I-TASSER results

I-TASSER results for job id Rv2807

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (384 residues)
MVSTTGMGRSTARRMLTGPGLPEPAEQVDGRRLRARGFSDDARALLEHVWALMGMPCGKY
LVVMLELWLPLEAAAGDLDKPFATEAAVAELKAMSAATVDRYLKPARERMRIKGISTTKP
SPLLRNSITIHTCSDEAPKVPGVIEADTVAHCGPSLIGEFARTLTMTDLVTGWTENASIR
NNAAKWILEGIKECQQRFPFPMTVFDSDCGGEFINHDVAGWLQARDIAQTRSRPYQKNDQ
AHVESKNNHVVRKHAFYWRYDTGEELELLNRLWPLVSLRCNFFTPTKKPVGYTSTVNGRR
KRIYDKPATPWQRLQASGVLDAQQLSTVAARIEGFNPADLTRQINAIQMQLLDLAKTKTE
ALATARHIDLQSLQPSINRLAKAK

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MVSTTGMGRSTARRMLTGPGLPEPAEQVDGRRLRARGFSDDARALLEHVWALMGMPCGKYLVVMLELWLPLEAAAGDLDKPFATEAAVAELKAMSAATVDRYLKPARERMRIKGISTTKPSPLLRNSITIHTCSDEAPKVPGVIEADTVAHCGPSLIGEFARTLTMTDLVTGWTENASIRNNAAKWILEGIKECQQRFPFPMTVFDSDCGGEFINHDVAGWLQARDIAQTRSRPYQKNDQAHVESKNNHVVRKHAFYWRYDTGEELELLNRLWPLVSLRCNFFTPTKKPVGYTSTVNGRRKRIYDKPATPWQRLQASGVLDAQQLSTVAARIEGFNPADLTRQINAIQMQLLDLAKTKTEALATARHIDLQSLQPSINRLAKAK
Prediction	CCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCEEEEHCCCCCCCCCCCEEEEEEEEHCCCCCEEEEHCCCCHHHHHHHHHHHHHHHHCCCCEEEEHCCCCCCCHHHHHHHHHHHCCEEEHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEHCCCEEEEHCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCC
Conf.Score	964468988999999985677888777777777777789999999999999868865566788899999999998555665557899999998755555666666655554455555666466556788887777777888858865445688878886799999998878959999957767999999999999995998569995899764449999999998997986899998765789999879999987755678999999999999999986576667654455455468767876578888778764678888789999999999889999999999999999998667776666677776677777765676679
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MVSTTGMGRSTARRMLTGPGLPEPAEQVDGRRLRARGFSDDARALLEHVWALMGMPCGKYLVVMLELWLPLEAAAGDLDKPFATEAAVAELKAMSAATVDRYLKPARERMRIKGISTTKPSPLLRNSITIHTCSDEAPKVPGVIEADTVAHCGPSLIGEFARTLTMTDLVTGWTENASIRNNAAKWILEGIKECQQRFPFPMTVFDSDCGGEFINHDVAGWLQARDIAQTRSRPYQKNDQAHVESKNNHVVRKHAFYWRYDTGEELELLNRLWPLVSLRCNFFTPTKKPVGYTSTVNGRRKRIYDKPATPWQRLQASGVLDAQQLSTVAARIEGFNPADLTRQINAIQMQLLDLAKTKTEALATARHIDLQSLQPSINRLAKAK
Prediction	603202101400121034444555555475544444423660240033013015211242024214410430342442544213430153025113432321245244535444444543453145504244143365422210200001122444434100000000220300000003330052014004201631513122030220110115202500572603132032223421030032044114300323414345014104201410220101122124224434545352343144032003201637414563354044114412124025304401530261154545544444425253035305525648
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCEEEEHCCCCCCCCCCCEEEEEEEEHCCCCCEEEEHCCCCHHHHHHHHHHHHHHHHCCCCEEEEHCCCCCCCHHHHHHHHHHHCCEEEHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEHCCCEEEEHCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCC
MVSTTGMGRSTARRMLTGPGLPEPAEQVDGRRLRARGFSDDARALLEHVWALMGMPCGKYLVVMLELWLPLEAAAGDLDKPFATEAAVAELKAMSAATVDRYLKPARERMRIKGISTTKPSPLLRNSITIHTCSDEAPKVPGVIEADTVAHCGPSLIGEFARTLTMTDLVTGWTENASIRNNAAKWILEGIKECQQRFPFPMTVFDSDCGGEFINHDVAGWLQARDIAQTRSRPYQKNDQAHVESKNNHVVRKHAFYWRYDTGEELELLNRLWPLVSLRCNFFTPTKKPVGYTSTVNGRRKRIYDKPATPWQRLQASGVLDAQQLSTVAARIEGFNPADLTRQINAIQMQLLDLAKTKTEALATARHIDLQSLQPSINRLAKAK

