I-TASSER results

I-TASSER results for job id Rv2629

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (374 residues)
MRSERLRWLVAAEGPFASVYFDDSHDTLDAVERREATWRDVRKHLESRDAKQELIDSLEE
AVRDSRPAVGQRGRALIATGEQVLVNEHLIGPPPATVIRLSDYPYVVPLIDLEMRRPTYV
FAAVDHTGADVKLYQGATISSTKIDGVGYPVHKPVTAGWNGYGDFQHTTEEAIRMNCRAV
ADHLTRLVDAADPEVVFVSGEVRSRTDLLSTLPQRVAVRVSQLHAGPRKSALDEEEIWDL
TSAEFTRRRYAEITNVAQQFEAEIGRGSGLAAQGLAEVCAALRDGDVDTLIVGELGEATV
VTGKARTTVARDADMLSELGEPVDRVARADEALPFAAIAVGAALVRDDNRIAPLDGVGAL
LRYAATNRLGSHRS

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRSERLRWLVAAEGPFASVYFDDSHDTLDAVERREATWRDVRKHLESRDAKQELIDSLEEAVRDSRPAVGQRGRALIATGEQVLVNEHLIGPPPATVIRLSDYPYVVPLIDLEMRRPTYVFAAVDHTGADVKLYQGATISSTKIDGVGYPVHKPVTAGWNGYGDFQHTTEEAIRMNCRAVADHLTRLVDAADPEVVFVSGEVRSRTDLLSTLPQRVAVRVSQLHAGPRKSALDEEEIWDLTSAEFTRRRYAEITNVAQQFEAEIGRGSGLAAQGLAEVCAALRDGDVDTLIVGELGEATVVTGKARTTVARDADMLSELGEPVDRVARADEALPFAAIAVGAALVRDDNRIAPLDGVGALLRYAATNRLGSHRS
Prediction	CCHHHHHHHHCCCCCEEEEEHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCEEEEEHCCCCEEEEEEHCCCCCCCEEEHCCCCCHHHHHHHHCCCCCEEEEEEHCCCEEEEEEHCCEEEEEEEHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHCCHHHHHHHHHHCCHHHHHHHEEHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEHCCHHHHHHHHHHCCCCEEEEHCCCCCEEEHCCCCCEHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCEEEHCCCCCCCCCCEEEEEHCCCCCCCCCCCC
Conf.Score	97899998766899789999779998757899999999999999998698899999999999856777888858999949956899975689987589986886589999997688988999998895799999788478999975887666678888654555889999999999999999999999976998899968989999999985889998754435788888889999999999999999999999999999999866899677589999999998887689885788875898699764557876766647876555458999999999859789987876455798799986689988865679
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRSERLRWLVAAEGPFASVYFDDSHDTLDAVERREATWRDVRKHLESRDAKQELIDSLEEAVRDSRPAVGQRGRALIATGEQVLVNEHLIGPPPATVIRLSDYPYVVPLIDLEMRRPTYVFAAVDHTGADVKLYQGATISSTKIDGVGYPVHKPVTAGWNGYGDFQHTTEEAIRMNCRAVADHLTRLVDAADPEVVFVSGEVRSRTDLLSTLPQRVAVRVSQLHAGPRKSALDEEEIWDLTSAEFTRRRYAEITNVAQQFEAEIGRGSGLAAQGLAEVCAALRDGDVDTLIVGELGEATVVTGKARTTVARDADMLSELGEPVDRVARADEALPFAAIAVGAALVRDDNRIAPLDGVGALLRYAATNRLGSHRS
Prediction	55263035017360000000011435465235413320440164057551466015303510462654424200000004531103321252244330211410102000401564220000000244030111444424335343562414244533352343133212510450044005202500663704100000346015302730374026202413413344424353025203510552434414510440263245751100200520150044220210002352623110054233124447305624554554340221012102416040123675344220000000023653336658
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCHHHHHHHHCCCCCEEEEEHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCEEEEEHCCCCEEEEEEHCCCCCCCEEEHCCCCCHHHHHHHHCCCCCEEEEEEHCCCEEEEEEHCCEEEEEEEHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHCCHHHHHHHHHHCCHHHHHHHEEHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEHCCHHHHHHHHHHCCCCEEEEHCCCCCEEEHCCCCCEHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCEEEHCCCCCCCCCCEEEEEHCCCCCCCCCCCC
MRSERLRWLVAAEGPFASVYFDDSHDTLDAVERREATWRDVRKHLESRDAKQELIDSLEEAVRDSRPAVGQRGRALIATGEQVLVNEHLIGPPPATVIRLSDYPYVVPLIDLEMRRPTYVFAAVDHTGADVKLYQGATISSTKIDGVGYPVHKPVTAGWNGYGDFQHTTEEAIRMNCRAVADHLTRLVDAADPEVVFVSGEVRSRTDLLSTLPQRVAVRVSQLHAGPRKSALDEEEIWDLTSAEFTRRRYAEITNVAQQFEAEIGRGSGLAAQGLAEVCAALRDGDVDTLIVGELGEATVVTGKARTTVARDADMLSELGEPVDRVARADEALPFAAIAVGAALVRDDNRIAPLDGVGALLRYAATNRLGSHRS

