I-TASSER results

I-TASSER results for job id Rv2743c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (270 residues)
MAVKAGQRRPWRSLLQRGVDTAGDLADLVAQKISVAIDPRARLLRRRRRALRWGLVFTAG
CLLWGLVTALLAAWGWFTSLLVITGTIAVTQAIPATLLLLRYRWLRSEPLPVRRPASVRR
LPPPGSAARPAMSALGASERGFFSLLGVMERGAMLPADEIRDLTAAANQTSAAMVATAAE
VVSMERAVQCSAASRSYLVPTINAFTAQLSTGVRQYNEMVTAAAQLVSSANGAGGAGPGQ
QRYREELAGATDRLVAWAQAFDELGGLPRR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MAVKAGQRRPWRSLLQRGVDTAGDLADLVAQKISVAIDPRARLLRRRRRALRWGLVFTAGCLLWGLVTALLAAWGWFTSLLVITGTIAVTQAIPATLLLLRYRWLRSEPLPVRRPASVRRLPPPGSAARPAMSALGASERGFFSLLGVMERGAMLPADEIRDLTAAANQTSAAMVATAAEVVSMERAVQCSAASRSYLVPTINAFTAQLSTGVRQYNEMVTAAAQLVSSANGAGGAGPGQQRYREELAGATDRLVAWAQAFDELGGLPRR
Prediction	CCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
Conf.Score	998878885788887678765899999999999999789999999999999999999999999999999887776688899988888899988999999999987789999999998888999887589999999999999999999997578899789999999999999999999999999999975895777779999999999999999999999999999874468887666665589999999999999999999998588999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MAVKAGQRRPWRSLLQRGVDTAGDLADLVAQKISVAIDPRARLLRRRRRALRWGLVFTAGCLLWGLVTALLAAWGWFTSLLVITGTIAVTQAIPATLLLLRYRWLRSEPLPVRRPASVRRLPPPGSAARPAMSALGASERGFFSLLGVMERGAMLPADEIRDLTAAANQTSAAMVATAAEVVSMERAVQCSAASRSYLVPTINAFTAQLSTGVRQYNEMVTAAAQLVSSANGAGGAGPGQQRYREELAGATDRLVAWAQAFDELGGLPRR
Prediction	753455445524521534253045025402521541543344343434303320221012023212111212121221111313232101001111211221331675423654455445123532203401520350142023003203444414554144035305401410341053033004127345533430353044025304500530350021003211335444344443543253035004303210400541473578
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
MAVKAGQRRPWRSLLQRGVDTAGDLADLVAQKISVAIDPRARLLRRRRRALRWGLVFTAGCLLWGLVTALLAAWGWFTSLLVITGTIAVTQAIPATLLLLRYRWLRSEPLPVRRPASVRRLPPPGSAARPAMSALGASERGFFSLLGVMERGAMLPADEIRDLTAAANQTSAAMVATAAEVVSMERAVQCSAASRSYLVPTINAFTAQLSTGVRQYNEMVTAAAQLVSSANGAGGAGPGQQRYREELAGATDRLVAWAQAFDELGGLPRR

4ke2A

0.14

0.10

0.73

1.13

dPPAS2

----------------MNIDPAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVA-------------------SAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP---------------------------------------

5cwoA

0.09

0.07

0.80

1.06

dPPAS2

-------------------PELEEWIRRAKEVAKEVEKVAQRAEEEGNPDLRDSAKELRRAVEEAIEEAKKQGNPELVEWVARAAKVAAEVIKVAIQAEKEGNRD---------------------LFRAALELVRAVIEAIEEAVKQGN-------PELVEWVARAAKVAAEVIKVAIQAEKERDLFRAALELVRAVIEAIEEAVKQGNPELVERVARLAKKAAELIKRAIRAEKEGNRDERREALERVREVIERIEELVRQG------

