I-TASSER results

I-TASSER results for job id Rv2681

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (438 residues)
MCPEPSHAGAAESEGTESEPTPLLRPAGGIPDLCVTVGEIAAAAELLDRGRGPFAVDAER
ASGFRYSGRAYLIQIRRAEAGTVLIDPVSHGGDPLTVLAPVAEVLSTNEWILHSADQDLP
CLAEVGMRPPALYDTELAGRLAGFDRVNLAAMVERLLGLGLTKGHGAADWSKRPLPSAWL
NYAALDVELLIELRAAISRVLAEQGKTDWAAQEFEHLRSFESRPPPAAARQDRWRRTSGI
HKVHDRRGLAAVRELWTARDRIAQRRDIAPRRILPDSAIIDAAIADPKSVDDLVALPVFG
GRNQRRSAAVWWAALAAARESPDPPEIAEPANGPPPPGRWVRRKPAAAARLDAARAALTE
VSQRVRVPTENLVSPDLVRRLCWEWEDISQSSPDPIAAVEAYLRTGQARAWQLELVVPIL
TAALTGAPDAGAQGDDGS

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MCPEPSHAGAAESEGTESEPTPLLRPAGGIPDLCVTVGEIAAAAELLDRGRGPFAVDAERASGFRYSGRAYLIQIRRAEAGTVLIDPVSHGGDPLTVLAPVAEVLSTNEWILHSADQDLPCLAEVGMRPPALYDTELAGRLAGFDRVNLAAMVERLLGLGLTKGHGAADWSKRPLPSAWLNYAALDVELLIELRAAISRVLAEQGKTDWAAQEFEHLRSFESRPPPAAARQDRWRRTSGIHKVHDRRGLAAVRELWTARDRIAQRRDIAPRRILPDSAIIDAAIADPKSVDDLVALPVFGGRNQRRSAAVWWAALAAARESPDPPEIAEPANGPPPPGRWVRRKPAAAARLDAARAALTEVSQRVRVPTENLVSPDLVRRLCWEWEDISQSSPDPIAAVEAYLRTGQARAWQLELVVPILTAALTGAPDAGAQGDDGS
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHCCHHHHHHHHHHHHHCCCCEEEEHCCCCCCCCCCEEEEEEEEHCCCCEEEEHCCCCCCHHHHHHHHHHHHHCCCEEEEHCCHHHHHHHHHHCCCCCCEHCHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
Conf.Score	998877889887667788988788888898767789999999999999889978999657999766775899999858985999967878766788999999986689589857658999999989967873439999999899876799999999899788556446878899999999999998899999999999999998868999999998887654677778866677876575445658999999999999999999989998855899999999998999999998777898789999999999999999868887667788889998655565586899999999999999999989997784899999999997677888777777889999987577578999999999999986577777788899
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MCPEPSHAGAAESEGTESEPTPLLRPAGGIPDLCVTVGEIAAAAELLDRGRGPFAVDAERASGFRYSGRAYLIQIRRAEAGTVLIDPVSHGGDPLTVLAPVAEVLSTNEWILHSADQDLPCLAEVGMRPPALYDTELAGRLAGFDRVNLAAMVERLLGLGLTKGHGAADWSKRPLPSAWLNYAALDVELLIELRAAISRVLAEQGKTDWAAQEFEHLRSFESRPPPAAARQDRWRRTSGIHKVHDRRGLAAVRELWTARDRIAQRRDIAPRRILPDSAIIDAAIADPKSVDDLVALPVFGGRNQRRSAAVWWAALAAARESPDPPEIAEPANGPPPPGRWVRRKPAAAARLDAARAALTEVSQRVRVPTENLVSPDLVRRLCWEWEDISQSSPDPIAAVEAYLRTGQARAWQLELVVPILTAALTGAPDAGAQGDDGS
Prediction	741425636345554566413413525741141032372045005203753500000001032332201000000014521000000022335105104301500632210000021002002402230300000000001031432102200210041414452334304444026500310030020011013102411442212202222212224233334324223100221222220222212202210021014203637212420032500130044316326203503514453034105201400450372552641541453143243235434403400530251044106627031410033620230022145356633432530341046340230012000420251055345454646648
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHCCHHHHHHHHHHHHHCCCCEEEEHCCCCCCCCCCEEEEEEEEHCCCCEEEEHCCCCCCHHHHHHHHHHHHHCCCEEEEHCCHHHHHHHHHHCCCCCCEHCHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
MCPEPSHAGAAESEGTESEPTPLLRPAGGIPDLCVTVGEIAAAAELLDRGRGPFAVDAERASGFRYSGRAYLIQIRRAEAGTVLIDPVSHGGDPLTVLAPVAEVLSTNEWILHSADQDLPCLAEVGMRPPALYDTELAGRLAGFDRVNLAAMVERLLGLGLTKGHGAADWSKRPLPSAWLNYAALDVELLIELRAAISRVLAEQGKTDWAAQEFEHLRSFESRPPPAAARQDRWRRTSGIHKVHDRRGLAAVRELWTARDRIAQRRDIAPRRILPDSAIIDAAIADPKSVDDLVALPVFGGRNQRRSAAVWWAALAAARESPDPPEIAEPANGPPPPGRWVRRKPAAAARLDAARAALTEVSQRVRVPTENLVSPDLVRRLCWEWEDISQSSPDPIAAVEAYLRTGQARAWQLELVVPILTAALTGAPDAGAQGDDGS

