I-TASSER results

I-TASSER results for job id Rv2817c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (338 residues)
MVQLYVSDSVSRISFADGRVIVWSEELGESQYPIETLDGITLFGRPTMTTPFIVEMLKRE
RDIQLFTTDGHYQGRISTPDVSYAPRLRQQVHRTDDPAFCLSLSKRIVSRKILNQQALIR
AHTSGQDVAESIRTMKHSLAWVDRSGSLAELNGFEGNAAKAYFTALGHLVPQEFAFQGRS
TRPPLDAFNSMVSLGYSLLYKNIIGAIERHSLNAYIGFLHQDSRGHATLASDLMEVWRAP
IIDDTVLRLIADGVVDTRAFSKNSDTGAVFATREATRSIARAFGNRIARTATYIKGDPHR
YTFQYALDLQLQSLVRVIEAGHPSRLVDIDITSEPSGA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MVQLYVSDSVSRISFADGRVIVWSEELGESQYPIETLDGITLFGRPTMTTPFIVEMLKRERDIQLFTTDGHYQGRISTPDVSYAPRLRQQVHRTDDPAFCLSLSKRIVSRKILNQQALIRAHTSGQDVAESIRTMKHSLAWVDRSGSLAELNGFEGNAAKAYFTALGHLVPQEFAFQGRSTRPPLDAFNSMVSLGYSLLYKNIIGAIERHSLNAYIGFLHQDSRGHATLASDLMEVWRAPIIDDTVLRLIADGVVDTRAFSKNSDTGAVFATREATRSIARAFGNRIARTATYIKGDPHRYTFQYALDLQLQSLVRVIEAGHPSRLVDIDITSEPSGA
Prediction	CCEEEEHCCCEEEEEHCCEEEEEHCCCEEEEEHCCEHCEEEEHCCCHCCHHHHHHHHHHCCEEEEHCCCCCEEEEEHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCEEHCCCCCEEHCHHHHHHHHHHHHHHHHHHHHCCCCCCEEHCHHHHHHHHHHHHHHHHHCCCCCCCEEEHCCCCCCCC
Conf.Score	98899977997999989999999989589998544556899958856599999999998995999789997579997788875999999999987978999999999999999999999998888568999999999999877679999999999999999999999986677778898889999978999999999999999999999899985688758999886568899888755789999999999899987765554578858859999999999999999865333456886767999999999999999988987775566467888889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MVQLYVSDSVSRISFADGRVIVWSEELGESQYPIETLDGITLFGRPTMTTPFIVEMLKRERDIQLFTTDGHYQGRISTPDVSYAPRLRQQVHRTDDPAFCLSLSKRIVSRKILNQQALIRAHTSGQDVAESIRTMKHSLAWVDRSGSLAELNGFEGNAAKAYFTALGHLVPQEFAFQGRSTRPPLDAFNSMVSLGYSLLYKNIIGAIERHSLNAYIGFLHQDSRGHATLASDLMEVWRAPIIDDTVLRLIADGVVDTRAFSKNSDTGAVFATREATRSIARAFGNRIARTATYIKGDPHRYTFQYALDLQLQSLVRVIEAGHPSRLVDIDITSEPSGA
Prediction	54300022550302255400002257643230204201100010202001300220063400000004411000000023222031122002102346200300120030003101200332344440351053045025305515316301310130032004002410366150541444444110000000000001010100011010000000001445432000000022020310020001003545155720344464210202640033005102620553151253563512022001100220031036644142042405522568
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCEEEEHCCCEEEEEHCCEEEEEHCCCEEEEEHCCEHCEEEEHCCCHCCHHHHHHHHHHCCEEEEHCCCCCEEEEEHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCEEHCCCCCEEHCHHHHHHHHHHHHHHHHHHHHCCCCCCEEHCHHHHHHHHHHHHHHHHHCCCCCCCEEEHCCCCCCCC
MVQLYVSDSVSRISFADGRVIVWSEELGESQYPIETLDGITLFGRPTMTTPFIVEMLKRERDIQLFTTDGHYQGRISTPDVSYAPRLRQQVHRTDDPAFCLSLSKRIVSRKILNQQALIRAHTSGQDVAESIRTMKHSLAWVDRSGSLAELNGFEGNAAKAYFTALGHLVPQEFAFQGRSTRPPLDAFNSMVSLGYSLLYKNIIGAIERHSLNAYIGFLHQDSRGHATLASDLMEVWRAPIIDDTVLRLIADGVVDTRAFSKNSDTGAVFATREATRSIARAFGNRIARTATYIKGDPHRYTFQYALDLQLQSLVRVIEAGHPSRLVDIDITSEPSGA

