I-TASSER results

Input Sequence in FASTA format

>protein (158 residues)
MMMNWRQTNITTKRCAQTRASSSASEFCGIFAAPGLMRNCHHGGSAPSAVGGSAVQLTVA
YGPQRFHGRCASNSSVRPLTTGGSWTPTSISSTDGGKAQGHDTHDRQISRRTVCQAASIL
ASILLETVAGPGEGIGPTTSVPLRAADARHTREGLQGR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 \| \| \| \| \| \| \| MMMNWRQTNITTKRCAQTRASSSASEFCGIFAAPGLMRNCHHGGSAPSAVGGSAVQLTVAYGPQRFHGRCASNSSVRPLTTGGSWTPTSISSTDGGKAQGHDTHDRQISRRTVCQAASILASILLETVAGPGEGIGPTTSVPLRAADARHTREGLQGR
Prediction	CCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEEEHCCCCHCCCCCCCCCCCCCCCCCCCCCCEHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
Conf.Score	99875445554666666655665556554434665444466788877666786678998748754455457888865667788766655546788755566664677778999999999999999974688888888766654344567777755789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 \| \| \| \| \| \| \| MMMNWRQTNITTKRCAQTRASSSASEFCGIFAAPGLMRNCHHGGSAPSAVGGSAVQLTVAYGPQRFHGRCASNSSVRPLTTGGSWTPTSISSTDGGKAQGHDTHDRQISRRTVCQAASILASILLETVAGPGEGIGPTTSVPLRAADARHTREGLQGR
Prediction	74441553513354135444564044001102132124303433533432334203110222354133403655414323444413344145474354544643545144421140141003011411234353233434231423536344643678
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140

                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEEEHCCCCHCCCCCCCCCCCCCCCCCCCCCCEHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
MMMNWRQTNITTKRCAQTRASSSASEFCGIFAAPGLMRNCHHGGSAPSAVGGSAVQLTVAYGPQRFHGRCASNSSVRPLTTGGSWTPTSISSTDGGKAQGHDTHDRQISRRTVCQAASILASILLETVAGPGEGIGPTTSVPLRAADARHTREGLQGR

5d50A

0.11

0.10

0.96

0.69

MUSTER

AMKS-RRKN--LNEIILRDFDDTQLRFAERVKSQNLVN---RWCTGIKNIGPAARIIEEAAREKFWLDVDHELDAVWTVEKQAAATLNAWMRKAGIGPATVNKAEVSTTIGVLSSLARAFGHEAYEMIIPVGAPGIIDYDHRMYAALPQEEKNKITSF

2muxA

0.12

0.11

0.88

0.67

dPPAS

MTVEQNVLQQSAAQKHQQTFLNQLREITGINDTQILQ-------QALKDSNGNLELAVAFLTAKNAKTPQQEETTYYQTALPGNDRYISVGSQADTNVIDLTGDDKD-------DLQRAIALSLAESNRAF-----RETGITDEEQAISRVLEASIAE

4ds2A

0.19

0.13

0.70

0.49

wdPPAS

--M----KNISNKRIIKDLKLLLEEVDANNEASPHSTATIYNADSVYGGAGN-TYQLSVLY-PHEYSPLVTGEGGI--V----FWTPD-------------------QHASDVIKLVLDRVFSQYK----------SRRDDDVPQDFAARVRRG----

4btgA1

0.16

0.15

0.97

0.67

wMUSTER

GNIDPVMYARLFFQYAQAGGALSVDELVNQFTNPEIWRKAYITGSSNRAIKADAV----KVPPTAILEQLRTLAPSE-HELFHHITTCHVLSPLGFILPDANALVDCVRASDLRRMLTALSSVMLQATFKAKGALAPALISQHLANAATTAFERSRGN

1qd7D

0.37

0.24

0.65

0.51

wPPAS

--INPNKLEVAVNRVAVVKG--------G-FSA-G--KNGHVGGKAPEAIKADAVPITI---PHEVIGHFGA-GEIKPASEG-----TGVIA--GGPA------------RAVLELAGILSKSI-----------GSNT--PIRA-----TFDGLK-K

2kb4A

0.24

0.18

0.73

0.52

dPPAS2

-MSDNNGTPEP--------QVETTS----VFRADLLKEMESSTGTAPASTGAGSALLVVKRGPARFLGRHPESDIFLDDVTEGEFEVVDVGSLNGTYVNR-----EPRNAQVMQTGDEIIGKFRLVFLAGPAE-------------------------

2lakA

0.16

0.13

0.84

0.57

PPAS

--MEKAMPESFVVR---EAAPTDPEKILRWMGTEAEVE--EPGGLGARFARGSFREVV----VHRYSFGWDGSEVVPPGSSLVEI---DLIEQGGG----HSGLPSAEQCAGHEEGWAHYLGRLTEVAAG-RDP-GPDPFYGRRLEHHHHHH------