3cymA

0.37

0.34

0.90

2.48

MUSTER

------------------EPKLLAEPREGVPNVIDTLPAFRDYCSELASSHGSLAADAERASGFRYGHEDWLVQFKRDGAGIGLLDPQALA-AAGADWNDFNRAVGDAVWILHDSLQDLPGFDELGMEPQRLFDTEIAARLLGLKRFGLAAVTEHFLGLTLAKEHSAADWSYRPLPRDWRNYAALDVELLIELETKMRAELKRQGKMEWAQEEFDYALKEGLGPRKEHLI--PWMHVSHITEVMDRQALAIVRALWTRRDELAREYDIAPTLLLSDSSIIEVAKRKPHNAAQFRSIRSINPIQRKIKPSMWKNIIQDALALPPSEWPDSA---PKSIRVWKERYPERLQVLNRVRKAVSQIAEDTRTPVEIVIKPQYLRNLCWTDEPRKRD-------VARFLSEQGARDWQVSLVAESVSRAIEG------------

3cymA

0.37

0.33

0.90

2.71

dPPAS

------------------EPKLLAEPREGVPNVIDTLPAFRDYCSELASSHGSLAADAERASGFRYGHEDWLVQFKRDGAGIGLLDPQALA-AAGADWNDFNRAVGDAVWILHDSLQDLPGFDELGMEPQRLFDTEIAARLLGLKRFGLAAVTEHFLGLTLAKEHSAADWSYRPLPRDWRNYAALDVELLIELETKMRAELKRQGKMEWAQEEFDYALKEGLGPRKEHLI--PWMHVSHITEMRDRQALAIVRALWTRRDELAREYDIAPTLLLSDSSIIEVAKRKPHNAAQFRSIRSINPIQRKIKPSMWKNIIQDALALPPSEWPD---SAPKSIRVWKERYPERLQVLNRVRKAVSQIAEDTRTPVEIVIKPQYLRNLCWTDEPRKRD-------VARFLSEQGARDWQVSLVAESVSRAIEG------------

