I-TASSER results

I-TASSER results for job id Rv2742c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (277 residues)
MLVDELGVKIVHAQHVPAPYLVQRMREIHERDENRQRHAQVDVQRRRDQPERGQHQHRRN
RDADHHPDGRTLAGQIVAHPVSHRVRQPRPVAIADVLPRVGPRADCVVAHSLQGSPRRRE
RRRGQTAHQRLGRRSGNAIACPLYLENAAGPEPDTKRAEGRRFGAFGGGDLRWMADRVPR
QGSGRRGLGSRSGAGVPQGADARGWRHTADGVPRVGQPAIRRGVPGFWCWLDHVLTGFGG
RNAICAIEDGVEPRVAWWALCTDFDVPRSMGRRTPGG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MLVDELGVKIVHAQHVPAPYLVQRMREIHERDENRQRHAQVDVQRRRDQPERGQHQHRRNRDADHHPDGRTLAGQIVAHPVSHRVRQPRPVAIADVLPRVGPRADCVVAHSLQGSPRRRERRRGQTAHQRLGRRSGNAIACPLYLENAAGPEPDTKRAEGRRFGAFGGGDLRWMADRVPRQGSGRRGLGSRSGAGVPQGADARGWRHTADGVPRVGQPAIRRGVPGFWCWLDHVLTGFGGRNAICAIEDGVEPRVAWWALCTDFDVPRSMGRRTPGG
Prediction	CCCCCCCEEEHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEHCCCCCCCCCCCCCHHHHHHCCCCCCCCCEEEEHCCCCCCHHHHHHCCCHHHHHHHHCCCEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHCCHHHHCCCCCCC
Conf.Score	9764445467646778867899999999997788887777677776567555566677647888998887556555545644456799874566655456888886455444678765666665656778765468857754444567889987545456544446887643334457777888777776778888877766665555667776666654457776444556655545898899999989878999999999875648876888999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MLVDELGVKIVHAQHVPAPYLVQRMREIHERDENRQRHAQVDVQRRRDQPERGQHQHRRNRDADHHPDGRTLAGQIVAHPVSHRVRQPRPVAIADVLPRVGPRADCVVAHSLQGSPRRRERRRGQTAHQRLGRRSGNAIACPLYLENAAGPEPDTKRAEGRRFGAFGGGDLRWMADRVPRQGSGRRGLGSRSGAGVPQGADARGWRHTADGVPRVGQPAIRRGVPGFWCWLDHVLTGFGGRNAICAIEDGVEPRVAWWALCTDFDVPRSMGRRTPGG
Prediction	6214412131131541303200520450264565454334242554464465354534555447434623200130003213331553412101420461444131111321333554454545443454144452300000021342344545454254441111223303110540455354443234454332354253531422431134234432444141410001000231444203301644150340031005415004604664568
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCEEEHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCEEEEEEHCCCCCCCCCCCCCHHHHHHCCCCCCCCCEEEEHCCCCCCHHHHHHCCCHHHHHHHHCCCEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHCCHHHHCCCCCCC
MLVDELGVKIVHAQHVPAPYLVQRMREIHERDENRQRHAQVDVQRRRDQPERGQHQHRRNRDADHHPDGRTLAGQIVAHPVSHRVRQPRPVAIADVLPRVGPRADCVVAHSLQGSPRRRERRRGQTAHQRLGRRSGNAIACPLYLENAAGPEPDTKRAEGRRFGAFGGGDLRWMADRVPRQGSGRRGLGSRSGAGVPQGADARGWRHTADGVPRVGQPAIRRGVPGFWCWLDHVLTGFGGRNAICAIEDGVEPRVAWWALCTDFDVPRSMGRRTPGG

3tt2A

0.18

0.17

0.93

0.69

MUSTER

TLPDRFIARAPVPAD--APAIARLIAACQEADGDEPDASAEEVLRDWEGLDLGQEAVVVAPDGELNRRYVQLSVYGYVHP-RFRGTWQWGEEWIQDRHLAPAEAQVTVQHYIRASS---------TSALRLEQHGYRPVRDIWVAITLDQPPPAPEWPEGITARTFVPGLYEAVEEAFGRPSTFERWLSTQSERKDPELETDSGLGQETAGKGWIGSVGVRRPWRGRGIALALLQEV-----FGVYYRRGVR--EVEPRLYRRAGVKHRHRKERPGS

5gaoE

0.10

0.09

0.90

0.55

dPPAS

-------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA----AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