1wi0A

0.30

0.20

0.66

Env-PPAS

------------------GSSGSSGPFCAMENQVLVIRKIPNSG---------AVDWTVHSGPQLFRDVLDVIGQVLP-----EATTTAFEYED-------EDGDR-ISDEEMKAMLSYYYSTVMEQQVN-GQLIEPLQIFP-RS-----------GP

5cwjA

0.13

0.97

0.66

MUSTER

---DSEEEQERIRRILKEARKSGTEESLRQ-AIEDVAQLAKKSQDSEVLEEAIRVILRIAKESGSEEALRQAIRAVAEIAKEAQ-DSEVLEELRIAKESGSEEALRQAIRAVAEIAKEAQDPRVLEEAIRVIRQIAEESGSEEARRQAERAEEEIRRR

1buvM

0.13

0.99

0.65

dPPAS

QGLKWQHNEITVGEYATYEAIRKAFRVWES-ATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQFVLPDDDRRGIQQLYGGE

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-4.00

Estimated TM-score = 0.29±0.09

Estimated RMSD = 14.3±3.8Å

Download Model 2

C-score=-5.00

Download Model 3

C-score=-5.00

Download Model 4

C-score=-5.00

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1itwA	0.573	4.47	0.075	0.911
2	1buvM	0.572	4.19	0.050	0.892
3	4zdaA	0.568	4.46	0.055	0.911
4	1eubA	0.566	3.96	0.045	0.842
5	2xs3A	0.564	4.26	0.073	0.867
6	2b0tA	0.563	4.50	0.076	0.899
7	2ddyA	0.562	4.25	0.086	0.873
8	1l6jA	0.561	4.16	0.065	0.873
9	1rm8A	0.560	4.38	0.062	0.899
10	1lwdA	0.557	4.49	0.075	0.892

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.08	4	2ro1A	ZN	Rep, Mult	28,40,67,70
2	0.06	3	1x11B	III	Rep, Mult	111,115
3	0.04	2	3ma2D	CA	Rep, Mult	60,62,63,64,66,94,97
4	0.04	2	4umoA	K	Rep, Mult	106,109,110
5	0.04	2	3j47V	III	Rep, Mult	116,120,123
6	0.04	2	1j95A	TBA	Rep, Mult	58,119
7	0.02	1	2xs4A	III	Rep, Mult	10,24,27,28,31,119
8	0.02	1	1ocyA	ZN	Rep, Mult	41,42
9	0.02	1	2fjcA	FE	Rep, Mult	122,126
10	0.02	1	3draB	ZN	Rep, Mult	105,114,150
11	0.02	1	3d5bF	MG	Rep, Mult	59,60,61
12	0.02	1	1xur0	III	Rep, Mult	124,125,147,150,151,154,155
13	0.02	1	2xquC	CVM	Rep, Mult	121,124
14	0.02	1	1uk4A	ATO	Rep, Mult	28,41,42
15	0.02	1	4zb6A	GDS	Rep, Mult	74,110
16	0.02	1	3pyoE	MG	Rep, Mult	69,90
17	0.02	1	2xquB	CVM	Rep, Mult	117,121

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.146	1aykA	0.541	4.24	0.097	0.848	3.4.24.7	NA
2	0.131	1eubA	0.566	3.96	0.045	0.842	3.4.24.-	NA
3	0.122	1hovA	0.549	4.28	0.067	0.854	3.4.24.24	NA
4	0.122	1bzsA	0.556	4.20	0.088	0.861	3.4.24.34	NA
5	0.119	1q3aB	0.554	4.14	0.074	0.854	3.4.24.22	NA
6	0.109	1rm8A	0.560	4.38	0.062	0.899	3.4.24.-	NA
7	0.077	1jizA	0.549	4.36	0.102	0.867	3.4.24.65	NA
8	0.066	4aykA	0.552	4.22	0.111	0.854	3.4.24.7	16,41,43,45,48
9	0.060	1eakD	0.556	4.34	0.086	0.873	3.4.24.24	47,60
10	0.060	1vlcA	0.549	4.64	0.072	0.880	1.1.1.85	NA
11	0.060	1t09B	0.551	4.62	0.047	0.905	1.1.1.42	59,68
12	0.060	2jsdA	0.548	4.38	0.043	0.873	3.4.24.-	NA
13	0.060	1pb3A	0.547	4.30	0.043	0.842	1.1.1.42	113,119
14	0.060	2b0tA	0.563	4.50	0.076	0.899	1.1.1.42	57
15	0.060	1p8fA	0.548	4.27	0.043	0.842	1.1.1.42	NA
16	0.060	1l6jA	0.561	4.16	0.065	0.873	3.4.24.35	NA
17	0.060	1hv5E	0.548	4.28	0.052	0.848	3.4.24.-	NA
18	0.060	1gxdA	0.553	4.22	0.058	0.880	3.4.24.24	NA
19	0.060	2d1cA	0.542	4.44	0.095	0.848	1.1.1.42	NA
20	0.060	1itwB	0.567	4.50	0.061	0.918	1.1.1.42	136
21	0.060	1bqqM	0.572	4.19	0.050	0.892	3.4.24.80	NA
22	0.060	1vqwA	0.543	4.03	0.059	0.823	1.14.13.-	NA
23	0.060	3dmsA	0.548	4.40	0.050	0.854	1.1.1.42	NA
24	0.060	1ks0A	0.174	4.64	0.019	0.291	3.4.24.24	NA
25	0.060	1su3B	0.555	4.26	0.096	0.854	3.4.24.7	NA
26	0.060	2d4vA	0.540	4.07	0.071	0.804	1.1.1.42	NA
27	0.060	2ddyA	0.562	4.25	0.086	0.873	3.4.24.23	126