3cymA

0.37

0.33

0.90

4.20

wdPPAS

------------------EPKLLAEPREGVPNVIDTLPAFRDYCSELASSHGSLAADAERASGFRYGHEDWLVQFKRDGAGIGLLDPQALA-AAGADWNDFNRAVGDAVWILHDSLQDLPGFDELGMEPQRLFDTEIAARLLGLKRFGLAAVTEHFLGLTLAKEHSAADWSYRPLPRDWRNYAALDVELLIELETKMRAELKRQGKMEWAQEEFDYALKEGLGPRKEHL--IPWMHVSHITEVMDRQALAIVRALWTRRDELAREYDIAPTLLLSDSSIIEVAKRKPHNAAQFRSIRSINPIQRKIKPSMWKNIIQDALALPPSEWPDSAP---KSIRVWKERYPERLQVLNRVRKAVSQIAEDTRTPVEIVIKPQYLRNLCWTDEPR-------KRDVARFLSEQGARDWQVSLVAESVSRAIEG------------

3cymA

0.37

0.33

0.90

3.40

wMUSTER

-------------------PKLLAEPREGVPNVIDTLPAFRDYCSELASSHGSLAADAERASGFRYGHEDWLVQFKRDGAGIGLLDPQALA-AAGADWNDFNRAVGDAVWILHDSLQDLPGFDELGMEPQRLFDTEIAARLLGLKRFGLAAVTEHFLGLTLAKEHSAADWSYRPLPRDWRNYAALDVELLIELETKMRAELKRQGKMEWAQEEFDYALKEGLGPRKEHLI--PWMHVSHITEVMDRQALAIVRALWTRRDELAREYDIAPTLLLSDSSIIEVAKRKPHNAAQFRSIRSINPIQRKIKPSMWKNIIQDALALPPSEWPDSA---PKSIRVWKERYPERLQVLNRVRKAVSQIAEDTRTPVEIVIKPQYLRNLCWTDEPRKRD-------VARFLSEQGARDWQVSLVAESVSRAIEG------------

3cymA

0.37

0.33

0.90

5.09

wPPAS

------------------EPKLLAEPREGVPNVIDTLPAFRDYCSELASSHGSLAADAERASGFRYGHEDWLVQFKRDGAGIGLLDPQALA-AAGADWNDFNRAVGDAVWILHDSLQDLPGFDELGMEPQRLFDTEIAARLLGLKRFGLAAVTEHFLGLTLAKEHSAADWSYRPLPRDWRNYAALDVELLIELETKMRAELKRQGKMEWAQEEFDYALKEGLGPRKEHLI--PWMHVSHITEVRDRQALAIVRALWTRRDELAREYDIAPTLLLSDSSIIEVAKRKPHNAAQFRSIRSINPIQRKIKPSMWKNIIQDALALPPSEWPDSA---PKSIRVWKERYPERLQVLNRVRKAVSQIAEDTRTPVEIVIKPQYLRNLCWTD-------EPRKRDVARFLSEQGARDWQVSLVAESVSRAIEG------------

3cymA

0.37

0.33

0.90

5.24

dPPAS2

------------------EPKLLAEPREGVPNVIDTLPAFRDYCSELASSHGSLAADAERASGFRYGHEDWLVQFKRDGAGIGLLDPQALA-AAGADWNDFNRAVGDAVWILHDSLQDLPGFDELGMEPQRLFDTEIAARLLGLKRFGLAAVTEHFLGLTLAKEHSAADWSYRPLPRDWRNYAALDVELLIELETKMRAELKRQGKMEWAQEEFDYALKEGLGPRKEHLI--PWMHVSHITEMRDRQALAIVRALWTRRDELAREYDIAPTLLLSDSSIIEVAKRKPHNAAQFRSIRSINPIQRKIKPSMWKNIIQDALALPPSEWPD---SAPKSIRVWKERYPERLQVLNRVRKAVSQIAEDTRTPVEIVIKPQYLRNLCWTDEPRKRD-------VARFLSEQGARDWQVSLVAESVSRAIEG------------

