I-TASSER results

I-TASSER results for job id Rv2613c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (195 residues)
MSDEDRTDRATEDHTIFDRGVGQRDQLQRLWTPYRMNYLAEAPVKRDPNSSASPAQPFTE
IPQLSDEEGLVVARGKLVYAVLNLYPYNPGHLMVVPYRRVSELEDLTDLESAELMAFTQK
AIRVIKNVSRPHGFNVGLNLGTSAGGSLAEHLHVHVVPRWGGDANFITIIGGSKVIPQLL
RDTRRLLATEWARQP

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 \| \| \| \| \| \| \| \| \| MSDEDRTDRATEDHTIFDRGVGQRDQLQRLWTPYRMNYLAEAPVKRDPNSSASPAQPFTEIPQLSDEEGLVVARGKLVYAVLNLYPYNPGHLMVVPYRRVSELEDLTDLESAELMAFTQKAIRVIKNVSRPHGFNVGLNLGTSAGGSLAEHLHVHVVPRWGGDANFITIIGGSKVIPQLLRDTRRLLATEWARQP
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHCHHCCCCCCEEEEHCCCEEEEHCCCCCCCCEEEEHCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHCCCCCCCCCCCCEEEEEHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
Conf.Score	998888888888875445689988865444667899988667888888888899996555455699886589877979999868989998689985767888655999999999999999999999997999589998588555887578569999679999888787778866798999999999999999789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 \| \| \| \| \| \| \| \| \| MSDEDRTDRATEDHTIFDRGVGQRDQLQRLWTPYRMNYLAEAPVKRDPNSSASPAQPFTEIPQLSDEEGLVVARGKLVYAVLNLYPYNPGHLMVVPYRRVSELEDLTDLESAELMAFTQKAIRVIKNVSRPHGFNVGLNLGTSAGGSLAEHLHVHVVPRWGGDANFITIIGGSKVIPQLLRDTRRLLATEWARQP
Prediction	654575666556543247522244450530000200210354546655646544410003017464561200032430000002323140000000242054147343620440151043005103721715300000002540421113133020000254145204234624233630551163027206758
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180

                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHCHHCCCCCCEEEEHCCCEEEEHCCCCCCCCEEEEHCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHCCCCCCCCCCCCEEEEEHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
MSDEDRTDRATEDHTIFDRGVGQRDQLQRLWTPYRMNYLAEAPVKRDPNSSASPAQPFTEIPQLSDEEGLVVARGKLVYAVLNLYPYNPGHLMVVPYRRVSELEDLTDLESAELMAFTQKAIRVIKNVSRPHGFNVGLNLGTSAGGSLAEHLHVHVVPRWGGDANFITIIGGSKVIPQLLRDTRRLLATEWARQP

3anoA

0.99

0.81

3.86

MUSTER

-------------HTIFDRGVGQRDQLQRLWTPYRA-------------------QPFTEIPQLSDEEGLVVARGKLVYAVLNLYPYNPGHLMVVPYRRVSELEDLTDLESAELMAFTQKAIRVIKNVSRPHGFNVGLNLGTSAGGSLAEHLHVHVVPRWGGDANFITII-----IPQLLRDTRRLLATEWARQP

3anoA

0.99

0.81

6.33

dPPAS

-------------HTIFDRGVGQRDQLQRLWTPYRA-------------------QPFTEIPQLSDEEGLVVARGKLVYAVLNLYPYNPGHLMVVPYRRVSELEDLTDLESAELMAFTQKAIRVIKNVSRPHGFNVGLNLGTSAGGSLAEHLHVHVVPRWGGDANFITII-----IPQLLRDTRRLLATEWARQP

3anoA

0.99

0.81

6.04

wdPPAS

-------------HTIFDRGVGQRDQLQRLWTPYR-------------------AQPFTEIPQLSDEEGLVVARGKLVYAVLNLYPYNPGHLMVVPYRRVSELEDLTDLESAELMAFTQKAIRVIKNVSRPHGFNVGLNLGTSAGGSLAEHLHVHVVPRWGGDANFITI-----IIPQLLRDTRRLLATEWARQP

3anoA

0.99

0.80

0.81

4.68

wMUSTER

--------------TIFDRGVGQRDQLQRLWTPYRA-------------------QPFTEIPQLSDEEGLVVARGKLVYAVLNLYPYNPGHLMVVPYRRVSELEDLTDLESAELMAFTQKAIRVIKNVSRPHGFNVGLNLGTSAGGSLAEHLHVHVVPRWGGDANFITII-----IPQLLRDTRRLLATEWARQP