3l2rA

0.17

0.14

0.80

1.15

wMUSTER

----------AELDQLLQGHYI---------KGYPKQYT---------FLEKVSRPEGVKIQSDRQKIVLQAHNLAHTG----REATLLKIANM-RKDVVKQLGR--QQCLITNASNKASGPILRPDRP--------QKPFDKFFIDYIGPLPPSQ--GYLYVLVVVDGMTGFTWLYPTKAPSTSATVKSLNVLTS-IAIP-KVIHSDQGAAFTSSTFAEWAKERGIHLEFSTPYHPQSSGKVERKNSDIKRLLTKLLVGRPTKWYDLLPVVQLALNN----YSPVLKYTPHQLLFGI-------DSNTPFANQDTLDLTREEELSLLQEIRTSL-------------------HPSTPPASSRSWSPVVQLVQERVARPASLR

3jcaA2

0.14

0.06

0.43

1.18

dPPAS

------------------------------------------------------------------------------------------------------------------------------HAPQLGVNPRGLKPRVLWQMDVTH---VSEFGKLKYVHVTVDTYSHFTFATARTGEATKDVLQHLAQSFAYMGIP-QKIKTDNAPAYVSRSIQEFLARWKISHVTGIPYNPQGQAIVERTHQNIKAQLNKLQKGKYYTPHHLLAHALFVLNHVN------------MDNQG----------HTAAERHWGPIS-----------------------------------------------------------------

3l2rA

0.17

0.14

0.81

1.68

wdPPAS

------------------AELDQLLQGHYI-KGYPKQYTYFLEDGKVKVSR----PEGVKIQSDRQKIVLQAHNLAHTG----REATLLKIAN---KDVVKQLGR--QQCLITNASNKASGPILRPDRPQKPF--------DKFFIDYIGPL-PPSQG-YLYVLVVVDGMTGFTWLYPTKAPSTSATVKSLNVLTS-IAIP-KVIHSDQGAAFTSSTFAEWAKERGIHLEFSTPYHPQSSGKVERKNSDIKRLLTKLLVGRPTKWYDLLPVVQLALNN----YSPVLKYTPHQLLFGI-------DSNTPFANQDTLDLTREEELSLLQEIRTSL-------------------PSTPPASSRSWSPVVGQLVQERVARPASLR

3jcaA2

0.14

0.06

0.43

1.90

wdPPAS

------------------------------------------------------------------------------------------------------------------------------HAPQLGVNPRGLKPRVLWQMDVTH---VSEFGKLKYVHVTVDTYSHFTFATARTGEATKDVLQHLAQSFAYMGIP-QKIKTDNAPAYVSRSIQEFLARWKISHVTGIPYNPQGQAIVERTHQNIKAQLNKLQKGKYYTPHHLLAHALFVLNHV------------NMDNQG----------HTAAERHWGPIS-----------------------------------------------------------------

