I-TASSER results

I-TASSER results for job id Rv2695

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (235 residues)
MAVDLDGVTTVLLPGTGSDNDYVRRAFSAPLRRAGAVLVTPVPHPGRLIDGYRAALDDAA
RDGPVVVGGVSLGAAVAAAWALEHPDRAVAVLAALPAWTGEPELAPAAQAARYTAARLRC
DGLAATTTRMRASSPVWLAEELTRSWRVQWPELPDAMEEAAAYVAPSRAELARLVAPLAV
AAAVDDPIHPLQVAADWVSVAPHAALRTVTLDEIGADAAALGSACLAALAEVSGA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MAVDLDGVTTVLLPGTGSDNDYVRRAFSAPLRRAGAVLVTPVPHPGRLIDGYRAALDDAARDGPVVVGGVSLGAAVAAAWALEHPDRAVAVLAALPAWTGEPELAPAAQAARYTAARLRCDGLAATTTRMRASSPVWLAEELTRSWRVQWPELPDAMEEAAAYVAPSRAELARLVAPLAVAAAVDDPIHPLQVAADWVSVAPHAALRTVTLDEIGADAAALGSACLAALAEVSGA
Prediction	CCCCCCCCEEEEHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEHCHHHHHHHHHHHHCCCHHHEEEEHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHCCCCCEEEEEHCCCCCCCHHHHHHHHHHCCCCEEEEEEHHHCCCCHHHHHHHHHHHHHHHHCC
Conf.Score	9888999779996899998889998887654666888889999887899999999999979998899987889999999999886655557776588889988656777788888888886599999997578977889999888875675799999999757899988875689888999867998889899999999899988999866767888578889999999999759
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MAVDLDGVTTVLLPGTGSDNDYVRRAFSAPLRRAGAVLVTPVPHPGRLIDGYRAALDDAARDGPVVVGGVSLGAAVAAAWALEHPDRAVAVLAALPAWTGEPELAPAAQAARYTAARLRCDGLAATTTRMRASSPVWLAEELTRSWRVQWPELPDAMEEAAAYVAPSRAELARLVAPLAVAAAVDDPIHPLQVAADWVSVAPHAALRTVTLDEIGADAAALGSACLAALAEVSGA
Prediction	6436364200000000003331021002230342424333252433420220041014117243010000000010001002410420110000000233455432233314321430354104301440434325303531342224325400300220043444436304503000000014422202261033004102604224031641341242014100300350478
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCEEEEHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEHCHHHHHHHHHHHHCCCHHHEEEEHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHCCCCCEEEEEHCCCCCCCHHHHHHHHHHCCCCEEEEEEHHHCCCCHHHHHHHHHHHHHHHHCC
MAVDLDGVTTVLLPGTGSDNDYVRRAFSAPLRRAGAVLVTPVPHPGRLIDGYRAALDDAARDGPVVVGGVSLGAAVAAAWALEHPDRAVAVLAALPAWTGEPELAPAAQAARYTAARLRCDGLAATTTRMRASSPVWLAEELTRSWRVQWPELPDAMEEAAAYVAPSRAELARLVAPLAVAAAVDDPIHPLQVAADWVSVAPHAALRTVTLDEIGADAAALGSACLAALAEVSGA

3om8A

0.19

0.99

1.97

MUSTER

LDGAAEKPLLALSNSIGTTLPALTRVLRYDARGHGASSVPPGPYTLARLGEDVLELLDALEVRRAHFLGLSLGGIVGQWLALHAPQRIERLVLANTSAWLGPAAQWDERIAAVLQAEDSETAAGFLGNWFPPALLERAEPVVERFRALATNRHGLAGSFAAVRDTDLRAQLARIERPTLVIAGAYDTVTAASHGELIAASIAGARLVTLPA---VHLSNVEPQAFEGAVLSFLGA

