I-TASSER results

I-TASSER results for job id Rv2769c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (275 residues)
MSFLTTQPEELAAAAGKLETIGSAMVAQNAAAAAPTTTGVIPAAADEISVLQAPLFTAYG
TLYQQVSAEAAAVYDLFVKTLGVSAGTYAATEAANSSAAASPLSGIASILGSTPGKVPSW
ISDIANIFNIGAGNWASAASDLLGLASGGLLPAAEEAALEEGLEGAGLSELGAAEAAVGE
APIAAGLGAAPLAAGLSRASSIGALSVPPSWAGQANLVSSTSTLQGAGWTTAAPHGAAGT
VIPGMPGLASATRSSAGFGAPRYGAKPIVVPKPAV

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MSFLTTQPEELAAAAGKLETIGSAMVAQNAAAAAPTTTGVIPAAADEISVLQAPLFTAYGTLYQQVSAEAAAVYDLFVKTLGVSAGTYAATEAANSSAAASPLSGIASILGSTPGKVPSWISDIANIFNIGAGNWASAASDLLGLASGGLLPAAEEAALEEGLEGAGLSELGAAEAAVGEAPIAAGLGAAPLAAGLSRASSIGALSVPPSWAGQANLVSSTSTLQGAGWTTAAPHGAAGTVIPGMPGLASATRSSAGFGAPRYGAKPIVVPKPAV
Prediction	CCEEHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEHCCCCCC
Conf.Score	97676456999999999999989999999876544555435666547999999999999999999999999999999999999999998888888777777777777665567766667777777777877887776676655677777677766667777666666666677777777777777777777666677766677778887766788887777777788766678888888888888888888888888888876555555589999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MSFLTTQPEELAAAAGKLETIGSAMVAQNAAAAAPTTTGVIPAAADEISVLQAPLFTAYGTLYQQVSAEAAAVYDLFVKTLGVSAGTYAATEAANSSAAASPLSGIASILGSTPGKVPSWISDIANIFNIGAGNWASAASDLLGLASGGLLPAAEEAALEEGLEGAGLSELGAAEAAVGEAPIAAGLGAAPLAAGLSRASSIGALSVPPSWAGQANLVSSTSTLQGAGWTTAAPHGAAGTVIPGMPGLASATRSSAGFGAPRYGAKPIVVPKPAV
Prediction	63204030330220033034032103202220012313303311212001000310231043023203200301430341043014301334333444344234213322413333333333333222233333333211322222333333334434244434333434433343333343333333332222223334332323122313343343444332433333322444443321101100123343331200110002032234358
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCEEHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEHCCCCCC
MSFLTTQPEELAAAAGKLETIGSAMVAQNAAAAAPTTTGVIPAAADEISVLQAPLFTAYGTLYQQVSAEAAAVYDLFVKTLGVSAGTYAATEAANSSAAASPLSGIASILGSTPGKVPSWISDIANIFNIGAGNWASAASDLLGLASGGLLPAAEEAALEEGLEGAGLSELGAAEAAVGEAPIAAGLGAAPLAAGLSRASSIGALSVPPSWAGQANLVSSTSTLQGAGWTTAAPHGAAGTVIPGMPGLASATRSSAGFGAPRYGAKPIVVPKPAV

2g38C

0.34

0.09

0.28

1.26

wdPPAS

-------PEALTVAATEVRRIRDRAIQSDAQVAPMTTA-VRPPAADLVSEKAATFLVEYARKYRQTIAAAAVVLEEFAHALTTG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

5gaoE

0.25

0.18

0.72

1.24

dPPAS2

----------------------------------------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-------------AA

2g38C

0.34

0.09

0.28

1.64

wPPAS

-------PEALTVAATEVRRIRDRAIQSDAQVAPMTTA-VRPPAADLVSEKAATFLVEYARKYRQTIAAAAVVLEEFAHALTTG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

5gaoE

0.24

0.98

1.69

PPAS

-----AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

4ke2A

0.20

0.14

0.71

1.22

dPPAS2

MNIDPAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP-------------------------------------------------------------------------------

4ke2A

0.20

0.14

0.71

1.23

PPAS

MNIDPAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP-------------------------------------------------------------------------------

