I-TASSER results

I-TASSER results for job id Rv2802c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (347 residues)
MARQPLEQRVARAAQAALARQRFVSAIDVLLGLGWLAPSHVDQWRQGRVDSLEQVVQANL
SKITAVMAALRRWARDRGLNPSETDYVARTRDRRRLRFSVTGEDAIERAYRTHWVSPELS
ERAVARQSRRPDLVVIMPVNDWSCASCGGSGDLMFLEDAGPLCLDCADLGHLVFLPSGDA
ALTRRAKRASRLSAVVVRWSRARKRYERQGILVEAEALERAENECLADAEVRARRRERDE
ARRANEDLRLQAEFGAAIRTLFPNCPAGRAEAIARHAATRGSGRIGRSAAGRALDPEAVR
LAVAASVRHIDTSFDELLMSGVDRETARHRVGEHVEEVLRDWRATSR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MARQPLEQRVARAAQAALARQRFVSAIDVLLGLGWLAPSHVDQWRQGRVDSLEQVVQANLSKITAVMAALRRWARDRGLNPSETDYVARTRDRRRLRFSVTGEDAIERAYRTHWVSPELSERAVARQSRRPDLVVIMPVNDWSCASCGGSGDLMFLEDAGPLCLDCADLGHLVFLPSGDAALTRRAKRASRLSAVVVRWSRARKRYERQGILVEAEALERAENECLADAEVRARRRERDEARRANEDLRLQAEFGAAIRTLFPNCPAGRAEAIARHAATRGSGRIGRSAAGRALDPEAVRLAVAASVRHIDTSFDELLMSGVDRETARHRVGEHVEEVLRDWRATSR
Prediction	CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEEHCCCCCCCCCCCCCEEEEHCCCCCEEEHCCCCCCEEEHCCCCHHHHHHHHHHCCCCCCEEEEEHCCCCEEEEEEEHCHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
Conf.Score	97788999999999999998798658899988777778888888876758899887489999999999999999998998886543445788755566788887555445544555555555666646788877887577665445788755899768997677668999868868999999999999855458779999789866667888659999999999865567777765567766566569999999999999967899999999999998666788776555678999999999999997578868999876888999999999999999999767889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MARQPLEQRVARAAQAALARQRFVSAIDVLLGLGWLAPSHVDQWRQGRVDSLEQVVQANLSKITAVMAALRRWARDRGLNPSETDYVARTRDRRRLRFSVTGEDAIERAYRTHWVSPELSERAVARQSRRPDLVVIMPVNDWSCASCGGSGDLMFLEDAGPLCLDCADLGHLVFLPSGDAALTRRAKRASRLSAVVVRWSRARKRYERQGILVEAEALERAENECLADAEVRARRRERDEARRANEDLRLQAEFGAAIRTLFPNCPAGRAEAIARHAATRGSGRIGRSAAGRALDPEAVRLAVAASVRHIDTSFDELLMSGVDRETARHRVGEHVEEVLRDWRATSR
Prediction	86565135202410341046531000010001001043631540251305102400504162013004202410574615244341444356545142355255634442344414552555245535544421113124654146254422010245743222515517202101411140042026305646330211364633412001014301530363154445433444654645355455512540251045103402442042005201544554344453452346400100000101132040250146415264014302630451056155668
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEEHCCCCCCCCCCCCCEEEEHCCCCCEEEHCCCCCCEEEHCCCCHHHHHHHHHHCCCCCCEEEEEHCCCCEEEEEEEHCHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
MARQPLEQRVARAAQAALARQRFVSAIDVLLGLGWLAPSHVDQWRQGRVDSLEQVVQANLSKITAVMAALRRWARDRGLNPSETDYVARTRDRRRLRFSVTGEDAIERAYRTHWVSPELSERAVARQSRRPDLVVIMPVNDWSCASCGGSGDLMFLEDAGPLCLDCADLGHLVFLPSGDAALTRRAKRASRLSAVVVRWSRARKRYERQGILVEAEALERAENECLADAEVRARRRERDEARRANEDLRLQAEFGAAIRTLFPNCPAGRAEAIARHAATRGSGRIGRSAAGRALDPEAVRLAVAASVRHIDTSFDELLMSGVDRETARHRVGEHVEEVLRDWRATSR