3cymA

0.37

0.33

0.90

4.21

PPAS

------------------EPKLLAEPREGVPNVIDTLPAFRDYCSELASSHGSLAADAERASGFRYGHEDWLVQFKRDGAGIGLLDPQALA-AAGADWNDFNRAVGDAVWILHDSLQDLPGFDELGMEPQRLFDTEIAARLLGLKRFGLAAVTEHFLGLTLAKEHSAADWSYRPLPRDWRNYAALDVELLIELETKMRAELKRQGKMEWAQEEFDYALKEGLGPRKEHLI--PWMHVSHITEMRDRQALAIVRALWTRRDELAREYDIAPTLLLSDSSIIEVAKRKPHNAAQFRSIRSINPIQRKIKPSMWKNIIQDALALPPSEWPDSA---PKSIRVWKERYPERLQVLNRVRKAVSQIAEDTRTPVEIVIKPQYLRNLCWTDEPRKRD-------VARFLSEQGARDWQVSLVAESVSRAIEG------------

3cymA

0.37

0.33

0.90

6.30

Env-PPAS

------------------EPKLLAEPREGVPNVIDTLPAFRDYCSELASSHGSLAADAERASGFRYGHEDWLVQFKRDGAGIGLLDPQALA-AAGADWNDFNRAVGDAVWILHDSLQDLPGFDELGMEPQRLFDTEIAARLLGLKRFGLAAVTEHFLGLTLAKEHSAADWSYRPLPRDWRNYAALDVELLIELETKMRAELKRQGKMEWAQEEFDYALKEGLGPRKEHLI--PWMHVSHITEMRDRQALAIVRALWTRRDELAREYDIAPTLLLSDSSIIEVAKRKPHNAAQFRSIRSINPIQRKIKPSMWKNIIQDALALPPSEWPDSA---PKSIRVWKERYPERLQVLNRVRKAVSQIAEDTRTPVEIVIKPQYLRNLCWTDEPRKRD-------VARFLSEQGARDWQVSLVAESVSRAIEG------------

1yt3A

0.24

0.20

0.85

2.41

MUSTER

----------------------------MNYQMITTDDALASLCEAVRA-FPAIALDTEFVRTRTYYPQLGLIQLFDGEH-LALIDPLGITD--WSPLKAILRD-PSITKFLHAGSEDLEVFLNVFELPQPLIDTQILAAFCGRPMWGFASMVEEYSGVTLDKSESRTDWLARPLTERQCEYAAADVWYLLPITAKLMVETEASGWLPAALDECRLMQMRRQEVVA---PEDAWRDITNAWQL-RTRQLACLQLLADWRLRKARERDLAVNFVVREEHLWSVARYMPGSLGELDSL-GLSGSEIRFHGKTLLALVEKAQTLPE--------DALPQPMLNLMDMPGYRKAFKAIKSLITDVSETHKISAELLASRRQINQLLNWHWKLKPQNNLP----------ELISGWRGELMAEALHNLLQEYPQ---------

1yt3A

0.24

0.21

0.85

2.60

dPPAS

----------------------------MNYQMITTDDALASLCEAVRA-FPAIALDTEFVRTRTYYPQLGLIQLFDGEH-LALIDPLGITD--WSPLKAILRD-PSITKFLHAGSEDLEVFLNVFELPQPLIDTQILAAFCGRPSWGFASMVEEYSGVTLDKSESRTDWLARPLTERQCEYAAADVWYLLPITAKLMVETEASGWLPAALDECRLMQMRRQEVV---APEDAWRDITNAWQL-RTRQLACLQLLADWRLRKARERDLAVNFVVREEHLWSVARYMPGSLGELDSL-GLSGSEIRFHGKTLLALVEKAQTLPE--------DALPQPMLNLMDMPGYRKAFKAIKSLITDVSETHKISAELLASRRQINQLLNWHWKLKPQNNLP----------ELISGWRGELMAEALHNLLQEYPQ---------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.10

Estimated TM-score = 0.70±0.12

Estimated RMSD = 7.2±4.2Å

Download Model 2

C-score=-0.19

Download Model 3

C-score=-2.53

Download Model 4

C-score=0.11

Download Model 5

C-score=-0.30

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3cymA	0.886	1.08	0.372	0.902
2	1yt3A	0.656	4.43	0.199	0.829
3	4nlbA	0.619	3.23	0.201	0.706
4	5c0wK	0.612	3.46	0.170	0.710
5	3safA	0.609	3.33	0.210	0.701
6	2hbkA	0.606	3.58	0.224	0.706
7	2kzzA	0.519	5.38	0.106	0.690
8	5dktA	0.507	5.30	0.109	0.667
9	3ikmD	0.500	6.33	0.077	0.724
10	2hhtA	0.496	5.23	0.083	0.655