3l2rA

0.18

0.14

0.80

1.99

wPPAS

---------AELDQLLQG----------HYIKGYPKQYTYFLEDGKVKVSR------GVKIQSDRQKIVLQAHNLAHTG----REATLLKIANM----VVKQLGR--QQCLITNASNKASGPILRPDRPQKPF--------DKFFIDYIGPL-PPSQG-YLYVLVVVDGMTGFTWLYPTKAPSTSATVKSLNVLT--IAIP-KVIHSDQGAAFTSSTFAEWAKERGIHLEFSTPYHPQSSGKVERKNSDIKRLLTKLLVGRPTKWYDLLPVVQLALNN----YSPVLKYTPHQLLFGI-------DSNTPFA---NQDTLD-------------LTREEELSLLQEIRTSLYH--PSTPPASSRSWSPVVQLVQERVARPASLR

3jcaA2

0.14

0.06

0.43

2.41

wPPAS

------------------------------------------------------------------------------------------------------------------------------HAPQLGVNPRGLKPRVLWQMDVTH---VSEFGKLKYVHVTVDTYSHFTFATARTGEATKDVLQHLAQSFAYMGIP-QKIKTDNAPAYVSRSIQEFLARWKISHVTGIPYNPQGQAIVERTHQNIKAQLNKLQKGKYYTPHHLLAHALFVLNHVN------------MDNQG----------HTAAERHWGPIS-----------------------------------------------------------------

3l2rA

0.15

0.12

0.81

1.40

PPAS

----------AELDQLLQGHYI---------KGYPKQYTYFLEDGKVKVSR---KII----QSDRQKIVLQAHNLAHTG----REATLLKIAN-NMRKDVVKQLGRCQQCLITNASNKASGPILRPDRPQKPF--------DKFFIDYIGPLPPSQ--GYLYVLVVVDGMTGFTWLYPTKAPSTSATVKSLNVLTS-IAIP-KVIHSDQGAAFTSSTFAEWAKERGIHLEFSTPYHPQSSGKVERKNSDIKRLLTKLLVGRPTKW----DLLPVVQLALNNTYSPVLKYTPHQLLFG-------IDSNTPFANQDTLDLT-------------------REEELSLLQEIRTSLYHPSTPPASSRSWSPVQLVQERVARPASLR

3jcaA2

0.14

0.06

0.43

3.96

dPPAS2

------------------------------------------------------------------------------------------------------------------------------HAPQLGVNPRGLKPRVLWQMDVTH---VSEFGKLKYVHVTVDTYSHFTFATARTGEATKDVLQHLAQSFAYMGIP-QKIKTDNAPAYVSRSIQEFLARWKISHVTGIPYNPQGQAIVERTHQNIKAQLNKLQKGKYYTPHHLLAHALFVLNHVN------------MDNQG----------HTAAERHWGPIS-----------------------------------------------------------------

3l2rA

0.15

0.12

0.84

3.10

Env-PPAS

----------AELDQLLQGHYI---------KGYPKQYTYFLEDGKVKVS----RPEGVKIQSDRQKIVLQAHNLAHTGREATLLKIANLYWWPNMRKDVVKQLGRCQQCLITNASNKASGPILRPDRPQKPF--------DKFFIDYIGPLPPSQ--GYLYVLVVVDGMTGFTWLYPTKAPSTSATVKSLNVLTS-IAIP-KVIHSDQGAAFTSSTFAEWAKERGIHLEFSTPYHPQSSGKVERKNSDIKRLLTKLLVGRPTKWY---DLLPVVQLALNNTYSPVLKYTPHQLLFG-------IDSNTPFANQDTLD----------------LTREEELSLLQEIRTSLYH--PSTPPASSRSWSPVVQLVQERVARPASLR