5egnA

0.17

0.99

1.89

dPPAS

YDSYGEGVPIVFLHPFSTNGGIWYFQTFPFARGHGRSDKPATGYSIMEHADDVVAVLDALKVDRAVFVGNSIGGMIAMQLNLDHPQRVIGNLILSSGTGLGEGMPPEAGAAFQNYIGAFGGLLEGAVSARSKRERPEILAVMKAHFSVPSNFPKHVFDAATAFAWNIKDRLSSIQAPTLVVAGEEDLVTTVANNQLLADNIPGAELRVIN--DVGHFYQLEPSEFNELLRGFVA-

5egnA

0.17

0.97

2.37

wdPPAS

YDSYGEGVPIVFLHPFSTN----NHVIVIDHRGHGRSDKPATGYSIMEHADDVVAVLDALKVDRAVFVGNSIGGMIAMQLNLDHPQRVIGNLILSSGTGLGEGMPPEAGAAFQNYIGAFGGLLEGAVSARSKRERPEILAVMKAHFSVPSNFPKHVFDAATAFAWNIKDRLSSIQAPTLVVAGEEDLVTTVANNQLLADNIPGAELRVIN--DVGHFYQLERPSEFNELLRGFVA

5egnA

0.18

0.17

0.97

2.55

wMUSTER

YDSYGEGVPIVFLHPFSTN----NHVIVIDHRGHGRSDKPATGYSIMEHADDVVAVLDALKVDRAVFVGNSIGGMIAMQLNLDHPQRVIGNLILSSGTGLGEGMPPEAGAAFQNYIGAFGGLLEGAVSARSKRERPEILAVMKAHFSVPSNFPKHVFDAATAFAWNIKDRLSSIQAPTLVVAGEEDLVTTVANNQLLADNIPGAELRVIN--DVGHFYQLERPSEFNELLRG--A

4dnpA

0.13

0.98

2.71

wPPAS

VRVVGSGRVLVLAHGFGTDQSAWNRILPFDLVCAGSVNPDFFDFTLDPYVDDLLHILDALGIDCCAYVGHSVSAMIGILASIRRPELFSKLILIGASPRFLNDEDGEIEKVFSAMEANYEAWVNGFAPLAVGADVPAAVREFSRTLFNMRPDITLFVSRTVF-NSDMRGVLGLVKVPCHIFQTARDHSVPASVATYLKNHLGGKTVHWLNIE--GHLPHLSPTLLAQELRRALS-

4dnpA

0.13

0.99

2.50

dPPAS2

VRVVGSGRVLVLAHGFGTDQSAWNRILPFDLVCAGSVNDFRRYTTLDPYVDDLLHILDALGIDCCAYVGHSVSAMIGILASIRRPELFSKLILIGASPRFLNDEDGEIEKVFSAMEANYEAWVNGFAPLAVGADVPAAVREFSRTLFNMRPDITLFVSRTVF-NSDMRGVLGLVKVPCHIFQTARDHSVPASVATYLKNHLGGKNTVHWL-NIEGHLPHLSPTLLAQELRRALS-

4dnpA

0.13

0.99

2.50

PPAS

VRVVGSGRVLVLAHGFGTDQSAWNRILPFDLVCAGSVNPDFFDFTLDPYVDDLLHILDALGIDCCAYVGHSVSAMIGILASIRRPELFSKLILIGASPRFLNDEDGEIEKVFSAMEANYEAWVNGFAPLAVGADVPAAVREFSRTLFNMRPDITLFVSRTVF-NSDMRGVLGLVKVPCHIFQTARDHSVPASVATYLKNHLGGKNTVHWL-NIEGHLPHLSPTLLAQELRRALS-

5egnA

0.17

0.97

3.09

Env-PPAS

YDSYGEGVPIVFLHPFSTNGGIWYFQTFPFARGHGRSDKPATGYSIMEHADDVVAVLDALKVDRAVFVGNSIGGMIAMQLNLDHPQRVIGNLILSSGTGLGEGMPPEAGAAFQNYIGAFGGLLEGAVSARSKRERPEILAVMKAHFSVPSNFPKHVFDAATAFAWNIKDRLSSIQAPTLVVAGEEDLVTTVANNQLLADNIPGAELRVIN--DVGHRPSEFNELLRGFV-----A

