I-TASSER results

I-TASSER results for job id Rv2787

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (587 residues)
MSTFRECRSMFDAAVKSYQSGDLANARAAFGRLTVENPDMSDGWLGLLACGDHHLDTLAG
AHQHSEALYSETRRVGLTDGELSAVVMAPMYLGLRVWSRATIGLAYASALIIADRHDEAA
ATLDDPVITEDTGAAQYRQFVMATLFHKTRSWSNLLKVTEISPPSGATDVRDEVADAVAA
LASTAAASLGQFQFALELAEQVSTTNPRVTADVTLTRAWCLRELGDDDAARVALSATTTG
DAPRTNTTAEQAGSPQPKFRHPYDDGRDLLVARRRPPAGDGWRKAVTKMTFGRVNPEPSA
KREQTDELIQRICAPLADVHKLAFVSAKGGVGKTTMTVLVGNAVARLRGDRVMAVDVDAD
LGDLSARFSERGGPQTNIEHFVSSQHTKRYADVRVHTVMNKDRLEMLGAQNDPRSTYKFG
PEDYGAAMQILETHCNVILLDCGTPVNGPLFSNILNDVTGLVVVASEDVRGVEGALVTLD
WLGAHGFGRLLQHTVVVLNAIQKTRSLVDCGAAENQFRKRVPDFFRIPYDPHLATGLAVD
FSSLKRRTRNAVLDLAGGLAQHYPASRVRPRGEDSWKTWIETMRQVG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSTFRECRSMFDAAVKSYQSGDLANARAAFGRLTVENPDMSDGWLGLLACGDHHLDTLAGAHQHSEALYSETRRVGLTDGELSAVVMAPMYLGLRVWSRATIGLAYASALIIADRHDEAAATLDDPVITEDTGAAQYRQFVMATLFHKTRSWSNLLKVTEISPPSGATDVRDEVADAVAALASTAAASLGQFQFALELAEQVSTTNPRVTADVTLTRAWCLRELGDDDAARVALSATTTGDAPRTNTTAEQAGSPQPKFRHPYDDGRDLLVARRRPPAGDGWRKAVTKMTFGRVNPEPSAKREQTDELIQRICAPLADVHKLAFVSAKGGVGKTTMTVLVGNAVARLRGDRVMAVDVDADLGDLSARFSERGGPQTNIEHFVSSQHTKRYADVRVHTVMNKDRLEMLGAQNDPRSTYKFGPEDYGAAMQILETHCNVILLDCGTPVNGPLFSNILNDVTGLVVVASEDVRGVEGALVTLDWLGAHGFGRLLQHTVVVLNAIQKTRSLVDCGAAENQFRKRVPDFFRIPYDPHLATGLAVDFSSLKRRTRNAVLDLAGGLAQHYPASRVRPRGEDSWKTWIETMRQVG
Prediction	CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHCCCEEEEHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEHCCCCCCHHHHHHHHHHHHHHHHCCEEEEEHCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEHCCCCCHHHHCCCHHHHHHHHHHHHHHCCEEEEHCCCCCCCHHHHHHHHHCCCEEEEHCCCHHHHHHHHHHHHHHHHHCCHHHHHCCEEEEHCCCCCCCCCCHHHHHHHHHHHCCEEEHCCCCCCCCCCEEEEHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCCC
Conf.Score	98789999997888876578889999999999999787776799999998899899999999999999999998768866556567667567876688799999999999875888999999986777788876589999999998764667999998757788788776578899999999998887778658888875667888645566777777766555887555555545678888887766676778888887776676456546677877578999999975555677879899999999999987578986999995899986899999999999999599699996798888655556777787554889987866565899998853368987998589995565568999999999999986999999699998668999999987959999677899999999999999998986666455899975689988788999999999874658986898545578567634588689999999999999975776666777667765554555559
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSTFRECRSMFDAAVKSYQSGDLANARAAFGRLTVENPDMSDGWLGLLACGDHHLDTLAGAHQHSEALYSETRRVGLTDGELSAVVMAPMYLGLRVWSRATIGLAYASALIIADRHDEAAATLDDPVITEDTGAAQYRQFVMATLFHKTRSWSNLLKVTEISPPSGATDVRDEVADAVAALASTAAASLGQFQFALELAEQVSTTNPRVTADVTLTRAWCLRELGDDDAARVALSATTTGDAPRTNTTAEQAGSPQPKFRHPYDDGRDLLVARRRPPAGDGWRKAVTKMTFGRVNPEPSAKREQTDELIQRICAPLADVHKLAFVSAKGGVGKTTMTVLVGNAVARLRGDRVMAVDVDADLGDLSARFSERGGPQTNIEHFVSSQHTKRYADVRVHTVMNKDRLEMLGAQNDPRSTYKFGPEDYGAAMQILETHCNVILLDCGTPVNGPLFSNILNDVTGLVVVASEDVRGVEGALVTLDWLGAHGFGRLLQHTVVVLNAIQKTRSLVDCGAAENQFRKRVPDFFRIPYDPHLATGLAVDFSSLKRRTRNAVLDLAGGLAQHYPASRVRPRGEDSWKTWIETMRQVG
Prediction	76444303311120121242622520250034006302500000000000113234002100200210030123151443201010200000001021130000000000044531630351055242365433130010000000010210430041144123452332231011002000010001001014025205425432220110010010001233353451332133112333222222232322421233232223222123433344222013002200122042444543433440353044324421000000031000000000000000021142100000000100000000225333300000013244223132034102412410102103233433440336103400520373000000000000101002000000000000000003003001300410362224511420000000014634323153026204530120010021410250220213314360030014002200531254553344664245115214638
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560                 580