4af1A

0.18

0.97

1.97

MUSTER

VPIEELKDYEGSGTQLVTIYIPPDKQISDVVAHVTQEHSEASNSKQTRTNVQDALTSIKDRLRYYDTFPPDNGMVVFSGGGGTEVLESPPQPIESFRYHCDSAFLTEPLAEMLGDKGLYGLIVLDRRESNVGWLKGKRVQPVKSAESLVP--GKQRKGGQSAQRFARLRLEAIDNFYQEVAGMADDLFVPKEIDGILVGGPSPTKDEFLDYLHHELQDKVLGKFDVSYTDESGLSDLVDAGQAALAEADLMDDKSDMEEFFEELNGG-KLATYGFEQTRRNLIMGSVDRLLVSEDLREDVVIYECPNTIDRRNTTCSDCGEEATEVEDAIDHLMSIADQRGTETHFISTDLTAFGGYAGILRYSTGV-------

4af1A

0.17

0.16

0.97

2.62

dPPAS

KVIEELKDYEGSGTQLVTIYIPPDKQISDVVAHVTQEHSEASKSKQTRTNVQDALTSIKDRLRYYDTFPPDNGMVVFSGGGRTDMVTEVLQPIESFRYHCDSAFLTEPLAEMLGDKGLYGLIVLDRRESNVGWLKGKRVQPVKSAESLVPG--KQRKGGQSAQRFARLRLEAIDNFYQEVAGMADDLFVRHEIDGILVGGPSPTKDEFLDYLHHELQDKVLGKFDVSYTDESGLSDLVDAGQAALAEADLMDDKSDMEEFFEELNGG-KLATYGFEQTRRNLIMGSVDRLLVSEDLREDVVIYPNDHEEYETIDRRNTSPEHTCSDCDAIDHLMSIADQRGTETHFISTDFEKFGGYAGILRYSTGV-------

4af1A

0.17

0.97

3.58

wdPPAS

VPIEELKDYEGSGTQLVTIYIPPDKQISDVVAHVTQEHSEASNSKQTRTNVQDALTSIKDRLRYYDTFPPDNGMVVFSGGGGTEVLESPPQPIESFRYHCDSAFLTEPLAEMLGDKGLYGLIVLDRRESNVGWLKGKRVQPVKSAESLVP--GKQRKGGQSAQRFARLRLEAIDNFYQEVAGMADDLFVRHEIDGILVGGPSPTKDEFLDGLHHELQDKVLGKFDVSYTDESGLSDLVDAGQAALAEADLMDDKSDMEEFFEELNGG-KLATYGFEQTRRNLIMGSVDRLLVSEDLREDVVIYECPNRNTSPEHTCSDCGEEATDREDAIDHLMSIADQRGTETHFISTDLTAFGGYAGILRYSTGV-------