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1bgxT	0.445	5.71	0.088	0.612	2.7.7.7	NA
2	0.060	3ikmD	0.500	6.33	0.077	0.724	2.7.7.7	NA
3	0.060	2a1rB	0.335	3.34	0.126	0.384	3.1.13.4	150
4	0.060	2ckjA	0.326	7.31	0.032	0.555	1.17.1.4,1.17.3.2	NA
5	0.060	2a1sC	0.342	3.78	0.127	0.402	3.1.13.4	59
6	0.060	2vdcF	0.395	7.38	0.047	0.678	1.4.1.13	58
7	0.060	2e1qA	0.298	7.45	0.042	0.514	1.17.3.2,1.17.1.4	NA
8	0.060	1yt3A	0.656	4.43	0.199	0.829	3.1.13.5	132,213
9	0.060	2wyhA	0.376	7.27	0.059	0.628	3.2.1.24	165
10	0.060	2g49A	0.276	7.41	0.026	0.473	3.4.24.56	NA
11	0.060	2vdcA	0.398	7.45	0.047	0.687	1.4.1.13	NA
12	0.060	1whvA	0.113	5.05	0.052	0.153	3.1.13.4	128,133,215
13	0.060	1tgoA	0.369	5.18	0.094	0.482	2.7.7.7	NA
14	0.060	2vz8B	0.381	7.46	0.052	0.662	2.3.1.85	113
15	0.060	1gl9B	0.311	7.48	0.059	0.539	5.99.1.3	NA
16	0.060	2qxfA	0.355	4.96	0.065	0.457	3.1.11.1	59
17	0.060	2vz9B	0.316	7.25	0.043	0.523	2.3.1.85	113
18	0.060	2ajqA	0.434	5.58	0.108	0.596	2.7.7.7	NA
19	0.060	3b8eC	0.337	7.83	0.061	0.596	3.6.3.9	135

