLQERLALL-------RRPGLSPEEAEALRKALAELLP---EEVRLPAKLGLLDLLAFLRLKGDEALGRLAELRGLAGALRNSAVHGFDVPSPKAVEGIARL-AQGLLQDLEARTALG-------------SPEPVPLG

4rgpA

0.17

0.10

0.60

1.57

dPPAS

--------------------------------------------------------------------------------------------------------------------------------------------------NATEQETLTILLDVYAYYQAYQIVKASQFSDDIIFLLELLKERRELNVDFLFQNQVHLQLDNAYEEELLANYIDLEAKLRNDHIIDFVRSVSPILYRLLRLQSQVDINDYIYDAKNDQYDTWKFDKHDSANPFVQNFVAKG-RDSKITSRSLADFIQLTPQAIKDNILLLRDFEKSVRNPLAHLIKPFDEEELHRTTGFSSQTFLEKIIQLAVNDKFYFDKVNELIKRIYQ-----

5fshA

0.20

0.18

0.89

1.49

wPPAS

YVLHT------PESARFLPRLRQDTGKDLYPVEI---GKS----D--VEAIYREVKRLLEKHPEVPVALDLTSGTKAMSAGLAAAGFF-YPKVRVVYVDNEDYELRRPRARILPNPHEAEVDALFAKEGKGEFGQAYFRGMVGRTGN-QAYALYALLAEMYRFGEALKAGRKLWLNHPLNARREALEAQVALLEAVDRFLKARDFALKEGVYGLARTLLHLAQEAKEEAAVLAALYAYRALELLLQERLALL-------RRPGLSPEEAEALRKALAELLP---EEVRLPAKLGLLDLLAFLRLKGDEALGRLAELRGLAGALRNSLVHGFDVPSPKAVEGIARL-AQGLLQDLEARTALG-------------SPEPVPLG

4rgpA

0.17

0.10

0.60

2.62

wdPPAS

--------------------------------------------------------------------------------------------------------------------------------------------------NATEQETLTILLDVYAYYQAYQIVKASQFSDDIIFLLELLKERRELNVDFLFQNQVHLQLDNAYEEELLANYIDLEAKLRNDHIIDFVRSVSPILYRLLRLQSQVDINDYIYDAKNDQYDTWKFDKHDSANPFVQNFVAKGR-DSKITSRSLADFIQLTDQAIKDNILLLRDFEKSVRNPLAHLIKPFDEEELHRTTGFSSQTFLEKIIQLA-NDKFYFDKVNELIKRIYQ-----

5fshA

0.19

0.17

0.91

2.75

dPPAS2

YVLHT-------PESARFLPRLRQDT-GKDLYPVEIGKSD-------VEAIYREVKRLLEKHPEVPVALDLTSGTKAMSAGLAAAGFFFYPKVRVVYVDNEDYELRRPRAGTLPNPHEAEVDALFAKEGKGEFGQAVGRTGNQAYALYALLAEMYRAWRALDFGEALKAGRKLWLNHPLNARREALEAQVALLEAVDRFLKARDFALKEGVYGLARTLLHLAQEAKEEAAVLAALYAYRALELLLQERLALL---------GRRPGLSPEEAEALRKALAELLPEEVRLPAKLGLLDLLAFLRLKGDEALGRLAELRGLAGALRNSLVHGFDVPSPKAVEGIARL-AQGLLQDLEARTALGPLS-----------PEPVPLG

4rgpA

0.18

0.11

0.60

1.32

wMUSTER

--------------------------------------------------------------------------------------------------------------------------------------------------NATEQETLTILLDVYAYYQAYQIVKASQFSDDIIFLLELLKERRELNNQVHLQELELTYLDNAYEEELLANYIDLEAKLRNDHIIDFVRSVSPILYRLLR--LQSQVADNDYIYDAKQYDTWKFDKHDSANPFVQNFVAK-GRDSKITSRSLADFIQLTPQAIKDNILLLRDFEKSVRNPLAHLIKPFDEEELHRTTGFSSQTFLEKIIQLAVNDKFYFDKVNELIKRIYQ-----

