I-TASSER results

I-TASSER results for job id Rv2568c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (341 residues)
MRDFHCPNCGQRLAFENSACLSCGSALGFSLGRMALLVIADDADVQLCANLHLAQCNWLV
PSDQLGGLCSSCVLTIERPSDTNTAGLAEFARAEGAKRRLIAELHELKLPIVGRDQDPDH
GLAFRLLSSAHENVTTGHQNGVITLDLAEGDDVHREQLRVEMDEPYRTLLGHFRHEIGHY
YFYRLIASSSDYLSRFNELFGDPDADYSQALDRHYRGGPPEGWQDSFVSSYATMHASEDW
AETFAHYLHIRDALDTAAWCGLAPASATFDRPALGPSAFNTIIDKWLPLSWSLNMVNRSM
GHDDLYPFVLPAAVLEKMRFIHTVVDEVAPDFEPAHSRRTV

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRDFHCPNCGQRLAFENSACLSCGSALGFSLGRMALLVIADDADVQLCANLHLAQCNWLVPSDQLGGLCSSCVLTIERPSDTNTAGLAEFARAEGAKRRLIAELHELKLPIVGRDQDPDHGLAFRLLSSAHENVTTGHQNGVITLDLAEGDDVHREQLRVEMDEPYRTLLGHFRHEIGHYYFYRLIASSSDYLSRFNELFGDPDADYSQALDRHYRGGPPEGWQDSFVSSYATMHASEDWAETFAHYLHIRDALDTAAWCGLAPASATFDRPALGPSAFNTIIDKWLPLSWSLNMVNRSMGHDDLYPFVLPAAVLEKMRFIHTVVDEVAPDFEPAHSRRTV
Prediction	CCCHCCCCCCCEEEEHCCCCCCCCCCEEEHCCCCEEEEHCCCCCEEHCCCCCCCCCEEHCCCCCCCHHCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEHCCCCCCCEHCCCCCEEEEEHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
Conf.Score	96555899997689865676788985665568886898578987676775566677466578998655478876687889999789999999999999999999998999998878899997567646899997655689879988533787999999999899578999999999999999999768965789999987999866999999999869999855665547776587567889999999999999999998988788888888888756999999999999999999998699988998788999999999999999865777655557889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRDFHCPNCGQRLAFENSACLSCGSALGFSLGRMALLVIADDADVQLCANLHLAQCNWLVPSDQLGGLCSSCVLTIERPSDTNTAGLAEFARAEGAKRRLIAELHELKLPIVGRDQDPDHGLAFRLLSSAHENVTTGHQNGVITLDLAEGDDVHREQLRVEMDEPYRTLLGHFRHEIGHYYFYRLIASSSDYLSRFNELFGDPDADYSQALDRHYRGGPPEGWQDSFVSSYATMHASEDWAETFAHYLHIRDALDTAAWCGLAPASATFDRPALGPSAFNTIIDKWLPLSWSLNMVNRSMGHDDLYPFVLPAAVLEKMRFIHTVVDEVAPDFEPAHSRRTV
Prediction	64404053161201011220331422000105322012037644122021242200100033755630020022032112163560252034004001200100340402234356327310001013577530100134020002043145541452365164302100000210000000000034356115301620315454045004511762327504631002001202100000000010001000000201002256261535224463034003100200100000011143440010102530250031002004523655554565556
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCHCCCCCCCEEEEHCCCCCCCCCCEEEHCCCCEEEEHCCCCCEEHCCCCCCCCCEEHCCCCCCCHHCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEHCCCCCCCEHCCCCCEEEEEHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
MRDFHCPNCGQRLAFENSACLSCGSALGFSLGRMALLVIADDADVQLCANLHLAQCNWLVPSDQLGGLCSSCVLTIERPSDTNTAGLAEFARAEGAKRRLIAELHELKLPIVGRDQDPDHGLAFRLLSSAHENVTTGHQNGVITLDLAEGDDVHREQLRVEMDEPYRTLLGHFRHEIGHYYFYRLIASSSDYLSRFNELFGDPDADYSQALDRHYRGGPPEGWQDSFVSSYATMHASEDWAETFAHYLHIRDALDTAAWCGLAPASATFDRPALGPSAFNTIIDKWLPLSWSLNMVNRSMGHDDLYPFVLPAAVLEKMRFIHTVVDEVAPDFEPAHSRRTV

4nfuB2

0.11

0.06

0.53

1.01

dPPAS

---------------------------------------------------------------------------------------------------------------------------------------------------FDMMFKKLNDMKISMAEWYKKKCKEVKIGYYDRFKTQLAFPSKEFDINIKNHHKSELNRFWKSVVEEVERRP-------QSDASILK---RRFLFSGNNYRRMIEPLDIAEYYLEGRK----EYRTTGRSHHYVMLEKWFGMESILIEKERCKKRDLSDLLTFDSCFWAEVEDSLIVINQLNTTVGMRDDVREV