3lfxE

0.19

0.18

0.92

2.78

MUSTER

MESVYLFSS-GTLKRKANTICLETESG-RKYIPVENVMDIKVFGEVDLNKRFLEFLSQKRIPIHFFNREGYYVGTFYPREYLNSGLILKQAEHYINQEKRMLIAREIVSRSFQNMVDFLKKRKVRA------DSLTRYKKKAEEASNVSELMGIEGNAREEYYSMIDSLVSDRFRIEKRTRRPPKNFANTLISFGNSLLYTTVLSLIYQTHLDPRIGYLHETNFRRFSLNLDIAELFKPAVVDRLFLNLVNTRQINEKHFDE-----ILMLNDEGKSLFVKNYEQALRETVFHK-KLNRYVSMRSLIKMELHKLEKHLIGEQVF--------------

3lfxE

0.19

0.18

0.92

3.30

dPPAS

MESVYLFSS-GTLKRKANTICLETESG-RKYIPVENVMDIKVFGEVDLNKRFLEFLSQKRIPIHFFNREGYYVGTFYPREYLNSGLILKQAEHYINQEKRMLIAREIVSRSFQNMVDFLKKRKVRA------DSLTRYKKKAEEASNVSELMGIEGNAREEYYSMIDSLVSDRFRIEKRTRRPPKNFANTLISFGNSLLYTTVLSLIYQTHLDPRIGYLHETNFRRFSLNLDIAELFKPAVVDRLFLNLVNTRQINEKHFDE-----ILMLNDEGKSLFVKNYEQALRETVFHK-KLNRYVSMRSLIKMELHKLEKHLIGEQVF--------------

3lfxE

0.20

0.18

0.92

4.62

wdPPAS

MESVYLFSS-GTLKRKANTICLETESG-RKYIPVENVMDIKVFGEVDLNKRFLEFLSQKRIPIHFFNREGYYVGTFYPREYLNSGLILKQAEHYINQEKRMLIAREIVSRSFQNMVDFLKKRKVRA------DSLTRYKKKAEEASNVSELMGIEGNAREEYYSMIDSLVSDEFRIEKRTRRPPKNFANTLISFGNSLLYTTVLSLIYQTHLDPRIGYLHETNFRRFSLNLDIAELFKPAVVDRLFLNLVNTRQINEKHFDE-----ILMLNDEGKSLFVKNYEQALRETVFHK-KLNRYVSMRSLIKMELHKLEKHLIGEQVF--------------

3lfxE

0.19

0.18

0.91

3.42

wMUSTER

-ESVYLFSS-GTLKRKANTICLETESG-RKYIPVENVMDIKVFGEVDLNKRFLEFLSQKRIPIHFFNREGYYVGTFYPREYLNSGLILKQAEHYINQEKRMLIAREIVSRSFQNMVDFLKKRKVRA------DSLTRYKKKAEEASNVSELMGIEGNAREEYYSMIDSLVSDEFRIEKRTRRPPKNFANTLISFGNSLLYTTVLSLIYQTHLDPRIGYLHETNFRRFSLNLDIAELFKPAVVDRLFLNLVNTRQINEKHFDE-----ILMLNDEGKSLFVKNYEQALRETVFHK-KLNRYVSMRSLIKMELHKLEKHLIGEQVF--------------