5fshA

0.18

0.17

0.91

1.24

PPAS

YVLHT------PESARFLPRLRQDTGKDLYPVEI-----GKSDVEAIYREVKRLLEKH----PEVPVALDLTSGTKAMSAGLAAAGFFFYPKVRVVYVDNEDYELRRPRAGTLPNPHEAEVDALFAKEGKGEFGRGMVGRTGQAYALYALLAEMYRAWRALDFGEALKAGRKLWLNHPLNARREALEAQVALLEAVDRFLKARDFALKEGVYGLARTLLHLAQEAKEEAAVLAALYAYRALELLLQERLALL---------GRRPGLSPEEAEALRKALAELLPEEVRLPAKLGLLDLLAFLRLKGDEALGRLAELRGLAGALRNSLVHGFDVPSPKAVEGIARL-AQGLLQDLEARTALGPLS-----------PEPVPLG

4rgpA

0.17

0.10

0.60

2.75

wPPAS

--------------------------------------------------------------------------------------------------------------------------------------------------NATEQETLTILLDVYAYYQAYQIVKASQFSDDIIFLLELLKERRELNVDFLFQNQVHLQLDNAYEEELLANYIDLEAKLRNDHIIDFVRSVSPILYRLLRLQSQVDINDYIYDAKNDQYDTWKFDKHDSANPFVQNFVAK-GRDSKITSRSLADFIQLTDQAIKDNILLLRDFEKSVRNPLAHLIKPFDEEELHRTTGFSSQTFLEKIIQLAVNDKFYFDKVNELIKRIYQ-----

5fshA

0.19

0.18

0.93

1.12

Env-PPAS

VSVHTEATALAILGAPESARFLPRLRQDTGKDLYPVEI-GKSDVEAIYREVKRLLEKH----PEVPVALDLTSGTKAMSAGLAAAGFFFYPKVRVVYVDNEDYELRRPRAGTLPNPHEAEVDALFAKEGKGEFGRGMVGRTGQAYALYALLAEMYRAWRALDFGEALKAGRKLWLNHPLNARREALEAQVALLEAVDRFLKARDFALKEGVYGLARTLLHLAQEAKEEAAVLAALYAYRALELLLQERLALL---------GRRPGLSPEEAEALRKALAELLPEEVRLPAKLGLLDLLAFLRLKGDEALGRLAELRGLAGALRNSLVHGFDVPSPKAVEGIARL-AQGLLQDLEARTALGPLSPEPV-----------PLG

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.94

Estimated TM-score = 0.60±0.14

Estimated RMSD = 8.8±4.6Å

Download Model 2

C-score=-3.34

Download Model 3

C-score=-3.43

Download Model 4

C-score=-3.26

Download Model 5

C-score=-2.72

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5fshA	0.814	2.81	0.177	0.916
2	4rgpA	0.469	3.95	0.085	0.586
3	5l4kZ	0.436	6.44	0.063	0.696
4	4cr2Z	0.435	6.26	0.053	0.678
5	5d06A	0.432	7.26	0.048	0.764
6	3s4wB	0.431	6.81	0.066	0.715
7	5jbdA	0.422	6.26	0.028	0.673
8	2q1fA	0.421	6.71	0.034	0.683
9	5i6fA	0.421	6.88	0.064	0.694
10	3hz3A	0.415	6.36	0.049	0.662

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.08	4	2ppbN	STD	Rep, Mult	232,235,236,237,240,347
2	0.06	3	4a01B	DMU	Rep, Mult	229,230,233
3	0.06	3	3vvkE	AZI	Rep, Mult	218,219,222,236,240,347
4	0.04	2	3ozgA	MG	Rep, Mult	128,136
5	0.02	1	3cknA	MN	Rep, Mult	128,329
6	0.02	1	2zxqA	MN	Rep, Mult	317,320,342
7	0.02	1	3u7qB	IMD	Rep, Mult	7,10
8	0.02	1	4zbdA	GSH	Rep, Mult	218,235
9	0.02	1	1kprA	III	Rep, Mult	244,314
10	0.02	1	3j47V	III	Rep, Mult	241,245,248
11	0.02	1	2onk2	III	Rep, Mult	213,214,216,217,218,219,220,221,222,223,242,246,247
12	0.02	1	3ibvA	CA	Rep, Mult	209,251
13	0.02	1	1dy0A	ZN	Rep, Mult	328,329
14	0.02	1	1xz1A	HLT	Rep, Mult	157,160,161
15	0.02	1	1sl0A	MG	Rep, Mult	45,118
16	0.02	1	4f8hD	LMD	Rep, Mult	243,247
17	0.02	1	3a6pA	III	Rep, Mult	218,241,249
18	0.02	1	3kllA	MAL	Rep, Mult	164,167,168,169

