I-TASSER results

I-TASSER results for job id Rv2744c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (270 residues)
MANPFVKAWKYLMALFSSKIDEHADPKVQIQQAIEEAQRTHQALTQQAAQVIGNQRQLEM
RLNRQLADIEKLQVNVRQALTLADQATAAGDAAKATEYNNAAEAFAAQLVTAEQSVEDLK
TLHDQALSAAAQAKKAVERNAMVLQQKIAERTKLLSQLEQAKMQEQVSASLRSMSELAAP
GNTPSLDEVRDKIERRYANAIGSAELAESSVQGRMLEVEQAGIQMAGHSRLEQIRASMRG
EALPAGGTTATPRPATETSGGAIAEQPYGQ

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MANPFVKAWKYLMALFSSKIDEHADPKVQIQQAIEEAQRTHQALTQQAAQVIGNQRQLEMRLNRQLADIEKLQVNVRQALTLADQATAAGDAAKATEYNNAAEAFAAQLVTAEQSVEDLKTLHDQALSAAAQAKKAVERNAMVLQQKIAERTKLLSQLEQAKMQEQVSASLRSMSELAAPGNTPSLDEVRDKIERRYANAIGSAELAESSVQGRMLEVEQAGIQMAGHSRLEQIRASMRGEALPAGGTTATPRPATETSGGAIAEQPYGQ
Prediction	CCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCC
Conf.Score	988679999999999999999875999999999999999999999999999999999999999999999999999999999979999999999999999999999999999999999999999999999999999999999999999999999999999999999999999875555556657999999999999999999999999858889999999987777999999999999855555666655555544445555456777569
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MANPFVKAWKYLMALFSSKIDEHADPKVQIQQAIEEAQRTHQALTQQAAQVIGNQRQLEMRLNRQLADIEKLQVNVRQALTLADQATAAGDAAKATEYNNAAEAFAAQLVTAEQSVEDLKTLHDQALSAAAQAKKAVERNAMVLQQKIAERTKLLSQLEQAKMQEQVSASLRSMSELAAPGNTPSLDEVRDKIERRYANAIGSAELAESSVQGRMLEVEQAGIQMAGHSRLEQIRASMRGEALPAGGTTATPRPATETSGGAIAEQPYGQ
Prediction	754305302410313034105625304300420042036314503530153125244145425514630551261044015404543355335525514510540354145145415514531550463155036415514541551444244134425425345404533544454446542530540353046214414034414755265333525546455504530550266157664565555555555555665554556578
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCC
MANPFVKAWKYLMALFSSKIDEHADPKVQIQQAIEEAQRTHQALTQQAAQVIGNQRQLEMRLNRQLADIEKLQVNVRQALTLADQATAAGDAAKATEYNNAAEAFAAQLVTAEQSVEDLKTLHDQALSAAAQAKKAVERNAMVLQQKIAERTKLLSQLEQAKMQEQVSASLRSMSELAAPGNTPSLDEVRDKIERRYANAIGSAELAESSVQGRMLEVEQAGIQMAGHSRLEQIRASMRGEALPAGGTTATPRPATETSGGAIAEQPYGQ

5cwmA

0.14

0.11

0.83

1.24

MUSTER

------------------------DPEDELKRVEKLVKEAEELLRQAKEKG------SEEDLEKALRTAEEAAREAKKVLEQAEKEGDPEVALRAVELVVRVAELLLRIAKESGS-EEALERALRVAEEAARLAKRVLELAEKQGDPEVALRAVELVVRVAELLLRIAKESG------SEEALERALRVAEEAARLAKRVLELAEKQGD--------PEVARRAVELVKRVAELLERIARESGSEEAKERAERVREEARELQERVKELRE

4wheA

0.12

0.06

0.51

1.10

dPPAS

---IFSRFADIVNANINALL---EDPQKLVRLMIQEMEDTLVEVRSTSARALAEKKQLTRRIEQASAREVEWQEKAELALLKEREDLARAALIEKQKLTDLIKSLEHEVTLVDDTLARMKKEIGELENKLSETRARQQALMLR-------------------------------------------------------------------------------------------------------------------------------

4wheA

0.18

0.09

0.51

1.96

wdPPAS

---IFSRFADIVNANINALL---EDPQKLVRLMIQEMEDTLVEVRSTSARALAEKKQLTRRIEQASAREVEWQEKAELALLKER--------------EDLARAALIEKQKLTDLIKSLEHEVTLVDDTLARMKKEIGELENKLSETRARQQALMLR-----------------------------------------------------------------------------------------------------------------