5ic0A

0.14

0.98

0.76

MUSTER

LASARTANPTAKRQFVQSAKEVANSTANLVKTIKALGDFTEENRAQCRAATAPLLEAVDNLSAFASSSVPAQISPEGRAAMEPIVISAKTMLESAGGLIQTARALAVNP---RDPPRWSVLAGHSRTVSDSIKKLITSMRDKAPGQLECETAIAALNSCLRDLDQASLAAVSSQEALHTQMLTAVQEI---SHLIEPLASAARAEASQLGHKVSQMAQYFEPLTLAAVGAASKTLSHPQQMALLDQTKTLAESALQLLYTAKEAGGNPKQ

5cwmA

0.10

0.08

0.84

0.76

dPPAS

-----------------------DPEDELKRVEKLVKEAEELLRQAKEKGSEEDLEKALRTAEEAAREAKKVLEQAEKEGDPEVALRAVELVVRVAELLLRIAKESGSE-----------------EALERALRVAEEAARLAKRVLELAEKQGD-PEVALRAVELVVRVAELLLRIAKESGSEEALERALRVAEEAARLAKRVLELAEKQGDPEVARRAVELVKRVAELLERIARESGSEEAKERAERVREEARELQERVKELRER---

5cwmA

0.11

0.09

0.83

0.66

wdPPAS

-----------------------D-PEDELKRVEKLVKEAEELLRQAKEKSEEDLEKALRTAEEAAREAKKVLEQAEKEGDPEVALRAVELVVRVAELLLRIAKESGS-----------------EEALERALRVAEEAARLAKRVLELAEKQG-DPEVALRAVELVVRVAELLLRIAKESGSEEALERALRVAEEAARLAKRVLELAEKQGDPEVARRAVELVKRVAELLERIARESGSEEAKERAERVREEARELQERVKELR---ER

5ic0A

0.13

0.12

0.93

0.77

wMUSTER

KTIKALDGDFTEENRAQCRAATAPLLEAVDNLSAFASNPEPEGRAAMEPIVISAKTMLESAGGLIQTARALAV-DPPRWSVLAGHSRTVSDSIKKLITSMRDKA------------------PGQLECETAIAALNSCLRDLDQASLAAVSQQLAPLTAVQEISHLIEPLASAARAEASQLGHKVSQMAQYFEPLTLAAVGAASKHPQQMALLDQTKTLAESALQLLYTAKEAGGNPKQAAHTQEALEEAVQMMTEAVEDLTTTLNEAAS

5cwmA

0.12

0.10

0.81

0.73

wPPAS

------DPEDELKRVEK----LVKEAEELLRQAKEKGSDLEKALRTAEEAAREAKKVLEQAEKEG------------------PEVALRAVELVVRVAELLLRIAKESGS---------------EEALERALRVAEEAARLAKRVLELAEGDPEVALRAVELVVRVAELLLRIAKESGSEEALERALRVAEEAARLAKRVLELAEKQ-PEVARRAVELVKRVAELLERIA----RESGSEEAKERAERVREEARELQERVKELR---ER

5cwmA

0.10

0.08

0.84

1.06

dPPAS2

-----------------------DPEDELKRVEKLVKEAEELLRQAKEKGSEEDLEKALRTAEEAAREAKKVLEQAEKEGDPEVALRAVELVVRVAELLLRIAKESGSE-----------------EALERALRVAEEAARLAKRVLELAEKQGD-PEVALRAVELVVRVAELLLRIAKESGSEEALERALRVAEEAARLAKRVLELAEKQGDPEVARRAVELVKRVAELLERIARESGSEEAKERAERVREEARELQERVKELRER---

5cwoA

0.12

0.10

0.81

0.94

PPAS

------------------------------PELEEWIRRAKEVAKEVEKVAQRAEEEGNPDLRDSAKELRRAVEEAIEEAKKQGNPELVEWVARAAKVAAEVIKVAIQAEKEGNR----------DLFRAALELVRAVIEAIEEAVKQGN-------PELVEWVARAAKVAAEVIKVAIQAEKEGNRDLF-RAALELVRAVIEAIEEAVKQGNPELVERVARLAKKAAELIKRAIRAE-KEGNRDERREALERVREVIERIEELVRQG--

