I-TASSER results

I-TASSER results for job id Rv2553c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (417 residues)
MPDGGHRHRAQPVSVRPNRHRRTRVSRAQRRHAQQIRRRRRVAGGFALSLLVVVVVVAVV
VGAKLWQTMLGFGNDYTGPGKRDIVIQIRAGDSTTAVGETLLKHGVVATVRAFVDAAHGN
TAISSIQPGFYRMRTEISAASAVARLTDPHNRVGKLVIPEGRQLDDTTDMKTNVVNPGIF
ALISRATCVDLDGTQRCVSVADLRAAASRSTPTMLSVPRWAVGPVMELGTDHRRIEGLIA
PGTFNIDPSASAETILATLISAGAVEYMKSGLVDTAKSLGLSPYDILVVASLVQQEANTQ
DFPKVARVIYNRLHEHRTLEFDSTVNYPLDRREVATSDTDRAQRTPWNTYMAQGLPATAI
CSPGVDALRAAEHPVPGDWLYFVTIDSQGTTLFTRDYQQHLANIELAKHNGVLDSAR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MPDGGHRHRAQPVSVRPNRHRRTRVSRAQRRHAQQIRRRRRVAGGFALSLLVVVVVVAVVVGAKLWQTMLGFGNDYTGPGKRDIVIQIRAGDSTTAVGETLLKHGVVATVRAFVDAAHGNTAISSIQPGFYRMRTEISAASAVARLTDPHNRVGKLVIPEGRQLDDTTDMKTNVVNPGIFALISRATCVDLDGTQRCVSVADLRAAASRSTPTMLSVPRWAVGPVMELGTDHRRIEGLIAPGTFNIDPSASAETILATLISAGAVEYMKSGLVDTAKSLGLSPYDILVVASLVQQEANTQDFPKVARVIYNRLHEHRTLEFDSTVNYPLDRREVATSDTDRAQRTPWNTYMAQGLPATAICSPGVDALRAAEHPVPGDWLYFVTIDSQGTTLFTRDYQQHLANIELAKHNGVLDSAR
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCEEEEHCCCCCHHHHHHHHHHCCCEEEEEEHCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHCHHHHCCCHHHHHHHHHHCCCCCCCCCEHCCCEEHCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEEHCCCCCEEHCCCHHHHHHHHHHHHHHCCCCCCC
Conf.Score	988766667788677888776776555545566666654457889999999999999999999999998755678888899859999889999999999999999988889999999996987888877998689999999999998676547999987998899999999866776588999987599988999875679999999975668766756667778875888899875557874657999999999999999999999985767777668999999999999988768968888889999999877998777855655368888888988858999877656799999998899899999997789999589999789986997799999999999999988655569
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MPDGGHRHRAQPVSVRPNRHRRTRVSRAQRRHAQQIRRRRRVAGGFALSLLVVVVVVAVVVGAKLWQTMLGFGNDYTGPGKRDIVIQIRAGDSTTAVGETLLKHGVVATVRAFVDAAHGNTAISSIQPGFYRMRTEISAASAVARLTDPHNRVGKLVIPEGRQLDDTTDMKTNVVNPGIFALISRATCVDLDGTQRCVSVADLRAAASRSTPTMLSVPRWAVGPVMELGTDHRRIEGLIAPGTFNIDPSASAETILATLISAGAVEYMKSGLVDTAKSLGLSPYDILVVASLVQQEANTQDFPKVARVIYNRLHEHRTLEFDSTVNYPLDRREVATSDTDRAQRTPWNTYMAQGLPATAICSPGVDALRAAEHPVPGDWLYFVTIDSQGTTLFTRDYQQHLANIELAKHNGVLDSAR
Prediction	565645654551465626655456455556555654344332011100100122122212212221111132244153556440202035433144005333754004113001000212545440200303045612031002102213322120101112203300420463444413420365442536303411426302530454224324234223441462635431000000000030347241440042015102520353515542743622021000000000411457223200000100045613010000000014436450245116471010013243211000011234003001205723000000226714130152163035005304644324568
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCEEEEHCCCCCHHHHHHHHHHCCCEEEEEEHCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHCHHHHCCCHHHHHHHHHHCCCCCCCCCEHCCCEEHCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEEHCCCCCEEHCCCHHHHHHHHHHHHHHCCCCCCC
MPDGGHRHRAQPVSVRPNRHRRTRVSRAQRRHAQQIRRRRRVAGGFALSLLVVVVVVAVVVGAKLWQTMLGFGNDYTGPGKRDIVIQIRAGDSTTAVGETLLKHGVVATVRAFVDAAHGNTAISSIQPGFYRMRTEISAASAVARLTDPHNRVGKLVIPEGRQLDDTTDMKTNVVNPGIFALISRATCVDLDGTQRCVSVADLRAAASRSTPTMLSVPRWAVGPVMELGTDHRRIEGLIAPGTFNIDPSASAETILATLISAGAVEYMKSGLVDTAKSLGLSPYDILVVASLVQQEANTQDFPKVARVIYNRLHEHRTLEFDSTVNYPLDRREVATSDTDRAQRTPWNTYMAQGLPATAICSPGVDALRAAEHPVPGDWLYFVTIDSQGTTLFTRDYQQHLANIELAKHNGVLDSAR