3nojA

0.19

0.14

0.74

0.56

wdPPAS

TLIGKTG-IVVRNIQRAELDSIDALGRL---------VATVHEAQNRKG-----------LSSKMRPQGTSLAGSAVT--V--LVAPGDNWMFHVAVEQCRPGD--VLVVSPSSPCTDG----GDLLATSLQARGVRALIV--------AGVRDTQTLRDMGFAVWARA---------AQ-GTVKETLGS-GGQLINPGADDDG-------VRRDECESTLVAAAERAGLEEEKRLRLAGELGLDIYK----MRERLEAK-NIEDL-----------

2p6pA

0.15

0.14

0.91

0.63

wMUSTER

PVVTGVGLPAVATTDLPIRHFITTDREIPSDPVAQARFTGRWFARMAASSLPRMLDFSRAWRPD----------LIVGGTMS-----YVAPLLALHL-----GVPHARQTWDAVDADGIHPGADAELRPELSELAPDLFIDICP--PSLRP-ANAAPARMMRHVATSRQCP--LEPWMYTRDTRQRTSGS-RVAKESYDRNFDFLRGLAKDLVRWDVRAEVPQARVGWTPLDVVAPTCAGGSTLTGLSAGVSVLEAPARRVADYGAAIALLPGEDST

3nojA

0.23

0.16

0.70

0.45

wPPAS

TLIGKTG--IVV-RNIAELDSIDALGRL---------VATVHEAQNR----KG-------LSSKMRPQGTSLAGSAVT--V--LVAPGDNWMFHVAVEQCRPG-DVLVVSP-----------------------SSP-------CTDGFG---DATSLQAR--GVRAAGDTQTLRDMVAQ-GTVKETLGSVGGQLIP-GAD-------DDGVRRDECESTLVAAAERAGLEEEKRLRLAGELGLDIYK----MRERLEAKLRYVDNIEDL-------

2f67A

0.24

0.12

0.52

0.59

dPPAS2

---------------------------------------------------------------HHHHHHRKIAGPAVFN--------PDGASYYNKV-----RELL-KKENVPLIPNEATEALDIRQKNIQIKDCDAVIAD---LSPFRGHEPDC----GTAFGAAANKVLTFTSDRRNR---------EKYGSGV----DKDNLRVEGFGLPFNLLYDGVEVFDSFESAFKYFLANFPS-------------------------------------

4y5sA

0.16

0.14

0.84

0.54

PPAS

---DQL-------QRLAADADVDRMCRLLEEDKG---FDVVESFNRELDVQMAIPPPKGERLLADKYPPHFVPNVATTCPTFRNLINPVIHAICEAY--FQRTGDYWLSAAFLGMPAQPFHRDDATHPLMHYEAPPVSLSVIFPLTEENGA-LGS-----HRWTEVGTPE---RDQAVLATGDQRAGGGNRTTAGKP----NSVQLTPFETYRTM-PREMVESMT------VLGQRMLGWRTMKPSD-VGINLI-------DDKRLENVLQLKAADS

1sk7A

0.20

0.13

0.64

Env-PPAS

-----------------------NLRSQRLNLLTNEPHQRLESLVKSKEPFASRDNFARF-----------VAAQYLFQDLEPLYRNE---ALARLFPG------------------LASRAR--DDAARADLA---DLGHPVPEGDQSVREADLSLAEGWLFGSKLGA--AFLFKKAA-----ALELDENFGAAEPEGGRAQGWKS-------------------FVAILDGIE--LNEEEERLAAKG---ASDAFNRFGDLL--ERTFA------

5cwqA

0.16

0.14

0.83

0.66

MUSTER

---EELERESEEAERR-LQEARKRSEEARERGDLKELAEALIEEARA--VQELARVACERGNSEEAERASEKAQRVLARKVSEEAREQGDDEVLALALIAIALAVLALAEVACCRGNSEEAERASEKAQRVLEEARKV------SEEAREQGDDEVLALALIAIALAVLALAEVACCRGNKEEAER-----------AYEDARR---VEEEARKVKESAEEQGDSEVKRLAEEAEQL-----AREARRHVQECRGGW------------LEHHH---

3umcA

0.14

0.11

0.80

0.54

dPPAS

-LYFQGRAILFDVFGTWRSSLIEQFQALEREGGTLPCVELTDRWRQQYKP----ADRVRNGQAPWQHLDQLHRQSLEALAGEFGLALDEALRITGFWHRLRPWPDTLAGHALKADYWLAALSNGNTALLDVARHAGDLLCA--DLFGHYKPDPQVYLGACRLLDL--------PPQEVLCAAHNYDLKAARA-LGLKTAFIARPLEYGPGQSQDLAAEQDWDLIASDLLDLHRQLAA----------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-4.80