3anoA

0.99

0.80

0.81

5.23

wPPAS

-------------HTIFDRGVGQRDQLQRLWTPYRA-------------------QPFTEIPQLSDEEGLVVARGKLVYAVLNLYPYNPGHLMVVPYRRVSELEDLTDLESAELMAFTQKAIRVIKNVSRPHGFNVGLNLGTSAGGSLAEHLHVHVVPRWGGDANFITI-----IIPQLLRDTRRLLATEWARQP

3anoA

0.99

0.81

7.46

dPPAS2

-------------HTIFDRGVGQRDQLQRLWTPYRA-------------------QPFTEIPQLSDEEGLVVARGKLVYAVLNLYPYNPGHLMVVPYRRVSELEDLTDLESAELMAFTQKAIRVIKNVSRPHGFNVGLNLGTSAGGSLAEHLHVHVVPRWGGDANFITII-----IPQLLRDTRRLLATEWARQP

3anoA

0.99

0.81

4.69

PPAS

-------------HTIFDRGVGQRDQLQRLWTPYRA-------------------QPFTEIPQLSDEEGLVVARGKLVYAVLNLYPYNPGHLMVVPYRRVSELEDLTDLESAELMAFTQKAIRVIKNVSRPHGFNVGLNLGTSAGGSLAEHLHVHVVPRWGGDANFITII-----IPQLLRDTRRLLATEWARQP

3anoA

0.99

0.81

5.35

Env-PPAS

-------------HTIFDRGVGQRDQLQRLWTPYRA-------------------QPFTEIPQLSDEEGLVVARGKLVYAVLNLYPYNPGHLMVVPYRRVSELEDLTDLESAELMAFTQKAIRVIKNVSRPHGFNVGLNLGTSAGGSLAEHLHVHVVPRWGGDANFITII-----IPQLLRDTRRLLATEWARQP

5cs2A

0.17

0.13

0.75

2.83

MUSTER

------------------------EKYKN--ILEKLEW---------YKNKSSEKYEFGIYE---IDKREVFITTKYSYGFVNNKPLLPGHILLTTLKKKKHYNDLDIEEIIDINLLCNFMCYIMGNLFNTTDFSIAIQDGKEAGQTV-DHVHIHIIPRKINDIRSIEQM------EEEANLIKSYINEKFS---

3ksvA

0.22

0.16

0.72

4.75

dPPAS

---------------------------------------------------MAANCIFCKIIK-GDIPCAKVAETSKALAFMDINPLSRGHMLVIPKEHASCLHELGMEDAADVGVLLAKASRAVAGPDGSMQYNVLQNNGSLAHQEVP-HVHFHIIPKTDEKTGLKIGWDTVKVASDELAEDAKRYSEAIAKI-

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.46

Estimated TM-score = 0.78±0.10

Estimated RMSD = 4.4±2.9Å

Download Model 2

C-score=-1.25

Download Model 3

C-score=-1.77

Download Model 4

C-score=-2.83

Download Model 5

C-score=-3.02

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2uv9D	0.493	4.97	0.066	0.790
2	2pffA	0.487	5.03	0.027	0.779
3	1st0A	0.466	4.11	0.106	0.641
4	5rhnA	0.447	2.73	0.177	0.538
5	2q43A	0.435	5.44	0.024	0.744
6	1d7vA	0.434	5.09	0.095	0.718
7	1htoX	0.426	5.41	0.058	0.713
8	1v7vA	0.419	5.63	0.037	0.728
9	2hc9A	0.418	5.56	0.073	0.718
10	1f1hL	0.418	5.53	0.054	0.708

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.54	53	1rzyA	5AS	Rep, Mult	57,58,61,81,82,83,84,85,93,139,145,146,147,148,153,155
2	0.12	17	3r6fA	ZN	Rep, Mult	56,59,99,151
3	0.09	9	3o1cA	ADN	Rep, Mult	58,61,81,82,83,84,85,93,147,153,155
4	0.03	4	2fhiA	IB2	Rep, Mult	82,83,93,135,136,137,139,147,148,153,155,157
5	0.02	3	3lb5D	UNL	Rep, Mult	58,67,68,81,82,83,84,93
6	0.01	2	5cs2A	III	Rep, Mult	87,135,137,139,143,144,145,147,155,157
7	0.01	1	1y23B	MG	Rep, Mult	190,193
8	0.01	2	3fitA	A	Rep, Mult	58,61,63,83,93,147
9	0.01	1	1fitA	FRU	Rep, Mult	128,129,130
10	0.01	1	3llj0	III	Rep, Mult	87,103,108,112,113,116,119,134,135,136,137,138,139,140,142,143,144,155,160
11	0.01	1	1xmmB	UUU	Rep, Mult	72,74,79