4z6gA

0.11

0.10

0.91

0.67

MUSTER

ERDRVQKKTFTKWVNKHLMKVRKHI--------NDL----YEDLRDGHISLLEVLSGIMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGL-----IWTIILHFQISDIYISGESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNA-RPDLVDMERVQIQSRENLEQAFEVAERLGVTRLLDAEDVDVPS----PDEKSVITYVSSIYDAFP---KVPEGGEGISATEVDSRWQEYQSRVDSLIPWI-KQHTILMSD-----NQYIHFKETEILAKEREKGRIEELYKLLEVWIEFGRILPQGYHPNDVEEEWGKLIIEMLEREKSLRP

4wsbB2

0.07

0.05

0.68

0.58

dPPAS

GNNESADMSIGTTVIKTNMINNDLGPATAQMAIQLFIKDYRYTYRCHRGDT-----NLETRRTKSIKRLWTETISKAGLLVADGGPNPY---------NLRNLHIPEVCLKWSLMDPDYRGRLCNPNNPFVHH-----------MEVESTNLAVVMPGPAKSLEYDAVATTHSWTPKRNRSILNTNQRGI------------------------LEDERIYQKCCQVFEKFFPSSTYRRPIGMASMLDAMLSRARIDARIDLESGSSQDFSEITNTCKAIEALK---------------------------------------------------------------

5ehkA2

0.14

0.10

0.76

0.53

wdPPAS

VP--------RRNQDDFLRDQ--VPVLVRAGIEHGAD-----RWRAG--QHL-RFRGEREKLWAGLLPEIGARLVEW-LA-ELGQYDP--------RY--GGDALAEFTETAFQHDSAAAISLLRLTRRAGFRYTLDEVT---------------------------------------ISAAALADAFGPPAPVVEPVPLVGGLQWAPDLFDGDPAAAWMSSTGGRRELPPDYRRDPARDPTGGWPLLRADEDGCQVLAAL----ESRDEAVRRFGTAYREAFRPTDS-------PSTQLRLVGSLLHM--TCNRLI--GGS-AERERSVLGLARGAVQDNLNRRR

5ca8A

0.10

0.09

0.90

0.70

wMUSTER

LQPKEFGEGINRLGDRLVVSNELFKPIDGWTMY----ERCWEQIETNKLPTQQILVA--QFKCDEIVESVFQEFLTK-----YQHHFKEVDAAPDFELGALFADLRQDAFED-RYNKAVYEQKRKKLRWL--NDKLKEVFDVHAKNLCNTLLEKFEKD-----LVALKGKDF-------AVNVKTLSTKLVED-----VNFQVSLMSLQGDLSLDEIILALTKDIDAIVAKQQVVE---NSIVNKSVKKLSASLSKSIQFELGDPNEETWDNVLQQFKGVYEKFGGDFGLGTS--STQNQQAIEKFKFKSWCQFYDVTHKLISREKLLALLQDRFDDKFRYYLNEQD

5ehkA2

0.14

0.10

0.76

0.67

wPPAS

L-------RLRRNQDDFLRDQ--VPVLVRAGIEHGAD-----RWRAG--QHL-RFRGEREKLWAGLLPEIGARLVEW-LA-ELGQYDP--------RY--GGDALAEFTETAFQHDSAAAISLLRLTRRAG-----------------------------------FRYTLDEVT----ISAAALADAFGPPAPVVEPVPLVGGLQWAPDLFDGDPAAAWMSSTGGRRELPPDYRRDPARDPTGGWPLLRADEDGCQVLAAL----ESRDEAVRRFGTAYREAFRPTDS-------PSTQLRLVGSLLH--MTCNRLI--GGS-AERERSVLGLARGAVQDNLNRRR

5cwnA

0.11

0.06

0.60

0.91

dPPAS2

MDPEEILERAKESLERAREASERGDEEEFRKAA----EKALELAKRLVEQAKKEGDPELVLEAAKVALRVAELAAKNG------------------------DKEVFKKAAESALEVAKRLVEVASKEGDPELVLEA------------------------------------------AKVALRVAELAAKNGD-------------------KEVFKKAAESALEVAKRLVEVASKEGDPELVEEAAKVAEEVRKLAKKQGD--EEVYEKARETAREV---------KEELKRVREEKGGWLEHH----------------------------------------