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.13	0.552	4.20	0.09	0.86	1slmA	GO:0004175 GO:0004222 GO:0004252 GO:0005509 GO:0005576 GO:0005578 GO:0005615 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0010727 GO:0016787 GO:0022617 GO:0030574 GO:0031012 GO:0032461 GO:0046872 GO:0071732 GO:1903209
1	0.12	0.554	4.14	0.07	0.85	1q3aB	GO:0004222 GO:0004252 GO:0005509 GO:0005576 GO:0005578 GO:0005615 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0016787 GO:0022617 GO:0030334 GO:0030574 GO:0031012 GO:0046872
2	0.10	0.556	4.20	0.09	0.86	1bzsA	GO:0004222 GO:0004252 GO:0005509 GO:0005576 GO:0005578 GO:0005615 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0016787 GO:0022617 GO:0030574 GO:0031012 GO:0035987 GO:0046872
3	0.09	0.549	4.22	0.08	0.85	3ba0A	GO:0004175 GO:0004222 GO:0004252 GO:0005509 GO:0005576 GO:0005578 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0014070 GO:0016787 GO:0022617 GO:0030574 GO:0031012 GO:0035313 GO:0042060 GO:0042493 GO:0046872 GO:0050679 GO:0060054
4	0.07	0.560	4.38	0.06	0.90	1rm8A	GO:0001503 GO:0001958 GO:0004222 GO:0005509 GO:0005576 GO:0005578 GO:0005796 GO:0005886 GO:0005887 GO:0006508 GO:0008047 GO:0008233 GO:0008237 GO:0008270 GO:0009986 GO:0016020 GO:0016021 GO:0016787 GO:0022617 GO:0030574 GO:0031012 GO:0035988 GO:0043085 GO:0046872 GO:0048701 GO:0060348 GO:0097094
5	0.07	0.572	4.19	0.05	0.89	1bqqM	GO:0001503 GO:0001525 GO:0001541 GO:0001666 GO:0001935 GO:0001958 GO:0004222 GO:0004252 GO:0005178 GO:0005509 GO:0005737 GO:0005796 GO:0005886 GO:0005887 GO:0005925 GO:0006508 GO:0006979 GO:0008233 GO:0008237 GO:0008270 GO:0008584 GO:0009612 GO:0009725 GO:0010831 GO:0010952 GO:0014070 GO:0016020 GO:0016021 GO:0016477 GO:0016504 GO:0016787 GO:0022617 GO:0030307 GO:0030324 GO:0030335 GO:0030574 GO:0031012 GO:0031410 GO:0031638 GO:0035987 GO:0035988 GO:0042470 GO:0043615 GO:0043627 GO:0044354 GO:0045579 GO:0045746 GO:0046872 GO:0048701 GO:0048754 GO:0048771 GO:0051895 GO:0060348 GO:0097094
6	0.07	0.548	4.38	0.04	0.87	2jsdA	GO:0004222 GO:0004252 GO:0005509 GO:0005576 GO:0005578 GO:0005615 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0016787 GO:0022617 GO:0030163 GO:0030574 GO:0031012 GO:0046872 GO:0070173 GO:0097186
7	0.07	0.530	4.54	0.09	0.87	2mzeA	GO:0004222 GO:0004252 GO:0005576 GO:0005578 GO:0005615 GO:0006508 GO:0007568 GO:0008201 GO:0008233 GO:0008237 GO:0008270 GO:0009986 GO:0016787 GO:0022617 GO:0030574 GO:0031012 GO:0031667 GO:0044849 GO:0046872 GO:0060135 GO:0070062 GO:0071260
8	0.07	0.564	4.17	0.09	0.87	4r3vA	GO:0004222 GO:0005576 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0009405 GO:0016787 GO:0031012 GO:0046872
9	0.07	0.548	4.28	0.05	0.85	1hv5E	GO:0004222 GO:0005509 GO:0005576 GO:0005578 GO:0006508 GO:0007275 GO:0008233 GO:0008237 GO:0008270 GO:0016787 GO:0030198 GO:0030199 GO:0030574 GO:0031012 GO:0045599 GO:0046872 GO:0071711