3lfxE

0.20

0.18

0.92

5.16

wPPAS

MESVYLFSS-GTLKRKANTICLETESG-RKYIPVENVMDIKVFGEVDLNKRFLEFLSQKRIPIHFFNREGYYVGTFYPREYLNSGLILKQAEHYINQEKRMLIAREIVSRSFQNMVDFLKKRKVRA------DSLTRYKKKAEEASNVSELMGIEGNAREEYYSMIDSLVSDEFRIEKRTRRPPKNFANTLISFGNSLLYTTVLSLIYQTHLDPRIGYLHETNFRRFSLNLDIAELFKPAVVDRLFLNLVNTRQINEKHFDE-----ILMLNDEGKSLFVKNYEQALRETVFHK-KLNRYVSMRSLIKMELHKLEKHLIGEQVF--------------

3lfxE

0.19

0.18

0.92

6.73

dPPAS2

MESVYLFSS-GTLKRKANTICLETESG-RKYIPVENVMDIKVFGEVDLNKRFLEFLSQKRIPIHFFNREGYYVGTFYPREYLNSGLILKQAEHYINQEKRMLIAREIVSRSFQNMVDFLKKRKVRA------DSLTRYKKKAEEASNVSELMGIEGNAREEYYSMIDSLVSDRFRIEKRTRRPPKNFANTLISFGNSLLYTTVLSLIYQTHLDPRIGYLHETNFRRFSLNLDIAELFKPAVVDRLFLNLVNTRQINEKHFDE-----ILMLNDEGKSLFVKNYEQALRETVFHK-KLNRYVSMRSLIKMELHKLEKHLIGEQVF--------------

3lfxE

0.20

0.18

0.92

4.40

PPAS

MESVYLFSS-GTLKRKANTICLETESG-RKYIPVENVMDIKVFGEVDLNKRFLEFLSQKRIPIHFFNREGYYVGTFYPREYLNSGLILKQAEHYINQEKRMLIAREIVSRSFQNMVDFLKKRKVRA------DSLTRYKKKAEEASNVSELMGIEGNAREEYYSMIDSLVSDEFRIEKRTRRPPKNFANTLISFGNSLLYTTVLSLIYQTHLDPRIGYLHETNFRRFSLNLDIAELFKPAVVDRLFLNLVNTRQINEKHFDE-----ILMLNDEGKSLFVKNYEQALRETVFHK-KLNRYVSMRSLIKMELHKLEKHLIGEQVF--------------

3lfxE

0.20

0.18

0.92

6.76

Env-PPAS

MESVYLFSS-GTLKRKANTICLETESG-RKYIPVENVMDIKVFGEVDLNKRFLEFLSQKRIPIHFFNREGYYVGTFYPREYLNSFLILKQAEHYINQEKRMLIAREIVSRSFQNMVDFLKKRKVR------ADSLTRYKKKAEEASNVSELMGIEGNAREEYYSMIDSLVSDEFRIEKRTRRPPKNFANTLISFGNSLLYTTVLSLIYQTHLDPRIGYLHETNFRRFSLNLDIAELFKPAVVDRLFLNLVNTRQINEKHFDE-----ILMLNDEGKSLFVKNYEQALRETVFHK-KLNRYVSMRSLIKMELHKLEKHLIGEQVF--------------

2yzsB

0.21

0.19

0.91

2.57

MUSTER

-RVYYINSH-GTLSRHENTLRFEN--EVKKDIPVEDVEEIFVFAELSLNTKLLNFLASKGIPLHFFNYYGYYTGTFYPRESSG-HLLIKQVEHYLDAQKRLYLAKSFVIGSILNLEYVYKIS------------ADTYLNKVKETNSIPE-LSVEAEFRKLCYKKLEEVT--GWELEKRTKRPPQNPLNALISFGNSLTYAKVLGEIYKTQLNPTVSYLH--EPSRFSLSLDVAEVFKPIFVDNLIIRLIQENKIDKTHFSTELN---TFLNEIGRKVFLKAFNELLETTIFYP-KLNRKVSHRTLIKLELYKLIKHLLEEEVYLPLNYGLK------

