I-TASSER results

I-TASSER results for job id Rv2571c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (355 residues)
MSASLLVRTACGGRAVAQRLRTVLWPITQTSVVAGLAWYLTHDVFNHPQAFFAPISAVVC
MSATNVLRARRAQQMIVGVALGIVLGAGVHALLGSGPIAMGVVVFIALSVAVLCARGLVA
QGLMFINQAAVSAVLVLVFASNGSVVFERLFDALVGGGLAIVFSILLFPPDPVVMLCSAR
ADVLAAVRDILAELVNTVSDPTSAPPDWPMAAADRLHQQLNGLIEVRANAAMVARRAPRR
WGVRSTVRDLDQQAVYLALLVSSVLHLARTIAGPGGDKLPTPVHAVLTDLAAGTGLADAD
PTAANEHAAAARATASTLQSAACGSNEVVRADIVQACVTDLQRVIERPGPSGMSA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSASLLVRTACGGRAVAQRLRTVLWPITQTSVVAGLAWYLTHDVFNHPQAFFAPISAVVCMSATNVLRARRAQQMIVGVALGIVLGAGVHALLGSGPIAMGVVVFIALSVAVLCARGLVAQGLMFINQAAVSAVLVLVFASNGSVVFERLFDALVGGGLAIVFSILLFPPDPVVMLCSARADVLAAVRDILAELVNTVSDPTSAPPDWPMAAADRLHQQLNGLIEVRANAAMVARRAPRRWGVRSTVRDLDQQAVYLALLVSSVLHLARTIAGPGGDKLPTPVHAVLTDLAAGTGLADADPTAANEHAAAARATASTLQSAACGSNEVVRADIVQACVTDLQRVIERPGPSGMSA
Prediction	CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCC
Conf.Score	9865777667787888877788999999999999999999999978898678988878875488789999999999999999999999999758979999999999999999999874565357899999999999736888656899999999999999999998579877889999999999999999999999998588668999999999999999999999998666655455666677899999999999999999999999998666765556799999999999999987565665456788999999988756556789999999999999999986455546789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSASLLVRTACGGRAVAQRLRTVLWPITQTSVVAGLAWYLTHDVFNHPQAFFAPISAVVCMSATNVLRARRAQQMIVGVALGIVLGAGVHALLGSGPIAMGVVVFIALSVAVLCARGLVAQGLMFINQAAVSAVLVLVFASNGSVVFERLFDALVGGGLAIVFSILLFPPDPVVMLCSARADVLAAVRDILAELVNTVSDPTSAPPDWPMAAADRLHQQLNGLIEVRANAAMVARRAPRRWGVRSTVRDLDQQAVYLALLVSSVLHLARTIAGPGGDKLPTPVHAVLTDLAAGTGLADADPTAANEHAAAARATASTLQSAACGSNEVVRADIVQACVTDLQRVIERPGPSGMSA
Prediction	5542224212430331031124101200100000000100010004361010000000000002132013100300000000121021000003321110001132122202111333333000000101300000000012221002001001100000110000001231254035203400520140033004104544454144015304503531540351154044113213222423530430330032023003101300331343465513540250043014003303534434454254145314414643443232112400410041044016214534358
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCC
MSASLLVRTACGGRAVAQRLRTVLWPITQTSVVAGLAWYLTHDVFNHPQAFFAPISAVVCMSATNVLRARRAQQMIVGVALGIVLGAGVHALLGSGPIAMGVVVFIALSVAVLCARGLVAQGLMFINQAAVSAVLVLVFASNGSVVFERLFDALVGGGLAIVFSILLFPPDPVVMLCSARADVLAAVRDILAELVNTVSDPTSAPPDWPMAAADRLHQQLNGLIEVRANAAMVARRAPRRWGVRSTVRDLDQQAVYLALLVSSVLHLARTIAGPGGDKLPTPVHAVLTDLAAGTGLADADPTAANEHAAAARATASTLQSAACGSNEVVRADIVQACVTDLQRVIERPGPSGMSA

4c0oA2

0.08

0.07

0.92

0.95

wPPAS

LPTDSHASLRDSLLTHIQNLKPVIVTQLALAIADLALQMCVQTLVEKVTSLPFLLEILTVLPLRIGANRRTEIIEDLAFYSSTVVSLLMTCVEKAG--DEKMLMKVFRCLGSWFNLG-VLDSNFMANNKLLALLFEVLQQDKTS---SNLHEAASDCVCSALYAI-----ENVETNLPLAMQLFQGVLTLETAYHMAVARED-------LDKVLNYCRIFTELCETFLEKIVCTPGQGLGLRTLELLLICAGHYEVVEISFNFWYRLGEHLYKTNDEVIHGIFKAYIQRLLHALARHCQGVPEETDDFGEFRMRVSDLVKDLIFLIG---------SMECFAQLYSTLKEGNPPA

