I-TASSER results

I-TASSER results for job id Rv2566

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (1140 residues)
MPLRPTQVSGTGRTRCAGRSGVISSAAMSIKVALEHRTSYTFDRLVRVYPHIVRLRPAPH
SRTSIEAYSLRIEPADHFINWQQDALGNFLARLVFPNPMRQLRITVGLIADLKVINPFDF
FIEDWAEIWPCAGMAYPKALADDLRPYLRPVDEDGDGSGPGELTQAWVRNFTVPDGTRTI
DFLVALNRAINADVGYCVRMEPGVQTPDFTLRTGVGSCRDSAWLLVSILRQFGLAARFVS
GYLVQLASDIEALDGPSGPAADFTDLHAWAEAYIPGAGWIGLDPTSGLLAGEGHIPLAAT
PHPASAAPISGGTDVCDTVLEFSNTVTRVHEDPRVTLPYTDESWKTICEVGQRVDERLAA
ADVRLTVGGEPTFVSVDNQVAEEWRTAADGPHKRERASDLAARLKAVWAPQGLIHRGQGR
WYPGEPLPRWQIALYWRTDGRPLWTNDALLADPWGAPPADPVDDDAAYRVLAGIADGLGL
PISQVRPAYEDPLSRLAAAVRMPAGDPVESGDDLGCDTNPDTPTGRAALLARLDEAITSP
AAYVLPLHRRDDGQGWASANWRLRRGRIVLLEGDSPAGLRLPLDSISWRPPRASFDADPV
AVRSTLPAELHTDRAVVEDPETAPTTALVAEVRGGLVHIFLPPTDALEHFIDLVARVEAA
ATTANCPVVIEGYGPPPDPRLTSTTITPDPGVIEVNIAPTASFAEQRQQLETLYQQARLA
RLTTEAFDVDGTHGGTGGGNHITLGGVTPADSPLLRRPDLLVSLLTYWQRHPSLSYLFAG
RFVGTTSQAPRVDEGRAEALYELEIAFAEILRLSPSSGGGRPQPWVTDRALRHLLTDITG
NTHRAEFCIDKLYSPDSARGRLGLLELRGFEMPPHLHMAMVQSLLVRSLVAWFWDQPLRA
PLIRHGANLHGRYLLPHFLIHDIADVAADLRAHGIAFETSWLDPFTEFRFPRIGTAVFDG
IEIELRGAIEPWHTLGEEATAAGTARYVDSSVERIQVRIIGADRHRYVVTCNGYPMPLLA
TDNPDIHVGGVRFKAWQPPSALHPTITVDGPLRFELIDIATATSCGGCTYHVAHPGGRAY
DEPPVNAVEAEARRARRFEATGFTPGKLDLSDIREKQARISTDIGAPGILDLRRVRTVQQ

