I-TASSER results

I-TASSER results for job id Rv2768c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (394 residues)
MDFGALPPEINSTRMYAGAGAAPLMAAGATWNGLAVELSTTASSVESVIMQLTTEQWLGP
ASMSMVVAAQPYLAWLTYTAESAAHAAAQAMASAAAFEAAFAMTVPPAEVAANRALLAAL
VATNVLGQNTPAIMATEAHYGEMWAQDALAMYGYAASSAAAGRLNPLITPSQTANMAGLA
GQAAAVSHAAAASTVQQVGLGSLISNLPNAVMGFASPLTSAADAAGLGGIIQDIEELLGI
TFVQNAINGAVNTTAWFVMATIPNAVFLGHAFAALNPATVTAAADAVPAAAAAAGLAHTV
TPVGVGGASLTASLGEASSVGGLSVPAGWSTAAPAMTSGTTALEGSGWAVPEEAGPVAAM
PGMAGISGAAKGAGAYAGPRYGFKPIVMPKQVVV

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MDFGALPPEINSTRMYAGAGAAPLMAAGATWNGLAVELSTTASSVESVIMQLTTEQWLGPASMSMVVAAQPYLAWLTYTAESAAHAAAQAMASAAAFEAAFAMTVPPAEVAANRALLAALVATNVLGQNTPAIMATEAHYGEMWAQDALAMYGYAASSAAAGRLNPLITPSQTANMAGLAGQAAAVSHAAAASTVQQVGLGSLISNLPNAVMGFASPLTSAADAAGLGGIIQDIEELLGITFVQNAINGAVNTTAWFVMATIPNAVFLGHAFAALNPATVTAAADAVPAAAAAAGLAHTVTPVGVGGASLTASLGEASSVGGLSVPAGWSTAAPAMTSGTTALEGSGWAVPEEAGPVAAMPGMAGISGAAKGAGAYAGPRYGFKPIVMPKQVVV
Prediction	CCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHCCCCCC
Conf.Score	9855588555565546799958899999999999999999999999999998657777779999999999999999999999999999999999999999986999999999999999999984467757899999999999999999999999999999987678899988788887654444444555667655456899999999988776556666777777665445555555665555555555555555555666545665545566666555666666666666667777777777787765566777777777788888877788878877777887778888888888888888888888888888887777776454688889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MDFGALPPEINSTRMYAGAGAAPLMAAGATWNGLAVELSTTASSVESVIMQLTTEQWLGPASMSMVVAAQPYLAWLTYTAESAAHAAAQAMASAAAFEAAFAMTVPPAEVAANRALLAALVATNVLGQNTPAIMATEAHYGEMWAQDALAMYGYAASSAAAGRLNPLITPSQTANMAGLAGQAAAVSHAAAASTVQQVGLGSLISNLPNAVMGFASPLTSAADAAGLGGIIQDIEELLGITFVQNAINGAVNTTAWFVMATIPNAVFLGHAFAALNPATVTAAADAVPAAAAAAGLAHTVTPVGVGGASLTASLGEASSVGGLSVPAGWSTAAPAMTSGTTALEGSGWAVPEEAGPVAAMPGMAGISGAAKGAGAYAGPRYGFKPIVMPKQVVV
Prediction	5411010001000102001100002200200230033022003102200010223312110000002003202310120033044203103100000210121213233011132100101010010010000030133044011100100100100000013144144124214453243433223322332333322222113201321232222122213223232223323332233332222322232333223132323211121332222221122333222222222323321221121110000112233113031133123222333333222322333233422223211111101211122133012111032201222347
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHCCCCCC
MDFGALPPEINSTRMYAGAGAAPLMAAGATWNGLAVELSTTASSVESVIMQLTTEQWLGPASMSMVVAAQPYLAWLTYTAESAAHAAAQAMASAAAFEAAFAMTVPPAEVAANRALLAALVATNVLGQNTPAIMATEAHYGEMWAQDALAMYGYAASSAAAGRLNPLITPSQTANMAGLAGQAAAVSHAAAASTVQQVGLGSLISNLPNAVMGFASPLTSAADAAGLGGIIQDIEELLGITFVQNAINGAVNTTAWFVMATIPNAVFLGHAFAALNPATVTAAADAVPAAAAAAGLAHTVTPVGVGGASLTASLGEASSVGGLSVPAGWSTAAPAMTSGTTALEGSGWAVPEEAGPVAAMPGMAGISGAAKGAGAYAGPRYGFKPIVMPKQVVV