4af1A

0.18

0.97

2.38

wMUSTER

FRIEELKDYEGSGTQLVTIYIPPDKQISDVVAHVTQEHSEASNSKQTRTNVQDALTSIKDRLRYYDTFPPDNGMVVFSGGGGTEVLESPPQPIESFRYHCDSAFLTEPLAEMLGDKGLYGLIVLDRRESNVGWLKGKRVQPVKSAESLVP--GKQRKGGQSAQRFARLRLEAIDNFYQEVAGMADDLFVRHEIDGILVGGPSPTKDEFLDYLHHELQDKVLGKFDVSYTDESGLSDLVDAGQAALAEADLMDDKSDMEEFFEELNGG-KLATYGFEQTRRNLIMGSVDRLLVSEDLREDVVIYECPNTIDRRNTSCSDCGEEEVDREDAIDHLMSIADQRGTETHFISTDLTAFGGYAGILRYSTGV-------

4af1A

0.17

0.16

0.97

3.77

wPPAS

VPIEELKDYEGSGTQLVTIYIPPDKQISDVVAHVTQEHSEASN-IKSKQTRTNVQDALTSIKDRYDTFPPDNGMVVFSGSGGTEVLESPPQPIESFRYHCDSAFLTEPLAEMLGDKGLYGLIVLDRRESNVGWLKGKRVQPVKSAESLVP--GKQRKGGQSAQRFARLRLEAIDNFYQEVAGMADDLFVRHEIDGILVGGPSPTKDEFLDYLHHELQDKVLGKFDVSYTDESGLSDLVDAGQAALAEADLMDDKSDMEEFFEELNGG-KLATYGFEQTRRNLIMGSVDRLLVSEDLREDVVIYECPNDHESPEHTCSDCGEEATDREDAIDHLMSIADQRGTETHFISTDLTAFGGYAGILRYSTGV-------

4af1A

0.17

0.16

0.97

6.72

dPPAS2

VPIEELKDYEGSGTQLVTIYIPPDKQISDVVAHVTQEHSEASKSKQTRTNVQDALTSIKDRLRYYDTFPPDNGMVVFSGGGRTDMVTEVLQPIESFRYHCDSAFLTEPLAEMLGDKGLYGLIVLDRRESNVGWLKGKRVQPVKSAESLVPG--KQRKGGQSAQRFARLRLEAIDNFYQEVAGMADDLFVRHEIDGILVGGPSPTKDEFLDYLHHELQDKVLGKFDVSYTDESGLSDLVDAGQAALAEADLMDDKSDMEEFFEELNGG-KLATYGFEQTRRNLIMGSVDRLLVSEDLREDVVIYPNDHEEYETIDRRNTSPEHTCSDCDAIDHLMSIADQRGTETHFISTDFEKFGGYAGILRYSTGV-------

4af1A

0.17

0.97

3.27

PPAS

VPIEELKDYEGSGTQLVTIYIPPDKQISDVVAHVTQEHSEASNSKQTRTNVQDALTSIKDRLRYYDTFPPDNGMVVFSGGGRTEVLESPPQPIESFRYHCDSAFLTEPLAEMLGDKGLYGLIVLDRRESNVGWLKGKRVQPVKSAESLVP--GKQRKGGQSAQRFARLRLEAIDNFYQEVAGMADDLFVRHEIDGILVGGPSPTKDEFLDYLHHELQDKVLGKFDVSYTDESGLSDLVDAGQAALAEADLMDDKSDMEEFFEELNGG-KLATYGFEQTRRNLIMGSVDRLLVSEDLREDVVIYECPNDHESPEHTCSDCGEEATDREDAIDHLMSIADQRGTETHFISTDFEKFGGYAGILRYSTGV-------