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHCCCEEEEHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEHCCCCCCHHHHHHHHHHHHHHHHCCEEEEEHCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEHCCCCCHHHHCCCHHHHHHHHHHHHHHCCEEEEHCCCCCCCHHHHHHHHHCCCEEEEHCCCHHHHHHHHHHHHHHHHHCCHHHHHCCEEEEHCCCCCCCCCCHHHHHHHHHHHCCEEEHCCCCCCCCCCEEEEHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCCC
MSTFRECRSMFDAAVKSYQSGDLANARAAFGRLTVENPDMSDGWLGLLACGDHHLDTLAGAHQHSEALYSETRRVGLTDGELSAVVMAPMYLGLRVWSRATIGLAYASALIIADRHDEAAATLDDPVITEDTGAAQYRQFVMATLFHKTRSWSNLLKVTEISPPSGATDVRDEVADAVAALASTAAASLGQFQFALELAEQVSTTNPRVTADVTLTRAWCLRELGDDDAARVALSATTTGDAPRTNTTAEQAGSPQPKFRHPYDDGRDLLVARRRPPAGDGWRKAVTKMTFGRVNPEPSAKREQTDELIQRICAPLADVHKLAFVSAKGGVGKTTMTVLVGNAVARLRGDRVMAVDVDADLGDLSARFSERGGPQTNIEHFVSSQHTKRYADVRVHTVMNKDRLEMLGAQNDPRSTYKFGPEDYGAAMQILETHCNVILLDCGTPVNGPLFSNILNDVTGLVVVASEDVRGVEGALVTLDWLGAHGFGRLLQHTVVVLNAIQKTRSLVDCGAAENQFRKRVPDFFRIPYDPHLATGLAVDFSSLKRRTRNAVLDLAGGLAQHYPASRVRPRGEDSWKTWIETMRQVG

4f3vA

0.17

0.08

0.45

1.22

MUSTER

M--TDRLASLFESAVSMLP-MSEARSLDLFTEITNYDESACDAWIGRIRCGDTDRVTLFRAWYSRRNFGQLSGSVQISMSTLNARIAIGLYITYPVTSPLAITMGFAACEAAQGNYADAMEALEAAPVAGSE---HLVAWMKAVVYGAAERWTDVIDQVKSA----GKWPDKFLAGAAGVAHGVAAANLALFTEAERRLTEANDSGEACARAIAWYLAMARRSQGNESAAVALLEWLQTTHPEPKVAAADPSYRLKTTTAEQIASRADPWDPGSVV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

