I-TASSER results

I-TASSER results for job id Rv2729c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (301 residues)
MASVEFATILALGAALLAGIGYVTLQRSARQVTAEEYVGHFTLFHLSLRHALWWLGSLAA
VASFTLQAIALTMGSVVLVQSLQATALLFALLIDARLTHHRCTPREWMWAVLLAGAVAVI
VMSGNPAAGTTRAPFSTWAVVAVVVVPAVVLCVVGARIASGSLSAVLLAVASSATLAVFT
VLTKGVVTELGEGFATLIRTPALYAWILVLPIGLMLQQSSLRVGALTASLPTITVARPVI
ASVLGITVLDEVLHTGRVALVALVAAVVVVVVATVALARDEVAMMTVSAGELGAAGQLAV
R

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MASVEFATILALGAALLAGIGYVTLQRSARQVTAEEYVGHFTLFHLSLRHALWWLGSLAAVASFTLQAIALTMGSVVLVQSLQATALLFALLIDARLTHHRCTPREWMWAVLLAGAVAVIVMSGNPAAGTTRAPFSTWAVVAVVVVPAVVLCVVGARIASGSLSAVLLAVASSATLAVFTVLTKGVVTELGEGFATLIRTPALYAWILVLPIGLMLQQSSLRVGALTASLPTITVARPVIASVLGITVLDEVLHTGRVALVALVAAVVVVVVATVALARDEVAMMTVSAGELGAAGQLAVR
Prediction	CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	9875899999999999999999999998876566677776467888875855899999999999999999997559999999999999999999999899987889999999999999998756888887777667899999999999999999987557875689999999999999999999999986566688887799999999999999999999987897646787999999999999999988888888999999999999999999998678777777777667788887889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MASVEFATILALGAALLAGIGYVTLQRSARQVTAEEYVGHFTLFHLSLRHALWWLGSLAAVASFTLQAIALTMGSVVLVQSLQATALLFALLIDARLTHHRCTPREWMWAVLLAGAVAVIVMSGNPAAGTTRAPFSTWAVVAVVVVPAVVLCVVGARIASGSLSAVLLAVASSATLAVFTVLTKGVVTELGEGFATLIRTPALYAWILVLPIGLMLQQSSLRVGALTASLPTITVARPVIASVLGITVLDEVLHTGRVALVALVAAVVVVVVATVALARDEVAMMTVSAGELGAAGQLAVR
Prediction	5451100000002012110102001431244245564243230012004321000000001112100010123020100003212200100100120143304321010000001110000000334444442422200000111112120111002333443200000000011101000001100221343023003323120101221211000020143240310100000010311221020001021432211000100110000100000022533654455654645553518
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
MASVEFATILALGAALLAGIGYVTLQRSARQVTAEEYVGHFTLFHLSLRHALWWLGSLAAVASFTLQAIALTMGSVVLVQSLQATALLFALLIDARLTHHRCTPREWMWAVLLAGAVAVIVMSGNPAAGTTRAPFSTWAVVAVVVVPAVVLCVVGARIASGSLSAVLLAVASSATLAVFTVLTKGVVTELGEGFATLIRTPALYAWILVLPIGLMLQQSSLRVGALTASLPTITVARPVIASVLGITVLDEVLHTGRVALVALVAAVVVVVVATVALARDEVAMMTVSAGELGAAGQLAVR

5i20A

0.17

0.15

0.88

1.28

MUSTER

--SRSSATLIGFTAILLWSTLALATSST-------GAVPPFLLTALTF--PVWVHGIGGLFGYHFFYFSALKLAPPAEAGLVAYLWPLLIVLFSAFLPGERLRPAHVAGALMGLAGTVVLLGAR--AGGFGFAPEYVPGYLAAAACAVIWSVYSVASRRFARVPTEVVAGFCLATAALSALCHILFEP--SVWPVGSEWLAVVALGIGPVGIAFYTWDIGMKRGDV-RLLGVLSYAAPVLSTLLLVVAGFAAPS------GALAIACALIVGGAAVATLLARRLES---------------

5i20A

0.14

0.12

0.86

1.11

dPPAS

VPPFLLTALTFTIGGAVGIAAGLARGVSVLRQP----------------WPVWVHGIGGLFGYHFFYFSALKLAPPAEAGLVAYLWPLLIVLFSAFLPGERLRPAHVAGALMGLAGTVVLLGARAGGFGFAPEYVPGYLAAAACAVIWSVYSVASRRFARVPTEVVAGFCLATAALSALCHILFE----PSVWPVGSEWLAVVALGIGPVGIAFYTWDIGMKRGDV-RLLGVLSYAAPVLSTLLLVVAGFAAPS------GALAIACALIVGGAAVATLLARRLES---------------