Estimated TM-score = 0.22±0.06

Estimated RMSD = 18.2±2.3Å

Download Model 2

C-score=-4.94

Download Model 3

C-score=-4.96

Download Model 4

C-score=-5.00

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4adyA	0.537	5.60	0.065	0.845
2	5l4kZ3	0.527	5.53	0.031	0.827
3	4b90A	0.519	5.81	0.049	0.838
4	2ftwA	0.515	5.76	0.058	0.823
5	1v4yA	0.514	5.65	0.091	0.812
6	3giqA1	0.507	5.84	0.070	0.812
7	4cr2Z	0.506	6.12	0.044	0.859
8	2ftyA	0.506	6.01	0.049	0.816
9	4ui9A2	0.505	5.90	0.064	0.834
10	1ua4A	0.496	5.83	0.031	0.816

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	5	3lggB	CFE	Rep, Mult	4,5,15,18,21,110,143
2	0.04	3	2eh3A	MG	Rep, Mult	33,36
3	0.04	3	2qvnA	GMP	Rep, Mult	5,6,81,143,145,232
4	0.04	3	2a8tA	MN	Rep, Mult	26,27
5	0.02	2	3ewdA	MCF	Rep, Mult	4,7,18,21
6	0.02	2	1krmA	PRH	Rep, Mult	2,143,166,265
7	0.02	2	3mduA	NGQ	Rep, Mult	169,227,230,231
8	0.02	2	1gc5A	ADP	Rep, Mult	259,260,263
9	0.02	2	1fz9C	ETI	Rep, Mult	40,41,44
10	0.01	1	1kcx0	III	Rep, Mult	132,133,268
11	0.01	1	2pg8C	OXY	Rep, Mult	219,223
12	0.01	1	1k70A	HPY	Rep, Mult	140,143,167
13	0.01	1	2qs8A	MG	Rep, Mult	12,15,232
14	0.01	1	3rn6A	IGA	Rep, Mult	45,75,264,265,271
15	0.01	1	1bpyA	MG	Rep, Mult	95,105,154
16	0.01	1	3ujpC	ZN	Rep, Mult	5,44
17	0.01	1	1un9A	MG	Rep, Mult	263,265
18	0.01	1	8icnA	ATP	Rep, Mult	74,95,105,166
19	0.01	1	4ireB	OXL	Rep, Mult	119,122
20	0.01	1	1f61A	MG	Rep, Mult	105,146

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3kvnX	0.461	5.81	0.059	0.751	3.1.1.1	235,253,260
2	0.060	3lggA	0.482	5.88	0.052	0.794	3.5.4.4	27
3	0.060	1xrtA	0.468	5.89	0.052	0.751	3.5.2.3	NA
4	0.060	3e0lA	0.492	5.14	0.075	0.740	3.5.4.3	NA
5	0.060	1a4lA	0.484	5.80	0.073	0.787	3.5.4.4	NA
6	0.060	1m7jA	0.515	5.45	0.084	0.801	3.5.1.81	NA
7	0.060	2i9uA	0.479	5.66	0.024	0.754	3.5.4.3	NA
8	0.060	3drwA	0.491	5.74	0.071	0.794	2.7.1.146	54
9	0.060	1ybqA	0.462	6.00	0.060	0.762	3.4.19.1	19
10	0.060	3e74B	0.475	6.07	0.077	0.801	3.5.2.5	19
11	0.060	1gkpA	0.466	5.90	0.067	0.762	3.5.2.2	NA
12	0.060	1a0dD	0.462	5.97	0.054	0.783	5.3.1.5	NA
13	0.060	1ra0A	0.489	5.26	0.071	0.747	3.5.4.1	40,235
14	0.060	2ftwA	0.515	5.76	0.058	0.823	3.5.2.2	242
15	0.060	1ynyB	0.472	5.79	0.051	0.754	3.5.2.2	82
16	0.060	2vr2A	0.466	5.92	0.054	0.762	3.5.2.2	NA
17	0.060	1gc5A	0.491	5.59	0.054	0.780	2.7.1.147	144
18	0.060	1a0cA	0.468	5.78	0.042	0.751	5.3.1.5	NA
19	0.060	2a3lA	0.470	6.08	0.045	0.791	3.5.4.6	44,253,255