3ea0B

0.18

0.07

0.40

1.16

dPPAS

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNAKRVFGFVSAKGGDGGSCIAANFAFALSQEPDIHVLAVDISLPFGDLD--YLSGNTHSQDLADISNASDRLDKSLLDTVQH-ISPSLDLIPSPATFEKIVNIEPERVSDLIHIAASFYDYIIVDFGASIDH-VGVWVLEHLDELCIVTTPSLQSLRRAGQLLKLCKEFEKP--ISRIEIILNRADT--SRITSDEIEKVIGRPIS--KRIPQDEDAQEGQSVLKVAPKSQLSKTIVDWALHLN---------------------------

4f3vA

0.15

0.07

0.46

1.61

dPPAS

-GHMTDRLASLFESAVSMLPMSEARSLDLFTEITNYDESACDAWIGRIRCGDTDRVTLFRAWYSRRNFGQLSGSVQISMSTLNARIAIGGLITYPVTSPLAITMGFAACEAAQGNYADAMEALEAAPVAGSE---HLVAWMKAVVYGAAERWTDVIDQVKSA----GKWPDKFLAGAAGVAHGVAAANLALFTEAERRLTEASPAGEACARAIAWYLAMARRSQGNESAAVALLEWLQTTHPEPKVAAKDPSYRLKTTTAEQIASRADPWDPGSVV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2bejA

0.23

0.09

0.40

1.94

wdPPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KVRRIALANQKGGVGKTTTAINLAAYLARLG-KRVLLVDLDPQGNATSGLGVR---AERGVYHLLQGEPLEG-------LVHPVDGFHLLPATPDLVGATVGAPTALREALR--DEGYDLVLLDAPPSL-SPLTLNALAAAEGVVVPVQAEYYALEGVAGLLATLEEV-PRLRLLGILVTMYDGRTLLAQQVEAQLRAHFGEKVFWTV-IPRNVRLAEGKTIAQHAPTSPGAHAYRRLAEEVMARVQEA---------------------

4f3vA

0.18

0.08

0.46

1.94

wdPPAS

M--TDRLASLFESAVSML-PMSEARSLDLFTEITNYDESACDAWIGRIRCGDTDRVTLFRAWYSRRNFGQLSGSVQISMSTLNARIAIGLYITYPVTSPLAITMGFAACEAAQGNYADAMEALEAAPVAGSE---HLVAWMKAVVYGAAERWTDVIDQVKSA----GKWPDKFLAGAAGVAHGVAAANLALFTEAERRLTEASPAGEACARAIAWYLAMARRSQGNESAAVALLEWLQTTHPEP-KVAAALKDPSYRLKTTT-AEQIASRADPWDPGSVV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

3ea0B

0.18

0.07

0.40

1.15

wMUSTER

----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NAKRVFGFVSAKGGDGGSCIAANFAFALSQEPDIHVLAVDISLPFGDLDYLSGNT--HSQDLADISNASDRLDKSLLDTVQH-ISPSLDLIPSPATFEKIVNIEPERVSDLIHIAASFYDYIIVDFGASIDH-VGVWVLEHLDELCIVTTPSLQSLRRAGQLLKLCKEFEKP--ISRIEIILNRADT--SRITSDEIEKVIGRPI--SKRIPQDEDAQEGQSVLKVAPKSQLSKTIVDWALHLN---------------------------

4f3vA

0.17

0.08

0.45

1.52

wMUSTER

M--TDRLASLFESAVSML-PMSEARSLDLFTEITNYDESACDAWIGRIRCGDTDRVTLFRAWYSRRNFGQLSGSVQISMSTLNARIAIGLYITYPVTSPLAITMGFAACEAAQGNYADAMEALEAAPVAG---SEHLVAWMKAVVYGAAERWTDVIDQVKSA----GKWPDKFLAGAAGVAHGVAAANLALFTEAERRLTEANDSGEACARAIAWYLAMARRSQGNESAAVALLEWLQTTHPEPKVAAADPSYRLKTTTAEQIASRADPWDPGSVV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2bejA

0.23

0.09

0.40

2.09

wPPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KVRRIALANQKGGVGKTTTAINLAAYLARLG-KRVLLVDLDPQGNATSGLGVR---AERGVYHLLQGEPLEG-------LVHPVDGFHLLPATPDLVGATV-APTALREALR--DEGYDLVLLDAPPSL-SPLTLNALAAAEGVVVPVQAEYYALEGVAGLLATLEEV-PRLRLLGILVTMYDGRTLLAQQVEAQLRAHFGEKVFWTV-IPRNVRLAEGKTIAQHAPTSPGAHAYRRLAEEVMARVQEA---------------------

