I-TASSER results

I-TASSER results for job id Rv2813

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (270 residues)
MMHKLISYYGFSRMPFGRDLAPGMLHRHSAHNEAVARIGWCIADRRIGVITGEVGAGKTV
AVRAALASLDRSRHTIIYLPDPTVGVQGIHHRIVASLGGQPLTHHATLAPQAADALAAEQ
AERGRTPVVVVEEAHLLGYDQLEALRLLTNHDLDSSSPFACLLIGQPTLRRRMKLGVLAA
LDQRIGLRYAMPPMTDTNTGSYLRHHLKLAGRDDALFSDDAIGLIHQTSRGYPRAVNNLA
LQALVAAFAADKAIVDESTTRTAIAEVTAD

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MMHKLISYYGFSRMPFGRDLAPGMLHRHSAHNEAVARIGWCIADRRIGVITGEVGAGKTVAVRAALASLDRSRHTIIYLPDPTVGVQGIHHRIVASLGGQPLTHHATLAPQAADALAAEQAERGRTPVVVVEEAHLLGYDQLEALRLLTNHDLDSSSPFACLLIGQPTLRRRMKLGVLAALDQRIGLRYAMPPMTDTNTGSYLRHHLKLAGRDDALFSDDAIGLIHQTSRGYPRAVNNLALQALVAAFAADKAIVDESTTRTAIAEVTAD
Prediction	CCCHHHHHHCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCEEEEHCCCCCCHHHHHHHHHHHHCCCCCEEEEHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEHCHHHCCHHHHHHHHHHHHCCCCCCCCEEEEHCCCHHHHHHHHCCCCHHHHHHCCEEEEHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
Conf.Score	985588998999998888999888447858999999999999989979999589999679999999994977758999869999999999999999899988887899999999999999988997799985776699999999999996567899878999879978999985888678886434589986999999999999999997999998999999999999899999999999999999999899989999999999999779
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MMHKLISYYGFSRMPFGRDLAPGMLHRHSAHNEAVARIGWCIADRRIGVITGEVGAGKTVAVRAALASLDRSRHTIIYLPDPTVGVQGIHHRIVASLGGQPLTHHATLAPQAADALAAEQAERGRTPVVVVEEAHLLGYDQLEALRLLTNHDLDSSSPFACLLIGQPTLRRRMKLGVLAALDQRIGLRYAMPPMTDTNTGSYLRHHLKLAGRDDALFSDDAIGLIHQTSRGYPRAVNNLALQALVAAFAADKAIVDESTTRTAIAEVTAD
Prediction	643423622404451054514262024164043014004302644210000024431110001100640475311000002332204200310054041424444342134104201421345543000000003323440031012012032563200000113344035316464143024000220202203360023004200431527532024500420052072102100300320031022474540336004300641578
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCHHHHHHCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCEEEEHCCCCCCHHHHHHHHHHHHCCCCCEEEEHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEHCHHHCCHHHHHHHHHHHHCCCCCCCCEEEEHCCCHHHHHHHHCCCCHHHHHHCCEEEEHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
MMHKLISYYGFSRMPFGRDLAPGMLHRHSAHNEAVARIGWCIADRRIGVITGEVGAGKTVAVRAALASLDRSRHTIIYLPDPTVGVQGIHHRIVASLGGQPLTHHATLAPQAADALAAEQAERGRTPVVVVEEAHLLGYDQLEALRLLTNHDLDSSSPFACLLIGQPTLRRRMKLGVLAALDQRIGLRYAMPPMTDTNTGSYLRHHLKLAGRDDALFSDDAIGLIHQTSRGYPRAVNNLALQALVAAFAADKAIVDESTTRTAIAEVTAD