2vsgA1

0.14

0.11

0.83

1.04

PPAS

E----LTAELRKTAGVAKMKVNSDLNSFKTLELTKMKLLTFAAPESKEALTLRALEAALNTDLRALRDNIANGIDRAVRATAYASEAAGALFSGIQTLHDA---------TDGTTYCLSASGQGSNGNAAMASQGCKPLALPELLTEDSYNTDVISDKGFPKISPLTNAQGQGKSGECGLFQAASGAQATNTGVQFSGGSRIGLGAIVAS-AAQQPTRPDLSDFSGTARNQADTLQLAQGPKP--------------------------------

1vsgA

0.16

0.15

0.98

0.84

MUSTER

KGFKQAFWQPLCQVSEELDDQPKGALFTLQAAASKIQKMRDAALRASIYAEINH--TNRAKAAVIVANHYAMKADSGLEALKQTLSSQEVTATATASYLKGRIDEYLNLLLQTKESGTSGCMMDTSGTNTVTKAGGTIGGVPCKLQLSPIQPKRPAATYLGKAGYVGLTRQADAANNFHDNDAESGHNTNGLGKSGQLSAAVGYVTVANS--QTAVTVQALDALQEASGAAHQPWIDAWKAKKALTGAETAEFRNETAGKTG--VEEALLKKKDS

2vsgA1

0.09

0.93

0.86

dPPAS

-THFGVK-YELWQPECELTAELRKTAGVAKMKVNSDLNSFKTLELTKMKLLTFAAKSKEALTLRALEAALNTDLRALRDNIANGIDRAVRATAYASEAAGALFSGIQTLHDATDGTTYCLSASGQGSNGNAAMASQGCKPLALPELLTEDSYNTDVISDKGFPKISPLTNAQGQGKSGECGLFQAASGAQATNTGVQFSGGSRINLGLGAIVASAAQQPTRPDLSDFSGTARNQADTLYGKAHASITELLQLAQGPKP-----------------

2vsgA1

0.13

0.11

0.84

0.67

wdPPAS

-T---ELWQPECELTAELRKTAGVAKMKVNSDLNSFKTL-----LTKMKLLTFAAKSKEALTLRALEAALNTDLRALRDNIANGIDRAVRATAYASEAAGALFSGIQTLHDATDGT-LSASGQGSNGNAAMASQGCKPLALPELLTEDSYNTDVISDKGFPKISPLTNAQGQGKSGECGLFQAASGAQATNTGVQFSGGSRIGAIVASAAQQPTRPDLSDFSGTARNQADTL--LQLAQGPKP--------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.82

Estimated TM-score = 0.50±0.15

Estimated RMSD = 10.1±4.6Å

Download Model 2

C-score=-3.21

Download Model 3

C-score=-3.61

Download Model 4

C-score=-4.58

Download Model 5

C-score=-4.96

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1vsgA	0.875	2.48	0.147	0.986
2	2vsgA	0.799	3.18	0.121	0.953
3	2y44A	0.544	3.25	0.149	0.651
4	4wjgE	0.522	3.82	0.096	0.669
5	4e40A	0.505	3.90	0.097	0.654
6	4iw0A3	0.479	4.34	0.021	0.636
7	4ut1A	0.478	5.52	0.124	0.727
8	3qweA	0.476	4.57	0.059	0.640
9	4akvA	0.475	4.64	0.044	0.647
10	2v0oA	0.473	4.63	0.058	0.644

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.08	4	1mhyD	FE	Rep, Mult	18,96,99,239
2	0.06	3	1brrA	ARC	Rep, Mult	47,63,64,67
3	0.06	3	1i4d0	III	Rep, Mult	17,18,27,30,33,37,63,66,67,69,70,73,77,237,241,245
4	0.04	2	2xqtB	DCW	Rep, Mult	56,63
5	0.04	2	2c88A	NA	Rep, Mult	50,51,52,53,60,64
6	0.04	2	3m4bA	ZN	Rep, Mult	12,46
7	0.04	2	4il4B	LSM	Rep, Mult	41,45,48
8	0.02	1	2qqdD	PYR	Rep, Mult	48,49
9	0.02	1	3h6kB	33T	Rep, Mult	81,88
10	0.02	1	4di0A	FE	Rep, Mult	6,10
11	0.02	1	2d2cA	CLA	Rep, Mult	43,78
12	0.02	1	1i490	III	Rep, Mult	17,21,24,28,31,34,35,38,41,42,46,48,52,59,62,63,65,66,69,73,88,236
13	0.02	1	3mgnD	DTR	Rep, Mult	44,47,48
14	0.02	1	1i4d1	III	Rep, Mult	13,16,19,20,22,23,25,26,27,29,30,93,96,100,103,104
15	0.02	1	4dr0A	MN	Rep, Mult	21,92,96,159,242