4l7aA

0.18

0.13

0.71

1.18

Env-PPAS

-------------------------SI-FDASEKEKSEFNPNIDFKYREHIESDYTHNLVPTD----------FWLSVK----LAKIVKHCWLEAYDEVGGLDFTRACAP-----------KVIHLIGSAS------WDKGTYTLGTAEGG--LKVTLYGNWLDLTNVDRNEYYFKVHHEFAHILHQKKN-YPVDYDKISAG---NYTPT--GWQNRKLAEVAPLGFVTPYAGSKPSEDIAEVTACFLTYEAQWENVTLAG---------------EKGKPIIDQKLAVKKYKDS----WQV-DLD--LLRKVIARRTNEISEL------------DLDHI

4l7aA

0.19

0.11

0.62

1.50

wdPPAS

--------------------------------------------------------------------------SIFDASEKEKSEFDRWLLENYTDFWLSVKLAKI---------DEVGG---DFTRACAPKHLIGWDKGTYTLGTAEGG--LKVTLYGNWLDLTNVDRNEYYFKVHHEFAHILHQKKN-YPVDYDKISAG---NYTPT--GWQNRKLAEVAPLGFVTPYAGSKPSEDIAEVTACFLT-EAQWENVTLAG---------------EKGKPIIDQKLAVKKYKDSWQ------DLD---LRKVIARRTNEISEL------------DLDHI

4l7aA

0.20

0.12

0.61

1.05

wPPAS

------------------------------------SIFDASEKEK---S------RWLL-----ENY---------NP------NIDREHI-DFWLSVKLAKIVKH-L-------EA-GGLDF-VI------HLIGWDKGTYTLGTAEGG------LKVTLLDLTNVDRNEYYFKVHHEFAHILHQKKN---VDYDKISAG---NYTPT--GWQNRKLAEVAPLGFVTPYAGSKPSEDIAEVTACFLT-EAQWENVTLAG---------------EKGKPIIDQKLAVKKYKDSWQ------DLD---LRKVIARRTNEISEL------------DLDHI

2m6nA

0.15

0.02

0.11

1.24

dPPAS2

-----------------SLCIRCNSPAKYDCYLQRATCKREGCGFDYCTKHTTKDC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

4l7aA

0.20

0.14

0.72

MUSTER

------------------------SI--FDASEKEKSEFDRLENYVNPYNIDFK--REHIESDYTHNL---------VP----TDFWLSVKLAKIVKHCWLEAYDEVG----GLD----RACAPKVI------HLIGWDKGTYTLGTAEGG--LKVTLYGNWLDLTNVDRNEYYFKVHHEFAHILHQKKN-YPVDYDKISAG---NYTP--TGWQNRKLAEVAPLGFVTPYAGSKPSEDIAEVTACFLTYEAQWENVTLAG---------------EKGKPIIDQKLAVKK----YKDSWQV-DLD--LLRKVIARRTN-----ISELDLDHIY-------

3angC

0.13

0.06

0.49

0.99

dPPAS

---------------------------------------------------------------------------------------------------------------------------------------------------------VREYQKKRRRESRGTFFNYYKEAVLLDYGSQLLAGLREEVRRLLAQGREPVEVLRHLFRVLAEGTARE--KDLLLPFYELLNPDPVRARAAFEALPLGDLIAEILKPLREQGVLRQDFSLERGRTLADLYFLSALRWAAYTP---------------GRDLAEELEKNLRLLLEGLVREAPAPG----

5a0pA

0.14

0.07

0.50

0.68

wdPPAS

--------------------------------------------------------------MDSTTI-NKDTLSQIV-NYDKNEANAMVNRLANIDGKYLNALKQNNLKIVVPKGWEGTGKTWD-----DVPGLGG-STVALRIGFSNKGKGHDAI--------------LELHETAHAIDHIVL-NDISKSAQFKQIFAKEGRSL-------------------GNVNYLGVYPEEFFAESFAYYYLNQDTNSKLKSA-----------CPQTYSFLQNLAK---------------------------------------------------------

4l7aA

0.21

0.14

0.69

0.93

wMUSTER

----------------------------FDASEKEKSEFDRLENYVNPYNIDFK--REHIESDYTHNL---------VP----TDFWLSVKLAKIVKHCWLEAYDEVG------------GLDFKVI------HLIGWDKGTYTLGTAEGG------LKVTLLDLTNVDRNEYYFKVHHEFAHILHQKKN-YPVDYDKISAG---NYTP--TGWQNRKLAEVAPLGFVTPYAGSKPSEDIAEVTACFLTYEAQWENVTLAG---------------EKGKPIIDQKLAVKK----YKDSWQV-DLD--LLRKVIARRTN-----ISELDLDHIY-------