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1f2oA	0.391	5.91	0.073	0.713	3.4.11.24	NA
2	0.060	1lgrA	0.427	5.69	0.058	0.733	6.3.1.2	NA
3	0.060	2hb6A	0.418	5.49	0.073	0.713	3.4.11.1	123
4	0.060	2vn7A	0.391	5.57	0.031	0.672	3.2.1.3	191
5	0.060	3eqoA	0.393	5.31	0.058	0.651	3.2.1.58	155
6	0.060	1g87B	0.361	5.62	0.017	0.651	3.2.1.4	NA
7	0.060	1htoA	0.422	5.50	0.078	0.713	6.3.1.2	NA
8	0.060	3l58A	0.385	5.90	0.049	0.728	3.4.23.46	123
9	0.060	2hb6B	0.418	5.49	0.073	0.713	3.4.11.1	150
10	0.060	2d3aA	0.402	5.87	0.065	0.718	6.3.1.2	NA
11	0.060	1bwkA	0.381	5.34	0.084	0.631	1.6.99.1	97
12	0.060	2j1pB	0.387	4.92	0.104	0.605	2.5.1.1,2.5.1.10,2.5.1.29	NA
13	0.060	2dgmC	0.389	5.82	0.048	0.687	4.1.1.15	NA
14	0.060	1ileA	0.386	5.71	0.104	0.708	6.1.1.5	NA
15	0.060	1l2aE	0.388	5.56	0.057	0.682	3.2.1.4	91
16	0.060	2w5vA	0.377	5.37	0.043	0.646	3.1.3.1	184
17	0.060	2qk5A	0.387	5.83	0.063	0.718	3.4.23.46	87
18	0.060	2zjiA	0.307	5.83	0.072	0.554	3.4.23.46	NA
19	0.060	1lf6A	0.356	5.84	0.055	0.656	3.2.1.3	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.60	0.668	2.14	0.81	0.73	3anoB	GO:0000166 GO:0003824 GO:0003877 GO:0005524 GO:0005886 GO:0015967 GO:0016740 GO:0016779 GO:0040007
1	0.37	0.562	2.99	0.19	0.67	3p0tA	GO:0003824
2	0.33	0.580	2.05	0.27	0.64	2fitA	GO:0000166 GO:0003824 GO:0005634 GO:0005737 GO:0005739 GO:0005829 GO:0006163 GO:0006351 GO:0006355 GO:0006915 GO:0009117 GO:0016787 GO:0031625 GO:0032435 GO:0042802 GO:0047710 GO:0070062 GO:0072332
3	0.31	0.579	2.75	0.24	0.67	3o0mA	GO:0000166 GO:0003824 GO:0004081 GO:0016787 GO:0046872
4	0.29	0.463	2.59	0.15	0.53	4njxA	GO:0000166 GO:0003824 GO:0005730 GO:0005739 GO:0006629 GO:0006694 GO:0006915 GO:0016787
5	0.29	0.581	2.42	0.19	0.66	3lb5C	GO:0003824
6	0.28	0.453	2.34	0.18	0.51	4zglD	GO:0003824
7	0.28	0.584	1.87	0.17	0.64	5cs2A	GO:0003824 GO:0008270 GO:0016787 GO:0047710
8	0.28	0.460	2.45	0.16	0.54	3n1sJ	GO:0000166 GO:0003824 GO:0005829 GO:0016787 GO:0043530 GO:0055130
9	0.26	0.465	2.77	0.16	0.54	1xquB	GO:0003824
10	0.23	0.601	2.61	0.24	0.68	2eo4A	GO:0003824 GO:0046872
11	0.21	0.787	1.06	0.99	0.81	3anoA	GO:0000166 GO:0003824 GO:0003877 GO:0005524 GO:0005886 GO:0015967 GO:0016740 GO:0016779 GO:0040007
12	0.13	0.507	2.23	0.21	0.56	1y23B	GO:0003824
13	0.07	0.499	2.51	0.19	0.56	3ksvA	GO:0003824 GO:0046872
14	0.07	0.507	2.28	0.20	0.56	3imiA	GO:0003824 GO:0046872
15	0.07	0.467	2.09	0.14	0.52	3r6fA	GO:0003824 GO:0046872
16	0.07	0.487	5.03	0.03	0.78	2pffA	GO:0000287 GO:0003824 GO:0004312 GO:0004315 GO:0004316 GO:0004321 GO:0005829 GO:0005835 GO:0006629 GO:0006631 GO:0006633 GO:0008152 GO:0008897 GO:0016491 GO:0016740 GO:0042759 GO:0046872 GO:0055114 GO:0102132
17	0.06	0.365	5.30	0.07	0.61	1t0uA	GO:0003824 GO:0004850 GO:0005737 GO:0005829 GO:0006974 GO:0009116 GO:0009166 GO:0016020 GO:0016740 GO:0016757 GO:0016763 GO:0042802 GO:0044206
18	0.06	0.304	5.73	0.06	0.53	2b4qA	GO:0004316 GO:0016491 GO:0055114 GO:0102132