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3errA	0.387	5.24	0.033	0.567	6.1.1.11	49
2	0.060	1fo4A	0.434	6.24	0.046	0.731	1.17.1.4	NA
3	0.060	1dofA	0.382	5.12	0.070	0.582	4.3.2.2	NA
4	0.060	1uzrB	0.392	4.20	0.104	0.520	1.17.4.1	74
5	0.060	1k62B	0.386	5.23	0.070	0.586	4.3.2.1	NA
6	0.060	1mhyD	0.410	4.20	0.036	0.542	1.14.13.25	NA
7	0.060	2ckjA	0.338	6.73	0.076	0.622	1.17.1.4,1.17.3.2	NA
8	0.060	3hmjA	0.422	5.94	0.065	0.691	2.3.1.86	NA
9	0.060	2e1qA	0.410	6.48	0.065	0.720	1.17.3.2,1.17.1.4	NA
10	0.060	3b8cA	0.415	6.66	0.053	0.753	3.6.3.6	NA
11	0.060	1eulA	0.434	6.24	0.083	0.738	3.6.3.8	NA
12	0.060	2hc8A	0.192	4.48	0.038	0.266	3.6.3.-	34
13	0.060	1jswB	0.384	5.11	0.078	0.582	4.3.1.1	69
14	0.060	3b8cB	0.415	6.66	0.053	0.753	3.6.3.6	27,89
15	0.060	3b8eC	0.410	6.28	0.057	0.724	3.6.3.9	NA
16	0.060	1yfeA	0.384	5.38	0.049	0.600	4.2.1.2	NA
17	0.060	2pffA	0.388	6.34	0.046	0.665	2.3.1.41,2.3.1.86	63
18	0.060	3b9jJ	0.247	5.61	0.024	0.396	1.17.1.4,1.17.3.2	93,97
19	0.060	3b9jC	0.282	6.42	0.042	0.491	1.17.3.2,1.17.1.4	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.28	0.799	3.18	0.12	0.95	2vsgA	GO:0005886 GO:0016020 GO:0020012 GO:0031225
1	0.21	0.875	2.48	0.15	0.99	1vsgA	GO:0005886 GO:0016020 GO:0020012 GO:0031225
2	0.09	0.503	3.91	0.10	0.65	5jdoA	GO:0016020 GO:0016021
3	0.07	0.476	4.57	0.06	0.64	3qweA	GO:0002230 GO:0005096 GO:0005622 GO:0005829 GO:0007165 GO:0034260 GO:0035556 GO:0043547 GO:0046872 GO:0051056 GO:0098779 GO:0098792
4	0.07	0.473	4.55	0.04	0.64	4akvB	GO:0000281 GO:0005737 GO:0005768 GO:0005829 GO:0006810 GO:0006886 GO:0006897 GO:0007032 GO:0007049 GO:0007067 GO:0015031 GO:0016020 GO:0016023 GO:0016050 GO:0016197 GO:0017038 GO:0019898 GO:0030659 GO:0031410 GO:0035091 GO:0036089 GO:0042802 GO:0044351 GO:0045806 GO:0051044 GO:0051301 GO:0097320 GO:2000009 GO:2000010
5	0.07	0.466	4.64	0.06	0.64	2rajA	GO:0000281 GO:0001726 GO:0005545 GO:0005737 GO:0005768 GO:0005794 GO:0005802 GO:0005886 GO:0005913 GO:0006810 GO:0006886 GO:0006897 GO:0006898 GO:0007049 GO:0007067 GO:0008289 GO:0015031 GO:0016020 GO:0016023 GO:0016050 GO:0016197 GO:0030136 GO:0030659 GO:0031234 GO:0031410 GO:0031625 GO:0032461 GO:0035091 GO:0036089 GO:0042803 GO:0042995 GO:0043547 GO:0045860 GO:0051044 GO:0051301 GO:0060988 GO:0070062 GO:0071933 GO:0097320 GO:0098609 GO:0098641