5cwiA

0.12

0.08

0.66

1.15

dPPAS2

------------------------------------------------------------------------------------------------------------------DIEKLCKKAESEAREARSKAEELRQRHPDSQAARDAQKLASQAEEAVKLACELAQEHPNADIAKLCIKAASEAAEAASKAAELAQRHPDSQAARDAIKLASQAAEAVKLACELAQEHPNADIAKLCIKAASEAAEAASKAAELAQRHPDSQAARDAIKLASQAAEAVKLACELAQEHPNADIAKKCIKAASEAAEEASKAAEEAQRHPDSQKARDEIKEASQKAEEVKERCER--------

4k1cA

0.08

0.92

1.14

PPAS

----------TAWRAAVYDLQYILKASPLNFLLVFVPLGLIWGHFQLSHTLTFLFNFLAII---LAAILANATEELADKA-GNTIGGLLNATFGNAVELIVSIIALKKGQVRIVQASML---SNLLLVLGLCFIFGGYNRVQQTAAQTMSSLLAIACASLLIPAAFRATLPFIDGKILELSRGTSIVILIVYVLFLYFQLGS--------HHALFEQQEEETDEVMSTISRNPHHSLSVKSSLVILLGTTVIISFCADFLVGTIDNVVESTGLSKT----IPIVGNAAEHVTSVLVAMKDKMDLALGVAIGSSLQVALFVTPFMVLVGWMITFETATLFIAVFLSNYLILDGESN

5cwmA

0.08

0.05

0.64

1.11

dPPAS2

----------------------------------------------------------------------------------------------DPEDELKRVEKLVKEAEELLRQAKEKGSEEDLEKALRTAEEAA-------REAKKVLEQAEKEGDPEVALRAV---ELVVRVAELLLRIAKESGSEEALERALRVAEEAARLAKRVLELAEKQGDPEVALRAVELVVRVAELLLRIAKESGSEEALERALRVAEEAARLAKRVLELAEKQGDPEVARRAVELVKRVAELLERIARESGSEEAKERAERVREEARELQERVKELRER-------------------------

5dlqB1

0.09

0.08

0.98

1.11

PPAS

LEKGSIESLRTFLLTYVLQRPNL--KYVREQILLAVAVIVKRGSLDKSIDCKSIFHEVSQLISSGNPTVQTLACSILTALLSEFSNCKRVFQEEDLRQIFMLTVGVLQEFSRRENLSAQMSSVFQRYLALANQVLSWNFLPPTESWREALLDSRVMELFFTVHRKIREDSDMAQDSLQCLAQLASLHGPIFPDEGSQVDY--AHFIEGLLNTINGIEIEDSEAVGISSIISNLITVFPRNVLTAIPSELFSSFVNCLTHLTCSFGRSAALEEVLDKDDM--VYMEAYDKLLESWLTLVRLFLATRHFLKLVFDMLVLQNTEMTTAAGEAFYTLVCLYQAEYSELVETLLSSQQDP

5cwoA

0.07

0.04

0.62

1.10

dPPAS2

------------------------------------------------------------------------------------------------------------------PELEEWIRRAKEVAKEVEKVAQRAEEEGNPDLRDSAKELRRAVEEAIEEAKKQG----NPELVEWVARAAKVAAEVIKVAIQAEKEGNRDLFRAALELVRAVIEAIEEAVKQGNPELVEWVARAAKVAAEVIKVAIQAEKEGNRDLFRAALELVRAVI--------EAIEEAVKQGNPELVERVA---RLAKKAAELIKRAIRAEKEGNRDERREALERVREVIERIEELVRQG-------

4wgvA

0.11

0.10

0.94

1.11

PPAS

MTVRLGIATGKDLAQMTRHF-----LSKPVAIIFWIIAELAIIATDIAEVIGSAIALDLIFGIP----------LIVGALITVFDVFLLLFIMRFGKIEAIVGTLIFTVLAIFVFEVFISSPQLTDILNGFVPHKEIVTNQGILYIALGIIGATIMPHNLYLHSSIVQSRKYD---RHDNEEKAQAIKYATIDSNLQLSIAFVVNCLLLTLGAALFTNDLGGFYDLYHALKTEPVLGATLGGVMSTLFAVALLASGQNSTITGTLAGQIVMEGFLRLSIPNWLRRLITRSLAVIPVIIC-FKGNSEKIEQLLVFSQVFLSIALPFSLIPLQLATS-INKTWVNIISWTLIVILSG