3umgA

0.15

0.13

0.86

0.70

Env-PPAS

VPFRSPSTGRNRAVLGTVVDWRTGIATAVADYAARHQEVDAVAFADRWRARYQPSMDAILSGAREFVTLDILHRENLDFVLRESG-IDPTNHDSGELDELARAWHVLTPWP---------------DSVPGLTAIKAE-----YIIGPLSNG---NTSLLLDMAKNAG-----IPW--DVIIGSDINRKYKPD-PQAYLRTAQVLGLHPGEVMAHNGDLEAAHATFILRPVEHGPHQTDDLAPTGSWDISATDITDLAAQLRAGS-----

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.46

Estimated TM-score = 0.43±0.14

Estimated RMSD = 11.7±4.5Å

Download Model 2

C-score=-2.54

Download Model 3

C-score=-3.92

Download Model 4

C-score=-4.24

Download Model 5

C-score=-4.72

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5cwmA	0.716	2.95	0.093	0.830
2	2x1gF	0.626	4.28	0.079	0.859
3	3icqT	0.612	3.91	0.058	0.793
4	2c9kA	0.602	4.72	0.045	0.811
5	1ciyA	0.594	4.47	0.068	0.800
6	4w8jA	0.591	4.74	0.057	0.811
7	4c0oA	0.589	4.22	0.067	0.774
8	2x19B	0.588	4.00	0.066	0.774
9	5hb4B	0.588	4.74	0.079	0.852
10	4kf7A	0.587	4.35	0.063	0.807

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.05	3	3hb3A	CA	Rep, Mult	205,208,212,213
2	0.04	2	5ezmA	MPG	Rep, Mult	29,69
3	0.03	2	1f59A	III	Rep, Mult	60,63,64,67,68,134,138
4	0.03	2	4z9hA	ASP	Rep, Mult	45,49
5	0.03	2	4qi1B	MPG	Rep, Mult	62,65,95,102
6	0.03	2	4ea0A	MG	Rep, Mult	17,20,24
7	0.03	2	3nteA	FE	Rep, Mult	156,159
8	0.03	2	5csdA	ACD	Rep, Mult	73,86,92,96,139,163,164,167,171,173,174,177,190,197
9	0.02	1	3f1eT	MG	Rep, Mult	126,131
10	0.02	1	2bf0X	CA	Rep, Mult	247,250
11	0.02	1	2bptA	III	Rep, Mult	192,195,196,199,200,250,253
12	0.02	1	1o6pB	III	Rep, Mult	67,71,139,142,143
13	0.02	1	5da5A	GOA	Rep, Mult	95,135
14	0.02	1	3fk7A	4DM	Rep, Mult	260,264
15	0.02	1	3rkoL	LFA	Rep, Mult	28,31,32,66
16	0.02	1	2x4hB	ZN	Rep, Mult	139,180
17	0.02	1	3dtuC	DMU	Rep, Mult	64,67,68,71
18	0.02	1	3omiC	TRD	Rep, Mult	38,41,45
19	0.02	1	5l8gB	CA	Rep, Mult	194,227,230
20	0.02	1	2b05E	III	Rep, Mult	40,41,93,94,97,166,169,173,177

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1m56A	0.507	5.45	0.031	0.796	1.9.3.1	NA
2	0.060	1s4bP	0.456	4.92	0.057	0.659	3.4.24.15	243
3	0.060	1dl2A	0.488	4.95	0.034	0.730	3.2.1.113	NA
4	0.060	2o36A	0.458	4.91	0.057	0.656	3.4.24.15	NA
5	0.060	1fp3A	0.466	5.39	0.046	0.711	5.1.3.8	93
6	0.060	1ihgA	0.461	4.85	0.053	0.656	5.2.1.8	NA
7	0.060	1h54B	0.450	4.71	0.035	0.644	2.4.1.8	NA
8	0.060	1f1sA	0.495	5.53	0.038	0.778	4.2.2.1	NA
9	0.060	1ho8A	0.481	4.49	0.044	0.667	3.6.3.14	191,196,246
10	0.060	3c5wA	0.445	4.52	0.124	0.615	3.1.3.16	174
11	0.060	1w6jA	0.461	5.87	0.065	0.737	5.4.99.7	NA
12	0.060	1ayxA	0.467	5.12	0.060	0.678	3.2.1.3	NA
13	0.060	1i1iP	0.463	5.13	0.040	0.681	3.4.24.16	NA
14	0.060	2vn7A	0.482	5.48	0.080	0.748	3.2.1.3	NA
15	0.060	2q1fA	0.491	5.47	0.040	0.752	4.2.2.21	109,168
16	0.060	2f6dA	0.469	5.45	0.055	0.726	3.2.1.3	NA
17	0.060	1nxcA	0.448	5.24	0.051	0.685	3.2.1.113	NA
18	0.060	1qd1B	0.319	5.57	0.056	0.500	2.1.2.5,4.3.1.4	NA
19	0.060	2pfdB	0.467	5.29	0.034	0.696	2.1.2.5,4.3.1.4	147,164,198