1dt9A

0.16

0.15

0.97

4.72

Env-PPAS

L-IKSLEAARGNGTSMISLIIPPKDQISRVAKMLADEFGTASNIKSRV-NRLSVLGAITSVQQRLYNKVPPNGLVVYCGEKKVNIDFEPFKPINTSLYLCDNKFHTEALTALLSDDSKFGFIVIDGSGALFGTLQGNTREVLHKFTVDLP--KKHGRGGQSALRFARLRMEKRHNYVRKVAETAVQLFDKVNVAGLVLAGSADFKTELSDMFDQRLQSKVLKLVDISYGGENGFNQAIELSTEVLSNVKFIQEKKLIGRYFDEISQDTGKYCFGVEDTLKALEMGAVEILIVYENLDIMRYVLILYLTPEQEK-----DKSHFTESMPLLEWFANNYKKFGATLEIVTDKSQEFGGIGGILRYRVDFQGM----

1dt9A

0.15

0.97

1.79

MUSTER

L-IKSLEAARGNGTSMISLIIPPKDQISRVAKMLADEFGTASNIKSRV-NRLSVLGAITSVQQRLYNKVPPNGLVVYCGEGKVNIDFEPFKPINTSLYLCDNKFHTEALTALLSDDSKFGFIVIDGSGALFGTLQGNTREVLHKFTVDLP--KKHGRGGQSALRFARLRMEKRHNYVRKVAETAVQLFDKVNVAGLVLAGSADFKTELSQMFDQRLQSKVLKLVDISYGGENGFNQAIELSTEVLSNVKFIQEKKLIGRYFDEISQDTGKYCFGVEDTLKALEMGAVEILIVYENLDIMRYVLIL--YLTPEQE---KDKSHFTESMPLLEWFANNYKKFGATLEIVTDKSQEFGGIGGILRYRVD---FQGM-

1dt9A

0.15

0.97

2.31

dPPAS

KLIKSLEAARGNGTSMISLIIPPKDQISRVAKMLADEFGTASNIKSRV-NRLSVLGAITSVQQRLYNKVPPNGLVVYCGEGKEKKVNIDFEPFNTSLYLCDNKFHTEALTALLSDDSKFGFIVIDGSGALFGTLQGNTREVLHKFTVDLP--KKHGRGGQSALRFARLRMEKRHNYVRKVAETAVQLFDKVNVAGLVLAGSADFKTELSDMFDQRLQSKVLKLVDISYGGENGFNQAIELSTEVLSNVKFIQEKKLIGRYFDEISQDTGKYCFGVEDTLKALEMGAVEILIVYENLDIMRYVLILYLTPEQE-----KDKSHFTESMPLLEWFANNYKKFGATLEIVTDKSQEFGGIGGILRYRVDFQGM----

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.81

Estimated TM-score = 0.82±0.08

Estimated RMSD = 5.0±3.2Å

Download Model 2

C-score=-1.44

Download Model 3

C-score=-2.34

Download Model 4

C-score=-2.18

Download Model 5

C-score=-4.71

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4af1A	0.930	1.61	0.162	0.973
2	1dt9A	0.644	5.08	0.109	0.896
3	3j15A	0.547	4.79	0.137	0.730
4	2vgnA	0.534	4.37	0.082	0.679
5	3e20C	0.532	2.91	0.153	0.604
6	4crnX	0.532	4.32	0.109	0.682
7	3obyA	0.447	5.41	0.121	0.636
8	3agkA	0.428	5.75	0.153	0.636
9	1mhsA	0.411	7.01	0.047	0.701
10	1ej6A	0.405	6.95	0.068	0.682