4f3vA

0.17

0.08

0.46

2.35

wPPAS

M--TDRLASLFESAVSML-PMSEARSLDLFTEITNYDESACDAWIGRIRCGDTDRVTLFRAWYSRRNFGQLSGSVQISMSTLNARIAIGLYITYPVTSPLAITMGFAACEAAQGNYADAMEALEAAPVAGSE---HLVAWMKAVVYGAAERWTDVIDQVKSA----GKWPDKFLAGAAGVAHGVAAANLALFTEAERRLTEANDSGEACARAIAWYLAMARRSQGNESAAVALLEWLQTTHPEPKVA-AALKDPSYRLKTTT-AEQIASRADPWDPGSVV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

3ea0B

0.17

0.07

0.40

2.55

dPPAS2

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNAKRVFGFVSAKGGDGGSCIAANFAFALSQEPDIHVLAVDISLPFGDLD--YLSGNTHSQDLADISNASDRLDKSLLDTVQH-ISPSLDLIPSPATFEKIVNIEPERVSDLIHIAASFYDYIIVDFGASIDH-VGVWVLEHLDELCIVTTPSLQSLRRAGQLLKLCKEFEKP--ISRIEIILNRADT--SRITSDEIEKVIGRPISKRI--PQDEDAQEGQSVLKVAPKSQLSKTIVDWALHLN---------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.43

Estimated TM-score = 0.34±0.11

Estimated RMSD = 16.4±3.0Å

Download Model 2

C-score=-3.68

Download Model 3

C-score=-3.70

Download Model 4

C-score=-3.66

Download Model 5

C-score=-3.76

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4wxxA	0.441	6.83	0.041	0.654
2	3pe3A	0.436	6.63	0.061	0.635
3	4f3vA	0.426	2.12	0.159	0.450
4	4ztxA	0.415	7.35	0.062	0.647
5	1xr2B	0.413	7.62	0.050	0.661
6	2jlbA	0.408	6.95	0.085	0.603
7	4zhjA	0.406	7.55	0.045	0.642
8	4bujB	0.403	6.12	0.040	0.564
9	2xvgA	0.401	7.27	0.045	0.617
10	5jouA	0.401	7.26	0.038	0.615

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.13	7	3ea0B	ATP	Rep, Mult	326,329,330,331,332,333,334,335,363,368,441,499,500,528,529,530,531,533
2	0.09	5	1l5rA	700	Rep, Mult	336,339,340,343,464,497
3	0.05	3	1c50A	CHI	Rep, Mult	336,340,522,528
4	0.05	3	3q9lA	ATP	Rep, Mult	328,329,468
5	0.04	2	1z62A	IAA	Rep, Mult	324,338,356,358
6	0.04	2	3dd1A	25D	Rep, Mult	338,340,344
7	0.04	2	3cejB	AVF	Rep, Mult	440,441,442,443,446
8	0.02	1	1exvB	700	Rep, Mult	464,474,478
9	0.02	1	1p2bA	GLC	Rep, Mult	338,339,341,342,352,354
10	0.02	1	3bd7A	CKB	Rep, Mult	466,471,472,473
11	0.02	1	1l5qA	CFF	Rep, Mult	344,347,349,350