5iy7M

0.16

0.13

0.78

0.56

wPPAS

LDA-TCPNHPDALVEDYRACPECGLVV---GDRV----IDVGSEWRTFSNDKADSQNPLLSDGDLSTM-ASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLP-----VDRTNNL-FKQVYE--QKSLKGRADAIA------SACLYIACRQEGVPRTFKEICAVSKKEIGRCFKLILKALE----------TSVDLITTGDFMSRFCSN-------PKQVQMAATH--ARKAVELD---LVPPISVAAAAIY-MASQASAEKRTQ---KEIGDIAG-DVTIRQSYRLIYPRAP--DLFPFKFDTP-VDKLQL---------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.11

Estimated TM-score = 0.36±0.12

Estimated RMSD = 14.0±3.9Å

Download Model 2

C-score=-3.57

Download Model 3

C-score=-4.10

Download Model 4

C-score=-4.89

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4l7aA	0.643	2.66	0.141	0.727
2	1jkyA	0.453	4.95	0.077	0.625
3	3c3lA	0.440	6.24	0.040	0.710
4	2fflA	0.439	6.22	0.080	0.707
5	4fyeA	0.425	6.50	0.031	0.704
6	3btaA	0.423	5.87	0.034	0.645
7	3se6A	0.422	6.62	0.045	0.713
8	2xdtA	0.419	6.77	0.029	0.719
9	3ebgA	0.418	6.31	0.060	0.680
10	1lmlA	0.417	5.70	0.057	0.622

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.21	11	2gtqA	ZN	Rep, Mult	179,183,238
2	0.11	6	3dtiA	ZN	Rep, Mult	175,176,179,242
3	0.06	3	3ndiA	ZN	Rep, Mult	20,23,48,56
4	0.04	2	3efoB	ZN	Rep, Mult	6,9,20,23
5	0.02	1	3perA	FE	Rep, Mult	164,176,179
6	0.02	1	3l2nA	CA	Rep, Mult	138,164,235
7	0.02	1	2zo4A	ZN	Rep, Mult	172,175,235,252
8	0.02	1	4a37A	ZN	Rep, Mult	138,164,249

