I-TASSER results

I-TASSER results for job id Rv2578c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (340 residues)
MRWARQAVAVNGMPVDDGALPGLQRIGLVRSVRAPQFDGITFHEVLCKSALNKVPNAAAL
PFRYTVNGYRGCSHACRYCFARPTHEYLDFNPGTDFDTQVVVKTNVAAVLRHELRRPSWR
RETVALGTNTDPYQRAEGRYALMPGIIGALAASGTPLSILTKGTLLRRDLPLIAEAAQQV
PVSVAVSLAVGDPELHRDVESGTPTPQARLALITAIRAAGLDCHVMVAPVLPQLTDSGEH
LDQLLGQIAAAGATGVTVFGLHLRGSTRGWFMCWLARAHPELVSRYRELYRRGPYLPPSY
REMLRERVAPLIAKYRLAGDHRPAPPETEAALVPVQATLF

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRWARQAVAVNGMPVDDGALPGLQRIGLVRSVRAPQFDGITFHEVLCKSALNKVPNAAALPFRYTVNGYRGCSHACRYCFARPTHEYLDFNPGTDFDTQVVVKTNVAAVLRHELRRPSWRRETVALGTNTDPYQRAEGRYALMPGIIGALAASGTPLSILTKGTLLRRDLPLIAEAAQQVPVSVAVSLAVGDPELHRDVESGTPTPQARLALITAIRAAGLDCHVMVAPVLPQLTDSGEHLDQLLGQIAAAGATGVTVFGLHLRGSTRGWFMCWLARAHPELVSRYRELYRRGPYLPPSYREMLRERVAPLIAKYRLAGDHRPAPPETEAALVPVQATLF
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHCCEEEHCCCCCCCCCCEEEEHCCCCCCCCCEEHCCCCCCCCCCCCCCCCCCCEEEHCCCHHHHHHHHHHHCCCCCCEEEHCCCCCCCCCHHHHHCHHHHHHHHHHHHCCCEEEEHCCCCHHHHHHHHHHHHHCCCEEEEEEHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEEHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEHCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCC
Conf.Score	9888877787777777777776667776666667777887999986446665578988998657886589987676544567765456888888877568865668999999999658888589976788888856788768999999999859978999778655788999999986698899998557998999874999999999999999999989989999975799889999999999999999899889999986795799999999999885699999999778888999999999999999999989998886455555667888777889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRWARQAVAVNGMPVDDGALPGLQRIGLVRSVRAPQFDGITFHEVLCKSALNKVPNAAALPFRYTVNGYRGCSHACRYCFARPTHEYLDFNPGTDFDTQVVVKTNVAAVLRHELRRPSWRRETVALGTNTDPYQRAEGRYALMPGIIGALAASGTPLSILTKGTLLRRDLPLIAEAAQQVPVSVAVSLAVGDPELHRDVESGTPTPQARLALITAIRAAGLDCHVMVAPVLPQLTDSGEHLDQLLGQIAAAGATGVTVFGLHLRGSTRGWFMCWLARAHPELVSRYRELYRRGPYLPPSYREMLRERVAPLIAKYRLAGDHRPAPPETEAALVPVQATLF
Prediction	6315434155654412311133364152355254462660413314021001304544411030001001001100100000302311424344414220202420141035105435453120100131200131343140021003003627020000032400340040045037422020102021235621441253302143004004302724030000000100001034620340052027040420000001024501520251046313511530261056442136500530251035005624043645523462655453411617
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHCCEEEHCCCCCCCCCCEEEEHCCCCCCCCCEEHCCCCCCCCCCCCCCCCCCCEEEHCCCHHHHHHHHHHHCCCCCCEEEHCCCCCCCCCHHHHHCHHHHHHHHHHHHCCCEEEEHCCCCHHHHHHHHHHHHHCCCEEEEEEHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEEHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEHCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCC
MRWARQAVAVNGMPVDDGALPGLQRIGLVRSVRAPQFDGITFHEVLCKSALNKVPNAAALPFRYTVNGYRGCSHACRYCFARPTHEYLDFNPGTDFDTQVVVKTNVAAVLRHELRRPSWRRETVALGTNTDPYQRAEGRYALMPGIIGALAASGTPLSILTKGTLLRRDLPLIAEAAQQVPVSVAVSLAVGDPELHRDVESGTPTPQARLALITAIRAAGLDCHVMVAPVLPQLTDSGEHLDQLLGQIAAAGATGVTVFGLHLRGSTRGWFMCWLARAHPELVSRYRELYRRGPYLPPSYREMLRERVAPLIAKYRLAGDHRPAPPETEAALVPVQATLF