3jcaA2

0.14

0.06

0.43

1.91

PPAS

------------------------------------------------------------------------------------------------------------------------------HAPQLGVNPRGLKPRVLWQMDVTHV---SEFGKLKYVHVTVDTYSHFTFATARTGEATKDVLQHLAQSFAYMGIP-QKIKTDNAPAYVSRSIQEFLARWKISHVTGIPYNPQGQAIVERTHQNIKAQLNKLQKGKYYTPHHLLAHALFVLNHVNMDNQG----------------------HTAAERHWGPIS-----------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.06

Estimated TM-score = 0.58±0.14

Estimated RMSD = 9.1±4.6Å

Download Model 2

C-score=-1.94

Download Model 3

C-score=-1.42

Download Model 4

C-score=-2.05

Download Model 5

C-score=-2.93

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3l2rA	0.752	2.48	0.147	0.818
2	3jcaA	0.454	4.00	0.096	0.570
3	1c0mC	0.416	2.87	0.114	0.464
4	4i43B	0.407	5.80	0.054	0.589
5	4fcyA	0.401	5.11	0.079	0.536
6	3hmjG	0.396	6.86	0.057	0.659
7	1llwA	0.394	7.06	0.055	0.677
8	2qf7A	0.392	7.00	0.024	0.661
9	3zzmA	0.389	6.34	0.048	0.615
10	1p4rA	0.389	6.67	0.065	0.633

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.30	22	3oybA	ZZX	Rep, Mult	147,208,210,235,237,238,244
2	0.12	10	3oyiA	MN	Rep, Mult	147,148,244,247
3	0.06	6	3os2A	QNA	Rep, Mult	237,244,245,248,251
4	0.05	6	3oydA	QNA	Rep, Mult	123,124,125,126,143,206,230,231,232,233,236,238,239,241,242,245,249,252,284,285
5	0.04	4	3os1A	NUC	Rep, Mult	147,150,151,208,209,210,211,235,244,251,379
6	0.03	3	4bacA	MG	Rep, Mult	147,208,213
7	0.02	2	4e7kA	NUC	Rep, Mult	147,208,209,211,235,244,379
8	0.02	2	1vseA	EPE	Rep, Mult	162,165,177,191
9	0.01	1	1a5wA	Y3	Rep, Mult	143,145,206,241,242
10	0.01	1	1czb0	III	Rep, Mult	189,192,195,196,199,200,221,225,267,270,273,274,278