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.13	7	3tr8A	MN	Rep, Mult	123,124,125,233
2	0.09	5	2ckjC	FES	Rep, Mult	340,341,343,361,362
3	0.07	4	2ckjD	FES	Rep, Mult	264,265,267,269,270,271,273
4	0.04	2	5b34A	4QL	Rep, Mult	173,176,180
5	0.04	2	3n4qA	MN	Rep, Mult	125,126,201
6	0.02	1	1v97A	CA	Rep, Mult	199,204,205,207,209
7	0.02	1	3uomA	CA	Rep, Mult	235,239
8	0.02	1	1q9xC	CA	Rep, Mult	125,288
9	0.02	1	2rb1X	261	Rep, Mult	362,363
10	0.02	1	3e1yA	ATP	Rep, Mult	91,94
11	0.02	1	1rkuB	MG	Rep, Mult	200,348
12	0.02	1	3rj8A	ZN	Rep, Mult	60,64

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3b9jI	0.151	5.92	0.056	0.233	1.17.1.4,1.17.3.2	NA
2	0.060	2hc8A	0.135	4.99	0.078	0.184	3.6.3.-	288,291
3	0.060	3b9jJ	0.211	6.59	0.055	0.342	1.17.1.4,1.17.3.2	124,202
4	0.060	1nj1A	0.366	6.70	0.037	0.602	6.1.1.15	NA
5	0.060	1e1yA	0.305	6.91	0.049	0.497	2.4.1.1	132
6	0.060	1ej6A	0.405	6.95	0.068	0.682	2.7.7.50	NA
7	0.060	3b9jC	0.348	7.29	0.033	0.615	1.17.3.2,1.17.1.4	244
8	0.060	2wghB	0.356	6.91	0.057	0.612	1.17.4.1	NA
9	0.060	1vlbA	0.364	6.66	0.057	0.602	1.2.99.7	332,357
10	0.060	1ofdA	0.333	7.07	0.040	0.572	1.4.7.1	NA
11	0.060	3l2pA	0.373	6.81	0.078	0.620	6.5.1.1	NA
12	0.060	1z7eD	0.358	6.82	0.053	0.607	2.1.2.-,1.1.1.-	289
13	0.060	1fo4A	0.370	7.04	0.052	0.631	1.17.1.4	NA
14	0.060	1nj8D	0.373	6.72	0.051	0.610	6.1.1.15	NA
15	0.060	3ebgA	0.370	6.69	0.062	0.610	3.4.11.-	NA
16	0.060	1mhsA	0.411	7.01	0.047	0.701	3.6.3.6	NA
17	0.060	3eifA	0.362	7.11	0.070	0.634	3.4.21.110	NA
18	0.060	2ckjA	0.362	6.88	0.054	0.596	1.17.1.4,1.17.3.2	NA
19	0.060	3b8cA	0.400	6.53	0.053	0.660	3.6.3.6	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.36	0.930	1.61	0.16	0.97	4af1A	GO:0005737 GO:0006412 GO:0006415 GO:0016149
1	0.24	0.710	4.90	0.11	0.97	4d5nA	GO:0000184 GO:0003723 GO:0003747 GO:0005634 GO:0005737 GO:0005829 GO:0006412 GO:0006415 GO:0006449 GO:0006479 GO:0008079 GO:0016149 GO:0043022 GO:0044822
2	0.13	0.539	5.10	0.13	0.75	3e1yC	GO:0000184 GO:0003723 GO:0003747 GO:0005634 GO:0005737 GO:0005829 GO:0006412 GO:0006415 GO:0006449 GO:0006479 GO:0008079 GO:0016149 GO:0043022 GO:0044822
3	0.11	0.347	3.31	0.17	0.41	3e20H	GO:0002184 GO:0005634 GO:0005737 GO:0005829 GO:0006412 GO:0006415 GO:0016149 GO:0018444
4	0.10	0.532	4.32	0.11	0.68	4crnX	GO:0003747 GO:0005737 GO:0005829 GO:0006353 GO:0006412 GO:0006415 GO:0010494 GO:0016149 GO:0018444