5i20A

0.15

0.14

0.89

2.10

wdPPAS

--SRSSATLIGFTAILLWSTLALATS--TGAVPPFLLTALTFTIGGAV--PVWVHGIGGLFGYHFFYFSALKLAPPAEAGLVAYLWPLLIVLFSAFLPGERLRPAHVAGALMGLAGTVVLLGAR--AGGFGFAPEYVPGYLAAAACAVIWSVYSVASRRFARVPTEVVAGFCLATAALSALCHILFEPSVWPV--GSEWLAVVALGIGPVGIAFYTWDIGMKRGDV-RLLGVLSYAAPVLSTLLLVVAGFAAPS------GALAIACALIVGGAAVATLLARRLES---------------

5i20A

0.14

0.12

0.86

1.58

wMUSTER

VPPFLLTALTFTIGGAVGIAAGLARGVSVLRQP-----------------PVWVHGIGGLFGYHFFYFSALKLAPPAEAGLVAYLWPLLIVLFSAFLPGERLRPAHVAGALMGLAGTVVLLGAR--AGGFGFAPEYVPGYLAAAACAVIWSVYSVASRRFARVPTEVVAGFCLATAALSALCHILFEPSVWPV--GSEWLAVVALGIGPVGIAFYTWDIGMKRGDV-RLLGVLSYAAPVLSTLLLVVAGFAAPS------GALAIACALIVGGAAVATLLARRLES---------------

5i20A

0.16

0.14

0.88

3.11

wPPAS

--SRSSATLIGFTAILLWSTLALATS--TGAVP-------LARGVSVLRQPVWVHGIGGLFGYHFFYFSALKLAPPAEAGLVAYLWPLLIVLFSAFLPGERLRPAHVAGALMGLAGTVVLLGAR--AGGFGFAPEYVPGYLAAAACAVIWSVYSVASRRFARVPTEVVAGFCLATAALSALCHILFEPSVWPVG--SEWLAVVALGIGPVGIAFYTWDIGMKRGDV-RLLGVLSYAAPVLSTLLLVVAGFAAPS------GALAIACALIVGGAAVATLLARRLES---------------

5i20A

0.13

0.11

0.86

2.07

dPPAS2

VPPFLLTALTFTIGGAVGIAAGLARGVSVLRQP----------------WPVWVHGIGGLFGYHFFYFSALKLAPPAEAGLVAYLWPLLIVLFSAFLPGERLRPAHVAGALMGLAGTVVLLGARA--GGFGFAPEYVPGYLAAAACAVIWSVYSVASRRFARVPTEVVAGFCLATAALSALCHILFEPSVWPVG--SEWLAVVALGIGPVGIAFYTWDIGMKRGDV-RLLGVLSYAAPVLSTLLLVVAGFAAPS------GALAIACALIVGGAAVATLLARRLES---------------

5i20A

0.13

0.11

0.86

2.23

PPAS

VPPFLLTALTFTIGGAVGIAAGLARGVSVLRQP-----------------PVWVHGIGGLFGYHFFYFSALKLAPPAEAGLVAYLWPLLIVLFSAFLPGERLRPAHVAGALMGLAGTVVLLGARA--GGFGFAPEYVPGYLAAAACAVIWSVYSVASRRFARVPTEVVAGFCLATAALSALCHILFEPSVWPVG--SEWLAVVALGIGPVGIAFYTWDIGMKRGDV-RLLGVLSYAAPVLSTLLLVVAGFAAPS------GALAIACALIVGGAAVATLLARRLES---------------

5i20A

0.15

0.13

0.91

2.29

Env-PPAS

SSATLIGFTAILLWSTLALATSSTGAVPPFLLTALTFTIGGAVGIAAGLAPVWVHGIGGLFGYHFFYFSALKLAPPAEAGLVAYLWPLLIVLFSAFLPGERLRPAHVAGALMGLAGTVVLLGAR--AGGFGFAPEYVPGYLAAAACAVIWSVYSVASRRFARVPTEVVAGFCLATAALSALCHILFEPSVWPVG--SEWLAVVALGIGPVGIAFYTWDIGMKRGDV-RLLGVLSYAAPVLSTLLLVVAGFAAPS------GALAIACALIVGGAAVATLLARRLES---------------