5cwqA

0.10

0.07

0.65

1.09

dPPAS2

-----------------------------------------------------------------------------------------------------------------EELERESEEAERRLQEARKRSEEARERGDLKELAEALIEEARAVQELARVACER---GNSEEAERASEKAQRVLEEARKVSEEAREQGDDEVLALALIAIALAVLALAEVACCRGNSEEAERASEKAQRVLEEARKVSEEAREQGDDEVLALALIAIALA-------VLALAEVACCRGNKEEAERAYEDARRVEEEARKVKESAEEQGDSEVKRLAEEAEQLAREARRHVQECRGGWLEHH

4kjsA

0.09

0.08

0.83

1.10

PPAS

--------------------------IFFILVAAGVPLSVIGSLMHWP-SAVLFAVYCVTI---ALASYMGRATESLSIRIGGLLNATFGNA----VELIISMFALKEGLTGIVLASLTGSVLGNLLLVAGLSFFVGGLKYARQEFNIHDARHNSGLLIFAIIVAFVIPEVFSVGNASKLNLSIGISIIMILLYVAALYFKSGKVATIVLFAATIVVAYISENLVHTFHSVAEQFGWSELFIGVIIVAIVGNAAEHASAIIMAFKNKMDIAVEIA---VGSTLQIAMFVAPVLVICSIFFPTSMP----------------------LVFTLPELVAMVSAVLLMIAISNDGDSN

4tqlA

0.07

0.04

0.63

1.08

dPPAS2

-----------------------------------------------------------------------------------------------------------------------YKQMVQELEKARDRMEKLY------KEMVELIQKAIELMRKIFQEVKQ----EVEKAIEEMKKLYDEAKKKIEQMIQQIKQGGDQKMEELLKRAKEEMKKVKDKMEKLLEKLKQIMQEKMEKLLKQLKEEMKKMKEKMEKLLKEMKQRMEEVKKKMDDELLEKIKKNIDDLKKIAEDLIKKAEENIKEAKKIAEQLVKRAKQLIEKAKQVAEELIKKILQLIEKAKEIAEKVLKG-

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.81

Estimated TM-score = 0.39±0.13

Estimated RMSD = 13.3±4.1Å

Download Model 2

C-score=-3.32

Download Model 3

C-score=-4.08

Download Model 4

C-score=-3.57

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4c0oA2	0.824	2.67	0.079	0.930
2	2x1gF	0.820	2.84	0.078	0.944
3	3icqT	0.759	3.37	0.058	0.915
4	3a6pA	0.724	4.18	0.085	0.932
5	3m1iC	0.708	4.14	0.061	0.907
6	5dlqB	0.689	4.53	0.079	0.907
7	3ea5B	0.688	4.17	0.077	0.870
8	1wa5C	0.678	4.59	0.073	0.907
9	2x19B2	0.670	3.91	0.096	0.851
10	5hb4B	0.666	5.08	0.067	0.913

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.09	5	1qgrA	III	Rep, Mult	26,59,63,101,104,105,108,111,115,149,156,160,163,218,222,225,259,262,266
2	0.09	5	1o6oA	III	Rep, Mult	132,135,136,140,186,189,190
3	0.05	3	3w3wA	III	Rep, Mult	26,27,29,30,33,34,108,111,112,153,156,159,160,163,211,214
4	0.03	2	2axtM	CLA	Rep, Mult	163,167
5	0.03	2	2e75G	OPC	Rep, Mult	150,154
6	0.02	1	3t1gA	ZN	Rep, Mult	189,193
7	0.02	1	2wycA	3LA	Rep, Mult	64,67
8	0.02	1	1f59A	III	Rep, Mult	78,81,82,85,86,120,124,128
9	0.02	1	3arcx	CLA	Rep, Mult	82,83,86
10	0.02	1	2ot8A	III	Rep, Mult	26,56,60,108,152,153,156,163,215,218,222,259,310
11	0.02	1	2q5dB	III	Rep, Mult	152,156,221
12	0.02	1	3gwzD	CA	Rep, Mult	148,152
13	0.02	1	1y66A	DIO	Rep, Mult	187,191
14	0.02	1	2bptA	III	Rep, Mult	188,191,192,195,196,246,249
15	0.02	1	1f59B	III	Rep, Mult	82,85,86,89,90,122,123,124,125,130
16	0.02	1	2wieD	CVM	Rep, Mult	89,92
17	0.02	1	1pjmB	III	Rep, Mult	26,52,56,60,62,105,108,112,115,116,156,159,160,163,215,218,222,262,266,268,271,279,284,321,324,325