4fhcA

0.14

0.13

0.89

1.60

MUSTER

-KFVPKLVYFEPEALSY--IKIRETTSHNQVRGIPGETELARYRNAKSTLVVGVRRTLKFSAEYAIPLATGCMGHCHYCYLQ---TTLGSKPY------IRVYVNIFAQAQKYINERAPEITRFEAACTSDIV-GIDHLTHSLKKAIEFIGATDYGLRFVTKYE----HVDHLLDARHNGKTRFRFSINS--RYVINHFEPGTSSFDGRLAAARKVAGAGYKLGFVVAPIYRH-EGWERGYFELFQELARQ-LSDLTFELIQHRKPAKRVIEQRYPKTRLDLDETKRKYKGIGKYVRDEEAKELEDTMRRYIEQF-FPGAYVQYFT--------------

4fhcA

0.13

0.12

0.89

1.83

dPPAS

-----KPFVPKLVYFEPEGIKIRETTSHNQVRGIPGETELARYRNAKSTLVVGVRRTLKFSAEYAIPLATGCMGHCHYCYLQTTLGSKPY---------IRVYVNIFAQAQKYINERAPEITRFEAACTSDIV-GIDHLTHSLKKAIEFIGATDYGLRFVTKYEHV----DHLLDARHNGKTRFRFSINS--RYVINHFEPGTSSFDGRLAAARKVAGAGYKLGFVVAPIYRHEGGYFELFQELARQLEGMDLSDLTFELIQHRKPAKRVIEQRYPKTRLDLDETKRKYKWGRYGIRDEEAKELEDTMRRYIEQF---FPGAYVQYFT------------

4fhcA

0.14

0.12

0.86

2.42

wdPPAS

LY--EKFTQMG--------IKIRETTSHNQVRGIPGETELARYRNAKSTLVVGVRRTLKFSAEYAIPLATGCMGHCHYCYLQT---TLGSKPY------IRVYVNIFAQAQKYINERAPEITRFEAACTSDIV-GIDHLTHSLKKAIEFIGATDYGLRFVTKYEHVDHLLDA----RHNGKTRFRFSINS--RYVINHFEPGTSSFDGRLAAARKVAGAGYKLGFVVAPIYRHEGGYFELFQELARQLEGMDLSDLTFELIQHRKPAKRVIEQRYPKTRLDLDETKRKYKIGKYVYRDEEAKELEDTMRRYIEQF-FT----------------------

4fhcA

0.15

0.13

0.87

1.95

wMUSTER

LY--EKFTQMG--------IKIRETTSHNQVRGIPGETELARYRNAKSTLVVGVRRTLKFSAEYAIPLATGCMGHCHYCYLQ---TTLGSKPY------IRVYVNIFAQAQKYINERAPEITRFEAACTSDIV-GIDHLTHSLKKAIEFIGATDYGLRFVTKYE----HVDHLLDARHNGKTRFRFSINS--RYVINHFEPGTSSFDGRLAAARKVAGAGYKLGFVVAPIYRH-EGWERGYFELFQELARQ-LSDLTFELIQHRKPAKRVIEQRYPKTRLDLDETKRKYYGIGKYVRDEEAKELEDTMRRYIEQF-FPGAYVQYFT--------------

