I-TASSER results

I-TASSER results for job id Rv2569c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (314 residues)
MSADSSLSLPLSGTHRYRVTHRTEYRYSDVVTSSYGRGFLTPRNSLRQRCVAHRLTIDPA
PADRSTSRDGYGNISSYFHVTEPHRTLTITSDSIVDVSPPPPGLYTSGPALQPWEAARPA
GLPGSLATEFTLDLNPPEITDAVREYAAPSFLPKRPLVEVLRDLASRIYTDFTYRSGSTT
ISTGVNEVLLAREGVCQDFARLAIACLRANGLAACYVSGYLATDPPPGKDRMIGIDATHA
WASVWTPQQPGRFEWLGLDPTNDQLVDQRYIVVGRGRDYADVPPLRGIIYTNSENSVIDV
SVDVVPFEGDALHA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSADSSLSLPLSGTHRYRVTHRTEYRYSDVVTSSYGRGFLTPRNSLRQRCVAHRLTIDPAPADRSTSRDGYGNISSYFHVTEPHRTLTITSDSIVDVSPPPPGLYTSGPALQPWEAARPAGLPGSLATEFTLDLNPPEITDAVREYAAPSFLPKRPLVEVLRDLASRIYTDFTYRSGSTTISTGVNEVLLAREGVCQDFARLAIACLRANGLAACYVSGYLATDPPPGKDRMIGIDATHAWASVWTPQQPGRFEWLGLDPTNDQLVDQRYIVVGRGRDYADVPPLRGIIYTNSENSVIDVSVDVVPFEGDALHA
Prediction	CCCCCCCCCCCCCEEEEEEEEEEEEEHCCCCCCCCEEEEEHCCCCCCEEEEEEEEEHCCCCCEEEEEHCCCCCEEEEEEEHCCCCEEEEEEEEEEEEHCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCEEHCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEEEEHCCCCCCCCCCCCCCCCCEEEEEEEHCCCCCCCCEEEHCCCCCCCCCCCEEEEEEHCCCCCCCCCEEEEHCCCCCEEEEEEEEEEHCCCCCCCC
Conf.Score	99887778888875899999999999688644477799998699999589999999958985789985889978999999588868999999999996789877778876565577578777656778775678899889999999999857899999999999999986446755778888899999998997645899999999999899778888887689999988766778757999999599888888589868999888888689987589567998566998788746899999999878776789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSADSSLSLPLSGTHRYRVTHRTEYRYSDVVTSSYGRGFLTPRNSLRQRCVAHRLTIDPAPADRSTSRDGYGNISSYFHVTEPHRTLTITSDSIVDVSPPPPGLYTSGPALQPWEAARPAGLPGSLATEFTLDLNPPEITDAVREYAAPSFLPKRPLVEVLRDLASRIYTDFTYRSGSTTISTGVNEVLLAREGVCQDFARLAIACLRANGLAACYVSGYLATDPPPGKDRMIGIDATHAWASVWTPQQPGRFEWLGLDPTNDQLVDQRYIVVGRGRDYADVPPLRGIIYTNSENSVIDVSVDVVPFEGDALHA
Prediction	84454435453310010204030403054003202010000016353030121304132343323223122111001020344143020102020203334332233532133134224341343213201241424613510150036115764310410330052026304132433524310110043331201000000000021130000000010123445444222422200000000012344431000000013222553000000011220010020111133443414040303325574378
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCEEEEEEEEEEEEEHCCCCCCCCEEEEEHCCCCCCEEEEEEEEEHCCCCCEEEEEHCCCCCEEEEEEEHCCCCEEEEEEEEEEEEHCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCEEHCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEEEEHCCCCCCCCCCCCCCCCCEEEEEEEHCCCCCCCCEEEHCCCCCCCCCCCEEEEEEHCCCCCCCCCEEEEHCCCCCEEEEEEEEEEHCCCCCCCC
MSADSSLSLPLSGTHRYRVTHRTEYRYSDVVTSSYGRGFLTPRNSLRQRCVAHRLTIDPAPADRSTSRDGYGNISSYFHVTEPHRTLTITSDSIVDVSPPPPGLYTSGPALQPWEAARPAGLPGSLATEFTLDLNPPEITDAVREYAAPSFLPKRPLVEVLRDLASRIYTDFTYRSGSTTISTGVNEVLLAREGVCQDFARLAIACLRANGLAACYVSGYLATDPPPGKDRMIGIDATHAWASVWTPQQPGRFEWLGLDPTNDQLVDQRYIVVGRGRDYADVPPLRGIIYTNSENSVIDVSVDVVPFEGDALHA