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 860 880 900 920 940 960 980 1000 1020 1040 1060 1080 1100 1120 1140 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MPLRPTQVSGTGRTRCAGRSGVISSAAMSIKVALEHRTSYTFDRLVRVYPHIVRLRPAPHSRTSIEAYSLRIEPADHFINWQQDALGNFLARLVFPNPMRQLRITVGLIADLKVINPFDFFIEDWAEIWPCAGMAYPKALADDLRPYLRPVDEDGDGSGPGELTQAWVRNFTVPDGTRTIDFLVALNRAINADVGYCVRMEPGVQTPDFTLRTGVGSCRDSAWLLVSILRQFGLAARFVSGYLVQLASDIEALDGPSGPAADFTDLHAWAEAYIPGAGWIGLDPTSGLLAGEGHIPLAATPHPASAAPISGGTDVCDTVLEFSNTVTRVHEDPRVTLPYTDESWKTICEVGQRVDERLAAADVRLTVGGEPTFVSVDNQVAEEWRTAADGPHKRERASDLAARLKAVWAPQGLIHRGQGRWYPGEPLPRWQIALYWRTDGRPLWTNDALLADPWGAPPADPVDDDAAYRVLAGIADGLGLPISQVRPAYEDPLSRLAAAVRMPAGDPVESGDDLGCDTNPDTPTGRAALLARLDEAITSPAAYVLPLHRRDDGQGWASANWRLRRGRIVLLEGDSPAGLRLPLDSISWRPPRASFDADPVAVRSTLPAELHTDRAVVEDPETAPTTALVAEVRGGLVHIFLPPTDALEHFIDLVARVEAAATTANCPVVIEGYGPPPDPRLTSTTITPDPGVIEVNIAPTASFAEQRQQLETLYQQARLARLTTEAFDVDGTHGGTGGGNHITLGGVTPADSPLLRRPDLLVSLLTYWQRHPSLSYLFAGRFVGTTSQAPRVDEGRAEALYELEIAFAEILRLSPSSGGGRPQPWVTDRALRHLLTDITGNTHRAEFCIDKLYSPDSARGRLGLLELRGFEMPPHLHMAMVQSLLVRSLVAWFWDQPLRAPLIRHGANLHGRYLLPHFLIHDIADVAADLRAHGIAFETSWLDPFTEFRFPRIGTAVFDGIEIELRGAIEPWHTLGEEATAAGTARYVDSSVERIQVRIIGADRHRYVVTCNGYPMPLLATDNPDIHVGGVRFKAWQPPSALHPTITVDGPLRFELIDIATATSCGGCTYHVAHPGGRAYDEPPVNAVEAEARRARRFEATGFTPGKLDLSDIREKQARISTDIGAPGILDLRRVRTVQQ
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEEEHCCCCCCCCEEEEEHCCCCCCCEEEEEEEEEHCCCEEEEEEHCCCCCEEEEEEHCCCCCEEEEEEEEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCEEEHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHCCCCEEEHCCCCCCCCCCCCEEEEHCCCCCCCCCCCCEHCCCCCEEEEEEEEEEEHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEHCCCCEEEHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEHCCCCCCCCCCCCHHHHHHEHCCCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHCCCCHCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEHCCHCCCCCCCEHCCCCCCCCCEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEHCCEEEEHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEHCCCCCCCCCEEEEEEHCCCCEEEEHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEHCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEHCCCCCCCCCCCCCEEEEHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEHCCEEEEEHCCCCCCCCCCCCCCCCCEEEEHCCCCEEEEEEEHCCCCCEEEEEHCCEHCCCCCCCCCCCEEEEEEEHCCCCCCCCCCCCCCCCCEEEEEEHCCCCCCHCCEEEEHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEHCCCCCCCCC
Conf.Score	988777788888776778888888888758999999999985887443777999987999996799999999678858878758888779999995887599999999999775788777777655457766666767888999998746666777887559999999985788998679999999999997645776678999999999988995457999999999999898656775547889998888889998767887556558999689985887689999888895888756886678886665578765789999999976588888999869999999999999999999796798688756886688888776666788899999999999999997888656654777899988867766654447997667885665788899998888899999999999999899877756644459999999997899999766777778877789999999999999757886589985544578888566676567775899579887555678888888998888999998888888887666777778887765568999997998999868875899999999999999999899799987999998634579986898589998578999999999999999999998688654467887778899876998789988898877869999999999858656776557887887889988777765678999999999875688999999968999999998875468887664444446899999887455664345789988999999999999999999677779987776566566765999999999999999998999897899999987577556999899999985356866656778888875888746535789998788898599999887758856888885799998745588877888888889858999866777754556887668999888889988999999999986555889898888877667788888988986455688886579
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 860 880 900 920 940 960 980 1000 1020 1040 1060 1080 1100 1120 1140 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MPLRPTQVSGTGRTRCAGRSGVISSAAMSIKVALEHRTSYTFDRLVRVYPHIVRLRPAPHSRTSIEAYSLRIEPADHFINWQQDALGNFLARLVFPNPMRQLRITVGLIADLKVINPFDFFIEDWAEIWPCAGMAYPKALADDLRPYLRPVDEDGDGSGPGELTQAWVRNFTVPDGTRTIDFLVALNRAINADVGYCVRMEPGVQTPDFTLRTGVGSCRDSAWLLVSILRQFGLAARFVSGYLVQLASDIEALDGPSGPAADFTDLHAWAEAYIPGAGWIGLDPTSGLLAGEGHIPLAATPHPASAAPISGGTDVCDTVLEFSNTVTRVHEDPRVTLPYTDESWKTICEVGQRVDERLAAADVRLTVGGEPTFVSVDNQVAEEWRTAADGPHKRERASDLAARLKAVWAPQGLIHRGQGRWYPGEPLPRWQIALYWRTDGRPLWTNDALLADPWGAPPADPVDDDAAYRVLAGIADGLGLPISQVRPAYEDPLSRLAAAVRMPAGDPVESGDDLGCDTNPDTPTGRAALLARLDEAITSPAAYVLPLHRRDDGQGWASANWRLRRGRIVLLEGDSPAGLRLPLDSISWRPPRASFDADPVAVRSTLPAELHTDRAVVEDPETAPTTALVAEVRGGLVHIFLPPTDALEHFIDLVARVEAAATTANCPVVIEGYGPPPDPRLTSTTITPDPGVIEVNIAPTASFAEQRQQLETLYQQARLARLTTEAFDVDGTHGGTGGGNHITLGGVTPADSPLLRRPDLLVSLLTYWQRHPSLSYLFAGRFVGTTSQAPRVDEGRAEALYELEIAFAEILRLSPSSGGGRPQPWVTDRALRHLLTDITGNTHRAEFCIDKLYSPDSARGRLGLLELRGFEMPPHLHMAMVQSLLVRSLVAWFWDQPLRAPLIRHGANLHGRYLLPHFLIHDIADVAADLRAHGIAFETSWLDPFTEFRFPRIGTAVFDGIEIELRGAIEPWHTLGEEATAAGTARYVDSSVERIQVRIIGADRHRYVVTCNGYPMPLLATDNPDIHVGGVRFKAWQPPSALHPTITVDGPLRFELIDIATATSCGGCTYHVAHPGGRAYDEPPVNAVEAEARRARRFEATGFTPGKLDLSDIREKQARISTDIGAPGILDLRRVRTVQQ
Prediction	642434624454442434354214432000102040303030430031000000000011220230202040424213121111110000000001320230101020101011120111103322221311311123101210110000022244242024002300330114431100000210041014203032432402200010031230000000000000000000000000000102344344242321110110000000000003300000000100013320000000010100000101123142323121303314341221421446214203400440144046430100102310100253253320224022440242044004202630010000000110101214001000000103103101433310022445453444335203400420063040445102000000000013035004504154444443444153441043014103420430000000010345432030040412541000011010001001021021334642132112443441454354644436524300000000002402000000004303200300100040054160000000000021110410100010000000100042053014103200300130100010011214101010000000002114211112113002000210110000000000110012200013120244100000000320453444565540100000000100000101011100000000101621300000000000001121000000000000000100241164401310140001000000013004300410361214044400200100000000103144010001100200100014444422011100011001010321344200000011200042144432100000000010110000002120100000122123101000000000020231321224141013103320342111114042442544434244423000000001144268
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560                 580                 600                 620                 640                 660                 680                 700                 720                 740                 760                 780                 800                 820                 840                 860                 880                 900                 920                 940                 960                 980                1000                1020                1040                1060                1080                1100                1120                1140