5egnA

0.18

0.17

0.97

1.95

MUSTER

YDSYGEGVPIVFLHPFSTN----NHVIVIDHRGHGRSDKPATGYSIMEHADDVVAVLDALKVDRAVFVGNSIGGMIAMQLNLDHPQRVIGNLILSSGTGLGEGMPPEAGAAFQNYIGAFGGLLEGAVSARSKRERPEILAVMKAHFSVPSNFPKHVFDAATAFAWNIKDRLSSIQAPTLVVAGEEDLVTTVANNQLLADNIPGAELRVIN--DVGHFYQLEPSEFNELLRGF--A

4dnpA

0.13

0.99

1.87

dPPAS

VRVVGSGRVLVLAHGFGTDQSAWNRILPFDLVCAGSVNDFRRYTTLDPYVDDLLHILDALGIDCCAYVGHSVSAMIGILASIRRPELFSKLILIGASPRFLNDEDGEIEKVFSAMEANYEAWVNGFAPLAVGADVPAAVREFSRTLFNMRPDITLFVSRTVF-NSDMRGVLGLVKVPCHIFQTARDHSVPASVATYLKNHLGGKNTVHWL-NIEGHLPHLSPTLLAQELRRALS-

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.36

Estimated TM-score = 0.76±0.10

Estimated RMSD = 4.9±3.2Å

Download Model 2

C-score=-1.89

Download Model 3

C-score=-0.98

Download Model 4

C-score=-0.69

Download Model 5

C-score=0.41

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5egnA	0.918	1.70	0.172	0.992
2	4dnpA	0.878	1.78	0.129	0.957
3	5cbkA	0.877	1.93	0.145	0.966
4	3hi4A	0.874	2.13	0.126	0.979
5	1a8qA	0.874	2.15	0.117	0.979
6	3fobB	0.874	2.07	0.122	0.975
7	3w06A	0.870	2.04	0.123	0.966
8	1womA	0.870	2.01	0.137	0.966
9	1brtA	0.869	2.15	0.117	0.979
10	1hkhA	0.869	2.16	0.130	0.979

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.45	64	1a8uA	BEZ	Rep, Mult	15,16,70,71,72,97,188,216
2	0.07	11	4g8cB	C6L	Rep, Mult	15,16,46,71,72,75,160,161,164,188,216
3	0.07	10	4etwA	ZMK	Rep, Mult	15,16,71,72,104,107,108,111,122,125,126,128,161,188,216
4	0.02	3	1ukbA	BEZ	Rep, Mult	24,127,130,142,217
5	0.02	3	4fblA	SPD	Rep, Mult	15,16,17,18,71,122,123,141,145,146,216
6	0.01	1	3hssB	MLA	Rep, Mult	130,145,149,217
7	0.01	2	3v1nA	HPK	Rep, Mult	14,15,20,21,24,25,131,138,142,217
8	0.01	1	1iunB	ACT	Rep, Mult	207,220,223
9	0.01	2	2xuaH	SHF	Rep, Mult	15,16,112,122,125,126,146,157,188
10	0.01	1	1uk8A	LEA	Rep, Mult	195,198,199,206
11	0.01	2	1iup0	III	Rep, Mult	177,184,198,201,202,203,204,205,206,207,208,209,210,213,224,227,228,231
12	0.00	1	2wm2A	CL	Rep, Mult	105,109,112,157