19	0.06	0.381	5.25	0.05	0.64	2hn9A	GO:0003824 GO:0004850 GO:0005737 GO:0009116 GO:0009166 GO:0016740 GO:0016757 GO:0016763 GO:0044206
20	0.06	0.371	5.32	0.07	0.61	5elpC	GO:0003824 GO:0008152 GO:0031177
21	0.06	0.356	6.02	0.04	0.67	3hhdC	GO:0001649 GO:0003824 GO:0004312 GO:0004313 GO:0004314 GO:0004315 GO:0004316 GO:0004317 GO:0004319 GO:0004320 GO:0005737 GO:0005739 GO:0005794 GO:0005829 GO:0005886 GO:0005913 GO:0006084 GO:0006629 GO:0006631 GO:0006633 GO:0008144 GO:0008152 GO:0009058 GO:0015939 GO:0016020 GO:0016295 GO:0016296 GO:0016297 GO:0016491 GO:0016740 GO:0016787 GO:0016788 GO:0016829 GO:0019171 GO:0030879 GO:0031177 GO:0031325 GO:0035338 GO:0042470 GO:0042587 GO:0042802 GO:0042803 GO:0044822 GO:0047117 GO:0047451 GO:0055114 GO:0070062 GO:0070402 GO:0071353 GO:0098609 GO:0098641 GO:0102132
22	0.06	0.353	5.40	0.06	0.61	5bp1A	GO:0003824 GO:0008152 GO:0016491 GO:0016740 GO:0016746 GO:0031177 GO:0050111 GO:0055114
23	0.06	0.374	5.17	0.06	0.59	1xg5C	GO:0005576 GO:0016491 GO:0055114
24	0.06	0.367	5.72	0.04	0.67	2c9hA	GO:0003824 GO:0004315 GO:0005737 GO:0005739 GO:0006629 GO:0006631 GO:0006633 GO:0006637 GO:0008152 GO:0016740 GO:0016746 GO:0016747 GO:0051790 GO:0051792
25	0.06	0.328	5.57	0.06	0.53	5cdyA	GO:0004316 GO:0006633 GO:0016491 GO:0051287 GO:0055114 GO:0102132
26	0.06	0.344	5.64	0.04	0.59	2gqdA	GO:0003824 GO:0006629 GO:0006631 GO:0006633 GO:0008152 GO:0016740 GO:0016746 GO:0016747 GO:0033817
27	0.06	0.374	5.61	0.04	0.66	3e60A	GO:0003824 GO:0006633 GO:0008152 GO:0016740 GO:0016746 GO:0016747 GO:0033817
28	0.06	0.331	5.58	0.08	0.56	1i01C	GO:0004316 GO:0005829 GO:0006629 GO:0006631 GO:0006633 GO:0008610 GO:0009102 GO:0016491 GO:0030497 GO:0042802 GO:0046872 GO:0050661 GO:0051287 GO:0055114 GO:0102132
29	0.06	0.369	5.57	0.07	0.62	1g0oC	GO:0016491 GO:0042438 GO:0047039 GO:0055114
30	0.06	0.382	5.66	0.04	0.68	4wkyA	GO:0003824 GO:0008152 GO:0031177
31	0.06	0.355	5.56	0.05	0.64	2hg4D	GO:0003824 GO:0008152 GO:0009058 GO:0016740 GO:0016746 GO:0016788 GO:0017000 GO:0031177 GO:0033068 GO:0047879 GO:0048037
32	0.06	0.345	6.15	0.06	0.66	3oytA	GO:0003824 GO:0004315 GO:0008152 GO:0016740 GO:0016746
33	0.06	0.333	5.67	0.05	0.58	1b3nA	GO:0003824 GO:0004315 GO:0005829 GO:0006629 GO:0006631 GO:0006633 GO:0008152 GO:0016740 GO:0016746 GO:0016747 GO:0033817
34	0.06	0.356	5.94	0.05	0.65	1tqyA	GO:0003824 GO:0008152 GO:0016740 GO:0016746 GO:0017000

Consensus prediction of GO terms

Molecular Function	GO:0005524	GO:0003877	GO:0031625	GO:0047710	GO:0042802	GO:0046872	GO:0004081
GO-Score	0.60	0.60	0.33	0.33	0.33	0.31	0.31
Biological Processes	GO:0015967	GO:0040007	GO:0008202	GO:0008610	GO:0032435	GO:0072332	GO:0006163	GO:0006355
GO-Score	0.60	0.60	0.58	0.58	0.33	0.33	0.33	0.33
Cellular Component	GO:0005886	GO:0043232	GO:0031981	GO:0005739	GO:0005829	GO:0070062
GO-Score	0.60	0.58	0.58	0.52	0.33	0.33

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.