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Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEEEHCCCCCCCCEEEEEHCCCCCCCEEEEEEEEEHCCCEEEEEEHCCCCCEEEEEEHCCCCCEEEEEEEEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCEEEHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHCCCCEEEHCCCCCCCCCCCCEEEEHCCCCCCCCCCCCEHCCCCCEEEEEEEEEEEHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEHCCCCEEEHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEHCCCCCCCCCCCCHHHHHHEHCCCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHCCCCHCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEHCCHCCCCCCCEHCCCCCCCCCEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEHCCEEEEHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEHCCCCCCCCCEEEEEEHCCCCEEEEHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEHCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEHCCCCCCCCCCCCCEEEEHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEHCCEEEEEHCCCCCCCCCCCCCCCCCEEEEHCCCCEEEEEEEHCCCCCEEEEEHCCEHCCCCCCCCCCCEEEEEEEHCCCCCCCCCCCCCCCCCEEEEEEHCCCCCCHCCEEEEHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEHCCCCCCCCC
MPLRPTQVSGTGRTRCAGRSGVISSAAMSIKVALEHRTSYTFDRLVRVYPHIVRLRPAPHSRTSIEAYSLRIEPADHFINWQQDALGNFLARLVFPNPMRQLRITVGLIADLKVINPFDFFIEDWAEIWPCAGMAYPKALADDLRPYLRPVDEDGDGSGPGELTQAWVRNFTVPDGTRTIDFLVALNRAINADVGYCVRMEPGVQTPDFTLRTGVGSCRDSAWLLVSILRQFGLAARFVSGYLVQLASDIEALDGPSGPAADFTDLHAWAEAYIPGAGWIGLDPTSGLLAGEGHIPLAATPHPASAAPISGGTDVCDTVLEFSNTVTRVHEDPRVTLPYTDESWKTICEVGQRVDERLAAADVRLTVGGEPTFVSVDNQVAEEWRTAADGPHKRERASDLAARLKAVWAPQGLIHRGQGRWYPGEPLPRWQIALYWRTDGRPLWTNDALLADPWGAPPADPVDDDAAYRVLAGIADGLGLPISQVRPAYEDPLSRLAAAVRMPAGDPVESGDDLGCDTNPDTPTGRAALLARLDEAITSPAAYVLPLHRRDDGQGWASANWRLRRGRIVLLEGDSPAGLRLPLDSISWRPPRASFDADPVAVRSTLPAELHTDRAVVEDPETAPTTALVAEVRGGLVHIFLPPTDALEHFIDLVARVEAAATTANCPVVIEGYGPPPDPRLTSTTITPDPGVIEVNIAPTASFAEQRQQLETLYQQARLARLTTEAFDVDGTHGGTGGGNHITLGGVTPADSPLLRRPDLLVSLLTYWQRHPSLSYLFAGRFVGTTSQAPRVDEGRAEALYELEIAFAEILRLSPSSGGGRPQPWVTDRALRHLLTDITGNTHRAEFCIDKLYSPDSARGRLGLLELRGFEMPPHLHMAMVQSLLVRSLVAWFWDQPLRAPLIRHGANLHGRYLLPHFLIHDIADVAADLRAHGIAFETSWLDPFTEFRFPRIGTAVFDGIEIELRGAIEPWHTLGEEATAAGTARYVDSSVERIQVRIIGADRHRYVVTCNGYPMPLLATDNPDIHVGGVRFKAWQPPSALHPTITVDGPLRFELIDIATATSCGGCTYHVAHPGGRAYDEPPVNAVEAEARRARRFEATGFTPGKLDLSDIREKQARISTDIGAPGILDLRRVRTVQQ