4fhcA

0.15

0.13

0.89

3.00

wPPAS

-KFVPK----EPEALSQMGIKIRETTSHNQVRGIPGETELARYRNAKSTLVVGVRRTLKFSAEYAIPLATGCMGHCHYCYLQ---TTLGSKPY------IRVYVNIFAQAQKYINERAPEITRFEAACTSDIV-GIDHLTHSLKKAIEFIGATDYGLRFVTKYEHVDHLLDA----RHNGKTRFRFSINS--RYVINHFEPGTSSFDGRLAAARKVAGAGYKLGFVVAPIYRHEGGYFELFQELARQLEGMDLSDLTFELIQHRKPAKRVIEQRYPKTRLDLDETKRKYYGIGKYVRDEEAKELEDTMRRYIEQF-----------------PGAYVQYF

4fhcA

0.14

0.12

0.84

4.63

dPPAS2

FTQMG--------------IKIRETTSHNQVRGIPGETELARYRNAKSTLVVGVRRTLKFSAEYAIPLATGCMGHCHYCYLQ---TTLGSKPY------IRVYVNIFAQAQKYINERAPEITRFEAACTSDIV-GIDHLTHSLKKAIEFIGATDYGLRFVTKYE----HVDHLLDARHNGKTRFRFSINS--RYVINHFEPGTSSFDGRLAAARKVAGAGYKLGFVVAPIYRHEGGYFELFQELARQLEGMDLSDLTFELIQHRKPAKRVIEQRYPKTRLDLDETKRKYKWGRYGIRDEEAKELEDTMRRYIEQF-------------------------

4fhcA

0.15

0.14

0.89

2.50

PPAS

-KFVPKLVYFEPEALSQMGIKIRETTSHNQVRGIPGETELARYRNAKSTLVVGVRRTLKFSAEYAIPLATGCMGHCHYCYLQ---TTLGSKPY------IRVYVNIFAQAQKYINERAPEITRFEAACTSDIV-GIDHLTHSLKKAIEFIGATDYGLRFVTKYE----HVDHLLDARHNGKTRFRFSINS--RYVINHFEPGTSSFDGRLAAARKVAGAGYKLGFVVAPIYRHEGGYFELFQELARQLEGMDLSDLTFELIQHRKPAKRVIEQRYPKTRLDLDETKRKYYGIGKYVRDEEAKELEDTMRRYIEQF-FPGAYT------------------

4fhcA

0.15

0.14

0.90

3.31

Env-PPAS

-KFVPKLVYFEPEALSQMGIKIRETTSHNQVRGIPGETELARYRNAKSTLVVGVRRTLKFSAEYAIPLATGCMGHCHYCYLQ---TTLGSKPY------IRVYVNIFAQAQKYINERAPEITRFEAACTSDIV-GIDHLTHSLKKAIEFIGATDYGLRFVTKYE----HVDHLLDARHNGKTRFRFSINS--RYVINHFEPGTSSFDGRLAAARKVAGAGYKLGFVVAPIYRHEGGYFELFQELARQLEGMDLSDLTFELIQHRKPAKRVIEQRYPKTRLDLDETKRKYYGIGKYVRDEEAKELEDTMRRYIEQF-F---------------PGAYVQYF

4fhcA1

0.14

0.09

0.61

1.07

MUSTER

-KFVPKFEPE-YEKFTQMGIKIRETTSHNQVRGIPGETELARYRNAKSTLVVGVRRTLKFSAEYAIPLATGCMGHCHYCYLQ---TTLGSKPY------IRVYVNIFAQAQKYINERAPEITRFEAACTSDIV-GIDHLTHSLKKAIEFIGATDYGLRFVTKYE----HVDHLLDARHNGKTRFRFSINS--RYVINHFEPGTSSFDGRLAAARKVAGAGYKLG--------------------------------------------------------------------------------------------------------------------

4fhcA1

0.14

0.09

0.60

1.39

dPPAS

-----KPFVPKLVYFEPEGIKIRETTSHNQVRGIPGETELARYRNAKSTLVVGVRRTLKFSAEYAIPLATGCMGHCHYCYLQ---TTLGSKPY------IRVYVNIFAQAQKYINERAPEITRFEAACTSDIV-GIDHLTHSLKKAIEFIGATDYGLRFVTKYEHV----DHLLDARHNGKTRFRFSINS--RYVINHFEPGTSSFDGRLAAARKVAGAGYKLG--------------------------------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.18