1fnnA

0.17

0.16

0.94

1.29

MUSTER

---------AIDDSVFSPSYVPKRLPH-QQLQQLDILLGNWLRNPGRATLLGRPGTGKTVTLRKLWELYKDKTARFVYINGFIYNFTAIIGEIARSLNIPFPRRGLS-RDEFLALLVEHLRERDLYMFLVLDDAFNLAPDILSTFIRLGQADKLGAFRIALVIVGHDAVLNNL----DPSTRGIMGYVIRFSPYTKDQIFDILLDRAKAGLAEG-SYSEDILQMIADITRGDARLAIDILYRSAYAAQQNGRKHIAPEDVRKSSKEVLFG

2qbyA1

0.14

0.12

0.86

1.17

dPPAS

-----------------IFINREYLLPDDQIRKIASILAPLYREENNIFIYGLTGTGKTAVVKFVLSKLHGKFKHVYINTRQIDTPYRVLADLLESLDVKVPFTGLS-IAELYRRLVKAVRDYGSQVVIVLDEIDAFVKKYDDILYKLSRINSEVNKISFIGITNDVKFVDLLDPRVKSSL---SEEEIIFPPYNAEELEDILTKRAQM-AFKPGVLPDNVIKLCAALAAGDARRALDLLRVSGEIAERMKDTKV---------------

2qbyA1

0.15

0.14

0.89

1.46

wdPPAS

---IFI-----NREYLLPDYIPDELPHREDQIRKIASLAPLYREENNIFIYGLTGTGKTAVVKFVLSKLHLGKFKHVYINTRQITPYRVLADLLESLDVKVPFTGLS-IAELYRRLVKAVRDYGSQVVIVLDEIDAFVKKYDDILYKLSRINSEVNKISFIGITNDVKFVDLLDPR----VKSSLSEEIIFPPYNAEELEDILTKRAQMA-FKPGVLPDNVIKLCAALAAGDARRALDLLRVSGEIAERMKDTKV---------------

1fnnA

0.17

0.16

0.95

1.65

wMUSTER

------AIVV-DDSVFSPSYVPKRLPH-QQLQQLDILLGNWLRNPGRATLLGRPGTGKTVTLRKLWELYKDKTARFVYINGFIYNFTAIIGEIARSLNIPFPRRGLS-RDEFLALLVEHLRERDLYMFLVLDDAFNLAPDILSTFIRLGEADKLGAFRIALVIVGHDAVLNNLD----PSTRGIMGYVIRFSPYTKDQIFDILLDRAKAGLAEG-SYSEDILQMIADITRGDARLAIDILYRSAYAAQQNGRKHIAPEDVRKSSKEVLFG

2qbyA1

0.15

0.14

0.89

1.72

wPPAS

---IFI-----NREYLLPDYIPDELPHREDQIRKIASLAPLYREENNIFIYGLTGTGKTAVVKFVLSKLHKGKFKHVYI--QIDTPYRVLADLLESLDVKVPFTGLS-IAELYRRLVKAVRDYGSQVVIVLDEIDAFKKYNDDILYKLSRINSEVNKISFIGITNDVKFVDLLDPR----VKSSLSEEIIFPPYNAEELEDILTKRAQMA-FKPGVLPDNVIKLCAALAAGDARRALDLLRVSGEIAERMKDTKV---------------

2qbyA1

0.15

0.13

0.86

1.96

dPPAS2

-----------------IFINREYLLPDDQIRKIASILAPLYREENNIFIYGLTGTGKTAVVKFVLSKLHLGKFKHVYINTRQITPYRVLADLLESLDVKVPFTGLS-IAELYRRLVKAVRDYGSQVVIVLDEIDAFVKKYDDILYKLSRINSEVNKISFIGITNDVKFVDLLDPRVKSSLS---EEEIIFPPYNAEELEDILTKRAQMA-FKPGVLPDNVIKLCAALAAGDARRALDLLRVSGEIAERMKDTKV---------------