4cgkA

0.10

0.09

0.95

1.37

wMUSTER

-------------SNLTAQQQEAQKQVDQIQEQVSAIQAEQSNLQAENDRLQAESKKLEGEITELSKNIVSRNQSLEKQARSATNGAVTSYINTIVNSKSITESRVAAMSEIVSANNKMLEQQKADKKAISEKQVANNDAINTVIANQQKLADDAQALTTKQAELKAAELSLAAEKATAEGEKASLLEQKAAAEAEARAAAVAEAAYKEKRASQQQSVLASANTNLTAQVQAVSESAAAPVRAKVRPTYSTNASSYPIGECTWGVKTLAP

4wheA

0.18

0.09

0.51

2.37

wPPAS

---IFSRFADIVNANINALL---EDPQKLVRLMIQEMEDTLVEVRSTSARALAEKKQLTRRIEQASAREVEWQEKAELALLKER--------------EDLARAALIEKQKLTDLIKSLEHEVTLVDDTLARMKKEIGELENKLSETRARQQALMLR-----------------------------------------------------------------------------------------------------------------

4wheA

0.12

0.06

0.51

2.30

dPPAS2

---IFSRFADIVNANINALL---EDPQKLVRLMIQEMEDTLVEVRSTSARALAEKKQLTRRIEQASAREVEWQEKAELALLKEREDLARAALIEKQKLTDLIKSLEHEVTLVDDTLARMKKEIGELENKLSETRARQQALMLR-------------------------------------------------------------------------------------------------------------------------------

4wheA

0.18

0.09

0.51

1.77

PPAS

---IFSRFADIVNANINALL---EDPQKLVRLMIQEMEDTLVEVRSTSARALAEKKQLTRRIEQASAREVEWQEKAELALLKER--------------EDLARAALIEKQKLTDLIKSLEHEVTLVDDTLARMKKEIGELENKLSETRARQQALMLR-----------------------------------------------------------------------------------------------------------------

4wheA

0.18

0.09

0.51

3.08

Env-PPAS

---IFSRFADIVNANINALL---EDPQKLVRLMIQEMEDTLVEVRSTSARALAEKKQLTRRIEQASAREVEWQEKAELALLKER--------------EDLARAALIEKQKLTDLIKSLEHEVTLVDDTLARMKKEIGELENKLSETRARQQALMLR-----------------------------------------------------------------------------------------------------------------

4tqlA

0.08

0.06

0.84

1.21

MUSTER

MVQELEKARDRMEKLYKEMVELIQKAIELMRKIFQEVKQEVEKAIEEMKKLYDEAKKKIEQMIQQIKQGGD-KQKMEELLKRAKEEMKKVKDKMEKLLEKLKQIMQEAKQKMEKLLKQLKEEMKKMKEKMEKLLKEMKQRMEEVKKKMDDELLEKIKKNIDDLKKIAEDLIKKAEE-NIKEAKKIAEQLVKRAKQLIEKAKQVAEELIKKILQLIEKAKEIAEKVLKG------------------------------------------

5cwqA

0.12

0.11

0.86

1.09

dPPAS

---------EELERESEEAERRLQEARKRSEEARERGDLKELAEALIEEARAVQELARVACERGNSEEAERASEKAQRVLEEARKVSEEAREQGDDEVLALALIAIALAVLALAEVACCRGNSEEAERASEKAQRVLEEARKVSEEAREQGDDEVLALALIAIALAVLALAEVACCRGN---KEEAERAYEDARRVEEEARKVKESAEEQGDSEVKRLAEEAEQLAREARRHVQECRGGWLEHHH-------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.22

Estimated TM-score = 0.35±0.12

Estimated RMSD = 13.7±4.0Å

Download Model 2

C-score=-3.97

Download Model 3

C-score=-3.84

Download Model 4

C-score=-3.33

Download Model 5

C-score=-4.13

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2x1gF	0.597	4.59	0.063	0.863
2	2x19B	0.570	3.88	0.034	0.752
3	2f6dA	0.480	5.34	0.069	0.748
4	1i8qA	0.471	5.52	0.034	0.715
5	2cqtA2	0.461	5.54	0.050	0.730
6	2g0dA	0.456	4.88	0.093	0.659
7	1z5hA	0.455	4.79	0.028	0.644
8	2uvfA	0.455	5.39	0.039	0.700
9	1v7vA	0.455	5.44	0.101	0.722
10	2e9mA	0.446	5.76	0.074	0.711