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3f9kI	0.363	2.47	0.103	0.396	2.7.7.49	147,175,208,247,249
2	0.060	1k6yA	0.347	2.61	0.108	0.380	2.7.7.49	147,172,175,208,227,229
3	0.060	1c0mA	0.416	2.87	0.115	0.464	2.7.7.49	208,210,230,241,244
4	0.060	2hg4C	0.377	6.93	0.056	0.643	2.3.1.94	252
5	0.060	1bl3C	0.364	2.70	0.127	0.401	2.7.7.49	142,177,197
6	0.060	1zczB	0.359	6.64	0.055	0.583	3.5.4.10,2.1.2.3	NA
7	0.060	3l2rA	0.752	2.48	0.147	0.818	2.7.7.7,2.7.7.49,3.1.26.4	177
8	0.060	1br2A	0.309	6.87	0.051	0.523	3.6.1.32	NA
9	0.060	1ug9A	0.365	6.90	0.047	0.620	3.2.1.70	244
10	0.060	2qf7B	0.376	7.30	0.029	0.656	6.4.1.1	NA
11	0.060	3l4uA	0.349	6.99	0.028	0.604	3.2.1.20,3.2.1.3	NA
12	0.060	2vz9B	0.373	6.86	0.042	0.620	2.3.1.85	NA
13	0.060	1vsdA	0.336	2.30	0.158	0.362	2.7.7.49	147,208,210
14	0.060	3dy5A	0.346	6.97	0.051	0.589	1.13.11.40,4.2.1.92	NA
15	0.060	1eulA	0.308	7.10	0.034	0.531	3.6.3.8	208
16	0.060	1hn0A	0.350	6.97	0.031	0.602	4.2.2.20	NA
17	0.060	1iwaA	0.349	6.42	0.034	0.547	4.1.1.39	170
18	0.060	2vkzG	0.397	6.83	0.057	0.656	2.3.1.38,3.1.2.14	212
19	0.060	1ej6A	0.375	6.79	0.058	0.628	2.7.7.50	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.27	0.757	2.74	0.15	0.83	4bacA	GO:0003676 GO:0003723 GO:0003824 GO:0003887 GO:0003964 GO:0004190 GO:0004518 GO:0004519 GO:0004523 GO:0006278 GO:0006310 GO:0006508 GO:0008152 GO:0008233 GO:0015074 GO:0016740 GO:0016779 GO:0016787 GO:0019012 GO:0030430 GO:0042025 GO:0046718 GO:0046872 GO:0071897 GO:0075713 GO:0075732 GO:0090305 GO:0090502
1	0.15	0.355	3.00	0.12	0.40	1ex4A	GO:0003676 GO:0003677 GO:0003723 GO:0003824 GO:0003887 GO:0003964 GO:0004190 GO:0004518 GO:0004519 GO:0004523 GO:0004533 GO:0005198 GO:0005576 GO:0005654 GO:0005829 GO:0005886 GO:0006278 GO:0006310 GO:0006508 GO:0008152 GO:0008233 GO:0008270 GO:0008289 GO:0008907 GO:0015074 GO:0016020 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0019012 GO:0019013 GO:0019028 GO:0019058 GO:0019061 GO:0019064 GO:0019068 GO:0019072 GO:0019076 GO:0020002 GO:0030260 GO:0030430 GO:0033644 GO:0039526 GO:0039651 GO:0039657 GO:0042025 GO:0042802 GO:0044174 GO:0046718 GO:0046872 GO:0051169 GO:0055036 GO:0072494 GO:0075713 GO:0075732 GO:0090305 GO:0090502 GO:0090503
2	0.13	0.363	2.26	0.14	0.39	4pa1A	GO:0003676 GO:0003677 GO:0003824 GO:0003964 GO:0004170 GO:0004190 GO:0004518 GO:0004519 GO:0004523 GO:0004533 GO:0006278 GO:0006310 GO:0006508 GO:0008152 GO:0008233 GO:0008270 GO:0009117 GO:0015074 GO:0016740 GO:0016779 GO:0016787 GO:0046080 GO:0046718 GO:0046872 GO:0075713 GO:0090305 GO:0090502 GO:0090503
3	0.13	0.443	3.32	0.09	0.51	5ejkA	GO:0003676 GO:0003677 GO:0003723 GO:0003824 GO:0003887 GO:0003964 GO:0004190 GO:0004518 GO:0004519 GO:0004523 GO:0005198 GO:0006278 GO:0006310 GO:0006508 GO:0008152 GO:0008233 GO:0008270 GO:0015074 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0019012 GO:0019013 GO:0019028 GO:0046718 GO:0046872 GO:0075713 GO:0090305 GO:0090502