5cwqA

0.17

0.11

0.67

0.71

PPAS

---EELERESEEAERRLQEARKRSEEARERGDLKELAEALIEEARAVQELARVACERGNSEEAERASEKAQRVLEEARKVSEEAREQGDDEVLALALIAIALAVLALAEVACCRGNSEEAERASEKAQRV-------------------------------------------------LEEARKVSEEAREQGDD---------------EVLALALIAIALAVLALAEVACCRGNKEEAERAYEDARRVEEEARKVKESAEEQGDSEVKRLAEEAEQLAR------------ARRHVQECRGGWLEHHH------------------------------------

1vhdA

0.14

0.13

0.91

0.69

Env-PPAS

-------------------SLWEFYPTDVFFGEKILEKRGNIIDLLGKRALV--VTGKSSSKKNGSLDDLKKLLDETEISPSFDNYRNDSFD-FVVGLGGSPDFAKAVAVLLKEKDLSVEDLYDREKVKHWLPVVEIPTTAGTGSEV---TPYSILTDPEGNKRGCTLFPVYAFL---DPRYTYSSDELTLSTGVDALSLSRKSTPPSDALAIEKIIHRNLPKAIEGNREARKKFVASCLAGIAQTGTTLAHALGYPLTTEKG-IKHGKATGVLPFVEVKEEDTVNH-IFGGSLLKFLKELGLYEKVAVSSEELEKWVEKGSRKNTPGTFTPEKIRNIYREALGVE-

4km5A

0.12

0.11

0.95

0.64

MUSTER

SKLRAVLEKLKLSRDDISTAAGMVGVVDHLLLR-DSAFRGVGLLNTG--SYYEHVKISAPNEFDVMFKEVPRIQLEEYSNTRAYYFVKFKRNPKENPLSQFLEGEILSASKMLSKFRKIIKEEINDIKDTD--VIMKRKRGGSPALISEKISVDIT-----LESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHAKEGNGFQEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKERFDKFSSYHVKTAFFHVCTQNPQ---DSQWDRKDLGLCFDNCVTYFLQCLRTEY--LFSSNLIDKRSKEFLTKQIEYERNN-PVFDE

5cwmA

0.16

0.10

0.65

0.56

dPPAS

-DPEDELKRVEKLVKEAEELLRQAKEKGSEEDLEKALRTAEEAAREAKKVLEQAEKEGDPEVALRAVELVVRVAELL----------------LRIAKESGSEEALERALRVAEEAARLAKRVLELAEKQGDPEVALRAVELVVRVA--------------------------------ELLLRIAKESGSEEAL-------------------ERALRVAEEAARLAKRVLELAEKQGDPEVARRAVELVKRVAELLERIARESGSEEAKERAERVREE----------ARELQERVKELRER-------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-4.07

Estimated TM-score = 0.28±0.09

Estimated RMSD = 16.7±2.9Å

Download Model 2

C-score=-5.00

Download Model 3

C-score=-5.00

Download Model 4

C-score=-5.00

Download Model 5

C-score=-4.17

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5ehkA	0.685	2.83	0.103	0.769
2	4wd9A	0.514	3.82	0.076	0.620
3	4kppA	0.413	5.48	0.061	0.599
4	1iduA	0.408	6.04	0.053	0.640
5	4k1cA	0.399	5.32	0.063	0.559
6	1v7vA	0.398	6.20	0.055	0.637
7	3zyyX	0.397	5.94	0.082	0.605
8	5amqA	0.397	6.24	0.029	0.643
9	1ka1A	0.392	6.16	0.063	0.623
10	2ztgA	0.390	6.57	0.042	0.645