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2r4uA	0.347	6.43	0.079	0.499	2.4.1.21	474,513
2	0.060	2zuwC	0.344	7.46	0.053	0.543	2.4.1.211	480
3	0.060	2q1fA	0.338	7.93	0.058	0.557	4.2.2.21	NA
4	0.060	3hhsB	0.337	7.57	0.038	0.540	1.14.18.1	NA
5	0.060	2c4mC	0.383	7.61	0.045	0.601	2.4.1.1	NA
6	0.060	1cp2A	0.354	3.74	0.115	0.409	1.18.6.1	328,333
7	0.060	1ygpA	0.393	6.94	0.044	0.586	2.4.1.1	NA
8	0.060	1de0A	0.358	3.68	0.142	0.412	1.18.6.1	328,333
9	0.060	1ahpA	0.390	6.86	0.061	0.578	2.4.1.1	NA
10	0.060	1iexA	0.359	7.44	0.039	0.566	3.2.1.58	NA
11	0.060	2nq5A	0.392	7.65	0.042	0.630	2.1.1.14	NA
12	0.060	1gz5A	0.362	6.32	0.065	0.509	2.4.1.15	NA
13	0.060	1ofdA	0.425	7.77	0.039	0.692	1.4.7.1	NA
14	0.060	1e1yA	0.390	6.99	0.054	0.586	2.4.1.1	NA
15	0.060	2qllA	0.387	7.43	0.048	0.603	2.4.1.1	NA
16	0.060	2vdcA	0.394	7.83	0.048	0.651	1.4.1.13	NA
17	0.060	3bq5A	0.403	7.69	0.039	0.656	2.1.1.14	NA
18	0.060	3f93A	0.367	7.39	0.044	0.569	3.2.1.-	540
19	0.060	1k32A	0.350	8.17	0.050	0.584	3.4.21.-	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.07	0.437	6.41	0.07	0.63	4xifA	GO:0000123 GO:0000791 GO:0001933 GO:0001934 GO:0005547 GO:0005634 GO:0005654 GO:0005737 GO:0005739 GO:0005829 GO:0005886 GO:0006041 GO:0006110 GO:0006486 GO:0006493 GO:0006915 GO:0007165 GO:0007584 GO:0008047 GO:0008134 GO:0008289 GO:0008375 GO:0010628 GO:0010801 GO:0016020 GO:0016262 GO:0016568 GO:0016740 GO:0016757 GO:0019904 GO:0030854 GO:0030900 GO:0031397 GO:0032868 GO:0032869 GO:0032922 GO:0033137 GO:0035020 GO:0042277 GO:0042588 GO:0043005 GO:0043025 GO:0043085 GO:0043981 GO:0043982 GO:0043984 GO:0043995 GO:0043996 GO:0045793 GO:0045862 GO:0045944 GO:0046626 GO:0046972 GO:0048015 GO:0048029 GO:0048312 GO:0048511 GO:0051571 GO:0060548 GO:0061087 GO:0070207 GO:0070208 GO:0070688 GO:0071222 GO:0071300 GO:0071333 GO:0080182 GO:0090315 GO:0090526 GO:0097237 GO:0097363 GO:1900038 GO:1900182 GO:1903428
1	0.07	0.440	6.79	0.04	0.65	4wxxB	GO:0000122 GO:0000792 GO:0003677 GO:0003682 GO:0003690 GO:0003723 GO:0003886 GO:0005634 GO:0005654 GO:0005657 GO:0005721 GO:0005737 GO:0006306 GO:0006351 GO:0006355 GO:0007265 GO:0007420 GO:0007568 GO:0008168 GO:0008270 GO:0008327 GO:0009008 GO:0009408 GO:0009636 GO:0010033 GO:0010212 GO:0010216 GO:0010288 GO:0010424 GO:0010468 GO:0010628 GO:0014823 GO:0016458 GO:0016568 GO:0016740 GO:0019904 GO:0030182 GO:0030331 GO:0031000 GO:0031667 GO:0032259 GO:0032355 GO:0032496 GO:0032776 GO:0033189 GO:0033574 GO:0036120 GO:0036276 GO:0042127 GO:0042493 GO:0042826 GO:0043025 GO:0043234 GO:0044026 GO:0045322 GO:0045471 GO:0045814 GO:0045892 GO:0046498 GO:0046499 GO:0046500 GO:0046872 GO:0051571 GO:0051573 GO:0051718 GO:0071230 GO:0071284 GO:0071560 GO:0090116 GO:0090309 GO:1990090 GO:1990841
2	0.07	0.440	6.69	0.07	0.64	5a01A	GO:0006486 GO:0006493 GO:0008375 GO:0016740 GO:0016757 GO:0035220 GO:0045475