4	0.12	0.454	4.00	0.10	0.57	3jcaA	GO:0003676 GO:0003677 GO:0003824 GO:0003887 GO:0003964 GO:0004518 GO:0004519 GO:0004523 GO:0006278 GO:0006310 GO:0008152 GO:0008270 GO:0015074 GO:0016740 GO:0016779 GO:0016787 GO:0046718 GO:0046872 GO:0075713 GO:0090305 GO:0090502
5	0.12	0.349	2.48	0.11	0.38	1k6yB	GO:0003676 GO:0003677 GO:0003723 GO:0003824 GO:0003887 GO:0003964 GO:0004190 GO:0004518 GO:0004519 GO:0004523 GO:0004533 GO:0005198 GO:0005546 GO:0006278 GO:0006310 GO:0006508 GO:0008152 GO:0008233 GO:0008270 GO:0008289 GO:0015074 GO:0016020 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0019012 GO:0019013 GO:0019028 GO:0019076 GO:0020002 GO:0030430 GO:0033644 GO:0039526 GO:0039651 GO:0039657 GO:0042025 GO:0042802 GO:0044174 GO:0046718 GO:0046872 GO:0055036 GO:0072494 GO:0075713 GO:0075732 GO:0090305 GO:0090502 GO:0090503
6	0.10	0.355	2.80	0.15	0.39	3kkrA	GO:0003676 GO:0003677 GO:0003723 GO:0003824 GO:0003887 GO:0003964 GO:0004190 GO:0004518 GO:0004519 GO:0004523 GO:0004533 GO:0006278 GO:0006310 GO:0006508 GO:0008152 GO:0008233 GO:0008270 GO:0015074 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0019012 GO:0019013 GO:0019028 GO:0019076 GO:0039660 GO:0046718 GO:0046872 GO:0075521 GO:0075606 GO:0075713 GO:0090305 GO:0090502 GO:0090503
7	0.07	0.363	2.60	0.12	0.40	1bi4C	GO:0003676 GO:0003677 GO:0003723 GO:0003824 GO:0003887 GO:0003964 GO:0004190 GO:0004518 GO:0004519 GO:0004523 GO:0004533 GO:0005198 GO:0005546 GO:0006278 GO:0006310 GO:0006508 GO:0008152 GO:0008233 GO:0008270 GO:0008289 GO:0015074 GO:0016020 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0019012 GO:0019013 GO:0019028 GO:0019076 GO:0020002 GO:0030430 GO:0033644 GO:0039526 GO:0039651 GO:0039657 GO:0042025 GO:0042802 GO:0044174 GO:0046718 GO:0046872 GO:0055036 GO:0072494 GO:0075713 GO:0075732 GO:0090305 GO:0090502 GO:0090503
8	0.06	0.377	3.10	0.10	0.43	3hpgB	GO:0003676 GO:0003677 GO:0003824 GO:0003964 GO:0004170 GO:0004190 GO:0004518 GO:0004519 GO:0004523 GO:0004533 GO:0006278 GO:0006310 GO:0006508 GO:0008152 GO:0008233 GO:0008270 GO:0009117 GO:0015074 GO:0016740 GO:0016779 GO:0016787 GO:0046080 GO:0046718 GO:0046872 GO:0075713 GO:0090305 GO:0090502 GO:0090503
9	0.06	0.347	6.35	0.05	0.54	1rblA	GO:0000287 GO:0004497 GO:0009853 GO:0015977 GO:0015979 GO:0016491 GO:0016829 GO:0016984 GO:0019253 GO:0046872 GO:0055114
10	0.06	0.363	2.47	0.10	0.40	3f9kA	GO:0003676 GO:0003677 GO:0003723 GO:0003824 GO:0003887 GO:0003964 GO:0004190 GO:0004518 GO:0004519 GO:0004523 GO:0004533 GO:0005198 GO:0006278 GO:0006310 GO:0006508 GO:0008152 GO:0008233 GO:0008270 GO:0008289 GO:0015074 GO:0016020 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0019012 GO:0019013 GO:0019028 GO:0019076 GO:0020002 GO:0030430 GO:0033644 GO:0039657 GO:0042025 GO:0044174 GO:0046718 GO:0046872 GO:0055036 GO:0072494 GO:0075713 GO:0075732 GO:0090305 GO:0090502 GO:0090503