3isrB

0.20

0.18

0.87

2.71

MUSTER

LYFQSNA--------KFKIHSDITYQVSP----TTFIFNVHALRTESQHILDESLIVTPPIEIEEFSYNSGTSRFVRLKATENTTFSSYTATVDTQYKVIDQRQELET---------VPVVDLDGDIIPFLFPSRYCQS-DKLQKLAYKEFGKIENVYSKVLAITDWIYNNVEYISGSTNSQTSAFDTITERAGVCRDFAHLGIALCRALSIPARYFTGYAFKLNPP---------DFHACFEAYIGG-----NWIIFDATRLVPL-NGLVKIATGRDAADAAV--ASIFGNAS-STNHVECASLDTDFTPFWY

3isrB

0.19

0.16

0.86

4.48

dPPAS

------------LYFQFKIHSDITYQV----SPTTFIFNVHALRTESQHILDESLIVTPPIEIEEFSYNSGTSRFVRLKATENTTFSSYTATVDTQYKVIDQRQELET---------VPVVDLDGDIIPFLFPSRYCQS-DKLQKLAYKEFGKIENVYSKVLAITDWIYNNVEYISGSTNSQTSAFDTITERAGVCRDFAHLGIALCRALSIPARYFTGYAFKLNPP---------DFHACFEAYIGG-----NWIIFDATRLVPL-NGLVKIATGRDAADAAV---ASIFGNASSTNHVECASLDTDFTPFWY

3isrB

0.19

0.17

0.87

6.59

wdPPAS

LYFQSN--------AKFKIHSDITYQVSPTT----FIFNVHALRTESQHILDESLIVTPPIEIEEFSYNSGTSRFVRLKATENTTFSSYTATVDTQYKVIDQRQELET---------VPVVDLDGDIIPFLFPSRYCQ-SDKLQKLAYKEFGKIENVYSKVLAITDWIYNNVEYISGSTNSQTSAFDTITERAGVCRDFAHLGIALCRALSIPARYFTGYAFKLNPP---------DFHACFEAYIGG-----NWIIFDATRLV-PLNGLVKIATGRDAADAAVASIF----NASSTNHVECASLDTDFTPFWY

3isrB

0.19

0.17

0.86

3.68

wMUSTER

FQSNA----------KFKIHSDITYQVSP----TTFIFNVHALRTESQHILDESLIVTPPIEIEEFSYNSGTSRFVRLKATENTTFSSYTATVDTQYKVIDQRQELET---------VPVVDLDGDIIPFLFPSRYCQS-DKLQKLAYKEFGKIENVYSKVLAITDWIYNNVEYISGSTNSQTSAFDTITERAGVCRDFAHLGIALCRALSIPARYFTGYAFKLNPP---------DFHACFEAYIGG-----NWIIFDATRLVPL-NGLVKIATGRDAADAAVASIF----NASSTNHVECASLDTDFTPFWY

3isrB

0.19

0.17

0.87

6.08

wPPAS

LYFQSN--------AKFKIHSDITYQVSPTT----FIFNVHALRTESQHILDESLIVTPPIEIEEFSYNSGTSRFVRLKATENTTFSSYTATVDTQYKVIDQRQELET---------VPVVDLDGDIIPFLFPSRYCQ-SDKLQKLAYKEFGKIENVYSKVLAITDWIYNNVEYISGSTNSQTSAFDTITERAGVCRDFAHLGIALCRALSIPARYFTGYAFKLNPP---------DFHACFEAYIGG-----NWIIFDATRLV-PLNGLVKIATGRDAADAAVASIF----NASSTNHVECASLDTDFTPFWY