4bxsV

0.11

0.10

0.90

1.14

MUSTER

NPIVYREYELDFKQEKPRDALSGLLGPTSLIIYFKNFA----TQPVSIHPQSAVYNKWSEGTSDVERLDDAVPPQSFKYVWNITADPPCLTYAYYSHVNMVRDFNSGLIGALLICKEGSLNANGSQKFFNREYVLMFSVFDESKN----WYRKPSLQYTINGFANGTLPDVQACAYDHISWHLIGMSSSPEIFSVHFNGQTEQNHYKVSTINLVGGASVTAKWLIVAKHLQAGM-----YGYLNIKDCGNPDMKIKNWE------------YFIA-AEEITWDYAPEIPSSVDRRYKAQYLDN----------FSNFIGKKYKKAVFRQYEDGNFTKP-TYAIWPKERGIGPVI--KAKVRDIVFKNLARPYSIYVKDAEGAIYHGKAVEPQVYTYKWTVLDTDEPTVKDSECITK----LYHSAVDMTRDIAS-----GLPLLVCKHKALSGVQNKADVEQHDENKSWYLEDNIKKYCSNPSAVKK--DDPKFYKSNVMYTLNGYAS--DRTEVLRFHQSE---VVQWHLTSVGTVDEIVPVHL------SGHTFLSKG--KHQDILNLFPMDNLGTWLLSSWGSCEMSNANYDDEDEGNEEEEEDDGDIFADIFIPSEGNKRRYYIAAEEVLKTTFKKAIFRSYLDDTFQTPSTGGEYEKHLGIL----G--P-------IIRAE--VDVIEIQFKNLAS-----RPYSLHAHGLLYEKSSEGRSYDDKSPELFKKDDAIMPNGVPPRSGPTDNTEK----CKSWA--YSPEKDIHSGLIICQKGMIDKYNRTIDIREFVLFFMVFDEEKSWYFPCSLHTFPAINGIPYQL-LTMYKDENVHWHLLNM------GGPKDIHVVNFHGQTFEEGREDNQLGVLPLLPGTFASIKMKPSKI--------GTWLLETEVGENQERGMQALFTVIDKDCKLPMGLASGIIQDSQISASGHVGKLARLNNTGKYNAWSIIKKEHEHPWIQIDVVITGIQTQGTVQLLQHSYTVE--YFVTYSEDGQNWITFKG----QMHFEGNSDGTTVKDPPIIARYIRLFYNRTFRIELLGCEVEGCSVPLGMEIKNKEITASSYKKTWWSSWEPFLARLNLEGGTNAPEVNNKDQWLQIDLQHLTKITS

5ifeA

0.12

0.10

0.90

1.07

MUSTER

VDMF-LTLQRATGISFAIHGNFSGTKQQEIVVS-KILELLRPDP--TGKVHTLLTVEVFGVIRSLMAFRLT--GTKDYIVVGSD--SGRIVILEYQPSKNMFEKIHQETFGKSGCRRIVPG--QFLAVDPKGRAVMISAIEKQKLVYILNRDAAARLTISSPLLVYHVVGVDVGFENPMFACLEMDYEEADNDPTGEAAANTQQTLTFYELDLGLNPLEEHGNFLITVPGG-GPSGVLICSYITYKNFGDQPDRNDLDDPERGMIFVCSATHKTKSMFFFLAQTEQGDIFEDM-KYFDTVPVAAAMCVLKGFL-ASEFGNHYLYQIAHLGDDDEEPEFSSAMPLEDTFFFQPRPLKNLVLVDELDSLS--PLFCQIADLANEDTPYVACGRGPRS-------SLR-------VLRHGLE---VSEELPGNPNAVWTVRRHIEDEFDAYIVSFVNASIGETVEEVTDSG-FLPTLSCSL-LGDDALVQVYPDGIRHIRADKRV-NEWKTPGKKTIVKCAVNQR-----QVVIALTGG------ELVYFEMDPSGQLNEYTERKMSADVVCMSLANVPPG-EQRSRFLAVGLVDNTVRIISLDPSDCLQPLSMQALPAQPESLCIV-LYLNIGLQNGVLLRT-----VLDP------------VTGDLSDTRTGSRP---VKLFRVRMQGQEAVLAMSSRSSYSYQSRFHLTPLSYETLEFSGFASEQCP-EGIVAIST--NTLRILALEKLGAVFNQVAFPLQYTPRKFVIHPE-----SNNLIIIET---DHNAYTEATKAQRKQQMAEEMVEAAGELAAEMAAAFLNENLSIFGAPKAGNGQWA-SVI-RVMNPIQGN--LDLVQLEQNEAA----FSVAVCRFWYVLVGVAKDLILNPRSVAGG-----------FV------YTYKLVNNGEKLE---FLHKTPVEEVPAAIAPFQGRVLIGVGKLLRVYDLGKKKQTIGHRVIVSDVQESFIWVRYKRNENQLIIFADDT-YPRWVTTLDYDTVAGADKFGRLPPNTNDEVDNGASQKAEVIMNYHVGETVLSLQKTTLIPGGSESSGVPFTS-HEDHDFFQHVEMH-EHPPLCGRDHLSFRSYYFPVKN----VIDCEQFNSMEP