4n7wA

0.09

0.08

0.93

1.03

MUSTER

M--VKITRLFPVWALLLSVAAYFRPTTFTGIGPYVGPL-RLDDFKRVLSR-PAPVAAATFLHYLIMPLTAWILAMLFRMPPDLSAGMVLVGSVSNVMIY-DVALSVTISAVSTLVGVFATPLLTR-VDATISVDVVGMLKSILQIVVIPITAGLVIHHTFTKTVKRIEPYLPAMSMVCILAIISAVVAGSQSHIASVGFVVIIAVILHNGIGLLSGYWGGKLFGDESTCRTLAIEVGSGLAATLGKIYFS-----PLAALPGALFSVWHNLSGSLLAGYWSGKPVKKDQE-----------

4n7wA

0.07

0.94

0.85

dPPAS

PVWALLLSVAAYFPTTFTGIGPYVGPLLMLIMFAMGVTLRLDDFKRVLSR-PAPVAAATFLHYLIMPLTAWILAMLFRMPPDLSAGMVLVGSVSNVMIYVALSVTISAVSTLVGVFATPLLTRLYVDATISVDVVGMLKSILQIVVIPITAGLVIHHTFTKTVKRIEPYLPAMSMVCILAIISAVVAGSQSHIASVGFVVIIAVILHNGIGLLSGYWGGKLFGFDESTCRTLAIEVGSGLAATLGKIYFS-----PLAALPGALFSVWHNLSGSLLAGYWSGKPVKKDQE-----------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.50

Estimated TM-score = 0.53±0.15

Estimated RMSD = 9.6±4.6Å

Download Model 2

C-score=-1.51

Download Model 3

C-score=-4.01

Download Model 4

C-score=-4.14

Download Model 5

C-score=-4.53

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5i20A	0.821	1.56	0.131	0.861
2	3o7pA	0.461	4.06	0.065	0.588
3	4nreA2	0.457	5.85	0.054	0.721
4	4g32A	0.454	6.03	0.057	0.744
5	2p0mA	0.454	5.64	0.046	0.704
6	5fx8A	0.453	6.06	0.108	0.728
7	5fnoA	0.453	5.90	0.111	0.724
8	4cl4A	0.451	4.78	0.092	0.615
9	3vf1A2	0.450	5.98	0.071	0.721
10	1no3A2	0.447	6.25	0.061	0.741

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.10	5	4h13A	CLA	Rep, Mult	240,243,244,247,265,268,271
2	0.04	2	1siwA	SF4	Rep, Mult	95,100,101,102,227
3	0.02	1	2wse1	CLA	Rep, Mult	241,245
4	0.02	1	4o6mB	MPG	Rep, Mult	11,12
5	0.02	1	3u32K	DCW	Rep, Mult	78,106,113
6	0.02	1	2oyyB	HEM	Rep, Mult	168,172
7	0.02	1	3zprB	2CV	Rep, Mult	66,70,82,86
8	0.02	1	4ezcA	BGC	Rep, Mult	53,54
9	0.02	1	1q90B	CLA	Rep, Mult	247,267,268,271,272,275
10	0.02	1	3mpnA	MTN	Rep, Mult	78,82,265
11	0.02	1	3v5uA	MYS	Rep, Mult	269,273,274
12	0.02	1	1n35A	CH1	Rep, Mult	7,16,17,211
13	0.02	1	3ze3D	ZN	Rep, Mult	229,281
14	0.02	1	2h2pA	SEK	Rep, Mult	223,225
15	0.02	1	2aiyB	IPH	Rep, Mult	87,90
16	0.02	1	1jvzA	CEN	Rep, Mult	214,216,219
17	0.02	1	1hu9A	4HM	Rep, Mult	7,10,11,14,61,214
18	0.02	1	1g6uA	TFA	Rep, Mult	57,58,59
19	0.02	1	2x2vH	DPV	Rep, Mult	79,87
20	0.02	1	1fbmD	RTL	Rep, Mult	71,78