2qbyA1

0.14

0.13

0.89

1.60

PPAS

----------IFINRLLPDYIPDELPHREDQIRKIASLAPLYREENNIFIYGLTGTGKTAVVKFVLSKLHLGKFKHVYINTRQITPYRVLADLLESLDVKVPFTGLS-IAELYRRLVKAVRDYGSQVVIVLDEIDAFVKKYDDILYKLSRINSEVNKISFIGITNDVKFVDLLDPR----VKSSLSEEIIFPPYNAEELEDILTKRAQM-AFKPGVLPDNVIKLCAALAAGDARRALDLLRVSGEIAERMKDTKV---------------

3glgG1

0.16

0.14

0.93

2.05

Env-PPAS

GLEVLFQGPHMSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCREIEQGRFVDLEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTLE---EPPEHVKFLLAT-ADP-QKL----PVTILSRC-LQFHLKALDVEQIRHQLEHILNEEHIA---HEPRALQLLARAAEGSLRDALSLTDQAIASGD----GQVSTQAVSAMLGTL--D

2qbyA

0.15

0.14

0.95

1.21

MUSTER

-IFINREYLLPDYIP-------ELPHREDQIRKIASILAPLYREENNIFIYGLTGTGKTAVVKFVLSKLHLGKFKHVYINTRQITPYRVLADLLESLDVKVPFTGLS-IAELYRRLVKAVRDYGSQVVIVLDEIDAFKKYNDDILYKLSRINSEVNKISFIGITNDVKFVDLLDPR----VKSSLSEEIIFPPYNAEELEDILTKRAQMA-FKPGVLPDNVIKLCAALAAGDARRALDLLRVSGEIAERMKDTKVKEEYVYMAKEEIERD

2qbyB1

0.15

0.13

0.91

1.12

dPPAS

------------KNP-KVFIDPLSVFKEDILRDAAIAIRYFVKNEFSNLFLGLTGTGKTFVSKYIFNEIEYKDVKQAYVNCREVTPQAVLSSLAGKLTGFSVPKHGINLGEYIDKIKNGTR--NIRAIIYLDEVDTL-VKRRGGDIVLYQLLRSDANISVIMISNDINVRDYM----EPRVLSSLGPSVIFKPYDAEQLKFILSKYAEYG-LIKGTYDDEILSYIAAISAGDARKAVNLLFRAAQLAS--GGGIIRKEHVDKAIVDYEQE

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.18

Estimated TM-score = 0.69±0.12

Estimated RMSD = 6.4±3.9Å

Download Model 2

C-score=-2.67

Download Model 3

C-score=-5.00

Download Model 4

C-score=-5.00

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2qbyA	0.895	1.57	0.152	0.948
2	2v1uA	0.867	2.20	0.151	0.956
3	1fnnA	0.864	2.29	0.151	0.956
4	1w5tB	0.825	2.53	0.184	0.948
5	2qbyB	0.822	2.31	0.144	0.926
6	4xgcD	0.793	3.52	0.125	0.974
7	4xgcE	0.716	3.64	0.149	0.896
8	4wvyA	0.711	3.66	0.123	0.881
9	2qenA	0.703	3.25	0.136	0.870
10	4xgcC	0.702	4.27	0.100	0.956

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.68	249	4ly6S	08T	Rep, Mult	23,24,25,54,55,56,57,58,59,60,132,133,165,202,206,233,234,237
2	0.04	11	3glfC	BEF	Rep, Mult	54,55,58,59,133,234
3	0.00	1	2qbyB	MG	Rep, Mult	59,132,165
4	0.00	2	3glfB	QNA	Rep, Mult	83,85,86,90,138,142