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.62	0.886	1.08	0.37	0.90	3cymA	GO:0000166 GO:0003676 GO:0003824 GO:0005622 GO:0006139 GO:0008408 GO:0044237 GO:0090305
1	0.55	0.656	4.43	0.20	0.83	1yt3A	GO:0000166 GO:0003676 GO:0003824 GO:0004518 GO:0004527 GO:0004540 GO:0005622 GO:0005737 GO:0006139 GO:0008033 GO:0008408 GO:0016787 GO:0033890 GO:0042780 GO:0044237 GO:0090305 GO:0090501 GO:0090503
2	0.38	0.363	2.74	0.16	0.40	2e6lA	GO:0003676 GO:0005524 GO:0006139 GO:0006310 GO:0008026 GO:0008408 GO:0046872 GO:0090305
3	0.38	0.361	2.90	0.17	0.40	2fbtA	GO:0000166 GO:0000287 GO:0000403 GO:0000405 GO:0000722 GO:0000723 GO:0000731 GO:0000732 GO:0000784 GO:0001302 GO:0003676 GO:0003677 GO:0003678 GO:0003682 GO:0003824 GO:0004003 GO:0004386 GO:0004518 GO:0004527 GO:0005524 GO:0005622 GO:0005634 GO:0005654 GO:0005730 GO:0005737 GO:0005813 GO:0006139 GO:0006259 GO:0006260 GO:0006281 GO:0006284 GO:0006302 GO:0006310 GO:0006974 GO:0006979 GO:0007420 GO:0007568 GO:0007569 GO:0008026 GO:0008152 GO:0008408 GO:0009267 GO:0009378 GO:0010225 GO:0010259 GO:0016787 GO:0016887 GO:0016925 GO:0030145 GO:0031297 GO:0032066 GO:0032389 GO:0032403 GO:0032508 GO:0040009 GO:0042803 GO:0042981 GO:0043005 GO:0043138 GO:0043140 GO:0044237 GO:0046872 GO:0051345 GO:0051880 GO:0071480 GO:0090305 GO:1901796
4	0.33	0.616	3.26	0.20	0.70	3sahB	GO:0000166 GO:0000175 GO:0000176 GO:0000178 GO:0000184 GO:0000460 GO:0000956 GO:0003676 GO:0003723 GO:0003824 GO:0004518 GO:0004527 GO:0004532 GO:0005622 GO:0005634 GO:0005654 GO:0005730 GO:0005737 GO:0006139 GO:0006364 GO:0006396 GO:0008408 GO:0009048 GO:0016020 GO:0016787 GO:0035327 GO:0044237 GO:0044822 GO:0071028 GO:0071034 GO:0071035 GO:0071044 GO:0071048 GO:0090305 GO:0090503
5	0.29	0.619	3.23	0.20	0.71	4nlbA	GO:0000166 GO:0000176 GO:0000177 GO:0003676 GO:0003824 GO:0005622 GO:0005634 GO:0005737 GO:0006139 GO:0006364 GO:0006396 GO:0008408 GO:0016049 GO:0044237 GO:0090305
6	0.25	0.612	3.46	0.17	0.71	5c0wK	GO:0000166 GO:0000175 GO:0000176 GO:0000178 GO:0000467 GO:0000973 GO:0003676 GO:0003723 GO:0003824 GO:0004518 GO:0004527 GO:0005622 GO:0005634 GO:0005730 GO:0006139 GO:0006364 GO:0006396 GO:0008408 GO:0016787 GO:0034473 GO:0034475 GO:0034476 GO:0044237 GO:0071033 GO:0071035 GO:0071036 GO:0071037 GO:0071038 GO:0071039 GO:0071040 GO:0071042 GO:0071044 GO:0071049 GO:0071051
7	0.16	0.442	3.21	0.17	0.50	5c0xK	GO:0000166 GO:0000175 GO:0000176 GO:0000178 GO:0000467 GO:0000973 GO:0003676 GO:0003723 GO:0003824 GO:0004518 GO:0004527 GO:0005622 GO:0005634 GO:0005730 GO:0006139 GO:0006364 GO:0006396 GO:0008408 GO:0016787 GO:0034473 GO:0034475 GO:0034476 GO:0044237 GO:0071033 GO:0071035 GO:0071036 GO:0071037 GO:0071038 GO:0071039 GO:0071040 GO:0071042 GO:0071044 GO:0071049 GO:0071051
8	0.06	0.244	6.64	0.03	0.38	3orgA
9	0.06	0.259	6.83	0.06	0.41	3utnX	GO:0002098 GO:0002143 GO:0004792 GO:0005737 GO:0005739 GO:0016740
10	0.06	0.258	6.96	0.04	0.42	4o33A	GO:0000166 GO:0004618 GO:0005524 GO:0005737 GO:0005829 GO:0006094 GO:0006096 GO:0016020 GO:0016301 GO:0016310 GO:0016740 GO:0030855 GO:0045121 GO:0061621 GO:0070062
11	0.06	0.241	5.92	0.07	0.36	3wozB	GO:0000226 GO:0000775 GO:0000776 GO:0000777 GO:0000922 GO:0002162 GO:0005694 GO:0005737 GO:0005794 GO:0005802 GO:0005815 GO:0005819 GO:0005856 GO:0005874 GO:0005881 GO:0005886 GO:0005925 GO:0005938 GO:0006903 GO:0007020 GO:0007026 GO:0007030 GO:0007049 GO:0007052 GO:0007067 GO:0007163 GO:0008017 GO:0010458 GO:0010470 GO:0010634 GO:0010717 GO:0016020 GO:0016477 GO:0030516 GO:0031023 GO:0031110 GO:0031113 GO:0031252 GO:0032587 GO:0032886 GO:0032956 GO:0034453 GO:0035791 GO:0042995 GO:0044295 GO:0045180 GO:0045921 GO:0051010 GO:0051015 GO:0051301 GO:0051321 GO:0051497 GO:0051895 GO:0072686 GO:0090002 GO:0090091 GO:1903690 GO:1903754 GO:1904261 GO:1990782
12	0.06	0.224	7.13	0.07	0.37	4wbtA	GO:0003824 GO:0004400 GO:0008152 GO:0008483 GO:0009058 GO:0016740 GO:0030170 GO:0080130
13	0.06	0.217	6.73	0.05	0.35	3iqeA	GO:0006730 GO:0008901 GO:0015948 GO:0016491 GO:0019386 GO:0030268 GO:0055114
14	0.06	0.210	3.39	0.18	0.24	2cprA	GO:0000166 GO:0000175 GO:0000176 GO:0000178 GO:0000184 GO:0000460 GO:0000956 GO:0003676 GO:0003723 GO:0003824 GO:0004518 GO:0004527 GO:0004532 GO:0005622 GO:0005634 GO:0005654 GO:0005730 GO:0005737 GO:0006139 GO:0006364 GO:0006396 GO:0008408 GO:0009048 GO:0016020 GO:0016787 GO:0035327 GO:0044237 GO:0044822 GO:0071028 GO:0071034 GO:0071035 GO:0071044 GO:0071048 GO:0090305 GO:0090503
15	0.06	0.207	6.43	0.06	0.33	2w3zA	GO:0003824 GO:0005975 GO:0016810 GO:0046872
16	0.06	0.201	5.90	0.07	0.29	1y44A	GO:0004518 GO:0004519 GO:0008033 GO:0008270 GO:0016787 GO:0016891 GO:0034414 GO:0042779 GO:0042781 GO:0046872 GO:0090502
17	0.06	0.194	6.96	0.02	0.32	1m3jA	GO:0005576 GO:0008289 GO:0009405 GO:0015485 GO:0016020 GO:0016021 GO:0019835 GO:0020002 GO:0033644 GO:0044179
18	0.06	0.202	6.92	0.04	0.32	2fk6A	GO:0004518 GO:0004519 GO:0008033 GO:0008270 GO:0016787 GO:0016891 GO:0034414 GO:0042779 GO:0042781 GO:0046872 GO:0090502