2yzsB

0.21

0.20

0.91

3.03

dPPAS

-RVYYINSH-GTLSRHENTLRFENEV--KKDIPVEDVEEIFVFAELSLNTKLLNFLASKGIPLHFFNYYGYYTGTFYPRESSG-HLLIKQVEHYLDAQKRLYLAKSFVIGSILNLEYVYKIS------------ADTYLNKVKETNSIPE-LSVEAEFRKLCYKKLEEVTG--WELEKRTKRPPQNPLNALISFGNSLTYAKVLGEIYKTQLNPTVSYLHE--PSRFSLSLDVAEVFKPIFVDNLIIRLIQENKIDKTHFST---ELNTFLNEIGRKVFLKAFNELLETTIFYP-KLNRKVSHRTLIKLELYKLIKHLLEEEVYLPLNYGGLK-----

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.16

Estimated TM-score = 0.87±0.07

Estimated RMSD = 4.1±2.7Å

Download Model 2

C-score=-2.46

Download Model 3

C-score=-2.12

Download Model 4

C-score=0.18

Download Model 5

C-score=1.16

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3lfxE	0.903	0.85	0.200	0.917
2	2yzsB	0.840	2.05	0.225	0.908
3	3godA	0.567	3.67	0.100	0.677
4	1aorA	0.436	6.69	0.040	0.728
5	1kekA	0.429	6.74	0.024	0.743
6	1b25A	0.425	6.59	0.051	0.707
7	3c3lA	0.420	7.09	0.051	0.751
8	1llwA2	0.400	6.79	0.036	0.692
9	3fahA	0.399	6.33	0.048	0.642
10	3ikmD1	0.392	6.97	0.060	0.686

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.44	7	3godB	MN	Rep, Mult	111,155,220,235
2	0.09	2	1lm1A	F3S	Rep, Mult	255,256,258,259,260,271,272,274,278,279
3	0.05	1	2c3oA	SF4	Rep, Mult	163,175,188,189,191,192,243,246,247
4	0.05	1	3c46A	2HP	Rep, Mult	200,234,235

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1lehA	0.369	6.01	0.046	0.571	1.4.1.9	62
2	0.060	1s76D	0.342	7.06	0.058	0.610	2.7.7.6	NA
3	0.060	1ps9A	0.375	6.39	0.037	0.604	1.3.1.34	196
4	0.060	3c46B	0.420	7.05	0.051	0.749	2.7.7.6	235,244
5	0.060	2e1qA	0.389	6.78	0.029	0.660	1.17.3.2,1.17.1.4	NA
6	0.060	1a17A	0.176	4.76	0.062	0.240	3.1.3.16	139,156
7	0.060	2aw5B	0.374	6.87	0.065	0.648	1.1.1.40	NA
8	0.060	2ohyB	0.375	5.98	0.067	0.586	5.4.3.6	NA
9	0.060	3ikmD	0.392	6.97	0.060	0.686	2.7.7.7	113
10	0.060	2ckjA	0.362	7.14	0.059	0.633	1.17.1.4,1.17.3.2	115
11	0.060	1o0sA	0.375	6.86	0.051	0.645	1.1.1.38	NA
12	0.060	3b9jC	0.312	6.18	0.047	0.497	1.17.3.2,1.17.1.4	NA
13	0.060	1vlbA	0.399	6.34	0.048	0.642	1.2.99.7	145
14	0.060	1b0pA	0.426	6.80	0.027	0.749	1.2.7.1	NA
15	0.060	2zxqA	0.386	6.67	0.033	0.648	3.2.1.97	165
16	0.060	1gq2A	0.369	6.72	0.059	0.630	1.1.1.40	NA
17	0.060	2rnpC	0.308	6.94	0.045	0.544	2.7.7.6	NA
18	0.060	1aroP	0.357	6.61	0.064	0.595	2.7.7.6	NA
19	0.060	2pdaA	0.426	6.85	0.033	0.751	1.2.7.1	147