3	0.06	0.408	6.95	0.09	0.60	2jlbA	GO:0046872
4	0.06	0.441	6.91	0.04	0.66	3av4A	GO:0000122 GO:0000183 GO:0000792 GO:0003677 GO:0003682 GO:0003690 GO:0003723 GO:0003824 GO:0003886 GO:0005634 GO:0005654 GO:0005657 GO:0005721 GO:0005737 GO:0006306 GO:0006351 GO:0006355 GO:0007265 GO:0007420 GO:0007568 GO:0008152 GO:0008168 GO:0008270 GO:0008327 GO:0009008 GO:0009408 GO:0009636 GO:0010033 GO:0010212 GO:0010216 GO:0010288 GO:0010424 GO:0010468 GO:0010628 GO:0014823 GO:0016458 GO:0016568 GO:0016740 GO:0019904 GO:0030182 GO:0030331 GO:0031000 GO:0031667 GO:0032259 GO:0032355 GO:0032496 GO:0032776 GO:0033189 GO:0033574 GO:0036120 GO:0036276 GO:0042127 GO:0042493 GO:0042826 GO:0043025 GO:0043045 GO:0043234 GO:0044026 GO:0045322 GO:0045471 GO:0045892 GO:0046498 GO:0046499 GO:0046500 GO:0046872 GO:0051571 GO:0051573 GO:0051718 GO:0071230 GO:0071284 GO:0071560 GO:0090116 GO:0090309 GO:1990090 GO:1990841
5	0.06	0.386	7.02	0.04	0.57	3q3eA	GO:0000166
6	0.06	0.374	5.66	0.08	0.50	5a31C	GO:0004842 GO:0005622 GO:0005654 GO:0005680 GO:0005829 GO:0006511 GO:0007049 GO:0007067 GO:0007080 GO:0007091 GO:0007096 GO:0016567 GO:0030071 GO:0031145 GO:0042787 GO:0043161 GO:0051301 GO:0051436 GO:0051437 GO:0051439 GO:0070979
7	0.06	0.388	6.72	0.09	0.57	5a31J	GO:0005634 GO:0005654 GO:0005680 GO:0005737 GO:0005813 GO:0005815 GO:0005819 GO:0005829 GO:0005856 GO:0005876 GO:0007049 GO:0007067 GO:0007088 GO:0008283 GO:0016567 GO:0031145 GO:0042787 GO:0043161 GO:0051301 GO:0051436 GO:0051437 GO:0051439 GO:0070979
8	0.06	0.314	6.94	0.04	0.47	5dseA	GO:0005737 GO:0005829 GO:0005886 GO:0016020 GO:0046854 GO:0090002
9	0.06	0.354	6.78	0.07	0.53	5a31Y	GO:0005634 GO:0005654 GO:0005680 GO:0005829 GO:0007049 GO:0007067 GO:0016567 GO:0019903 GO:0031145 GO:0042787 GO:0043161 GO:0051301 GO:0051436 GO:0051437 GO:0051439 GO:0070979
10	0.06	0.341	7.14	0.07	0.53	5a31F	GO:0005634 GO:0005654 GO:0005680 GO:0005737 GO:0005813 GO:0005819 GO:0005829 GO:0005876 GO:0007091 GO:0008283 GO:0016567 GO:0019903 GO:0031145 GO:0042787 GO:0043161 GO:0051436 GO:0051437 GO:0051439 GO:0070979
11	0.06	0.384	6.82	0.05	0.56	3q3eB	GO:0000166
12	0.06	0.337	3.53	0.08	0.38	5a6cB	GO:0000132 GO:0000166 GO:0000922 GO:0001965 GO:0005092 GO:0005654 GO:0005737 GO:0005829 GO:0005856 GO:0005886 GO:0005911 GO:0005912 GO:0005913 GO:0005938 GO:0007052 GO:0007155 GO:0007165 GO:0007186 GO:0007267 GO:0008022 GO:0017016 GO:0030054 GO:0030695 GO:0034332 GO:0042802 GO:0043547 GO:0045177 GO:0050790 GO:0051661 GO:0060487 GO:0090557 GO:0097431 GO:0098609 GO:0098641