3isrB

0.21

0.05

0.25

2.56

dPPAS

---------------------------LYFQFKIHSDITYQV----SPTTFIFNVHALRTESQHILDESLIVTPPIEIEEFSYNSGTSRFVRLKATENTTFSSYTATVDTQYKVIDQRQEL-----------ETVPVVDLDGDIIPFLFPSRYCQ-----SDKLQKLAYKE-FGKIENVYSKVLAITDWIYNNVEYISGSTNSQTSAFDTITERAGVCRDFAHLGIALCRALSIPARYFTGYAFKLNPP---------------DFHACFEAYIGG-NWIIFDAT-RLVPLNGLVKIATGRDAADAAVAS-IFGNASSTNHVECASLDTDFTPFW---YDKNSLKGLSFQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

3tonA

0.15

0.11

0.70

0.97

wMUSTER

YPDENGASAENCTARASNSSGVPF---------------CYFVND---LYSVSDVQYNSH----GATADISLKSSVY----ANAFPST---------PVNPLRLDVTYHKN----EMLQFKIYDPNKNR-----------------YEVPVPLNIPSMP------------SSTPEGQLYDVLIK-----KNPFGIEIRRKSTGTIIWDS--QLLGFTFSDMFIRIST-----LPSKYLYGFSYRRDLEWHSRDQPPGYKKNSYGVHPYYMGLEEDGSAHGV-----LLLNSNAMDVTFQPLPA----LTYRTTGGVLDFYVFLTPELVTQQELIGRPVMVPYWSL-DSEIASLYDEMVAAQIPYDV----QYSDIDYMERQDFTLS----PKFAGFPALINRMKADGMR--ILILDPASGNETQPYPAFTRGV-FIKYGDIVW---KVWPDFPDVVVNGSLDWDSQVELYRA-------YVAFPDFFRNSTAKWWKREIEELYNNPQNPERSLKFDGMWID--------------MNEPSSF----VNGAVSPGCRDASL------------NHP----------PYMPHLESRDRGLSSKTLCMESQQILPDGS------------LVQHYN---------VHNLYGWSQTRPTYEAVQEVTGQGVVITTF--PSSGRW-AGHWLGD------N---TAAWDQLKKSIIGMMEFSLF-------ISYTG--ADICG-----FQDAE---------YEMCVRWMQLGAFYP-FSRNHNT--IGTRRQDP----SWDVAFVNISRTVLQTRYT----------PYLYTLMHKAHTEGVT--VVRP-LLHE--F-VSDQV---------TWDID--------QFLL--------------------GPAF----LVP---------V----------LERN-----------------ARNVTAYFPRAR--WYDYGVDINARGEWKTLPAPLDHINLHVRG-----------GYILPWQE-------------------PALNTHLSRQKFMGFKIALDDEGTAGG--WLFW---DGQSIDTYGKGLYSASQNTMQHIIFNNYITGTNPVGSVPVTSVSISVSPSF-QVLSIDVTDSLHN

3isrB

0.20

0.05

0.25

2.61

wdPPAS

---------------------------LYFQFKIHSDITYQVSPTT----FIFNVHALRTESQHILDESLIVTPPIEIEEFSYNSGTSRFVRLKATENTTFSSYTATVDTQYKVIDQRQE-----------LETVPVVDLDGDIIPFLFPSRYCQ-----SDKLQKLAYKE-FGKIENVYSKVLAITDWIYNNVEYISGSTNSQTSAFDTITERAGVCRDFAHLGIALCRALSIPARYFTGYAFKLNPP---------------DFHACFEAYIGG-NWIIFDATRLV-PLNGLVKIATGRDAADAAVAS-IFGNASSTNHVECASLDTDFTPFW---YDKNSLKGLSFQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

4acqA

0.13

0.12

0.94

1.07

MUSTER

VPLHT----ETTEKGCVLLSYL--NETVTVSASLESRSLFTDLEAENDVLHCVAFAPKSSSNEEVMFLTVQVKPTQEFKKRTTVMVKNEDSLVFVQTDKSIYTVKFRVVSMDENFHPLNELIPLVYIQDPKGNRIAQWQSFQLEGGLKQFSFPLSSEPFQG----SYKVVVQKKSGGRTEHPF-TVEEFVLPKFEVQVTVPKIITILEEEMLYTYGKPVPGHVT-VSICRKYSAFCEKFSGQLNCFYQQVKTKVFQLKRKEYEMKLHTEAQIQEEGTVELTGRQSSEITRTITKLSFVKVDSHFRQIPFFGLVDGKGVPIPNKVIFIRGNEANYYSNATTDEHGLVQFSI----TTNVMGTSLTVRVNYKDRSPCYGYQWVSEEHEEAFSPSKSFVHLEP---MSHELPCGHTQTVQAHYILNGGTLKKLSFYYLIMAKGGIVRTGTHGLLVKQEDMKGHFSISIPVKSDIAPVARLLIY---AVLPTGD----VIGDSAKYDVENCLANKVDLSFSPSQSLPASHAHLRVTAAPQSVCALRAVDLLMKPDAELSASSVYNLLPEKDLTGFPGDCINRHNVYINGITYTPVSSTNEKDMYSFLEDMNSKIRKPKMCETVRKYFPETWIWDLVVVNEVGVTVP--DTITEWKAGAFCLSEISSTASLPFFVELTMPYSVIRLKATVLNYLPKCIRVSVQLEAS-PAFLAVPVEKEQAPHCICANGRQWAVTPKSLGNV---NFTVSAEALESQPSVPRKDTVIKPLLVEPEGLRASVSVLGDILGSAMQNLQMPYGCGENMVLFAPNIYVLDYLNET---QQLTPEIKSKAIGYLNTGYQRQLNYKH---DGSYSTNQGNTWLTAFVLKTFAIDEAHITQALIWLSQRQKDNGCFRSSGSLLNNAIKGGVEDEVTLSAYITIALLEI-------PLTVTHPVVRNALFCLESAWKTAQEGD------HGSHVYTLLAYAFALAGNQDKRKEVLKSLN---EEAVKKDNSVHWERPQKPKAPVGHFYEP--------QAPSAEVEMTS--YVLLAYLTAQPAPTSATNIVKWITKQAQGGFSSTQ-VVALHALSKYGAATFTRTGKAAQVTIQSSGTFSSKFQVDNNNRLLL---SLPELPG