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.49	0.902	0.88	0.20	0.92	4xtkE	GO:0003677 GO:0004518 GO:0004519 GO:0016787 GO:0043571 GO:0046872 GO:0051607 GO:0090305
1	0.37	0.845	2.05	0.22	0.91	2yzsB	GO:0003677 GO:0004518 GO:0004519 GO:0016787 GO:0043571 GO:0046872 GO:0051607 GO:0090305
2	0.28	0.718	3.39	0.21	0.83	4n06B	GO:0003677 GO:0003723 GO:0004518 GO:0004519 GO:0016787 GO:0043571 GO:0046872 GO:0051607 GO:0090305
3	0.26	0.572	3.94	0.10	0.70	3godA	GO:0003677 GO:0004518 GO:0004519 GO:0016787 GO:0043571 GO:0046872 GO:0051607 GO:0090305
4	0.26	0.684	2.82	0.17	0.76	4wj0A	GO:0003677 GO:0004518 GO:0004519 GO:0016787 GO:0043571 GO:0046872 GO:0051607 GO:0090305
5	0.24	0.648	3.99	0.09	0.81	5fclA	GO:0003677 GO:0004518 GO:0004519 GO:0016787 GO:0043571 GO:0046872 GO:0051607 GO:0090305
6	0.16	0.503	4.44	0.12	0.67	4qdlC	GO:0003677 GO:0004518 GO:0004519 GO:0005737 GO:0006281 GO:0006974 GO:0008821 GO:0016787 GO:0017108 GO:0043571 GO:0046872 GO:0051607 GO:0090305
7	0.15	0.528	3.94	0.12	0.63	5dqzB	GO:0003677 GO:0004518 GO:0004519 GO:0005737 GO:0006281 GO:0006974 GO:0008821 GO:0016787 GO:0017108 GO:0043571 GO:0046872 GO:0051607 GO:0090305
8	0.06	0.425	6.59	0.05	0.71	1b25A	GO:0009055 GO:0016491 GO:0016625 GO:0046872 GO:0051536 GO:0051539 GO:0055114
9	0.06	0.436	6.69	0.04	0.73	1aorA	GO:0009055 GO:0016491 GO:0016625 GO:0033726 GO:0046872 GO:0051536 GO:0051539 GO:0055114
10	0.06	0.414	6.66	0.05	0.70	4z3wC	GO:0009055 GO:0016491 GO:0016625 GO:0051536 GO:0055114
11	0.06	0.352	6.23	0.04	0.57	2yl2B	GO:0000166 GO:0001894 GO:0003824 GO:0003989 GO:0004075 GO:0005524 GO:0005730 GO:0005737 GO:0005739 GO:0005829 GO:0006084 GO:0006629 GO:0006631 GO:0006633 GO:0006768 GO:0006853 GO:0008152 GO:0015629 GO:0016874 GO:0031325 GO:0035338 GO:0044268 GO:0046872 GO:0051289 GO:0055088 GO:0070062 GO:0071380 GO:2001295
12	0.06	0.326	6.81	0.05	0.56	2y2lB	GO:0008658 GO:0008955 GO:0016020 GO:0016021 GO:0016740 GO:0016746 GO:0016757
13	0.06	0.296	6.55	0.03	0.48	3egwB	GO:0005737 GO:0005886 GO:0008940 GO:0009055 GO:0009061 GO:0009325 GO:0016020 GO:0016491 GO:0031224 GO:0031235 GO:0042126 GO:0042128 GO:0044799 GO:0046872 GO:0051536 GO:0051538 GO:0051539 GO:0055114
14	0.06	0.309	6.92	0.04	0.54	4iibA	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0008422 GO:0016787 GO:0016798 GO:0030245 GO:0102483
15	0.06	0.277	6.11	0.03	0.43	4lk3B	GO:0005739 GO:0005794 GO:0016020 GO:0016021 GO:0016829 GO:0016831 GO:0032580 GO:0033320 GO:0042803 GO:0048040 GO:0051262 GO:0070062 GO:0070403
16	0.06	0.249	6.72	0.05	0.42	4ee9A	GO:0004553 GO:0005975 GO:0008152 GO:0008810 GO:0016787 GO:0016798
17	0.06	0.246	6.27	0.04	0.39	3hv9A	GO:0000160 GO:0000166 GO:0005622 GO:0006355
18	0.06	0.226	5.14	0.04	0.32	4j4mB	GO:0004222 GO:0006508 GO:0008237 GO:0046872

Consensus prediction of GO terms

Molecular Function	GO:0046872	GO:0003677	GO:0004519
GO-Score	0.87	0.87	0.87
Biological Processes	GO:0051607	GO:0043571	GO:0090305
GO-Score	0.87	0.87	0.87
Cellular Component
GO-Score

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.