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.293	1ixsB	0.638	3.29	0.142	0.785	3.6.4.12	234
2	0.270	1njgA	0.648	3.24	0.146	0.789	2.7.7.7	57,63,133,135,137,167,234
3	0.262	1in5A	0.654	3.06	0.146	0.785	3.6.4.12	234
4	0.090	2c9oC	0.689	3.66	0.115	0.859	3.6.1.-	234
5	0.067	3glfG	0.666	3.71	0.147	0.837	2.7.7.7	NA
6	0.060	2qf7B	0.405	6.24	0.060	0.693	6.4.1.1	NA
7	0.060	1xxiA	0.542	4.34	0.072	0.741	2.7.7.7	231,235
8	0.060	2epoA	0.438	5.62	0.077	0.693	3.2.1.52	132
9	0.060	2c9oA	0.689	3.69	0.112	0.863	3.6.4.12	234
10	0.060	1hv8A	0.489	5.10	0.080	0.715	3.6.4.13	NA
11	0.060	3kx2B	0.486	4.44	0.099	0.656	3.6.4.13	239,242,256
12	0.060	3kw3B	0.445	5.96	0.084	0.733	5.1.1.1	178
13	0.060	2hyiI	0.442	4.98	0.068	0.641	3.6.4.13	29,59
14	0.060	1nsfA	0.619	3.67	0.090	0.781	3.6.4.6	58
15	0.060	3e5pB	0.445	5.92	0.074	0.733	5.1.1.1	171
16	0.060	2epoB	0.395	5.58	0.060	0.619	3.2.1.52	132
17	0.060	2w00B	0.515	4.79	0.089	0.730	3.1.21.3	NA
18	0.060	3b9pA	0.632	3.74	0.110	0.811	3.6.4.3	57,59,203
19	0.060	1a5tA	0.551	3.90	0.168	0.726	2.7.7.7	55,239
20	0.060	1pjrA	0.456	5.16	0.074	0.670	3.6.4.12	NA
21	0.060	1w36D	0.430	4.88	0.116	0.604	3.1.11.5	137,148
22	0.060	2db3A	0.456	5.16	0.098	0.670	3.6.4.13	137,167
23	0.060	3cioA	0.438	5.18	0.071	0.652	2.7.10.2	30
24	0.060	1xtkA	0.488	4.83	0.057	0.700	3.6.4.13	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.43	0.864	2.29	0.15	0.96	1fnnA	GO:0000166 GO:0005524 GO:0006260 GO:0051301
1	0.39	0.895	1.57	0.15	0.95	2qbyA	GO:0000166 GO:0003677 GO:0005524 GO:0006260
2	0.38	0.867	2.20	0.15	0.96	2v1uA	GO:0000166 GO:0003677 GO:0005524 GO:0006260
3	0.37	0.830	2.45	0.18	0.95	1w5sB	GO:0000166 GO:0003677 GO:0005524 GO:0006260
4	0.36	0.660	3.22	0.16	0.80	3pvsD
5	0.34	0.822	2.31	0.14	0.93	2qbyB	GO:0000166 GO:0003677 GO:0005524 GO:0006260
6	0.33	0.793	3.52	0.12	0.97	4xgcD	GO:0000808 GO:0003677 GO:0003688 GO:0005634 GO:0005664 GO:0006260 GO:0006270
7	0.31	0.642	3.79	0.12	0.81	1ofhA	GO:0000166 GO:0005524 GO:0005737 GO:0006508 GO:0009376 GO:0016887 GO:0043335 GO:0070011
8	0.29	0.716	3.64	0.15	0.90	4xgcE	GO:0000166 GO:0000808 GO:0003677 GO:0005524 GO:0005634 GO:0005664 GO:0006260 GO:0006261 GO:0006270 GO:0006342 GO:0007052 GO:0007076 GO:0046331
9	0.27	0.649	3.61	0.10	0.82	1g4aE	GO:0000166 GO:0005524 GO:0005737 GO:0005829 GO:0006508 GO:0009376 GO:0009408 GO:0016020 GO:0016887 GO:0042802 GO:0043335 GO:0070011