6	0.07	0.472	4.55	0.05	0.62	4iwoA	GO:0000166 GO:0002218 GO:0002376 GO:0003676 GO:0004672 GO:0004674 GO:0005524 GO:0005737 GO:0005829 GO:0006468 GO:0006954 GO:0007249 GO:0009615 GO:0010008 GO:0010629 GO:0016032 GO:0016301 GO:0016310 GO:0016740 GO:0018105 GO:0032480 GO:0032481 GO:0032606 GO:0032727 GO:0032728 GO:0033138 GO:0035666 GO:0043123 GO:0044565 GO:0045087 GO:0045359 GO:0045944 GO:0050830 GO:0051219 GO:0051607 GO:1901214 GO:1904417
7	0.06	0.441	5.48	0.05	0.66	2d4yA	GO:0005198 GO:0005576 GO:0009288 GO:0009424 GO:0044780 GO:0071973
8	0.06	0.478	5.52	0.12	0.73	4ut1A	GO:0005198 GO:0009424 GO:0044780
9	0.06	0.317	5.86	0.03	0.50	4l4uA	GO:0000160 GO:0000166 GO:0003677 GO:0005524 GO:0005622 GO:0006351 GO:0006355 GO:0008134 GO:0043565
10	0.06	0.448	3.94	0.04	0.58	4iw0A	GO:0000166 GO:0002218 GO:0002376 GO:0003676 GO:0004672 GO:0004674 GO:0005524 GO:0005737 GO:0005829 GO:0006468 GO:0006954 GO:0007249 GO:0009615 GO:0010008 GO:0010629 GO:0016032 GO:0016301 GO:0016310 GO:0016740 GO:0018105 GO:0032480 GO:0032481 GO:0032606 GO:0032727 GO:0032728 GO:0033138 GO:0035666 GO:0043123 GO:0044565 GO:0045087 GO:0045359 GO:0045944 GO:0050830 GO:0051219 GO:0051607 GO:1901214 GO:1904417
11	0.06	0.301	6.12	0.05	0.49	1lpfA	GO:0004148 GO:0005737 GO:0006096 GO:0016491 GO:0016668 GO:0045454 GO:0050660 GO:0055114
12	0.06	0.286	5.20	0.05	0.41	4xtrA	GO:0000166 GO:0000750 GO:0005085 GO:0005524 GO:0005737 GO:0005783 GO:0005794 GO:0006620 GO:0006810 GO:0006890 GO:0009408 GO:0010038 GO:0016192 GO:0016787 GO:0016887 GO:0042802 GO:0043529 GO:0043547 GO:0045048 GO:0046685 GO:0046872 GO:0051082 GO:1990507
13	0.06	0.234	6.57	0.06	0.43	2w5vA	GO:0003824 GO:0008152 GO:0016311 GO:0016791 GO:0046872
14	0.06	0.266	6.74	0.04	0.49	2wssA	GO:0000166 GO:0005524 GO:0005739 GO:0005743 GO:0005753 GO:0005886 GO:0006754 GO:0006810 GO:0006811 GO:0015986 GO:0015991 GO:0015992 GO:0016020 GO:0016820 GO:0033178 GO:0045261 GO:0046034 GO:0046933 GO:0046961
15	0.06	0.258	6.32	0.03	0.44	4dziC	GO:0016787
16	0.06	0.283	6.58	0.07	0.50	3kx6A	GO:0003824 GO:0004332 GO:0006096 GO:0016829
17	0.06	0.275	5.29	0.04	0.41	1aj8A	GO:0003824 GO:0005737 GO:0006099 GO:0008152 GO:0016740 GO:0046912
18	0.06	0.240	6.43	0.03	0.41	2dybA	GO:0002479 GO:0005737 GO:0005768 GO:0005829 GO:0006955 GO:0008289 GO:0010008 GO:0016020 GO:0016176 GO:0032010 GO:0032266 GO:0035091 GO:0043020 GO:0043085 GO:0045454 GO:0046983 GO:0048010 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0005096	GO:0046872	GO:0035091	GO:0042802
GO-Score	0.07	0.07	0.07	0.07
Biological Processes	GO:0020012
GO-Score	0.43
Cellular Component	GO:0005886	GO:0031225
GO-Score	0.43	0.43

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.