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2ivfA	0.382	6.82	0.055	0.691	1.17.99.2	NA
2	0.060	2p0mB	0.427	6.07	0.044	0.688	1.13.11.33	12,16
3	0.060	2eq9D	0.375	6.12	0.097	0.605	1.8.1.4	157
4	0.060	1jehA	0.362	5.93	0.039	0.575	1.8.1.4	NA
5	0.060	3cf4A	0.389	6.35	0.042	0.651	1.2.99.2	NA
6	0.060	1mo9A	0.394	6.14	0.060	0.638	1.8.1.5	NA
7	0.060	1oqzB	0.399	6.43	0.071	0.681	3.5.1.93	NA
8	0.060	1q16A	0.405	6.58	0.066	0.718	1.7.99.4	NA
9	0.060	1no3A	0.445	6.24	0.101	0.734	1.13.11.12	NA
10	0.060	3k1dA	0.386	5.58	0.049	0.595	2.4.1.18	NA
11	0.060	2iukB	0.448	6.02	0.080	0.714	1.13.11.12	233
12	0.060	3bkkA	0.373	5.90	0.047	0.595	3.4.15.1	NA
13	0.060	1n1hA	0.391	6.76	0.046	0.698	2.7.7.48	229,234
14	0.060	2eq6A	0.371	6.31	0.084	0.611	1.8.1.4	137
15	0.060	1mokA	0.388	6.02	0.041	0.628	1.8.1.5	90
16	0.060	1zmcD	0.376	6.16	0.053	0.608	1.8.1.4	NA
17	0.060	2zxcA	0.394	5.75	0.120	0.615	3.5.1.23	NA
18	0.060	3dk9A	0.379	6.18	0.065	0.621	1.8.1.7	NA
19	0.060	1grtA	0.376	6.22	0.065	0.621	1.8.1.7	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.26	0.826	1.80	0.13	0.87	5i20E	GO:0016020 GO:0016021
1	0.17	0.634	1.30	0.15	0.66	5i20F	GO:0016020 GO:0016021
2	0.14	0.454	5.83	0.04	0.71	3fg3A	GO:0003824 GO:0004096 GO:0005506 GO:0005737 GO:0006629 GO:0006631 GO:0006633 GO:0008152 GO:0016020 GO:0016491 GO:0016702 GO:0016829 GO:0019369 GO:0020037 GO:0031408 GO:0046872 GO:0047677 GO:0047987 GO:0051213 GO:0055114 GO:0098869
3	0.07	0.458	5.82	0.07	0.72	4g33A	GO:0016165 GO:0016491 GO:0016702 GO:0042597 GO:0046872 GO:0051213 GO:0055114
4	0.07	0.453	5.90	0.11	0.72	5fnoA	GO:0005576 GO:0016491 GO:0016702 GO:0046872 GO:0050584 GO:0051213 GO:0055114
5	0.07	0.440	5.64	0.05	0.69	3rdeA	GO:0001503 GO:0002820 GO:0004052 GO:0005506 GO:0005546 GO:0005737 GO:0005811 GO:0005829 GO:0005886 GO:0006629 GO:0006631 GO:0006646 GO:0008289 GO:0010811 GO:0016020 GO:0016491 GO:0016702 GO:0019369 GO:0019372 GO:0030282 GO:0030838 GO:0031234 GO:0034976 GO:0035358 GO:0035963 GO:0042060 GO:0043277 GO:0043651 GO:0046872 GO:0050473 GO:0051213 GO:0055114 GO:0070374 GO:0071277 GO:1901074 GO:2001303
6	0.07	0.442	5.85	0.07	0.70	3o8yA	GO:0002526 GO:0002540 GO:0004051 GO:0005506 GO:0005615 GO:0005634 GO:0005635 GO:0005641 GO:0005737 GO:0005829 GO:0006691 GO:0006954 GO:0007584 GO:0016020 GO:0016363 GO:0016491 GO:0016702 GO:0019233 GO:0019369 GO:0019370 GO:0019372 GO:0030425 GO:0031965 GO:0042383 GO:0045907 GO:0046872 GO:0051213 GO:0055093 GO:0055114 GO:2001300
7	0.07	0.457	5.85	0.05	0.72	4nreA	GO:0005506 GO:0005509 GO:0005622 GO:0005634 GO:0005737 GO:0005829 GO:0005856 GO:0005886 GO:0006629 GO:0006915 GO:0008285 GO:0008289 GO:0010744 GO:0016020 GO:0016165 GO:0016491 GO:0016702 GO:0019369 GO:0019372 GO:0019898 GO:0030336 GO:0030850 GO:0030856 GO:0035360 GO:0036403 GO:0043651 GO:0045618 GO:0045786 GO:0045926 GO:0046872 GO:0050473 GO:0051122 GO:0051213 GO:0055114 GO:0070062 GO:0090197