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	3	1hu9A	FE	Rep, Mult	108,113,276,307
2	0.06	3	3psrA	ZN	Rep, Mult	309,315
3	0.04	2	3wmnA	MQ8	Rep, Mult	335,339
4	0.04	2	1rxsA	V7O	Rep, Mult	308,309
5	0.04	2	5mbaA	AZI	Rep, Mult	155,327,330,331
6	0.02	1	4khoA	CA	Rep, Mult	104,107
7	0.02	1	3e1nA	UNK	Rep, Mult	116,270
8	0.02	1	1v7vA	CA	Rep, Mult	264,268,269
9	0.02	1	3aq0F	PPV	Rep, Mult	287,309
10	0.02	1	3kniX	MG	Rep, Mult	312,315
11	0.02	1	3k57A	MG	Rep, Mult	179,315
12	0.02	1	2istA	BCT	Rep, Mult	337,340
13	0.02	1	3h45X	PO4	Rep, Mult	207,208,220,298,305
14	0.02	1	1o7dC	MAN	Rep, Mult	109,308
15	0.02	1	5erjA	CPT	Rep, Mult	122,261
16	0.02	1	3zvwC	MG	Rep, Mult	138,139
17	0.02	1	1k9yA	PO4	Rep, Mult	207,294,295,298,299
18	0.02	1	4e9uA	MG	Rep, Mult	124,152
19	0.02	1	3h3oX	EDO	Rep, Mult	183,184,185,188,218,246
20	0.02	1	3pfdB	IOD	Rep, Mult	324,325,328