3isrB

0.21

0.05

0.25

1.00

wMUSTER

---------------------------SNAKFKIHSDITYQVSP----TTFIFNVHALRTESQHILDESLIVTPPIEIEEFSYNSGTSRFVRLKATENTTFSSYTATVDTQYKVIDQ-----RQELETVP------VVDLDGDIIPFLFPSRYCQ-----SDKLQKLAYKE-FGKIENVYSKVLAITDWIYNNVEYISGSTNSQTSAFDTITERAGVCRDFAHLGIALCRALSIPARYFTGYAFKLNPP---------------DFHACFEAYIGG-NWIIFDATRLV-PLNGLVKIATGRDAADAAVAS-IFGNASSTNHVECASLDTDFTP-FWYDKN-------------------------SLKG--SFQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

4m5dA

0.12

0.09

0.79

1.07

MUSTER

VPFVDPKPIPQNTNYKFNKAGIYQPNGSSIDTLLT--LNFRCLHKRSVYLAYL----THHLLILLKKDKLDSFLQLEYSYFDNDPL-LPILRISCSKDYNRFSINLLIGFPYKVFEPKKLLPNRNCIRILPATPLYNFSVLSSSTHENYTKKQTESFVEATVLGRLWLQQRGFSSNMSHSGSLGGFGTFEFTILMAALLNGGGINS--NKILLHGFSSYQLFKGVIKYLATMDLCH---DGHLQFHSNPASKYIDEGFQTP----------TLFDKSTKVNIKMTVSSYQEYAGETLRMLNNVVQDQ-LTNISRFDNLKYDLCYDVQLPLGKAATFGSMERVKFTLENFLAHKITNVARYA-IQIEMVGQKSDFPIT-----KRKVYSNTGGNHFNFDFVRVKLI--VNPDKLVTKG-----P-TMSTAAVFKNFW-KDGS-VW-------------STSSSEPIISSIVNFALQKHVSKKAQISN------ETIKKFHNFLPLPNLPSSAKTSVLN-----LSSFFNLKKSFDD-LYKII---LPL-------------------SVKSILPVGSA-FRYLCQPVPFAYSDPDFFQD-FETSPKWPDEIT---------------SLE---------------AKTAFLLKIQEELSANSSTYRSFFSRDESIPYNLEIVTLNILTPE-GGFKFRVLTE---RDEILYLRAIANARNELKPELEATFLKFTAK-------------------YLASVRHTRTLENISHSYQFYSPVVRKRWLD--TH--LLLGHITDELAELIAIKPFVD-----PAPYFIPGSLENGFLKVLKFISQWNWKDDPLILD-LVKPEE-------------RLTLQYKGIQMNFTNLRNSLQFFVASKNDPSGILYSSGI---LPIATRLTALAKVAVNLLQTHGL--NQQTINLLF----PGL------DFVVDLRTPIGLKSSCGILSAPSNFPKMTYQLVKYLNLKYKNS----LILSSRKY-IGVNGGEKGDKNVITGLIK---------PL--FKGAHKFRVNLDCNVKPVDD-------------ENVILN-KEAIFHEIAAF---GN---NFETD-----------------------------

3isrB

0.21

0.05

0.25

1.15

wPPAS

---------------------------LNAKFKIHSDITYQVS-PT---TFIFNVHALRTESQHILDESLIVTPPIEIEEFSYNSGTSRFVRLKATENTTFSSYTATVDTQYKVIDQ-----RQELETVP------VVDLDGDIIPFLFPSRYCQ-----SDKLQKLAYKE-FGKIENVYSKVLAITDWIYNNVEYISGSTNSQTSAFDTITERAGVCRDFAHLGIALCRALSIPARYFTGYAFKLNPP---------------DFHACFEAYIGG-NWIIFDATRLV-PLNGLVKIATGRDAADAAVASIF--NASSTNHVECASLDTDFTP-FWYD--KNSLKGLSFQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