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.339	1a88A	0.868	2.24	0.170	0.979	1.11.1.10	71,186
2	0.259	2pu5A	0.839	2.96	0.168	0.987	3.7.1.8	82
3	0.194	3cn7A	0.588	2.46	0.148	0.668	3.1.1.1	71,185
4	0.167	2qvbB	0.793	3.01	0.168	0.962	3.8.1.5	NA
5	0.148	1j1iA	0.808	2.65	0.132	0.936	3.7.1.8	71
6	0.142	1y37A	0.821	2.92	0.139	0.979	3.8.1.3	NA
7	0.140	1u2eA	0.838	2.89	0.126	0.983	3.7.1.-	71
8	0.135	3a2lA	0.807	2.90	0.119	0.966	3.8.1.5	32
9	0.132	3bf7A	0.761	2.98	0.136	0.906	3.1.-.-	71
10	0.131	1mt3A	0.821	3.03	0.104	0.979	3.4.11.5	NA
11	0.131	1ehyA	0.794	3.29	0.140	0.975	3.3.2.10	186
12	0.127	3hjuA	0.790	2.87	0.127	0.923	3.1.1.23	71
13	0.116	2r11D	0.771	3.26	0.118	0.940	3.1.1.1	72,97
14	0.115	1dwoA	0.741	3.14	0.097	0.902	4.1.2.37	71,186
15	0.110	1qj4A	0.741	3.15	0.094	0.902	4.1.2.37	71,186
16	0.067	1i6wB	0.535	2.78	0.114	0.630	3.1.1.3	186
17	0.060	1zoiA	0.864	2.31	0.143	0.979	3.1.1.-	71,186
18	0.060	1iunB	0.830	2.99	0.139	0.979	3.7.1.9	94,186
19	0.060	1qtrA	0.820	2.67	0.151	0.957	3.4.11.5	NA
20	0.060	1mj5A	0.796	2.96	0.155	0.962	3.8.1.5	NA
21	0.060	1a7uA	0.871	2.13	0.117	0.979	1.11.1.10	71,186
22	0.060	1k8qA	0.794	3.21	0.096	0.970	3.1.1.3	NA
23	0.060	1m33A	0.823	2.35	0.176	0.940	3.1.1.1	NA
24	0.060	3g0iA	0.784	3.16	0.134	0.953	3.3.2.3	95,138
25	0.060	1a88B	0.867	2.26	0.170	0.979	1.11.1.10	94
26	0.060	3nwoA	0.799	3.32	0.135	0.962	3.4.11.5	71
27	0.060	2og1A	0.839	2.97	0.168	0.987	3.7.1.8	9
28	0.060	1va4A	0.875	2.12	0.126	0.979	3.1.1.2	21,71,219
29	0.060	1azwA	0.820	2.67	0.173	0.962	3.4.11.5	NA
30	0.060	1a8qA	0.874	2.15	0.117	0.979	1.11.1.10	71,186
31	0.060	1a8sA	0.866	2.30	0.126	0.979	1.11.1.10	71,186
32	0.060	2ocgA	0.793	2.32	0.128	0.898	3.1.-.-	13,71,73,77,186,194,206
33	0.060	1c4xA	0.845	2.64	0.191	0.979	3.7.1.8	NA
34	0.060	3e3aB	0.835	2.56	0.132	0.970	1.11.1.-	15,17
35	0.060	2vf2A	0.834	2.97	0.190	0.983	3.7.1.8	15,35,72