5	0.10	0.532	2.92	0.15	0.60	3e20B	GO:0002184 GO:0005634 GO:0005737 GO:0005829 GO:0006412 GO:0006415 GO:0016149 GO:0018444
6	0.08	0.644	5.08	0.11	0.90	1dt9A	GO:0000184 GO:0003723 GO:0003747 GO:0005634 GO:0005737 GO:0005829 GO:0006412 GO:0006415 GO:0006449 GO:0006479 GO:0008079 GO:0016149 GO:0043022 GO:0044822
7	0.07	0.386	4.82	0.08	0.51	3wxmB	GO:0004518 GO:0004519 GO:0005737 GO:0016787 GO:0046872 GO:0070481 GO:0070966 GO:0071025 GO:0090305
8	0.06	0.399	4.54	0.06	0.52	3obwA	GO:0004518 GO:0004519 GO:0005737 GO:0016787 GO:0046872 GO:0070481 GO:0070966 GO:0071025 GO:0090305
9	0.06	0.385	5.94	0.11	0.55	3vmfB	GO:0005737 GO:0006412 GO:0006415 GO:0016149
10	0.06	0.373	4.74	0.04	0.49	3mcaB	GO:0000294 GO:0004518 GO:0004519 GO:0005634 GO:0005737 GO:0005829 GO:0007049 GO:0007067 GO:0016787 GO:0032790 GO:0046872 GO:0051301 GO:0051321 GO:0070317 GO:0070481 GO:0070966 GO:0071025 GO:0090305
11	0.06	0.359	4.58	0.08	0.47	2qi2A	GO:0004518 GO:0004519 GO:0005737 GO:0016787 GO:0046872 GO:0070481 GO:0070966 GO:0071025 GO:0090305
12	0.06	0.290	6.90	0.04	0.49	1ks8A	GO:0000272 GO:0003824 GO:0004553 GO:0005975 GO:0008152 GO:0008810 GO:0016787 GO:0016798 GO:0030245 GO:0046872
13	0.06	0.297	3.10	0.20	0.34	3ir9A	GO:0005737 GO:0006412 GO:0006415 GO:0016149
14	0.06	0.243	7.15	0.03	0.42	3kowB	GO:0003824 GO:0008152 GO:0016853 GO:0031419 GO:0046872 GO:0046983 GO:0047831
15	0.06	0.239	7.28	0.02	0.41	1hm8A	GO:0000287 GO:0000902 GO:0003824 GO:0003977 GO:0005737 GO:0006048 GO:0008152 GO:0008360 GO:0009058 GO:0009103 GO:0009245 GO:0009252 GO:0016740 GO:0016746 GO:0016779 GO:0019134 GO:0046872 GO:0071555
16	0.06	0.202	7.20	0.03	0.36	4knsA	GO:0005507 GO:0006807 GO:0046872 GO:0050421 GO:0055114
17	0.06	0.220	5.86	0.08	0.33	4ohqB	GO:0003824 GO:0004807 GO:0005739 GO:0005829 GO:0006094 GO:0006096 GO:0006642 GO:0008152 GO:0009507 GO:0009536 GO:0009570 GO:0009579 GO:0009658 GO:0009941 GO:0016853 GO:0019253 GO:0019563 GO:0032504 GO:0046166 GO:0048046 GO:0080022
18	0.06	0.208	6.73	0.05	0.34	3t7vA	GO:0003824 GO:0008652 GO:0016765 GO:0016853 GO:0016866 GO:0046872 GO:0051188 GO:0051536 GO:0051539 GO:0071524

Consensus prediction of GO terms

Molecular Function	GO:0016149	GO:0044822	GO:0043022
GO-Score	0.66	0.34	0.34
Biological Processes	GO:0006449	GO:0000184	GO:0006479
GO-Score	0.34	0.34	0.34
Cellular Component	GO:0005829	GO:0005634	GO:0043234
GO-Score	0.47	0.41	0.40

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.