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1iduA	0.408	6.04	0.053	0.640	1.11.1.10	NA
2	0.060	3b9jJ	0.254	6.71	0.040	0.435	1.17.1.4,1.17.3.2	202
3	0.060	1fo4A	0.340	6.74	0.022	0.571	1.17.1.4	NA
4	0.060	2zf5Y	0.371	6.25	0.070	0.605	2.7.1.30	180
5	0.060	2ztgA	0.390	6.57	0.042	0.645	6.1.1.7	NA
6	0.060	1lf6A	0.386	6.45	0.050	0.634	3.2.1.3	53
7	0.060	2ckjA	0.332	6.52	0.025	0.536	1.17.1.4,1.17.3.2	NA
8	0.060	1ug9A	0.380	6.42	0.061	0.623	3.2.1.70	53,118
9	0.060	3b9jI	0.227	5.10	0.027	0.320	1.17.1.4,1.17.3.2	221
10	0.060	1ti6A	0.369	7.33	0.052	0.669	1.97.1.2	211
11	0.060	1vncA	0.394	6.40	0.067	0.645	1.11.1.10	119,181
12	0.060	1ctsA	0.358	6.05	0.061	0.559	2.3.3.1,4.1.3.7	276
13	0.060	1k9yA	0.393	6.22	0.063	0.628	3.1.3.7	NA
14	0.060	2ifcC	0.367	5.97	0.050	0.562	2.3.3.1	NA
15	0.060	3flcX	0.378	6.44	0.054	0.628	2.7.1.30	NA
16	0.060	1e6vA	0.364	6.60	0.034	0.594	2.8.4.1	315
17	0.060	3kvnX	0.365	6.35	0.045	0.588	3.1.1.1	258
18	0.060	1ei5A	0.375	6.56	0.064	0.620	3.4.11.19	NA
19	0.060	2iukA	0.350	6.63	0.026	0.576	1.13.11.12	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.06	0.514	3.82	0.08	0.62	4wd9A	GO:0005886 GO:0006810 GO:0016020 GO:0016021
1	0.06	0.316	6.29	0.06	0.51	2bo4A	GO:0016740 GO:0016758 GO:0046872 GO:0051479
2	0.06	0.273	6.28	0.07	0.44	4xfvA	GO:0002098 GO:0005634 GO:0005654 GO:0005737 GO:0006351 GO:0006355 GO:0006357 GO:0006810 GO:0008017 GO:0015031 GO:0032447 GO:0033588
3	0.06	0.290	5.94	0.04	0.45	4ac8A	GO:0004748 GO:0005506 GO:0005829 GO:0005971 GO:0009186 GO:0009263 GO:0016491 GO:0030145 GO:0046872 GO:0055114
4	0.06	0.295	6.43	0.05	0.48	3jacA	GO:0005261 GO:0005783 GO:0005789 GO:0005886 GO:0006810 GO:0006811 GO:0006812 GO:0008381 GO:0016020 GO:0016021 GO:0031258 GO:0033116 GO:0033625 GO:0033634 GO:0034220 GO:0042391 GO:0042995 GO:0050982 GO:0098655
5	0.06	0.262	6.13	0.07	0.42	3hc6A	GO:0000122 GO:0000980 GO:0001077 GO:0001080 GO:0001190 GO:0002376 GO:0003677 GO:0003690 GO:0003700 GO:0003705 GO:0003707 GO:0003713 GO:0003714 GO:0004872 GO:0004879 GO:0004887 GO:0005634 GO:0005654 GO:0005719 GO:0006109 GO:0006351 GO:0006355 GO:0006357 GO:0006367 GO:0006954 GO:0007165 GO:0007219 GO:0008206 GO:0008270 GO:0009749 GO:0010988 GO:0015721 GO:0016922 GO:0030522 GO:0032052 GO:0032496 GO:0034142 GO:0034255 GO:0034971 GO:0035356 GO:0038181 GO:0038183 GO:0038185 GO:0042277 GO:0043066 GO:0043124 GO:0043401 GO:0043565 GO:0045087 GO:0045944 GO:0046872 GO:0046965 GO:0048565 GO:0061178 GO:0070857 GO:0070858 GO:0071398 GO:0071417 GO:0072615 GO:0090181 GO:1902122 GO:1902714 GO:1904468 GO:2000213 GO:2001250
6	0.06	0.308	6.68	0.07	0.51	3c0kA	GO:0003723 GO:0005737 GO:0005829 GO:0006364 GO:0008168 GO:0008649 GO:0009383 GO:0016434 GO:0016740 GO:0031167 GO:0032259 GO:0044010 GO:0070475
7	0.06	0.271	7.03	0.05	0.48	3jroA	GO:0000139 GO:0005198 GO:0005634 GO:0005643 GO:0005773 GO:0005774 GO:0005783 GO:0005789 GO:0006810 GO:0012507 GO:0015031 GO:0016020 GO:0016192 GO:0030127 GO:0030433 GO:0031080 GO:0031081 GO:0031410 GO:0035859 GO:0042802 GO:0043547 GO:0045893 GO:0051028 GO:0090114 GO:1904263
8	0.06	0.252	5.90	0.06	0.38	4q04B	GO:0005509 GO:0046872
9	0.06	0.238	6.41	0.04	0.39	4f2pB	GO:0003824 GO:0008652 GO:0008782 GO:0008930 GO:0009086 GO:0009116 GO:0009164 GO:0016787 GO:0019284 GO:0019509
10	0.06	0.226	6.96	0.04	0.40	3cawA	GO:0046872
11	0.06	0.235	6.11	0.07	0.37	4g89A	GO:0003824 GO:0008652 GO:0008782 GO:0008930 GO:0009086 GO:0009116 GO:0009164 GO:0016787 GO:0019284 GO:0019509
12	0.06	0.238	6.47	0.04	0.39	2h7yA	GO:0003824 GO:0008152 GO:0009058 GO:0016740 GO:0016746 GO:0016747 GO:0016788 GO:0017000 GO:0031177 GO:0033068
13	0.06	0.290	6.74	0.06	0.50	1h3eA	GO:0000166 GO:0003723 GO:0004812 GO:0004831 GO:0005524 GO:0005737 GO:0006412 GO:0006418 GO:0006437 GO:0016874
14	0.06	0.220	5.91	0.04	0.34	3rk1B	GO:0000166 GO:0005524
15	0.06	0.251	5.73	0.04	0.38	3we7A	GO:0046872
16	0.06	0.232	5.52	0.03	0.34	3hnrA	GO:0008152 GO:0008168 GO:0008757 GO:0016740 GO:0032259
17	0.06	0.199	5.53	0.11	0.29	2lakA	GO:0006950
18	0.06	0.171	6.03	0.01	0.27	3lncA	GO:0000166 GO:0004385 GO:0005524 GO:0005737 GO:0006163 GO:0016301 GO:0016310 GO:0016740 GO:0046037 GO:0046710

Consensus prediction of GO terms

Molecular Function	GO:0008017	GO:0016758	GO:0005506	GO:0004748	GO:0005261	GO:0030145	GO:0008381
GO-Score	0.06	0.06	0.06	0.06	0.06	0.06	0.06
Biological Processes	GO:0051234
GO-Score	0.36
Cellular Component	GO:0016021	GO:0033588	GO:0005654	GO:0005971	GO:0005789	GO:0031258	GO:0033116
GO-Score	0.12	0.06	0.06	0.06	0.06	0.06	0.06

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.