10	0.07	0.543	4.24	0.09	0.84	3lmcA	GO:0006508 GO:0008237 GO:0008270 GO:0046872
11	0.07	0.553	4.22	0.06	0.88	1gxdA	GO:0001525 GO:0001666 GO:0001955 GO:0001957 GO:0004222 GO:0004252 GO:0005576 GO:0005578 GO:0005615 GO:0005634 GO:0005737 GO:0005739 GO:0005886 GO:0006508 GO:0007566 GO:0008233 GO:0008237 GO:0008270 GO:0016020 GO:0016787 GO:0022617 GO:0030017 GO:0030574 GO:0031012 GO:0035987 GO:0044267 GO:0045089 GO:0046872 GO:0048013 GO:0048705 GO:0060325 GO:0060346 GO:0071230
12	0.07	0.573	4.47	0.07	0.91	1itwA	GO:0004450 GO:0005737 GO:0006097 GO:0006099 GO:0016491 GO:0016616 GO:0046872 GO:0055114
13	0.07	0.554	4.13	0.04	0.85	4fu4A	GO:0001503 GO:0001554 GO:0001649 GO:0001666 GO:0001958 GO:0001968 GO:0003417 GO:0004222 GO:0004252 GO:0005509 GO:0005518 GO:0005576 GO:0005578 GO:0005615 GO:0005764 GO:0005794 GO:0006508 GO:0007507 GO:0007567 GO:0008233 GO:0008237 GO:0008270 GO:0009612 GO:0016787 GO:0022617 GO:0030282 GO:0030574 GO:0031012 GO:0035116 GO:0042493 GO:0043171 GO:0043627 GO:0044267 GO:0044849 GO:0046581 GO:0046872 GO:0048306 GO:0050750 GO:0051216 GO:0060349 GO:0071498 GO:1904244
14	0.07	0.537	4.29	0.04	0.82	1af0A	GO:0004222 GO:0005509 GO:0005576 GO:0005615 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0009405 GO:0016787 GO:0031012 GO:0046872
15	0.07	0.522	4.12	0.04	0.77	3hdaP	GO:0004222 GO:0005509 GO:0005576 GO:0005615 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0016787 GO:0031012 GO:0046872
16	0.07	0.552	4.26	0.07	0.87	5cuhA	GO:0001501 GO:0001503 GO:0001934 GO:0004175 GO:0004222 GO:0004252 GO:0005518 GO:0005576 GO:0005578 GO:0005615 GO:0006508 GO:0007566 GO:0008233 GO:0008237 GO:0008270 GO:0016787 GO:0022617 GO:0030198 GO:0030225 GO:0030574 GO:0031012 GO:0035987 GO:0042802 GO:0043065 GO:0043066 GO:0043388 GO:0045742 GO:0046872 GO:0048013 GO:0050900 GO:0051549 GO:0070062 GO:0090200 GO:1900122 GO:2001243 GO:2001258 GO:2001268
17	0.07	0.553	4.25	0.09	0.86	3ayuA	GO:0001525 GO:0001666 GO:0001955 GO:0001957 GO:0004222 GO:0004252 GO:0005576 GO:0005578 GO:0005615 GO:0005634 GO:0005737 GO:0005739 GO:0005886 GO:0006508 GO:0007566 GO:0008233 GO:0008237 GO:0008270 GO:0016020 GO:0016787 GO:0022617 GO:0030017 GO:0030574 GO:0031012 GO:0035987 GO:0044267 GO:0045089 GO:0046872 GO:0048013 GO:0048705 GO:0060325 GO:0060346 GO:0071230
18	0.07	0.555	4.26	0.10	0.85	1su3B	GO:0004175 GO:0004222 GO:0004252 GO:0005509 GO:0005576 GO:0005578 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0016032 GO:0016787 GO:0022617 GO:0030574 GO:0031012 GO:0032461 GO:0044267 GO:0046872 GO:0050900

Consensus prediction of GO terms

Molecular Function	GO:0004222	GO:0005509	GO:0008270	GO:0004252
GO-Score	0.41	0.41	0.41	0.37
Biological Processes	GO:0030574	GO:0022617	GO:0006508
GO-Score	0.41	0.41	0.41
Cellular Component	GO:0005578	GO:0005615
GO-Score	0.41	0.31

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.

I-TASSER results for job id Rv2730

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]