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	3	3leeB	MG	Rep, Mult	21,24,25
2	0.06	3	2ri9A	UUU	Rep, Mult	12,13,80,84,87,91
3	0.04	2	4tocL	FE2	Rep, Mult	187,190,191
4	0.04	2	3nvoB	ZN	Rep, Mult	168,234
5	0.04	2	3wmoP	BCL	Rep, Mult	206,207
6	0.02	1	5csdA	ACD	Rep, Mult	83,100,106,110,137,162,163,166,170,173,174,186,193
7	0.02	1	3nteB	FE	Rep, Mult	151,215
8	0.02	1	3wmoO	CRT	Rep, Mult	224,234
9	0.02	1	5ecfI	ACD	Rep, Mult	80,83,103,106,133,134,137,162,163,166,189,193
10	0.02	1	3u24A	IMD	Rep, Mult	71,74,75
11	0.02	1	2cqsA	SO4	Rep, Mult	43,45,104
12	0.02	1	2w6dA	CPL	Rep, Mult	176,177,192,193,195,196
13	0.02	1	2ri8B	GOL	Rep, Mult	141,145,157,159
14	0.02	1	1fz4C	CA	Rep, Mult	68,70
15	0.02	1	2w6dB	CPL	Rep, Mult	175,176,177,178,179,192,193,195
16	0.02	1	3rdhA	3RD	Rep, Mult	103,161,162,223,226
17	0.02	1	1gd2I	III	Rep, Mult	116,119,120
18	0.02	1	2onhA	MN	Rep, Mult	196,199,203
19	0.02	1	2zoxA	PNG	Rep, Mult	50,51,54,55,69
20	0.02	1	5dqqA	CA	Rep, Mult	91,159