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1i8qA	0.477	5.58	0.052	0.710	4.2.2.1	91
2	0.060	3b95B	0.425	4.84	0.052	0.594	2.1.1.43	76,113,115
3	0.060	3btaA	0.418	6.44	0.042	0.670	3.4.24.69	NA
4	0.060	3c5wA	0.469	4.39	0.104	0.614	3.1.3.16	16
5	0.060	1rw9A	0.457	5.71	0.060	0.676	4.2.2.5	NA
6	0.060	1cb8A	0.429	6.06	0.030	0.659	4.2.2.5	NA
7	0.060	2g25A	0.424	6.50	0.039	0.701	1.2.4.1	NA
8	0.060	2np0A	0.431	6.42	0.037	0.699	3.4.24.69	NA
9	0.060	1z0hB	0.254	7.14	0.026	0.451	3.4.24.69	73
10	0.060	2uveA	0.416	6.34	0.067	0.662	3.2.1.82	NA
11	0.060	2qtcB	0.424	6.36	0.039	0.693	1.2.4.1	79
12	0.060	1ho8A	0.566	4.52	0.054	0.761	3.6.3.14	159,166,214
13	0.060	1dboA	0.434	6.33	0.034	0.707	4.2.2.19	NA
14	0.060	2gtqA	0.472	5.81	0.079	0.710	3.4.11.2	NA
15	0.060	1gaiA	0.442	5.63	0.063	0.662	3.2.1.3	NA
16	0.060	2vn4A	0.439	5.77	0.069	0.668	3.2.1.3	NA
17	0.060	2vn7A	0.438	5.90	0.077	0.670	3.2.1.3	156
18	0.060	2dqmA	0.431	6.38	0.074	0.676	3.4.11.2	NA
19	0.060	1l8aA	0.425	6.46	0.042	0.701	1.2.4.1	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.28	0.820	2.84	0.08	0.94	2x1gF	GO:0005737 GO:0006606 GO:0006886 GO:0007270 GO:0008139 GO:0008536 GO:0008565 GO:0031965 GO:0042331 GO:0050804
1	0.24	0.773	2.99	0.08	0.90	3zkvA	GO:0005737 GO:0006606 GO:0006886 GO:0007270 GO:0008139 GO:0008536 GO:0008565 GO:0031965 GO:0042331 GO:0050804
2	0.23	0.784	2.96	0.09	0.91	3zjyE	GO:0005634 GO:0005737 GO:0006606 GO:0006810 GO:0006886 GO:0008139 GO:0008536 GO:0008565 GO:0015031 GO:0031965
3	0.16	0.809	2.78	0.08	0.92	4ol0B	GO:0004872 GO:0005634 GO:0005737 GO:0006810 GO:0008139 GO:0008565 GO:0015031 GO:0031965 GO:0035048 GO:0042802 GO:0043231
4	0.16	0.790	2.71	0.08	0.89	4c0qA	GO:0004872 GO:0005634 GO:0005737 GO:0006810 GO:0008139 GO:0008565 GO:0015031 GO:0031965 GO:0035048 GO:0042802 GO:0043231
5	0.16	0.614	4.47	0.06	0.81	4c0qB	GO:0004872 GO:0005634 GO:0005737 GO:0006810 GO:0008139 GO:0008565 GO:0015031 GO:0031965 GO:0035048 GO:0042802 GO:0043231
6	0.13	0.473	3.84	0.07	0.59	3tt9A	GO:0002159 GO:0005080 GO:0005634 GO:0005654 GO:0005882 GO:0005886 GO:0005911 GO:0005912 GO:0005913 GO:0007155 GO:0007507 GO:0008285 GO:0010765 GO:0014704 GO:0016021 GO:0016264 GO:0016337 GO:0017080 GO:0019215 GO:0030054 GO:0030057 GO:0030336 GO:0032947 GO:0034334 GO:0044325 GO:0045110 GO:0045294 GO:0048496 GO:0055010 GO:0055088 GO:0086001 GO:0086002 GO:0086005 GO:0086019 GO:0086064 GO:0086073 GO:0086083 GO:0086091 GO:0090002 GO:0098641 GO:0098911 GO:2000810
7	0.12	0.714	4.01	0.08	0.90	5difC	GO:0000055 GO:0000776 GO:0005634 GO:0005737 GO:0005816 GO:0006406 GO:0006611 GO:0006810 GO:0006886 GO:0008536 GO:0008565 GO:0015031 GO:0034501 GO:0048471