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.30	0.564	3.90	0.04	0.74	3gb8A	GO:0000055 GO:0000056 GO:0000122 GO:0000776 GO:0003723 GO:0005215 GO:0005487 GO:0005634 GO:0005635 GO:0005642 GO:0005654 GO:0005730 GO:0005737 GO:0005829 GO:0006611 GO:0006810 GO:0006886 GO:0007062 GO:0008536 GO:0008565 GO:0010824 GO:0015030 GO:0015031 GO:0016020 GO:0016032 GO:0019904 GO:0030529 GO:0031965 GO:0034504 GO:0042176 GO:0042493 GO:0043231 GO:0043488 GO:0046825 GO:0051028 GO:0075733
1	0.17	0.612	3.91	0.06	0.79	3icqT	GO:0000049 GO:0003723 GO:0005525 GO:0005634 GO:0005635 GO:0005643 GO:0005737 GO:0005829 GO:0006409 GO:0006605 GO:0006810 GO:0008033 GO:0008536 GO:0015932 GO:0016363 GO:0071528
2	0.11	0.510	4.99	0.04	0.76	4uvkA	GO:0000755 GO:0003682 GO:0005634 GO:0005829 GO:0006473 GO:0007064 GO:0009847 GO:0031505 GO:0031618 GO:0031934 GO:0034990 GO:1990707
3	0.07	0.630	4.38	0.10	0.87	3zkvA	GO:0005737 GO:0006606 GO:0006886 GO:0007270 GO:0008139 GO:0008536 GO:0008565 GO:0031965 GO:0042331 GO:0050804
4	0.07	0.585	4.34	0.07	0.78	4c0qB	GO:0004872 GO:0005634 GO:0005737 GO:0006810 GO:0008139 GO:0008565 GO:0015031 GO:0031965 GO:0035048 GO:0042802 GO:0043231
5	0.07	0.626	4.28	0.08	0.86	2x1gF	GO:0005737 GO:0006606 GO:0006886 GO:0007270 GO:0008139 GO:0008536 GO:0008565 GO:0031965 GO:0042331 GO:0050804
6	0.07	0.563	4.43	0.05	0.76	3zjyE	GO:0005634 GO:0005737 GO:0006606 GO:0006810 GO:0006886 GO:0008139 GO:0008536 GO:0008565 GO:0015031 GO:0031965
7	0.07	0.507	4.64	0.08	0.70	4bsmA	GO:0000055 GO:0000056 GO:0000122 GO:0000776 GO:0003723 GO:0005215 GO:0005487 GO:0005634 GO:0005635 GO:0005642 GO:0005654 GO:0005730 GO:0005737 GO:0005829 GO:0006611 GO:0006810 GO:0006886 GO:0007062 GO:0008536 GO:0008565 GO:0010824 GO:0015030 GO:0015031 GO:0016020 GO:0016032 GO:0019904 GO:0030529 GO:0031965 GO:0034504 GO:0042176 GO:0042493 GO:0043231 GO:0043488 GO:0046825 GO:0051028 GO:0075733
8	0.07	0.584	4.22	0.07	0.79	3a6pA	GO:0000049 GO:0003723 GO:0003729 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0006611 GO:0006810 GO:0006886 GO:0008536 GO:0008565 GO:0015031 GO:0031047 GO:0035281 GO:0042565 GO:0044822 GO:0070883 GO:0090631 GO:1900370
9	0.07	0.577	3.91	0.07	0.76	3wyfC	GO:0000055 GO:0000776 GO:0005634 GO:0005737 GO:0005816 GO:0006406 GO:0006611 GO:0006810 GO:0006886 GO:0008536 GO:0008565 GO:0015031 GO:0034501 GO:0048471