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1crlA	0.406	6.66	0.041	0.733	3.1.1.3	NA
2	0.060	2vn4A	0.425	5.95	0.061	0.685	3.2.1.3	22
3	0.060	1ug9A	0.440	5.74	0.062	0.693	3.2.1.70	NA
4	0.060	1gz7A	0.371	6.13	0.041	0.626	3.1.1.3	NA
5	0.060	1tnzL	0.414	5.70	0.051	0.644	2.5.1.59	NA
6	0.060	1cleA	0.402	6.32	0.047	0.707	3.1.1.3	NA
7	0.060	2rnpC	0.411	6.28	0.013	0.719	2.7.7.6	NA
8	0.060	1cb8A	0.428	5.44	0.045	0.656	4.2.2.5	NA
9	0.060	1gnxA	0.431	5.70	0.036	0.693	3.2.1.21	NA
10	0.060	1js4A	0.415	5.23	0.081	0.633	3.2.1.4	NA
11	0.060	1mswD	0.354	6.49	0.039	0.607	2.7.7.6	NA
12	0.060	2uveA	0.453	5.38	0.053	0.704	3.2.1.82	NA
13	0.060	1z1wA	0.433	4.92	0.028	0.630	3.4.11.-	NA
14	0.060	2cqsA	0.465	5.63	0.044	0.737	2.4.1.20	70
15	0.060	1gonA	0.434	5.71	0.051	0.689	3.2.1.21	NA
16	0.060	2vn7A	0.430	6.00	0.057	0.693	3.2.1.3	NA
17	0.060	1kktA	0.445	5.80	0.061	0.719	3.2.1.113	NA
18	0.060	1g87B	0.417	5.19	0.021	0.622	3.2.1.4	NA
19	0.060	1f1sA	0.471	5.52	0.034	0.715	4.2.2.1	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.07	0.615	4.45	0.05	0.85	3zkvA	GO:0005737 GO:0006606 GO:0006886 GO:0007270 GO:0008139 GO:0008536 GO:0008565 GO:0031965 GO:0042331 GO:0050804
1	0.07	0.587	3.88	0.04	0.77	2xwuB	GO:0005634 GO:0005737 GO:0006606 GO:0006810 GO:0006886 GO:0008139 GO:0008536 GO:0008565 GO:0015031 GO:0031965
2	0.07	0.597	4.59	0.06	0.86	2x1gF	GO:0005737 GO:0006606 GO:0006886 GO:0007270 GO:0008139 GO:0008536 GO:0008565 GO:0031965 GO:0042331 GO:0050804
3	0.07	0.583	3.92	0.04	0.77	3zjyE	GO:0005634 GO:0005737 GO:0006606 GO:0006810 GO:0006886 GO:0008139 GO:0008536 GO:0008565 GO:0015031 GO:0031965
4	0.07	0.518	3.71	0.06	0.68	4c0qA	GO:0004872 GO:0005634 GO:0005737 GO:0006810 GO:0008139 GO:0008565 GO:0015031 GO:0031965 GO:0035048 GO:0042802 GO:0043231
5	0.07	0.546	4.09	0.07	0.73	4c0qB	GO:0004872 GO:0005634 GO:0005737 GO:0006810 GO:0008139 GO:0008565 GO:0015031 GO:0031965 GO:0035048 GO:0042802 GO:0043231
6	0.07	0.557	4.08	0.06	0.73	5difC	GO:0000055 GO:0000776 GO:0005634 GO:0005737 GO:0005816 GO:0006406 GO:0006611 GO:0006810 GO:0006886 GO:0008536 GO:0008565 GO:0015031 GO:0034501 GO:0048471
7	0.07	0.560	4.23	0.05	0.77	4ol0B	GO:0004872 GO:0005634 GO:0005737 GO:0006810 GO:0008139 GO:0008565 GO:0015031 GO:0031965 GO:0035048 GO:0042802 GO:0043231
8	0.07	0.586	4.51	0.08	0.83	3wyfC	GO:0000055 GO:0000776 GO:0005634 GO:0005737 GO:0005816 GO:0006406 GO:0006611 GO:0006810 GO:0006886 GO:0008536 GO:0008565 GO:0015031 GO:0034501 GO:0048471
9	0.06	0.346	6.61	0.03	0.65	3a5vA
10	0.06	0.307	5.92	0.05	0.49	5bmwB	GO:0003824 GO:0004807 GO:0006094 GO:0006096 GO:0006098 GO:0008152 GO:0016853 GO:0042802
11	0.06	0.282	5.65	0.05	0.45	2htmC	GO:0003824 GO:0005737 GO:0009228 GO:0009229 GO:0016740 GO:0016783
12	0.06	0.305	6.37	0.05	0.54	2gieA	GO:0003677 GO:0004518 GO:0004519 GO:0009036 GO:0009307 GO:0016787 GO:0090305
13	0.06	0.300	5.86	0.04	0.49	1x87A	GO:0005737 GO:0006547 GO:0006548 GO:0016153 GO:0016829 GO:0019556 GO:0019557
14	0.06	0.256	5.74	0.05	0.41	1ks4A	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0008810 GO:0016787 GO:0016798
15	0.06	0.255	6.14	0.06	0.43	4muzA	GO:0003824 GO:0004590 GO:0006207 GO:0006221 GO:0008152 GO:0016829 GO:0016831 GO:0044205
16	0.06	0.240	3.98	0.03	0.31	1evsA	GO:0002675 GO:0005125 GO:0005147 GO:0005576 GO:0005615 GO:0005622 GO:0006955 GO:0007275 GO:0007422 GO:0008083 GO:0008283 GO:0008284 GO:0008285 GO:0009408 GO:0033138 GO:0038165 GO:0040008 GO:0042503 GO:0042506 GO:0042508 GO:0042517 GO:0043410 GO:0045835 GO:0045944 GO:0046888 GO:0048266 GO:0050731 GO:0051781 GO:2001235
17	0.06	0.220	5.98	0.03	0.36	4gqnB	GO:0016491 GO:0055114
18	0.06	0.219	5.03	0.05	0.32	2lbmA	GO:0000166 GO:0000228 GO:0000781 GO:0000784 GO:0000792 GO:0003677 GO:0003678 GO:0003682 GO:0004386 GO:0005524 GO:0005634 GO:0005694 GO:0005720 GO:0005721 GO:0006281 GO:0006306 GO:0006310 GO:0006334 GO:0006336 GO:0006338 GO:0006351 GO:0006355 GO:0006974 GO:0007283 GO:0010571 GO:0015616 GO:0016568 GO:0016605 GO:0016787 GO:0030330 GO:0030900 GO:0031297 GO:0031933 GO:0032206 GO:0032508 GO:0035064 GO:0035128 GO:0035264 GO:0042393 GO:0045944 GO:0046872 GO:0060009 GO:0070087 GO:0070198 GO:0070603 GO:0072520 GO:0072711 GO:1900112 GO:1901581 GO:1901582 GO:1904908 GO:1990707

Consensus prediction of GO terms

Molecular Function	GO:0022892	GO:0005048	GO:0017016
GO-Score	0.58	0.58	0.48
Biological Processes	GO:1902593	GO:0017038	GO:0044744
GO-Score	0.48	0.48	0.48
Cellular Component	GO:0005635	GO:0031090
GO-Score	0.58	0.58

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.