3isrB

0.21

0.05

0.25

7.31

dPPAS2

---------------------------LYFQFKIHSDITYQV----SPTTFIFNVHALRTESQHILDESLIVTPPIEIEEFSYNSGTSRFVRLKATENTTFSSYTATVDTQYKVIDQRQEL-----------ETVPVVDLDGDIIPFLFPSRYCQ-----SDKLQKLAYKE-FGKIENVYSKVLAITDWIYNNVEYISGSTNSQTSAFDTITERAGVCRDFAHLGIALCRALSIPARYFTGYAFKLNPP---------------DFHACFEAYIGG-NWIIFDAT-RLVPLNGLVKIATGRDAADAAVAS-IFGNASSTNHVECASLDTDFTPFW---YDKNSLKGLSFQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 4 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.05

Estimated TM-score = 0.72±0.11

Estimated RMSD = 9.1±4.6Å

Download Model 2

C-score=-0.48

Download Model 3

C-score=-2.20

Download Model 4

C-score=-0.60

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4bxsV	0.845	3.38	0.089	0.908
2	2j5wA	0.648	4.10	0.090	0.717
3	2r7eA	0.427	4.24	0.077	0.476
4	2r7eB	0.359	4.51	0.047	0.406
5	1sddB	0.349	4.17	0.059	0.387
6	4kf7A	0.302	9.65	0.058	0.485
7	3hmjG	0.295	9.27	0.048	0.461
8	3s4wB	0.294	9.38	0.049	0.458
9	3ecqB	0.293	9.13	0.042	0.446
10	1aozA	0.292	4.69	0.090	0.330

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	2	2j5wA	OXY	Rep, Mult	49,51,95,97,866,868,918
2	0.06	2	3ffzB	NA	Rep, Mult	62,65,66,68,69
3	0.03	1	1gk9B	EDO	Rep, Mult	721,756,758
4	0.03	1	2vo9A	ZN	Rep, Mult	267,283,415
5	0.03	1	1d7pM	CYS	Rep, Mult	92,183,216,218
6	0.03	1	2hryA	MG	Rep, Mult	220,362
7	0.03	1	1dvfD	ZN	Rep, Mult	267,283
8	0.03	1	1hfuA	UUU	Rep, Mult	46,47,48,103
9	0.03	1	2pi4A	MG	Rep, Mult	793,1058
10	0.03	1	3n3oB	ADP	Rep, Mult	786,790,904
11	0.03	1	1kcwA	O	Rep, Mult	49,50,51,55,866,868
12	0.03	1	2fuqA	ZN	Rep, Mult	771,793,843
13	0.03	1	1tt4A	MG	Rep, Mult	631,741,866
14	0.03	1	2io9A	MG	Rep, Mult	694,696
15	0.03	1	3lp1A	MN	Rep, Mult	730,843,850

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.092	2j5wA	0.648	4.10	0.090	0.717	1.16.3.1	NA
2	0.060	3c46B	0.250	9.42	0.042	0.390	2.7.7.6	71
3	0.060	1ea0A	0.268	9.64	0.037	0.428	1.4.1.13	106
4	0.060	2h5uA	0.287	4.54	0.079	0.323	1.10.3.2	NA
5	0.060	2pdaA	0.263	9.76	0.038	0.424	1.2.7.1	NA
6	0.060	2np0A	0.241	9.77	0.024	0.391	3.4.24.69	NA
7	0.060	2g49A	0.258	9.00	0.051	0.393	3.4.24.56	NA
8	0.060	3h09B	0.258	9.00	0.034	0.391	3.4.21.72	NA
9	0.060	2uv8G	0.294	9.18	0.029	0.455	2.3.1.86	NA
10	0.060	1ofdA	0.273	9.84	0.037	0.445	1.4.7.1	NA
11	0.060	2pffB	0.281	9.05	0.060	0.429	2.3.1.86	107
12	0.060	2fqfA	0.270	4.91	0.085	0.309	1.-.-.-	NA
13	0.060	2qt6A	0.287	4.51	0.092	0.322	1.10.3.2	NA
14	0.060	1a65A	0.288	4.70	0.081	0.326	1.10.3.2	NA
15	0.060	1v10A	0.284	4.65	0.087	0.321	1.10.3.2	NA
16	0.060	2dqmA	0.256	8.73	0.039	0.382	3.4.11.2	NA
17	0.060	1aozA	0.292	4.69	0.090	0.330	1.10.3.3	NA
18	0.060	2hrgA	0.290	4.43	0.096	0.325	1.10.3.2	NA
19	0.060	1asqA	0.293	4.49	0.092	0.330	1.10.3.3	56,84
20	0.060	1bxrA	0.275	9.45	0.034	0.432	6.3.5.5	19