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.38	0.863	2.41	0.14	0.99	3v48A	GO:0006212 GO:0016787 GO:0016811 GO:0019740
1	0.36	0.886	1.73	0.16	0.96	4ihaA	GO:0005634 GO:0005737 GO:0010223 GO:0016787 GO:1901601
2	0.33	0.869	1.89	0.13	0.96	4ih4A	GO:0005634 GO:0005737 GO:0010223 GO:0016787 GO:1901601 GO:1902348
3	0.32	0.869	2.16	0.13	0.98	1hkhA	GO:0003824 GO:0004601 GO:0098869
4	0.32	0.836	2.37	0.16	0.96	1m33A	GO:0005737 GO:0009102 GO:0016787 GO:0052689 GO:0090499
5	0.31	0.802	3.11	0.19	0.96	4psuA	GO:0016787
6	0.31	0.872	2.04	0.12	0.97	4dnqI	GO:0010223 GO:0016787 GO:0016788 GO:1901601
7	0.30	0.840	2.34	0.14	0.96	4x00A	GO:0016787
8	0.30	0.834	2.43	0.16	0.96	4nmwA	GO:0005737 GO:0009102 GO:0016787 GO:0052689
9	0.29	0.871	2.06	0.14	0.97	2xuaH	GO:0016787 GO:0042952 GO:0047570
10	0.29	0.848	2.46	0.14	0.97	4rncA	GO:0016787 GO:0052689
11	0.28	0.794	3.29	0.14	0.97	1ehyA	GO:0003824 GO:0016787
12	0.28	0.868	2.24	0.17	0.98	1a88A	GO:0003824 GO:0004601 GO:0016491 GO:0016691 GO:0055114 GO:0098869
13	0.27	0.797	3.12	0.17	0.96	3kxpA	GO:0016787 GO:0042803 GO:0042820 GO:0047411
14	0.26	0.797	3.06	0.14	0.96	2yysA	GO:0006508 GO:0008233
15	0.25	0.714	2.69	0.12	0.84	3pf8A	GO:0016787
16	0.25	0.833	2.81	0.13	0.98	2xmzA	GO:0009234 GO:0016787 GO:0016829 GO:0070205
17	0.22	0.786	2.91	0.16	0.94	4gdmC	GO:0005829 GO:0009234 GO:0016787 GO:0016829 GO:0070205
18	0.22	0.870	2.01	0.14	0.97	1womA	GO:0016787
19	0.21	0.761	2.98	0.14	0.91	3bf7A	GO:0005829 GO:0016787 GO:0016790 GO:0052689
20	0.21	0.854	2.38	0.18	0.97	3om8B	GO:0016787 GO:0042952 GO:0047570
21	0.20	0.872	2.01	0.12	0.97	4htaA	GO:0005634 GO:0005737 GO:0005829 GO:0009640 GO:0009704 GO:0016787 GO:0080167
22	0.20	0.839	2.97	0.17	0.99	2og1A	GO:0003824 GO:0016787 GO:0016823 GO:0018771 GO:0018774 GO:0019439
23	0.20	0.845	2.78	0.14	0.99	4f0jA	GO:0003824 GO:0016787
24	0.19	0.821	3.18	0.13	0.98	4opmA	GO:0004806 GO:0016787
25	0.19	0.828	2.82	0.14	0.98	3b12A	GO:0003824 GO:0016787 GO:0018785
26	0.19	0.824	2.98	0.18	0.98	2e3jA	GO:0003824 GO:0016787
27	0.19	0.826	2.87	0.15	0.98	3r3uA	GO:0003824 GO:0016787 GO:0018785
28	0.19	0.826	2.79	0.17	0.97	4nvrA	GO:0016740 GO:0016746 GO:0016787 GO:0046872
29	0.17	0.874	2.15	0.12	0.98	1a8qA	GO:0003824 GO:0004601 GO:0016491 GO:0017000 GO:0055114 GO:0098869
30	0.15	0.810	2.66	0.14	0.94	4ns4A	GO:0016787 GO:0016788
31	0.15	0.793	2.32	0.13	0.90	2ocgA	GO:0005739 GO:0005741 GO:0006520 GO:0006805 GO:0009636 GO:0016787 GO:0047658 GO:0070062
32	0.14	0.841	2.91	0.17	0.98	4i3fA	GO:0016787
33	0.14	0.821	3.03	0.10	0.98	1mt3A	GO:0004177 GO:0006508 GO:0008233 GO:0016787
34	0.13	0.802	3.03	0.16	0.96	4b9aA	GO:0003824 GO:0009062 GO:0016298 GO:0016787
35	0.07	0.703	3.38	0.10	0.87	3fnbA	GO:0004252 GO:0006508

Consensus prediction of GO terms

Molecular Function	GO:0016811	GO:0004601	GO:0090499
GO-Score	0.38	0.32	0.32
Biological Processes	GO:1901601	GO:0010223	GO:0019740	GO:0006212	GO:1902348	GO:0098869	GO:0009102
GO-Score	0.57	0.57	0.38	0.38	0.33	0.32	0.32
Cellular Component	GO:0005737	GO:0005634
GO-Score	0.71	0.57

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.