13	0.06	0.325	3.70	0.10	0.37	1w3bA	GO:0000123 GO:0000791 GO:0001933 GO:0001934 GO:0005547 GO:0005634 GO:0005654 GO:0005737 GO:0005739 GO:0005829 GO:0005886 GO:0006041 GO:0006110 GO:0006486 GO:0006493 GO:0006915 GO:0007165 GO:0007584 GO:0008047 GO:0008134 GO:0008289 GO:0008375 GO:0010628 GO:0010801 GO:0016020 GO:0016262 GO:0016568 GO:0016740 GO:0016757 GO:0019904 GO:0030854 GO:0030900 GO:0031397 GO:0032868 GO:0032869 GO:0032922 GO:0033137 GO:0035020 GO:0042277 GO:0042588 GO:0043005 GO:0043025 GO:0043085 GO:0043981 GO:0043982 GO:0043984 GO:0043995 GO:0043996 GO:0045793 GO:0045862 GO:0045944 GO:0046626 GO:0046972 GO:0048015 GO:0048029 GO:0048312 GO:0048511 GO:0051571 GO:0060548 GO:0061087 GO:0070207 GO:0070208 GO:0070688 GO:0071222 GO:0071300 GO:0071333 GO:0080182 GO:0090315 GO:0090526 GO:0097237 GO:0097363 GO:1900038 GO:1900182 GO:1903428
14	0.06	0.335	3.71	0.09	0.39	4a1sA	GO:0000132 GO:0005938 GO:0007400 GO:0007405 GO:0008105 GO:0008356 GO:0019904 GO:0030695 GO:0040001 GO:0045167 GO:0045175 GO:0045177 GO:0045179 GO:0045185 GO:0050790 GO:0051294 GO:0055059
15	0.06	0.308	4.17	0.07	0.37	1w3bB	GO:0000123 GO:0000791 GO:0001933 GO:0001934 GO:0005547 GO:0005634 GO:0005654 GO:0005737 GO:0005739 GO:0005829 GO:0005886 GO:0006041 GO:0006110 GO:0006486 GO:0006493 GO:0006915 GO:0007165 GO:0007584 GO:0008047 GO:0008134 GO:0008289 GO:0008375 GO:0010628 GO:0010801 GO:0016020 GO:0016262 GO:0016568 GO:0016740 GO:0016757 GO:0019904 GO:0030854 GO:0030900 GO:0031397 GO:0032868 GO:0032869 GO:0032922 GO:0033137 GO:0035020 GO:0042277 GO:0042588 GO:0043005 GO:0043025 GO:0043085 GO:0043981 GO:0043982 GO:0043984 GO:0043995 GO:0043996 GO:0045793 GO:0045862 GO:0045944 GO:0046626 GO:0046972 GO:0048015 GO:0048029 GO:0048312 GO:0048511 GO:0051571 GO:0060548 GO:0061087 GO:0070207 GO:0070208 GO:0070688 GO:0071222 GO:0071300 GO:0071333 GO:0080182 GO:0090315 GO:0090526 GO:0097237 GO:0097363 GO:1900038 GO:1900182 GO:1903428
16	0.06	0.340	7.02	0.07	0.51	2xt6A	GO:0003824 GO:0004149 GO:0004591 GO:0006099 GO:0008152 GO:0008683 GO:0016491 GO:0016624 GO:0016740 GO:0016746 GO:0016829 GO:0016831 GO:0030976 GO:0046872 GO:0050439 GO:0055114
17	0.06	0.343	6.57	0.06	0.49	5dseC	GO:0005737 GO:0005829 GO:0005886 GO:0016020 GO:0046854 GO:0090002
18	0.06	0.305	7.10	0.07	0.47	1wao1	GO:0000165 GO:0001933 GO:0001965 GO:0003723 GO:0004721 GO:0004722 GO:0004871 GO:0005524 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0005886 GO:0006281 GO:0006351 GO:0006470 GO:0006974 GO:0007067 GO:0008017 GO:0008289 GO:0010288 GO:0016020 GO:0016576 GO:0016787 GO:0031072 GO:0042802 GO:0043005 GO:0043025 GO:0043123 GO:0043204 GO:0043231 GO:0043234 GO:0043278 GO:0043531 GO:0046872 GO:0051259 GO:0051291 GO:0060548 GO:0070301 GO:0071276 GO:0071944 GO:1901215 GO:1990635 GO:2000324

Consensus prediction of GO terms

Molecular Function	GO:0005515	GO:0043169	GO:0003824
GO-Score	0.36	0.36	0.33
Biological Processes	GO:0010468	GO:0051569	GO:0031062
GO-Score	0.36	0.36	0.36
Cellular Component	GO:0044297	GO:0036477	GO:0031981
GO-Score	0.36	0.36	0.36

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.