Estimated TM-score = 0.69±0.12

Estimated RMSD = 6.8±4.1Å

Download Model 2

C-score=-1.34

Download Model 3

C-score=-2.90

Download Model 4

C-score=-1.09

Download Model 5

C-score=-3.65

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4fhcA	0.845	1.95	0.126	0.909
2	5exiA	0.562	3.43	0.121	0.671
3	3c8fA	0.560	3.73	0.155	0.685
4	4r33A	0.559	3.88	0.080	0.697
5	4u0oB	0.558	3.55	0.102	0.679
6	1r30B	0.552	3.51	0.096	0.673
7	2yx0A	0.550	4.35	0.111	0.712
8	3iixA	0.547	3.69	0.099	0.673
9	3rf9A	0.547	3.53	0.101	0.662
10	4k36A	0.547	4.33	0.087	0.703

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.40	10	4fhcA	EEM	Rep, Mult	78,79,80,81,127,130,131,160,162,187,226,228,229,262,263,264
2	0.13	4	3rf9A	SF4	Rep, Mult	72,74,75,76,79,82,128,130,162
3	0.03	1	4fhfA	0TT	Rep, Mult	80,84,125,128,160,185,261,264,324,326

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.069	3cb8A	0.558	3.57	0.113	0.676	1.97.1.4	78,82
2	0.066	1r30B	0.552	3.51	0.096	0.673	2.8.1.6	72,76,79
3	0.060	3f4vA	0.488	5.08	0.052	0.671	3.2.1.21	NA
4	0.060	3cmjA	0.508	5.16	0.072	0.721	3.2.1.21	NA
5	0.060	1b1yA	0.492	4.84	0.058	0.668	3.2.1.2	NA
6	0.060	1gonA	0.517	5.03	0.080	0.724	3.2.1.21	NA
7	0.060	2cerA	0.498	5.37	0.077	0.724	3.2.1.23	160
8	0.060	1itxA	0.498	4.57	0.060	0.668	3.2.1.14	NA
9	0.060	2dgaA	0.509	5.35	0.052	0.732	3.2.1.21	NA
10	0.060	2pbgA	0.520	5.31	0.059	0.753	3.2.1.85	NA
11	0.060	1myrA	0.505	5.15	0.073	0.724	3.2.1.147	255
12	0.060	3gnoA	0.504	5.31	0.066	0.732	3.2.1.21	NA
13	0.060	1qoxM	0.511	5.14	0.079	0.724	3.2.1.21	NA
14	0.060	1t7lA	0.438	5.04	0.038	0.603	2.1.1.14	NA
15	0.060	3b9eA	0.504	5.14	0.042	0.712	3.2.1.14	NA
16	0.060	3bq5A	0.468	4.70	0.050	0.632	2.1.1.14	NA
17	0.060	2vr5A	0.511	5.71	0.046	0.776	3.2.1.-	200
18	0.060	1edqA	0.503	5.03	0.063	0.700	3.2.1.14	NA
19	0.060	1od0B	0.510	5.12	0.080	0.724	3.2.1.21	NA
20	0.060	1vffA	0.508	5.09	0.057	0.718	3.2.1.21	NA
21	0.060	3gnrA	0.503	5.23	0.044	0.721	3.2.1.21	202