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.07	0.508	5.80	0.08	0.81	3gipA	GO:0016787 GO:0016810 GO:0016811 GO:0047421
1	0.07	0.484	6.05	0.07	0.81	3e74B	GO:0000256 GO:0004038 GO:0005737 GO:0006144 GO:0008270 GO:0009442 GO:0016787 GO:0016810 GO:0046872 GO:0050897
2	0.07	0.474	5.87	0.06	0.77	3dc8A	GO:0005737 GO:0016787 GO:0016810 GO:0046872
3	0.07	0.514	5.93	0.05	0.86	3jcpN	GO:0000502 GO:0004175 GO:0005634 GO:0006511 GO:0008540 GO:0030234 GO:0030674 GO:0034515 GO:0042176 GO:0043161 GO:0043248 GO:0050790
4	0.07	0.477	5.61	0.06	0.76	4cqbA	GO:0005737 GO:0016787 GO:0016810 GO:0018764 GO:0019381 GO:0046872
5	0.07	0.469	5.90	0.06	0.76	1k1dA	GO:0005737 GO:0016787 GO:0016810 GO:0046872
6	0.07	0.482	6.08	0.07	0.81	4gz7A	GO:0005737 GO:0016787 GO:0016810 GO:0046872
7	0.07	0.475	5.74	0.05	0.77	4v1xE	GO:0005737 GO:0016787 GO:0016810 GO:0018788 GO:0019381 GO:0046872
8	0.07	0.469	5.93	0.05	0.77	4tqtD	GO:0004157 GO:0005737 GO:0016787 GO:0016810
9	0.07	0.449	6.03	0.06	0.75	2z00A	GO:0004151 GO:0006221 GO:0008270 GO:0016787 GO:0016810 GO:0016812 GO:0044205 GO:0046872
10	0.07	0.519	5.81	0.05	0.84	4b90A	GO:0005737 GO:0005829 GO:0007165 GO:0007399 GO:0007411 GO:0008017 GO:0016787 GO:0016810 GO:0030425 GO:0043025
11	0.07	0.482	6.00	0.06	0.80	4cnuA	GO:0005615 GO:0005737 GO:0005829 GO:0010975 GO:0010976 GO:0010977 GO:0016787 GO:0016810 GO:0017124 GO:0030027 GO:0030334 GO:0030336 GO:0030426 GO:0031005 GO:0031941 GO:0035374 GO:0042995 GO:0044297 GO:0048666 GO:0048678 GO:0051017 GO:0051260 GO:0051491 GO:0051764 GO:0070382 GO:0071345
12	0.07	0.476	5.83	0.06	0.76	1nfgA	GO:0005737 GO:0016787 GO:0016810 GO:0046872
13	0.07	0.515	5.45	0.08	0.80	1m7jA	GO:0016787 GO:0016810 GO:0016811 GO:0046872 GO:0047420
14	0.07	0.462	6.00	0.06	0.76	1ybqA	GO:0005737 GO:0005829 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0008798 GO:0016787 GO:0016810 GO:0046872
15	0.07	0.466	5.92	0.05	0.76	2vr2A	GO:0002058 GO:0002059 GO:0004157 GO:0005737 GO:0005829 GO:0006208 GO:0006210 GO:0006212 GO:0008270 GO:0016597 GO:0016787 GO:0016810 GO:0019482 GO:0019860 GO:0046135 GO:0046872 GO:0051219 GO:0051260 GO:0051289 GO:0070062
16	0.07	0.472	5.89	0.08	0.76	3sfwA	GO:0005737 GO:0016787 GO:0016810 GO:0046872
17	0.07	0.467	6.22	0.06	0.80	4b3zD	GO:0000226 GO:0005737 GO:0005815 GO:0005819 GO:0005829 GO:0005856 GO:0006139 GO:0007399 GO:0007411 GO:0010977 GO:0016787 GO:0016810 GO:0031005 GO:0048666 GO:1904530
18	0.07	0.467	5.94	0.07	0.76	3hpaA

Consensus prediction of GO terms

Molecular Function	GO:0043169	GO:0003824
GO-Score	0.37	0.33
Biological Processes	GO:0043248	GO:0009442	GO:0043161	GO:0042176	GO:0050790	GO:0019381	GO:0006144
GO-Score	0.07	0.07	0.07	0.07	0.07	0.07	0.07
Cellular Component	GO:0044424
GO-Score	0.37

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.