10	0.07	0.568	4.26	0.07	0.78	3gjxA	GO:0000055 GO:0000056 GO:0000122 GO:0000776 GO:0003723 GO:0005487 GO:0005634 GO:0005642 GO:0005654 GO:0005730 GO:0005737 GO:0006611 GO:0006810 GO:0006886 GO:0008536 GO:0008565 GO:0010824 GO:0015030 GO:0015031 GO:0016020 GO:0019904 GO:0030529 GO:0031965 GO:0034504 GO:0042176 GO:0042493 GO:0043231 GO:0046825 GO:0051028
11	0.07	0.575	3.92	0.07	0.76	5difC	GO:0000055 GO:0000776 GO:0005634 GO:0005737 GO:0005816 GO:0006406 GO:0006611 GO:0006810 GO:0006886 GO:0008536 GO:0008565 GO:0015031 GO:0034501 GO:0048471
12	0.07	0.594	4.20	0.06	0.79	4ol0B	GO:0004872 GO:0005634 GO:0005737 GO:0006810 GO:0008139 GO:0008565 GO:0015031 GO:0031965 GO:0035048 GO:0042802 GO:0043231
13	0.07	0.609	3.91	0.05	0.80	2xwuB	GO:0005634 GO:0005737 GO:0006606 GO:0006810 GO:0006886 GO:0008139 GO:0008536 GO:0008565 GO:0015031 GO:0031965
14	0.07	0.548	4.02	0.07	0.73	4c0qA	GO:0004872 GO:0005634 GO:0005737 GO:0006810 GO:0008139 GO:0008565 GO:0015031 GO:0031965 GO:0035048 GO:0042802 GO:0043231
15	0.06	0.408	4.10	0.06	0.54	2y4uA	GO:0004860 GO:0005737 GO:0005783 GO:0005788 GO:0005790 GO:0005829 GO:0006417 GO:0006986 GO:0016020 GO:0019901 GO:0031205 GO:0036494 GO:0036498 GO:0043066 GO:0051087 GO:0051603 GO:0051607 GO:0051787 GO:0070062 GO:0070417 GO:1903561 GO:1903912 GO:1904030
16	0.06	0.393	6.34	0.05	0.68	3o8lA	GO:0000166 GO:0003824 GO:0003872 GO:0005524 GO:0005737 GO:0006002 GO:0006096 GO:0008022 GO:0008152 GO:0016301 GO:0016310 GO:0016740 GO:0046872 GO:0061615
17	0.06	0.302	6.05	0.07	0.51	3wwpA	GO:0016829 GO:0046872
18	0.06	0.316	6.45	0.04	0.56	1x87A	GO:0005737 GO:0006547 GO:0006548 GO:0016153 GO:0016829 GO:0019556 GO:0019557

Consensus prediction of GO terms

Molecular Function	GO:0008536	GO:0003723	GO:0008565	GO:0032561	GO:0035639	GO:0022891	GO:0032550
GO-Score	0.45	0.41	0.39	0.34	0.34	0.34	0.34
Biological Processes	GO:0046794	GO:0051246	GO:0000054	GO:1902583	GO:0030163	GO:0043487	GO:0006611	GO:0033365	GO:0046822	GO:0046605	GO:0006357	GO:0000819	GO:0019058	GO:0009894	GO:0042221	GO:0033157	GO:0045892	GO:0051298	GO:0034470	GO:0006409	GO:0006399
GO-Score	0.59	0.59	0.59	0.59	0.59	0.59	0.59	0.59	0.59	0.59	0.59	0.59	0.59	0.59	0.59	0.59	0.59	0.59	0.34	0.34	0.34
Cellular Component	GO:0042175	GO:1990904	GO:0016604	GO:0098589	GO:0000775	GO:0043234	GO:0005829	GO:0031965	GO:0034399
GO-Score	0.59	0.59	0.59	0.59	0.59	0.59	0.48	0.39	0.34

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.