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.35	0.845	1.95	0.13	0.91	4fhcA	GO:0003913 GO:0016829 GO:0046872 GO:0051536 GO:0051539
1	0.23	0.552	3.51	0.10	0.67	1r30B	GO:0003824 GO:0004076 GO:0005506 GO:0009102 GO:0016740 GO:0046872 GO:0051536 GO:0051537 GO:0051539
2	0.17	0.560	3.73	0.15	0.69	3c8fA	GO:0003824 GO:0005737 GO:0005829 GO:0005975 GO:0006006 GO:0006974 GO:0016491 GO:0018307 GO:0043365 GO:0046872 GO:0051536 GO:0051539 GO:0055114
3	0.10	0.546	3.73	0.09	0.67	3t7vA	GO:0003824 GO:0008652 GO:0016765 GO:0016853 GO:0016866 GO:0046872 GO:0051188 GO:0051536 GO:0051539 GO:0071524
4	0.07	0.411	2.89	0.11	0.47	3canA	GO:0003824 GO:0016491 GO:0016829 GO:0051536 GO:0051539 GO:0055114
5	0.07	0.559	3.63	0.10	0.68	4u0pB	GO:0003824 GO:0005737 GO:0009107 GO:0009249 GO:0016740 GO:0016783 GO:0016992 GO:0046872 GO:0051536 GO:0051539
6	0.07	0.559	3.88	0.08	0.70	4r33A	GO:0003824 GO:0046872 GO:0051536 GO:0051539
7	0.07	0.552	3.69	0.10	0.68	5ff2A	GO:0003824 GO:0016491 GO:0016765 GO:0046872 GO:0051188 GO:0051536 GO:0051537 GO:0051539 GO:0055114
8	0.07	0.548	3.78	0.09	0.67	5hr7A	GO:0000049 GO:0002935 GO:0003824 GO:0005737 GO:0005829 GO:0006364 GO:0008033 GO:0008168 GO:0008173 GO:0016740 GO:0019843 GO:0030488 GO:0032259 GO:0046677 GO:0046872 GO:0051536 GO:0051539 GO:0070040 GO:0070475
9	0.07	0.542	3.96	0.10	0.69	4rtbA	GO:0003824 GO:0009228 GO:0046872 GO:0051536 GO:0051539
10	0.07	0.541	4.16	0.08	0.69	4wcxA	GO:0003824 GO:0046872 GO:0051536 GO:0051539
11	0.06	0.449	4.67	0.11	0.60	2y7dD	GO:0003824 GO:0016740 GO:0019475 GO:0046872
12	0.06	0.375	5.89	0.09	0.58	1dj3A	GO:0000166 GO:0004019 GO:0005525 GO:0006164 GO:0009507 GO:0009536 GO:0016874 GO:0044208 GO:0046872
13	0.06	0.361	5.99	0.06	0.55	4k3uA	GO:0016787
14	0.06	0.377	5.48	0.07	0.56	2v40A	GO:0000166 GO:0000287 GO:0002376 GO:0004019 GO:0005525 GO:0005737 GO:0005829 GO:0005886 GO:0006164 GO:0006167 GO:0006531 GO:0009168 GO:0014074 GO:0016874 GO:0042301 GO:0044208 GO:0046040 GO:0046872 GO:0060359 GO:0070062 GO:0071257
15	0.06	0.397	4.77	0.03	0.54	1f3tB	GO:0003824 GO:0004586 GO:0006596 GO:0016829 GO:0016831 GO:0033387
16	0.06	0.286	6.11	0.04	0.45	4ii4A	GO:0005829 GO:0010124 GO:0016491 GO:0055114 GO:0097266
17	0.06	0.285	6.76	0.04	0.49	2jiiB	GO:0000166 GO:0004672 GO:0004674 GO:0005524 GO:0005634 GO:0005737 GO:0006468 GO:0008360 GO:0018105 GO:0019903 GO:0032516 GO:0070373
18	0.06	0.275	6.10	0.05	0.42	4goxA	GO:0003824 GO:0008152 GO:0016740 GO:0031177

Consensus prediction of GO terms

Molecular Function	GO:0051539	GO:0046914	GO:0070283	GO:0016783	GO:0003913	GO:0043364
GO-Score	0.65	0.45	0.45	0.45	0.35	0.35
Biological Processes	GO:0072330	GO:0006768	GO:0042364	GO:0006464	GO:0019318	GO:0033554
GO-Score	0.45	0.45	0.45	0.35	0.35	0.35
Cellular Component	GO:0044444
GO-Score	0.35

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.