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3b9jJ	0.197	6.80	0.011	0.335	1.17.1.4,1.17.3.2	248
2	0.060	1fo4A	0.375	7.10	0.058	0.644	1.17.1.4	NA
3	0.060	3eqlM	0.368	6.89	0.054	0.615	2.7.7.6	235
4	0.060	1ug9A	0.386	6.96	0.051	0.657	3.2.1.70	NA
5	0.060	2q1fA	0.421	6.71	0.034	0.683	4.2.2.21	70
6	0.060	3b9jI	0.170	4.91	0.023	0.233	1.17.1.4,1.17.3.2	212,238
7	0.060	2hg4C	0.372	6.98	0.056	0.628	2.3.1.94	303,309,313,322
8	0.060	2x0sA	0.361	6.90	0.065	0.607	2.7.9.1	NA
9	0.060	2o7qA	0.375	7.37	0.046	0.667	4.2.1.10,1.1.1.25	NA
10	0.060	3b9jC	0.260	6.49	0.040	0.411	1.17.3.2,1.17.1.4	NA
11	0.060	3hz3A	0.415	6.36	0.049	0.662	2.4.1.5	NA
12	0.060	1gytA	0.330	7.03	0.055	0.555	3.4.11.1	NA
13	0.060	1gytJ	0.337	6.76	0.046	0.550	3.4.11.1	216
14	0.060	3fwmA	0.326	7.10	0.035	0.565	2.4.1.129,	NA
15	0.060	2zxqA	0.387	7.37	0.037	0.694	3.2.1.97	7
16	0.060	3fwlA	0.371	6.92	0.056	0.623	2.4.1.129	NA
17	0.060	1kc7A	0.382	6.55	0.034	0.628	2.7.9.1	NA
18	0.060	3eqlD	0.357	6.42	0.041	0.568	2.7.7.6	NA
19	0.060	1ynnD	0.282	7.10	0.020	0.482	2.7.7.6	316