8	0.07	0.454	5.64	0.05	0.70	2p0mA	GO:0001503 GO:0002820 GO:0004052 GO:0005506 GO:0005546 GO:0005737 GO:0005811 GO:0005829 GO:0005886 GO:0006629 GO:0006631 GO:0006646 GO:0008289 GO:0010811 GO:0016020 GO:0016491 GO:0016702 GO:0019369 GO:0019372 GO:0030282 GO:0030838 GO:0031234 GO:0034976 GO:0035358 GO:0035963 GO:0042060 GO:0043277 GO:0043651 GO:0046872 GO:0050473 GO:0051122 GO:0051213 GO:0055114 GO:0070374 GO:0071277 GO:1901074 GO:2001303
9	0.07	0.450	5.98	0.07	0.72	3vf1A	GO:0005506 GO:0016491 GO:0016702 GO:0046872 GO:0051213 GO:0055114
10	0.07	0.453	6.06	0.11	0.73	5fx8A	GO:0005576 GO:0016491 GO:0016702 GO:0046872 GO:0050584 GO:0051213 GO:0055114
11	0.07	0.448	5.68	0.08	0.70	2iukA	GO:0005737 GO:0006629 GO:0006631 GO:0006633 GO:0016491 GO:0016702 GO:0031408 GO:0046872 GO:0051213 GO:0055114
12	0.06	0.446	5.89	0.05	0.70	3dy5A	GO:0003824 GO:0004096 GO:0005506 GO:0005737 GO:0006629 GO:0006631 GO:0006633 GO:0008152 GO:0016020 GO:0016491 GO:0016702 GO:0016829 GO:0019369 GO:0020037 GO:0031408 GO:0046872 GO:0047677 GO:0047987 GO:0051213 GO:0055114 GO:0098869
13	0.06	0.448	5.77	0.09	0.71	1ygeA	GO:0005737 GO:0006629 GO:0006631 GO:0006633 GO:0016165 GO:0016491 GO:0016702 GO:0031408 GO:0046872 GO:0051213 GO:0055114
14	0.06	0.414	6.49	0.05	0.71	3d3lA	GO:0004052 GO:0005506 GO:0005737 GO:0005829 GO:0006629 GO:0006631 GO:0006928 GO:0007568 GO:0008284 GO:0010595 GO:0010628 GO:0010656 GO:0010942 GO:0016020 GO:0016165 GO:0016491 GO:0016702 GO:0016787 GO:0019369 GO:0019372 GO:0019395 GO:0030307 GO:0030335 GO:0042383 GO:0042554 GO:0043065 GO:0043066 GO:0043280 GO:0043651 GO:0045603 GO:0045766 GO:0045785 GO:0045909 GO:0046872 GO:0047977 GO:0048661 GO:0051120 GO:0051121 GO:0051122 GO:0051213 GO:0051901 GO:0055114 GO:0061436 GO:0070062 GO:0071396 GO:0072593 GO:0090331 GO:1901751 GO:2001300 GO:2001303 GO:2001306
15	0.06	0.445	6.24	0.10	0.73	1no3A	GO:0005737 GO:0006629 GO:0006631 GO:0006633 GO:0016491 GO:0016702 GO:0031408 GO:0046872 GO:0051213 GO:0055114
16	0.06	0.435	6.37	0.05	0.72	3v99B	GO:0002526 GO:0002540 GO:0004051 GO:0005506 GO:0005615 GO:0005634 GO:0005635 GO:0005641 GO:0005737 GO:0005829 GO:0006691 GO:0006954 GO:0007584 GO:0016020 GO:0016363 GO:0016491 GO:0016702 GO:0019233 GO:0019369 GO:0019370 GO:0019372 GO:0030425 GO:0031965 GO:0042383 GO:0045907 GO:0046872 GO:0051213 GO:0055093 GO:0055114 GO:2001300
17	0.06	0.341	6.12	0.04	0.56	1qo0B	GO:0006865 GO:0016301 GO:0016310 GO:0016740 GO:0033218 GO:0034251 GO:0051346
18	0.06	0.390	3.87	0.03	0.48	3o7qA	GO:0005886 GO:0005887 GO:0005975 GO:0006004 GO:0006810 GO:0008643 GO:0015150 GO:0015293 GO:0015517 GO:0015518 GO:0015535 GO:0015751 GO:0015756 GO:0015757 GO:0016020 GO:0016021 GO:0055085

Consensus prediction of GO terms

Molecular Function	GO:0051213	GO:0016701	GO:0043169
GO-Score	0.50	0.50	0.50
Biological Processes	GO:0044710
GO-Score	0.50
Cellular Component	GO:0016021
GO-Score	0.39

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.