2g38B

0.30

0.13

0.44

1.48

MUSTER

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

5gaoE

0.27

0.23

0.86

1.66

PPAS

-------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA--AAAAAAAAAAAAAAAAAAAAAAAAA-------AAAAAAAAAAAAAAAAA----AAAAAAAAAAAAAAAAAAAAAAAAAAAA--------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK----------

2g38B

0.30

0.13

0.44

1.75

dPPAS

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2g38B

0.32

0.14

0.43

3.01

wdPPAS

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALS-TPWKAPPPIA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2g38B

0.32

0.14

0.43

1.98

wMUSTER

--FEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKTPWKAPPPIA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2g38B

0.32

0.14

0.43

4.45

wPPAS

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALS-TPWKAPPPIA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2g38B

0.32

0.14

0.44

3.74

dPPAS2

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKTPWKAPPPIA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2g38B

0.32

0.14

0.43

3.40

PPAS

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALS-TPWKAPPPIA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2g38B

0.32

0.14

0.44

4.12

Env-PPAS

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKTPWKAPPPIA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

4iu8A

0.10

0.09

0.94

0.81

MUSTER

RDWK---PE-NPAF----NKGKHIARRNLWISVSCLLLAFCVWLFSAVTVNLNKIGLLTALPSVSGALLRVPYSFVPIFGGRRWTVFSTAILIIPCVWLGIAVQTPFGIFIVIALLCGFAGANFASSGNISFFFPKA--------KQGSALGINGGLGNLGVSVQLVAPL---VIFVPVFAFLGVNGVPQADGSVSLANAAWIWVPLLAIATIAAWSGNDIALWLLSLLYLATFGSFIGFSAGFALAKTQFPDVNILRLAFFGPFIGAIARSVTLINFIFAIFSALLFLTLPGTGSGNFIAFYAVFGLFLTAGLGSGSTFQIAVIFRQITIYRVKKGQAHKEAVTETAAALGFISAIGAVGGFFIPQAFGSLNTGSPVGAKVF--LIF---YIV

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-4.30

Estimated TM-score = 0.26±0.08

Estimated RMSD = 17.8±2.5Å

Download Model 2

C-score=-3.08

Download Model 3

C-score=-3.31

Download Model 4

C-score=-3.39

Download Model 5

C-score=-4.02

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3ayfA2	0.424	6.33	0.060	0.642
2	2g38B	0.411	1.86	0.273	0.436
3	1m56A	0.400	6.39	0.071	0.632
4	1uwkA	0.394	6.33	0.070	0.609
5	1xmeA	0.393	6.72	0.060	0.647
6	2fknB	0.391	6.41	0.066	0.612
7	1w07B	0.388	6.25	0.036	0.586
8	1fftA	0.386	6.73	0.058	0.632
9	4zhjA	0.386	7.00	0.049	0.645
10	4iggA	0.384	6.23	0.038	0.571

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	3	1m57G	PEH	Rep, Mult	22,24,31,85,89,90
2	0.04	2	3dtuC	DXC	Rep, Mult	92,95,96,99,154,157
3	0.04	2	2jstB	HLT	Rep, Mult	31,34,69
4	0.04	2	4zzbA	XE	Rep, Mult	110,140,143,144
5	0.04	2	1tqqA	NCO	Rep, Mult	133,137
6	0.04	2	3gjoA	III	Rep, Mult	150,154
7	0.02	1	3iilA	MG	Rep, Mult	8,9
8	0.02	1	2izzA	NAD	Rep, Mult	124,125
9	0.02	1	1cxpA	UUU	Rep, Mult	75,76
10	0.02	1	3ej8D	H4B	Rep, Mult	57,97
11	0.02	1	5buoA	ZN	Rep, Mult	109,139
12	0.02	1	4owfB	III	Rep, Mult	63,66,67,70,74
13	0.02	1	3omiA	DMU	Rep, Mult	156,159,323,324
14	0.02	1	3cvsC	NUC	Rep, Mult	130,131,132
15	0.02	1	2g381	III	Rep, Mult	3,14,15,17,18,19,20,23,24,27,30,31,33,34,37,38,40,41,44,45,48,57,65,72,75,83,86,90,97,154,155,158,162,165,166,168,169,171,172,174
16	0.02	1	3d5aF	MG	Rep, Mult	34,37
17	0.02	1	3c9iC	XE	Rep, Mult	110,113
18	0.02	1	3ag3A	PEK	Rep, Mult	32,36,91
19	0.02	1	2r9rB	PGW	Rep, Mult	48,52
20	0.02	1	3nteA	FE	Rep, Mult	106,109