3isrB

0.20

0.17

0.86

15.42

dPPAS2

------------LYFQFKIHSDITYQV----SPTTFIFNVHALRTESQHILDESLIVTPPIEIEEFSYNSGTSRFVRLKATENTTFSSYTATVDTQYKVIDQRQELET---------VPVVDLDGDIIPFLFPSRYCQS-DKLQKLAYKEFGKIENVYSKVLAITDWIYNNVEYISGSTNSQTSAFDTITERAGVCRDFAHLGIALCRALSIPARYFTGYAFKLNPP---------DFHACFEAYIGG-----NWIIFDATRLVPL-NGLVKIATGRDAADAAV--ASIFGNAS-STNHVECASLDTDFTPFWY

3isrB

0.20

0.17

0.86

4.44

PPAS

------------LYFQFKIHSDITYQVS-PT---TFIFNVHALRTESQHILDESLIVTPPIEIEEFSYNSGTSRFVRLKATENTTFSSYTATVDTQYKVIDQRQELET---------VPVVDLDGDIIPFLFPSRYCQ-SDKLQKLAYKEFGKIENVYSKVLAITDWIYNNVEYISGSTNSQTSAFDTITERAGVCRDFAHLGIALCRALSIPARYFTGYAFKLNPP---------DFHACFEAYIGG-----NWIIFDATRLV-PLNGLVKIATGRDAADAAV--ASIFGNAS-STNHVECASLDTDFTPFWY

3isrB

0.20

0.18

0.87

5.67

Env-PPAS

LYFQSNA--------KFKIHSDITYQVS-PT---TFIFNVHALRTESQHILDESLIVTPPIEIEEFSYNSGTSRFVRLKATENTTFSSYTATVDTQYKVIDQRQELET---------VPVVDLDGDIIPFLFPSRYCQS-DKLQKLAYKEFGKIENVYSKVLAITDWIYNNVEYISGSTNSQTSAFDTITERAGVCRDFAHLGIALCRALSIPARYFTGYAFKLNPP---------DFHACFEAYIGG-----NWIIFDATRL-VPLNGLVKIATGRDAADAAV--ASIFGNAS-STNHVECASLDTDFTPFWY

4xz7A

0.12

0.11

0.91

1.05

MUSTER

LSTREELEEFGKNNNFLVINGKVTQNIHD-----FPHILVMNKGDMRELRFSGNGDLHNSMEPKRIHALFKIELDSNKRQLLNAAGLGTAENSLKNINGMTIYSHGLTVDNKYYEDYSKYTHNSVKNINV-TKERFIANDDLIHKLIESSAMKQSSERDKVKAFVQYVANHTTYDDINYYLGSDLFAVTERQKAMCVGFSTTAARAFNMLGLPAYVVVGKN------------AEGVPHATARVYYDK-----KWHTIDGTGFITKYSEKHFSTIGEDSYDVVEA---QEPKAERNYMIID--AMKQKTADLLL

4xz7A2

0.14

0.07

0.51

1.35

dPPAS

-----------------------------------------------------------------------------------------------------------------------------------TKERFIANDDLIHKLIESSAMKQSSERDKVKAFVQYVANHTTYADINYYLGSDLFAVTERQKAMCVGFSTTAARAFNMLGLPAYVVVGKN------------AEGVPHATARVYYDK-----KWHTIDGTGFITKYSEKHFSTIGEDSY------DVVEAGQEPKAERNYMIIDSNYESWAMK

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.95

Estimated TM-score = 0.84±0.08

Estimated RMSD = 4.3±2.9Å

Download Model 2

C-score=-2.61

Download Model 3

C-score=-2.44

Download Model 4

C-score=-2.17

Download Model 5

C-score=-2.27

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3isrB	0.831	1.60	0.179	0.873
2	1l9mB	0.479	4.15	0.098	0.592
3	2q3zA	0.467	4.18	0.111	0.580
4	3kd4A	0.435	4.80	0.079	0.576
5	3u84A	0.392	4.18	0.094	0.494
6	3fgwA	0.389	5.74	0.033	0.612
7	3i39X	0.387	6.48	0.058	0.637
8	2f4mA	0.386	4.50	0.164	0.490
9	3d9wA	0.382	4.19	0.145	0.490
10	2qshA1	0.379	4.40	0.072	0.490