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.18	0.845	3.38	0.09	0.91	4bxsV	GO:0004252 GO:0005507 GO:0005576 GO:0006508 GO:0007596 GO:0010952 GO:0016504 GO:0035807 GO:0044469 GO:0046872
1	0.08	0.652	4.00	0.09	0.72	4ejxA	GO:0001889 GO:0004322 GO:0005507 GO:0005576 GO:0005615 GO:0005765 GO:0006810 GO:0006811 GO:0006825 GO:0006879 GO:0007568 GO:0007584 GO:0016491 GO:0030324 GO:0046658 GO:0046688 GO:0046872 GO:0051087 GO:0055114 GO:0070062 GO:0072562
2	0.06	0.427	4.24	0.08	0.48	2r7eA	GO:0000139 GO:0002576 GO:0005507 GO:0005576 GO:0005615 GO:0005788 GO:0005886 GO:0006888 GO:0006953 GO:0007596 GO:0007597 GO:0007599 GO:0016491 GO:0030134 GO:0030168 GO:0031093 GO:0033116 GO:0046872 GO:0048208 GO:0055114
3	0.06	0.426	4.21	0.09	0.47	3cdzA	GO:0000139 GO:0002576 GO:0005507 GO:0005576 GO:0005615 GO:0005788 GO:0005886 GO:0006888 GO:0006953 GO:0007596 GO:0007597 GO:0007599 GO:0016491 GO:0030134 GO:0030168 GO:0031093 GO:0033116 GO:0046872 GO:0048208 GO:0055114
4	0.06	0.359	4.51	0.05	0.41	2r7eB	GO:0000139 GO:0002576 GO:0005507 GO:0005576 GO:0005615 GO:0005788 GO:0005886 GO:0006888 GO:0006953 GO:0007596 GO:0007597 GO:0007599 GO:0016491 GO:0030134 GO:0030168 GO:0031093 GO:0033116 GO:0046872 GO:0048208 GO:0055114
5	0.06	0.349	4.17	0.06	0.39	1sddB	GO:0005507 GO:0005576 GO:0007596 GO:0007599 GO:0030168 GO:0046872
6	0.06	0.356	4.31	0.06	0.40	4bdvB	GO:0000139 GO:0002576 GO:0005507 GO:0005576 GO:0005615 GO:0005788 GO:0005886 GO:0006888 GO:0006953 GO:0007596 GO:0007597 GO:0007599 GO:0016491 GO:0030134 GO:0030168 GO:0031093 GO:0033116 GO:0046872 GO:0048208 GO:0055114
7	0.06	0.292	4.69	0.09	0.33	1aozA	GO:0005507 GO:0005576 GO:0008447 GO:0016491 GO:0046872 GO:0055114
8	0.06	0.289	4.69	0.08	0.33	3ppsA	GO:0005507 GO:0016491 GO:0046872 GO:0052716 GO:0055114
9	0.06	0.288	4.54	0.09	0.32	5e9nA	GO:0005507 GO:0016491 GO:0046872 GO:0052716 GO:0055114
10	0.06	0.288	4.70	0.08	0.33	1a65A	GO:0005507 GO:0016491 GO:0046872 GO:0052716 GO:0055114
11	0.06	0.286	4.71	0.09	0.32	1zpuA	GO:0004322 GO:0005381 GO:0005507 GO:0005886 GO:0006810 GO:0006811 GO:0006827 GO:0016020 GO:0016021 GO:0016491 GO:0033215 GO:0033573 GO:0046688 GO:0046872 GO:0055072 GO:0055114 GO:1901684
12	0.06	0.260	4.23	0.09	0.29	3aw5A	GO:0005507 GO:0016020 GO:0016021 GO:0016491 GO:0016722 GO:0046872 GO:0055114
13	0.06	0.264	4.31	0.09	0.29	5afaA	GO:0005507 GO:0016491 GO:0046872 GO:0052716 GO:0055114
14	0.06	0.245	4.40	0.10	0.28	4f7kA	GO:0005507 GO:0016491 GO:0052716 GO:0055114
15	0.06	0.184	8.00	0.04	0.27	2qqlA	GO:0001525 GO:0001938 GO:0002116 GO:0004872 GO:0005021 GO:0005576 GO:0005886 GO:0007155 GO:0007275 GO:0007399 GO:0007411 GO:0008201 GO:0010595 GO:0016020 GO:0016021 GO:0017154 GO:0019838 GO:0019955 GO:0021675 GO:0030154 GO:0038084 GO:0046872 GO:0048010 GO:0048846 GO:0061549 GO:0097490 GO:0097491 GO:1902285
16	0.06	0.281	4.70	0.09	0.32	3sqrA	GO:0005507 GO:0016491 GO:0046872 GO:0055114
17	0.06	0.186	3.96	0.11	0.21	4knsA	GO:0005507 GO:0006807 GO:0046872 GO:0050421 GO:0055114
18	0.06	0.193	4.09	0.07	0.21	3g5wA	GO:0005507 GO:0016491 GO:0046872 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0005507	GO:0061134	GO:0004175	GO:0008236	GO:0008047
GO-Score	0.38	0.36	0.36	0.36	0.36
Biological Processes	GO:0044710	GO:0001775	GO:0002526	GO:0048207	GO:0006461	GO:0006901	GO:0045055	GO:0090114	GO:0072378	GO:0030194	GO:0044468	GO:0052547	GO:0035806	GO:0044483	GO:0051345	GO:0045862
GO-Score	0.49	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36
Cellular Component	GO:0044421	GO:0071944	GO:0098588	GO:0005793	GO:0030135	GO:0070013	GO:0030133	GO:0031091	GO:0034774	GO:0044431	GO:0044432
GO-Score	0.49	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.