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2gtqA	0.344	7.01	0.043	0.581	3.4.11.2	NA
2	0.060	2o36A	0.338	7.31	0.041	0.591	3.4.24.15	NA
3	0.060	1uwkA	0.394	6.33	0.070	0.609	4.2.1.49	1,18,268
4	0.060	1br2A	0.304	6.24	0.048	0.462	3.6.1.32	NA
5	0.060	1jroB	0.362	7.03	0.064	0.614	1.1.1.204	NA
6	0.060	1s4bP	0.337	7.29	0.038	0.589	3.4.24.15	98,154
7	0.060	1n63B	0.376	6.97	0.055	0.629	1.2.99.2	NA
8	0.060	2rd0A	0.360	6.21	0.048	0.558	2.7.1.153	NA
9	0.060	1m56A	0.400	6.39	0.071	0.632	1.9.3.1	37
10	0.060	1w6jA	0.364	6.79	0.043	0.602	5.4.99.7	153
11	0.060	1qleA	0.396	6.42	0.078	0.629	1.9.3.1	37
12	0.060	2fonB	0.389	6.27	0.032	0.589	1.3.3.6	45
13	0.060	2o6yA	0.347	5.54	0.087	0.482	4.3.1.-	NA
14	0.060	1jqnA	0.361	7.17	0.053	0.622	4.1.1.31	NA
15	0.060	3ffzA	0.353	6.41	0.039	0.546	3.4.24.69	NA
16	0.060	1mhsA	0.340	5.81	0.039	0.487	3.6.3.6	NA
17	0.060	1y791	0.352	7.16	0.051	0.614	3.4.15.5	154
18	0.060	3btaA	0.349	6.15	0.049	0.530	3.4.24.69	NA
19	0.060	1w07B	0.388	6.25	0.036	0.586	1.3.3.6	70