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.10	5	1i8nA	ROP	Rep, Mult	198,201
2	0.08	4	5d63A	III	Rep, Mult	174,195,196,197,238,239,273
3	0.04	2	2b0qA	MG	Rep, Mult	259,278
4	0.04	2	1dd1C	SO4	Rep, Mult	192,198,201
5	0.04	2	1btgB	ZN	Rep, Mult	239,259
6	0.04	2	5d62A	III	Rep, Mult	174,195,196,238,239,259,261,262
7	0.04	2	5k6xA	FUC	Rep, Mult	216,218
8	0.02	1	2wtfB	CA	Rep, Mult	140,198
9	0.02	1	2h8pC	GOA	Rep, Mult	219,220
10	0.02	1	3hiaC	PC	Rep, Mult	241,255
11	0.02	1	4f8hA	LMD	Rep, Mult	200,203
12	0.02	1	1lm1A	F3S	Rep, Mult	198,200,201,204,205,215,277,278
13	0.02	1	1mfaL	ABE	Rep, Mult	245,255
14	0.02	1	1nufA	CA	Rep, Mult	203,206,210,213

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.078	2vfbA	0.358	3.99	0.141	0.449	2.3.1.5	196,239,259
2	0.060	1itwB	0.357	6.51	0.058	0.621	1.1.1.42	200
3	0.060	1jqoA	0.364	6.69	0.061	0.627	4.1.1.31	NA
4	0.060	2eabA	0.349	6.28	0.051	0.573	3.2.1.63	NA
5	0.060	1ileA	0.341	6.36	0.052	0.564	6.1.1.5	194
6	0.060	1kv3A	0.480	3.91	0.124	0.586	2.3.2.13	196,259
7	0.060	2vpiA	0.206	6.08	0.040	0.334	6.3.5.2	NA
8	0.060	1gw0A	0.345	6.69	0.030	0.592	1.10.3.2	NA
9	0.060	1e2tA	0.367	3.98	0.160	0.455	2.3.1.118	196,239,259
10	0.060	1e1eB	0.306	6.84	0.061	0.551	3.2.1.21	173
11	0.060	2q3zA	0.467	4.18	0.111	0.580	2.3.2.13	NA
12	0.060	3fu7B	0.348	6.47	0.069	0.596	1.10.3.2	211,256
13	0.060	1llwA	0.360	6.13	0.050	0.576	1.4.7.1	NA
14	0.060	1hcuB	0.348	6.80	0.043	0.602	3.2.1.113	43
15	0.060	2d0vA	0.361	6.17	0.043	0.596	1.1.99.8	NA
16	0.060	1l9mB	0.479	4.15	0.098	0.592	2.3.2.13	196,239
17	0.060	1lrwA	0.324	6.19	0.037	0.522	1.1.99.8	NA
18	0.060	2j5wA	0.368	7.05	0.030	0.678	1.16.3.1	NA
19	0.060	2qfwD	0.351	5.56	0.037	0.529	1.1.1.42	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.42	0.838	1.64	0.17	0.88	3isrB	GO:0006508 GO:0008233
1	0.10	0.292	6.95	0.04	0.53	1f13A	GO:0002576 GO:0003810 GO:0005576 GO:0005737 GO:0007596 GO:0007599 GO:0016740 GO:0016746 GO:0018149 GO:0031093 GO:0042060 GO:0046872 GO:0072562
2	0.07	0.480	3.95	0.12	0.59	4pygA	GO:0003810 GO:0005737 GO:0005739 GO:0005783 GO:0005829 GO:0005925 GO:0007200 GO:0016740 GO:0016746 GO:0018149 GO:0031012 GO:0031226 GO:0032471 GO:0043065 GO:0043277 GO:0045785 GO:0046872 GO:0051561 GO:0060445 GO:0060662 GO:0070062
3	0.07	0.479	4.15	0.10	0.59	1l9mB	GO:0003810 GO:0003824 GO:0005509 GO:0005737 GO:0006464 GO:0016740 GO:0016746 GO:0018149 GO:0030216 GO:0031069 GO:0031234 GO:0031424 GO:0043163 GO:0046872 GO:0051262 GO:0070062