Consensus prediction of GO terms

Molecular Function	GO:0005524	GO:0033890	GO:0043140	GO:0032403	GO:0000403	GO:0051880	GO:0000405	GO:0003682	GO:0042803	GO:0030145	GO:0009378	GO:0000287	GO:0000175	GO:0044822
GO-Score	0.62	0.55	0.38	0.38	0.38	0.38	0.38	0.38	0.38	0.38	0.38	0.38	0.34	0.34
Biological Processes	GO:0090503	GO:0042780	GO:0006284	GO:0032508	GO:0071480	GO:0016925	GO:0001302	GO:0000732	GO:0040009	GO:0042981	GO:0032066	GO:0000731	GO:0006979	GO:0007420	GO:0006302	GO:0031297	GO:0010225	GO:0000722	GO:1901796	GO:0010259	GO:0009267	GO:0051345	GO:0000460	GO:0000184	GO:0071048	GO:0071044	GO:0071035	GO:0009048	GO:0071034
GO-Score	0.70	0.55	0.38	0.38	0.38	0.38	0.38	0.38	0.38	0.38	0.38	0.38	0.38	0.38	0.38	0.38	0.38	0.38	0.38	0.38	0.38	0.38	0.34	0.34	0.34	0.34	0.34	0.34	0.34
Cellular Component	GO:0005737	GO:0005654	GO:0005730	GO:0005813	GO:0032389	GO:0000784	GO:0043005	GO:0000176	GO:0016020	GO:0035327
GO-Score	0.81	0.59	0.59	0.38	0.38	0.38	0.38	0.34	0.34	0.34

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.