10	0.24	0.639	3.80	0.12	0.82	3h4mA	GO:0000166 GO:0000502 GO:0003924 GO:0005524 GO:0005737 GO:0008540 GO:0010498 GO:0016787 GO:0016887 GO:0017025 GO:0022623 GO:0030163 GO:0030433 GO:0031595 GO:0031597 GO:0036402 GO:0043273 GO:0043335 GO:0045899 GO:1901800
11	0.24	0.651	3.59	0.11	0.82	1e94E	GO:0000166 GO:0005524 GO:0005737 GO:0005829 GO:0006508 GO:0009376 GO:0009408 GO:0016020 GO:0016887 GO:0042802 GO:0043335 GO:0070011
12	0.24	0.635	3.59	0.10	0.80	1g3iA	GO:0000166 GO:0005524 GO:0005737 GO:0006508 GO:0009376 GO:0016887 GO:0043335 GO:0070011
13	0.21	0.699	3.27	0.12	0.87	2fnaA	GO:0000166 GO:0005524
14	0.20	0.635	3.69	0.12	0.81	3whkA	GO:0000166 GO:0000502 GO:0005524 GO:0005634 GO:0005737 GO:0006511 GO:0008540 GO:0010498 GO:0016787 GO:0016887 GO:0017025 GO:0022623 GO:0030163 GO:0030433 GO:0031595 GO:0031597 GO:0036402 GO:0043335 GO:0045899 GO:0070682 GO:1901800
15	0.18	0.637	3.86	0.10	0.81	1l8qA	GO:0000166 GO:0003677 GO:0003688 GO:0005524 GO:0005737 GO:0006260 GO:0006270 GO:0006275 GO:0043565
16	0.17	0.630	3.84	0.10	0.82	5a5bI	GO:0000166 GO:0000502 GO:0005524 GO:0005634 GO:0005737 GO:0006511 GO:0008540 GO:0016787 GO:0016887 GO:0017025 GO:0030163 GO:0030433 GO:0031503 GO:0031595 GO:0031597 GO:0036402 GO:0043171 GO:0045732 GO:0045899 GO:0070651 GO:0070682 GO:1901800
17	0.17	0.605	3.48	0.15	0.76	4xgcA	GO:0000166 GO:0003677 GO:0003682 GO:0005524 GO:0005634 GO:0005664 GO:0006260 GO:0006261 GO:0006270 GO:0006277 GO:0006342 GO:0008283 GO:0019233 GO:0022008 GO:0042023
18	0.15	0.628	3.69	0.12	0.81	3jcpH	GO:0000166 GO:0000502 GO:0005524 GO:0005634 GO:0005737 GO:0006511 GO:0008540 GO:0016787 GO:0016887 GO:0017025 GO:0030163 GO:0030433 GO:0031595 GO:0031597 GO:0036402 GO:0045732 GO:0045899 GO:0070682 GO:1901800
19	0.14	0.614	3.98	0.10	0.81	4d80F	GO:0005524
20	0.12	0.611	4.04	0.12	0.81	5a5bL	GO:0000166 GO:0000502 GO:0005524 GO:0005634 GO:0005737 GO:0006289 GO:0008540 GO:0016787 GO:0016887 GO:0017025 GO:0019904 GO:0030163 GO:0030433 GO:0031595 GO:0031597 GO:0032968 GO:0036402 GO:0045899 GO:0070682 GO:1901800
21	0.10	0.620	3.93	0.14	0.81	5a5bM	GO:0000166 GO:0000502 GO:0005524 GO:0005634 GO:0005737 GO:0006511 GO:0008540 GO:0016787 GO:0016887 GO:0017025 GO:0030163 GO:0030433 GO:0031595 GO:0031597 GO:0036402 GO:0045899 GO:0070682 GO:1901800

Consensus prediction of GO terms

Molecular Function	GO:0005524	GO:0003677
GO-Score	0.86	0.76
Biological Processes	GO:0006260	GO:0051301
GO-Score	0.86	0.43
Cellular Component
GO-Score

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.