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2j5wA	0.397	6.82	0.041	0.683	1.16.3.1	NA
2	0.060	1z7hA	0.394	5.72	0.024	0.595	3.4.24.68	NA
3	0.060	2imcB	0.393	6.33	0.060	0.625	3.4.24.69	298
4	0.060	2etfB	0.395	6.31	0.076	0.636	3.4.24.69	NA
5	0.060	2vuaA	0.294	6.99	0.044	0.513	3.4.24.69	247,251,305
6	0.060	1f6wA	0.396	6.28	0.063	0.636	3.1.1.13,3.1.1.3	NA
7	0.060	2w2dA	0.402	6.52	0.058	0.663	3.4.24.69	298
8	0.060	1e1hC	0.306	5.18	0.067	0.440	3.4.24.69	NA
9	0.060	3debA	0.394	6.29	0.055	0.645	3.4.24.69	NA
10	0.060	1yqyA	0.451	5.05	0.081	0.636	3.4.24.83	NA
11	0.060	1aroP	0.376	6.92	0.050	0.660	2.7.7.6	NA
12	0.060	1jkyA	0.453	4.95	0.077	0.625	3.4.24.83	231
13	0.060	3ebgA	0.418	6.31	0.060	0.680	3.4.11.-	NA
14	0.060	1b41A	0.391	6.31	0.070	0.636	3.1.1.7	NA
15	0.060	1zkxB	0.381	5.95	0.036	0.589	3.4.24.69	247
16	0.060	2np0A	0.403	6.21	0.073	0.657	3.4.24.69	247
17	0.060	1e1hD	0.176	5.05	0.009	0.243	3.4.24.69	NA
18	0.060	1zb7A	0.395	6.11	0.065	0.625	3.4.24.69	247
19	0.060	1n1zA	0.401	6.34	0.066	0.633	5.5.1.8	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.30	0.453	4.95	0.08	0.62	1jkyA	GO:0000122 GO:0001933 GO:0003824 GO:0005576 GO:0005829 GO:0005886 GO:0006508 GO:0008233 GO:0008237 GO:0009405 GO:0010008 GO:0010629 GO:0016787 GO:0035897 GO:0043409 GO:0044533 GO:0046872 GO:0061136 GO:0097300 GO:1903140
1	0.11	0.451	4.75	0.08	0.62	1zxvA	GO:0003824 GO:0005576 GO:0006508 GO:0008237 GO:0009405 GO:0046872
2	0.06	0.305	7.05	0.04	0.53	4be4A	GO:0016787
3	0.06	0.347	5.78	0.05	0.52	1xfuA	GO:0000166 GO:0003824 GO:0004016 GO:0005516 GO:0005524 GO:0005576 GO:0005829 GO:0005886 GO:0006171 GO:0006508 GO:0008237 GO:0008294 GO:0009405 GO:0010008 GO:0016829 GO:0046872 GO:0052007
4	0.06	0.346	5.07	0.06	0.48	4fxqA	GO:0000166 GO:0003824 GO:0005576 GO:0006508 GO:0008237 GO:0009405 GO:0016740 GO:0016779 GO:0046872
5	0.06	0.407	6.76	0.04	0.69	3c46A	GO:0000166 GO:0003899 GO:0005524 GO:0005525 GO:0016740 GO:0016779 GO:0019012 GO:0032774 GO:0046872
6	0.06	0.319	6.28	0.06	0.51	1y2mB	GO:0003824 GO:0005737 GO:0006559 GO:0009698 GO:0009800 GO:0016829 GO:0016841 GO:0045548 GO:0052883
7	0.06	0.323	6.35	0.04	0.53	2gq3A	GO:0000287 GO:0003824 GO:0004474 GO:0005576 GO:0005618 GO:0005737 GO:0005829 GO:0005886 GO:0006097 GO:0006099 GO:0015936 GO:0016740 GO:0030145 GO:0046872
8	0.06	0.298	7.42	0.04	0.55	4qnuA	GO:0002098 GO:0006400 GO:0008033 GO:0016300 GO:0016740 GO:0016765 GO:0030488
9	0.06	0.267	6.70	0.04	0.45	1opeA	GO:0005739 GO:0008152 GO:0008260 GO:0008410 GO:0016740 GO:0042803 GO:0046950 GO:0046952
10	0.06	0.277	6.95	0.03	0.48	3jzdA	GO:0000166 GO:0016491 GO:0046872 GO:0055114
11	0.06	0.271	6.81	0.04	0.47	3iv7A	GO:0016491 GO:0018506 GO:0046872 GO:0055114
12	0.06	0.289	6.75	0.09	0.48	2z0qA	GO:0005085 GO:0005089 GO:0005622 GO:0005737 GO:0035023 GO:0035556 GO:0043547
13	0.06	0.284	6.17	0.07	0.46	1jkfA	GO:0004512 GO:0005737 GO:0006021 GO:0006629 GO:0008654 GO:0016853
14	0.06	0.288	6.51	0.04	0.48	4lcdA	GO:0000151 GO:0000209 GO:0004842 GO:0005634 GO:0005737 GO:0005794 GO:0005856 GO:0005934 GO:0006333 GO:0006511 GO:0006513 GO:0006808 GO:0007005 GO:0010008 GO:0010793 GO:0010794 GO:0010795 GO:0010796 GO:0016567 GO:0016874 GO:0019220 GO:0030479 GO:0031234 GO:0031384 GO:0032436 GO:0032443 GO:0032511 GO:0032880 GO:0032956 GO:0034517 GO:0034644 GO:0035091 GO:0042493 GO:0042787 GO:0043130 GO:0043161 GO:0043162 GO:0045723 GO:0045807 GO:0045944 GO:0048260 GO:0051865 GO:0061630 GO:0070086 GO:2000203 GO:2000232 GO:2000235 GO:2000238
15	0.06	0.252	7.09	0.03	0.45	1p1fA	GO:0004512 GO:0005737 GO:0006021 GO:0006629 GO:0008654 GO:0016853
16	0.06	0.261	6.59	0.07	0.43	2v1uA	GO:0000166 GO:0003677 GO:0005524 GO:0006260
17	0.06	0.303	6.13	0.06	0.48	1jkiA	GO:0004512 GO:0005737 GO:0006021 GO:0006629 GO:0008654 GO:0016853
18	0.06	0.267	6.58	0.05	0.44	1m3eB	GO:0005739 GO:0008152 GO:0008260 GO:0008410 GO:0016740 GO:0042803 GO:0046950 GO:0046952

Consensus prediction of GO terms

Molecular Function	GO:0008237	GO:0046872
GO-Score	0.46	0.46
Biological Processes	GO:0009405	GO:0044533	GO:0035897	GO:0061136	GO:0000122	GO:0043409	GO:0097300	GO:1903140
GO-Score	0.46	0.30	0.30	0.30	0.30	0.30	0.30	0.30
Cellular Component	GO:0005576	GO:0010008	GO:0005829	GO:0005886
GO-Score	0.46	0.35	0.35	0.35

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.