8	0.09	0.610	4.82	0.08	0.83	1xm9A	GO:0004871 GO:0005521 GO:0005634 GO:0005654 GO:0005882 GO:0005886 GO:0007155 GO:0007165 GO:0007275 GO:0016337 GO:0019215 GO:0030054 GO:0030057 GO:0030280 GO:0043231 GO:0045110 GO:0070062
9	0.08	0.753	3.31	0.10	0.91	2xwuB	GO:0005634 GO:0005737 GO:0006606 GO:0006810 GO:0006886 GO:0008139 GO:0008536 GO:0008565 GO:0015031 GO:0031965
10	0.07	0.716	4.17	0.07	0.91	3wyfC	GO:0000055 GO:0000776 GO:0005634 GO:0005737 GO:0005816 GO:0006406 GO:0006611 GO:0006810 GO:0006886 GO:0008536 GO:0008565 GO:0015031 GO:0034501 GO:0048471
11	0.07	0.628	4.63	0.09	0.85	3l6xA	GO:0005102 GO:0005634 GO:0005737 GO:0005829 GO:0005886 GO:0005911 GO:0005913 GO:0005915 GO:0006351 GO:0006355 GO:0007155 GO:0007420 GO:0016020 GO:0016055 GO:0016337 GO:0019901 GO:0030027 GO:0030426 GO:0030496 GO:0034332 GO:0043197 GO:0045202 GO:0045296 GO:0050839 GO:0070062 GO:0090090 GO:0098641
12	0.07	0.458	5.87	0.07	0.70	2iw3B	GO:0000166 GO:0001933 GO:0003723 GO:0003746 GO:0005524 GO:0005737 GO:0005840 GO:0006412 GO:0006414 GO:0006415 GO:0006469 GO:0010494 GO:0016887 GO:0019843 GO:0022626 GO:0042788
13	0.06	0.333	6.54	0.04	0.54	3a5vA
14	0.06	0.352	6.96	0.05	0.61	2hivA	GO:0000166 GO:0003677 GO:0003909 GO:0003910 GO:0005524 GO:0005737 GO:0006260 GO:0006273 GO:0006281 GO:0006310 GO:0006974 GO:0007049 GO:0016874 GO:0046872 GO:0051103 GO:0051301 GO:0071897
15	0.06	0.350	5.65	0.06	0.51	1x87A	GO:0005737 GO:0006547 GO:0006548 GO:0016153 GO:0016829 GO:0019556 GO:0019557
16	0.06	0.236	5.22	0.07	0.34	5bmwB	GO:0003824 GO:0004807 GO:0006094 GO:0006096 GO:0006098 GO:0008152 GO:0016853 GO:0042802
17	0.06	0.248	6.07	0.04	0.39	2gieA	GO:0003677 GO:0004518 GO:0004519 GO:0009036 GO:0009307 GO:0016787 GO:0090305
18	0.06	0.252	6.06	0.03	0.39	4rk9A	GO:0005215 GO:0006810
19	0.06	0.223	5.88	0.01	0.34	1ks4A	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0008810 GO:0016787 GO:0016798
20	0.06	0.199	6.69	0.05	0.33	2yn3C	GO:0005509 GO:0007156 GO:0016020 GO:0016491 GO:0030151 GO:0046872 GO:0055114
21	0.06	0.166	3.22	0.04	0.19	4exnA	GO:0001934 GO:0002376 GO:0005125 GO:0005157 GO:0005576 GO:0005615 GO:0006954 GO:0008083 GO:0008284 GO:0045087 GO:0045651 GO:0045657

Consensus prediction of GO terms

Molecular Function	GO:0008139	GO:0008565	GO:0060089	GO:0008536
GO-Score	0.70	0.70	0.59	0.58
Biological Processes	GO:0006606	GO:0007270	GO:0042331	GO:0050804
GO-Score	0.58	0.45	0.45	0.45
Cellular Component	GO:0031965	GO:0005737
GO-Score	0.70	0.70

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.