4	0.07	0.467	4.18	0.11	0.58	2q3zA	GO:0003810 GO:0005737 GO:0005739 GO:0005783 GO:0005829 GO:0005925 GO:0007200 GO:0016740 GO:0016746 GO:0018149 GO:0031012 GO:0031226 GO:0032471 GO:0043065 GO:0043277 GO:0045785 GO:0046872 GO:0051561 GO:0060445 GO:0060662 GO:0070062
5	0.07	0.288	6.32	0.02	0.48	1g0dA	GO:0003810 GO:0016740 GO:0016746 GO:0018149 GO:0046872
6	0.07	0.434	4.48	0.11	0.55	3s3sA	GO:0003810 GO:0005737 GO:0005739 GO:0005783 GO:0005829 GO:0005925 GO:0007200 GO:0016740 GO:0016746 GO:0018149 GO:0031012 GO:0031226 GO:0032471 GO:0043065 GO:0043277 GO:0045785 GO:0046872 GO:0051561 GO:0060445 GO:0060662 GO:0070062
7	0.06	0.279	6.99	0.03	0.51	4r2bA	GO:0005215 GO:0006810
8	0.06	0.281	6.81	0.04	0.50	4aw6A	GO:0004222 GO:0005634 GO:0005637 GO:0005783 GO:0005789 GO:0006508 GO:0006998 GO:0008233 GO:0008235 GO:0008237 GO:0016020 GO:0016021 GO:0016787 GO:0030327 GO:0046872 GO:0070062 GO:0071586
9	0.06	0.283	6.48	0.03	0.47	3ucpA	GO:0046872 GO:0055114
10	0.06	0.260	6.68	0.04	0.45	3czmB	GO:0003824 GO:0004459 GO:0005975 GO:0016491 GO:0016616 GO:0019752 GO:0055114
11	0.06	0.249	6.36	0.04	0.42	2p0rA	GO:0004198 GO:0005509 GO:0005622 GO:0005737 GO:0006508 GO:0007586 GO:0008233 GO:0008234 GO:0016787 GO:0046872
12	0.06	0.242	6.51	0.04	0.40	2aryA	GO:0004198 GO:0005509 GO:0005622 GO:0005737 GO:0005739 GO:0005764 GO:0005829 GO:0005886 GO:0005925 GO:0006508 GO:0008092 GO:0008233 GO:0008234 GO:0008284 GO:0016020 GO:0016241 GO:0016540 GO:0016787 GO:0022617 GO:0032801 GO:0046872 GO:0060056 GO:0070062
13	0.06	0.241	6.19	0.05	0.40	4mwaF	GO:0003824 GO:0005506 GO:0008299 GO:0016114 GO:0016491 GO:0019288 GO:0044237 GO:0046429 GO:0046872 GO:0051536 GO:0051539 GO:0055114
14	0.06	0.235	6.14	0.05	0.39	2p1gB	GO:0008152 GO:0016787 GO:0016798 GO:0045493
15	0.06	0.205	5.93	0.05	0.32	4lubB	GO:0004664 GO:0008152 GO:0008652 GO:0009073 GO:0009094 GO:0016597 GO:0016829
16	0.06	0.194	6.05	0.04	0.32	1wwyA	GO:0000103 GO:0000502 GO:0005634 GO:0005737 GO:0005739 GO:0006457 GO:0006662 GO:0015035 GO:0015036 GO:0016671 GO:0034599 GO:0045454 GO:0055114 GO:0070062
17	0.06	0.200	5.04	0.05	0.29	3hiuD
18	0.06	0.178	4.67	0.06	0.25	2xzzA	GO:0001533 GO:0003810 GO:0006464 GO:0010838 GO:0016020 GO:0016740 GO:0016746 GO:0018149 GO:0030216 GO:0031224 GO:0031424 GO:0043163 GO:0045787 GO:0046872 GO:0070062

Consensus prediction of GO terms

Molecular Function	GO:0016755	GO:0043169	GO:0008233
GO-Score	0.53	0.53	0.42
Biological Processes	GO:0006464	GO:0006508
GO-Score	0.53	0.42
Cellular Component	GO:0044424	GO:0031988	GO:1903561
GO-Score	0.53	0.37	0.37

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.