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.24	0.419	1.76	0.30	0.44	4kxrB	GO:0005576 GO:0009405 GO:0009986
1	0.14	0.382	6.66	0.05	0.62	1occA	GO:0004129 GO:0005506 GO:0005739 GO:0005743 GO:0006119 GO:0009055 GO:0009060 GO:0016020 GO:0016021 GO:0016491 GO:0020037 GO:0045277 GO:0046872 GO:0055114 GO:0070469 GO:1902600
2	0.09	0.400	6.39	0.07	0.63	1m56A	GO:0004129 GO:0005506 GO:0005507 GO:0005886 GO:0006119 GO:0006810 GO:0006811 GO:0009055 GO:0009060 GO:0015992 GO:0016020 GO:0016021 GO:0016491 GO:0020037 GO:0022900 GO:0046872 GO:0055114 GO:0070469 GO:1902600
3	0.06	0.424	6.33	0.06	0.64	3ayfA	GO:0004129 GO:0005506 GO:0009055 GO:0009060 GO:0016020 GO:0016021 GO:0020037 GO:0046872 GO:0055114 GO:1902600
4	0.06	0.394	6.33	0.07	0.61	1uwkA	GO:0005737 GO:0006547 GO:0006548 GO:0016153 GO:0016829 GO:0019556 GO:0019557
5	0.06	0.380	6.44	0.06	0.60	2yevA	GO:0004129 GO:0005506 GO:0005507 GO:0005886 GO:0006119 GO:0006810 GO:0006811 GO:0009055 GO:0009060 GO:0015002 GO:0015992 GO:0016020 GO:0016021 GO:0016491 GO:0020037 GO:0022900 GO:0022904 GO:0046872 GO:0055114 GO:0070469 GO:1902600
6	0.06	0.391	6.41	0.07	0.61	2fknB	GO:0005737 GO:0006547 GO:0006548 GO:0016153 GO:0016829 GO:0019556 GO:0019557
7	0.06	0.396	6.42	0.08	0.63	1qleA	GO:0004129 GO:0005506 GO:0005507 GO:0005886 GO:0006119 GO:0006810 GO:0006811 GO:0009055 GO:0009060 GO:0015992 GO:0016020 GO:0016021 GO:0016491 GO:0020037 GO:0022900 GO:0046872 GO:0055114 GO:0070469 GO:1902600
8	0.06	0.386	6.73	0.06	0.63	1fftA	GO:0004129 GO:0005506 GO:0005507 GO:0005886 GO:0005887 GO:0006811 GO:0009055 GO:0009060 GO:0009319 GO:0009486 GO:0015078 GO:0015453 GO:0015990 GO:0015992 GO:0016020 GO:0016021 GO:0016491 GO:0016682 GO:0019646 GO:0020037 GO:0046872 GO:0048039 GO:0055114 GO:0070469
9	0.06	0.398	6.55	0.09	0.64	3eh3A	GO:0004129 GO:0005506 GO:0005886 GO:0006119 GO:0006811 GO:0009055 GO:0009060 GO:0015992 GO:0016020 GO:0016021 GO:0016491 GO:0020037 GO:0046872 GO:0055114 GO:0070469 GO:1902600
10	0.06	0.383	6.68	0.06	0.61	3o0rB	GO:0004129 GO:0005506 GO:0005886 GO:0009055 GO:0009060 GO:0016020 GO:0016021 GO:0016491 GO:0016966 GO:0019333 GO:0020037 GO:0046872 GO:0055114 GO:0070469 GO:1902600
11	0.06	0.381	6.51	0.06	0.61	5djqA	GO:0004129 GO:0005506 GO:0005507 GO:0005886 GO:0005887 GO:0006119 GO:0009055 GO:0009060 GO:0015078 GO:0015990 GO:0015992 GO:0016020 GO:0016021 GO:0016491 GO:0016705 GO:0019411 GO:0019646 GO:0019825 GO:0020037 GO:0045154 GO:0045278 GO:0046872 GO:0055114 GO:0070069 GO:0070469 GO:0070470 GO:1902600
12	0.06	0.311	6.71	0.04	0.50	1x87A	GO:0005737 GO:0006547 GO:0006548 GO:0016153 GO:0016829 GO:0019556 GO:0019557
13	0.06	0.323	6.50	0.04	0.52	4aayA	GO:0016491 GO:0030151 GO:0046872 GO:0051536 GO:0051538 GO:0055114
14	0.06	0.375	6.72	0.06	0.60	4xydA	GO:0004129 GO:0005506 GO:0009055 GO:0009060 GO:0016020 GO:0016021 GO:0016491 GO:0016966 GO:0020037 GO:0055114 GO:0070469 GO:1902600
15	0.06	0.268	7.24	0.04	0.46	1ivhA	GO:0000062 GO:0003995 GO:0005739 GO:0005759 GO:0006552 GO:0008152 GO:0008470 GO:0009055 GO:0009083 GO:0016491 GO:0016627 GO:0033539 GO:0050660 GO:0052890 GO:0055088 GO:0055114
16	0.06	0.246	5.67	0.07	0.36	2vcvA	GO:0004364 GO:0005737 GO:0005829 GO:0006749 GO:0008152 GO:0016740 GO:0070062 GO:1901687
17	0.06	0.256	6.55	0.03	0.41	4v85AW	GO:0000166 GO:0003924 GO:0005525 GO:0005737 GO:0005829 GO:0006412 GO:0006415 GO:0006449 GO:0016149 GO:0016150 GO:0019003
18	0.06	0.242	5.45	0.09	0.35	4q5rA	GO:0004364 GO:0016740

Consensus prediction of GO terms

Molecular Function	GO:0046914	GO:0009055	GO:0016676	GO:0046906	GO:0015002	GO:0015078
GO-Score	0.54	0.54	0.54	0.54	0.54	0.54
Biological Processes	GO:0098662	GO:0045333	GO:0015992	GO:0051704	GO:0046034	GO:0016310
GO-Score	0.54	0.54	0.54	0.47	0.43	0.43
Cellular Component	GO:0031224	GO:0044464
GO-Score	0.43	0.39

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.