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.07	0.406	6.90	0.06	0.68	3jcpN	GO:0000502 GO:0004175 GO:0005634 GO:0006511 GO:0008540 GO:0030234 GO:0030674 GO:0034515 GO:0042176 GO:0043161 GO:0043248 GO:0050790
1	0.06	0.432	6.58	0.05	0.70	5a5bZ	GO:0000502 GO:0004175 GO:0005634 GO:0006511 GO:0008540 GO:0030234 GO:0030674 GO:0034515 GO:0042176 GO:0043161 GO:0050790
2	0.06	0.217	7.01	0.05	0.37	2zooA	GO:0005507 GO:0006807 GO:0009055 GO:0016491 GO:0020037 GO:0046872 GO:0050421 GO:0055114
3	0.06	0.235	6.49	0.05	0.37	3dhuA	GO:0003824 GO:0004556 GO:0005975 GO:0008152 GO:0016787 GO:0016798
4	0.06	0.232	6.83	0.03	0.38	2qa1A	GO:0000166 GO:0016491 GO:0055114 GO:0071949
5	0.06	0.272	7.35	0.01	0.49	4aieA	GO:0003824 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0043896 GO:0046872
6	0.06	0.261	4.87	0.06	0.35	2vq2A
7	0.06	0.245	6.83	0.02	0.40	2nzwC	GO:0006486 GO:0008417 GO:0016020 GO:0016740 GO:0016757 GO:0036065
8	0.06	0.240	7.17	0.04	0.42	3l7jB	GO:0016020 GO:0047355
9	0.06	0.260	7.03	0.04	0.44	3ueqA	GO:0003824 GO:0005576 GO:0005975 GO:0016740 GO:0016757 GO:0047669
10	0.06	0.255	6.59	0.04	0.41	1rqgA	GO:0000049 GO:0000166 GO:0003723 GO:0004812 GO:0004825 GO:0005524 GO:0005737 GO:0006412 GO:0006418 GO:0006431 GO:0016874 GO:0046872
11	0.06	0.227	6.67	0.03	0.37	4cbhD	GO:0000166 GO:0001172 GO:0003723 GO:0003968 GO:0004175 GO:0004197 GO:0004252 GO:0004386 GO:0005216 GO:0005524 GO:0006508 GO:0006810 GO:0006811 GO:0008026 GO:0008233 GO:0008234 GO:0008236 GO:0016020 GO:0016021 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0016817 GO:0017111 GO:0019012 GO:0019062 GO:0019079 GO:0019082 GO:0030430 GO:0030683 GO:0033644 GO:0033897 GO:0034220 GO:0039503 GO:0039520 GO:0039548 GO:0039654 GO:0039663 GO:0039694 GO:0039707 GO:0042025 GO:0044228 GO:0044385 GO:0046718 GO:0051259 GO:0055036 GO:0070008 GO:0090502 GO:1903608 GO:1990219
12	0.06	0.250	6.26	0.09	0.40	1c0gA	GO:0000166 GO:0000281 GO:0000902 GO:0001891 GO:0005200 GO:0005524 GO:0005737 GO:0005856 GO:0005884 GO:0006897 GO:0006909 GO:0006935 GO:0006972 GO:0015629 GO:0016192 GO:0017022 GO:0030864 GO:0031143 GO:0031252 GO:0032009 GO:0032010 GO:0042331 GO:0044291 GO:0044351 GO:0045335 GO:0060187
13	0.06	0.237	6.70	0.05	0.39	4cbhA	GO:0000166 GO:0001172 GO:0003723 GO:0003968 GO:0004175 GO:0004197 GO:0004252 GO:0004386 GO:0005216 GO:0005524 GO:0006508 GO:0006810 GO:0006811 GO:0008026 GO:0008233 GO:0008234 GO:0008236 GO:0016020 GO:0016021 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0016817 GO:0017111 GO:0019012 GO:0019062 GO:0019079 GO:0019082 GO:0030430 GO:0030683 GO:0033644 GO:0033897 GO:0034220 GO:0039503 GO:0039520 GO:0039548 GO:0039654 GO:0039663 GO:0039694 GO:0039707 GO:0042025 GO:0044228 GO:0044385 GO:0046718 GO:0051259 GO:0055036 GO:0070008 GO:0090502 GO:1903608 GO:1990219
14	0.06	0.231	6.67	0.06	0.38	3ejwA	GO:0043190
15	0.06	0.236	6.67	0.02	0.38	5dzvB	GO:0005509 GO:0005886 GO:0007155 GO:0007156 GO:0016020 GO:0016021
16	0.06	0.236	6.64	0.03	0.38	4uorA	GO:0003824 GO:0008152 GO:0008484 GO:0016020 GO:0016021 GO:0046872
17	0.06	0.254	6.75	0.04	0.42	4gklA	GO:0003824 GO:0005975
18	0.06	0.227	6.69	0.04	0.37	1gqeA	GO:0003747 GO:0005737 GO:0005829 GO:0006412 GO:0006415 GO:0016149 GO:0043022

Consensus prediction of GO terms

Molecular Function	GO:0030234	GO:0030674	GO:0004175	GO:0020037	GO:0009055	GO:0050421	GO:0071949	GO:0004556	GO:0005507
GO-Score	0.13	0.13	0.13	0.06	0.06	0.06	0.06	0.06	0.06
Biological Processes	GO:0042176	GO:0050790	GO:0043161	GO:0055114	GO:0043248	GO:0006807	GO:0005975
GO-Score	0.13	0.13	0.13	0.12	0.07	0.06	0.06
Cellular Component	GO:0008540	GO:0034515	GO:0005634
GO-Score	0.13	0.13	0.13

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.