11	0.06	0.342	2.72	0.12	0.38	1c6vA	GO:0003676 GO:0003677 GO:0003723 GO:0003824 GO:0003887 GO:0003964 GO:0004190 GO:0004518 GO:0004519 GO:0004523 GO:0004533 GO:0005198 GO:0006278 GO:0006310 GO:0006508 GO:0008152 GO:0008233 GO:0008270 GO:0015074 GO:0016020 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0019012 GO:0019013 GO:0019028 GO:0019076 GO:0020002 GO:0030430 GO:0033644 GO:0039657 GO:0042025 GO:0046718 GO:0046872 GO:0075713 GO:0075732 GO:0090305 GO:0090502 GO:0090503
12	0.06	0.281	1.94	0.11	0.30	5cz2F	GO:0003676 GO:0003677 GO:0003824 GO:0003887 GO:0003964 GO:0004518 GO:0004519 GO:0004523 GO:0006278 GO:0006310 GO:0008152 GO:0008270 GO:0015074 GO:0016740 GO:0016779 GO:0016787 GO:0046718 GO:0046872 GO:0075713 GO:0090305 GO:0090502
13	0.06	0.223	5.72	0.03	0.33	4pfxA	GO:0000166 GO:0016740
14	0.06	0.269	6.63	0.03	0.44	3ctzA	GO:0004177 GO:0005737 GO:0006508 GO:0008233 GO:0008237 GO:0010815 GO:0016787 GO:0030145 GO:0042803 GO:0046872 GO:0070006 GO:0070062
15	0.06	0.170	4.79	0.07	0.23	2anvA	GO:0003796 GO:0003824 GO:0008152 GO:0009253 GO:0016787 GO:0016798 GO:0016998 GO:0019076 GO:0019835 GO:0030430 GO:0042742
16	0.06	0.179	5.86	0.05	0.28	1ckvA	GO:0004497 GO:0006725 GO:0015049 GO:0015050 GO:0015947 GO:0016491 GO:0055114
17	0.06	0.127	5.34	0.02	0.18	1gxeA	GO:0001671 GO:0003007 GO:0003779 GO:0005829 GO:0005863 GO:0006942 GO:0007155 GO:0008307 GO:0014705 GO:0017022 GO:0030017 GO:0030049 GO:0031432 GO:0031672 GO:0032036 GO:0032781 GO:0032971 GO:0032982 GO:0042802 GO:0046872 GO:0055010 GO:0060048
18	0.06	0.114	2.94	0.02	0.13	1wjbA	GO:0003676 GO:0003677 GO:0003723 GO:0003824 GO:0003887 GO:0003964 GO:0004190 GO:0004518 GO:0004519 GO:0004523 GO:0004533 GO:0005198 GO:0005546 GO:0006278 GO:0006310 GO:0006508 GO:0008152 GO:0008233 GO:0008270 GO:0008289 GO:0015074 GO:0016020 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0019012 GO:0019013 GO:0019028 GO:0019076 GO:0020002 GO:0030430 GO:0033644 GO:0039526 GO:0039651 GO:0039657 GO:0042025 GO:0042802 GO:0044174 GO:0046718 GO:0046872 GO:0055036 GO:0072494 GO:0075713 GO:0075732 GO:0090305 GO:0090502 GO:0090503

Consensus prediction of GO terms

Molecular Function	GO:0004523	GO:0003964	GO:0004190	GO:0016896	GO:0003887	GO:0003723	GO:0003677	GO:0008270	GO:0005515
GO-Score	0.59	0.59	0.53	0.53	0.53	0.46	0.43	0.43	0.30
Biological Processes	GO:0006278	GO:0015074	GO:0006310	GO:0075713	GO:0090502	GO:0075732	GO:0039656	GO:0039712	GO:0043280	GO:0019051	GO:0022607	GO:0039663	GO:0010629
GO-Score	0.59	0.59	0.59	0.59	0.59	0.38	0.30	0.30	0.30	0.30	0.30	0.30	0.30
Cellular Component	GO:0019028	GO:0042025	GO:0044444	GO:0044184	GO:0071944	GO:0031981	GO:0044218
GO-Score	0.52	0.38	0.30	0.30	0.30	0.30	0.30

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.