2r1fA

0.25

0.15

0.60

1.81

MUSTER

----------------------------------------------------------------------------------------------------------------------------HFKAGTYRFTPQTV--RELKLLESGKEAQFPLRLVEGR-LSDYLKQLREAPYI--------KHTLSD------DKYATVAQALE--------------------LENPEWIEGWFWPDTWYT-ANTTDVALLKRAHKKVKAVDSAW-EGRADGLP-YKDKNQLVTASIIEKETAASERDQVASVFINRLRIGR-LQTDPTVIYGGERYNGKLSRADLETPTAYNTYTITGLPPGAIATPGADSLKAAAHPAKTPYLYFVAD-GKGGHTFNTNLASHNKSVQDYLKVLKEKNAQ

4iiwA

0.25

0.18

0.71

2.10

MUSTER

-------------------------------------------------------------------------------SKEKITVEIPAGSSISDISTILEDKKVINNASIFSFYVKYNND-TNLKAGNYELSPAN-TDQIVKKQEGKTVAPAKLVIPEGYTLDQIADRIVAYQP-----------KLKKADVLKT-DDPEFVASIKA-------YPETVTNDVLN-KSIKHPLEGYLYPATYTFKGTDVSAEQIITEVKATDVNIAKYRDELTKQKS----VHKFLTSSIIEKEATENVDRKIASVFYNRLAKDR-LQTDPTVLYALGEHKSKTTYKDLEVDSPYNTYKNNGLPPGPISNSG-DSSEAALYPEKSDYLYFLA----NKVYFSKTLEEHNKLKE------------

4iiwA

0.25

0.18

0.71

2.60

dPPAS

-------------------------------------------------------------------------------SKEKITVEIPAGSSISDISTILEDKKVINNASIFSFYVKYNND-TNLKAGNYELSPAN-TDQIVKKQEGKTVAPAKLVIPEGYTLDQIADRIVAYQPK--------------------LKKADVLKTDDPEFVASIKAYPETVTNDVLNKSIKHPLEGYLYPATYTFKGTDVSAEQIITEVKATDVNIAKYRDELTKQKS----VHKFLTSSIIEKEATENVDRKIASVFYNRLAKDR-LQTDPTVLYALGEHKSKTTYKDLEVDSPYNTYKNNGLPPGPISNSG-DSSEAALYPEKSDYLYFLA----NKVYFSKTLEEHNKLKE------------

4iiwA

0.25

0.18

0.71

4.59

wdPPAS

-------------------------------------------------------------------------------SKEKITVEIPAGSSISDISTILEDKKVINNASIFSFYVKYNND-TNLKAGNYELSPAN-TDQIVKKQEGKTVAPAKLVIPEGYTLDQIADRIVAYQ------------PKLKKADVLKTDDPEFVASIKA-------YPETVTNDVLN-KSIKHPLEGYLYPATYTFKGTDVSAEQIITEVKATDVNIAKYRDELTKQ----KSVHKFLTSSIIEKEATENVDRKIASVFYNRLAKDR-LQTDPTVLYALGEHKSKTTYKDLEVDSPYNTYKNNGLPPGPISNSG-DSSEAALYPEKSDYLYFLA----NKVYFSKTLEEHNKLKE------------

4iiwA

0.25

0.18

0.70

2.70

wMUSTER

--------------------------------------------------------------------------------KEKITVEIPAGSSISDISTILEDKKVINNASIFSFYVKYNND-TNLKAGNYELSPAN-TDQIVKKQEGKTVAPAKLVIPEGYTLDQIADRIVAYQPK------------LKKADVLKTDDPEFVASIKA-------YPETVTNDVLN-KSIKHPLEGYLYPATYTFKGTDVSAEQIITEVKATDVNIAKYRDELTKQKS----VHKFLTSSIIEKEATENVDRKIASVFYNRLAKDR-LQTDPTVLYALGEHKSKTTYKDLEVDSPYNTYKNNGLPPGPISNSG-DSSEAALYPEKSDYLYFLA----NKVYFSKTLEEHNKLKE------------

4iiwA

0.25

0.18

0.71

4.96

wPPAS

-------------------------------------------------------------------------------SKEKITVEIPAGSSISDISTILEDKKVINNASIFSFYVKYNN-DTNLKAGNYELSPAN-TDQIVKKQEGKTVAPAKLVIPEGYTLDQIADRIVAYQ------------PKLKKADVLKTDDPEFVASIKA-------YPETVTNDVLN-KSIKHPLEGYLYPATYTFKGTDVSAEQIITEVKATDVNIAKYRDELTKQ----KSVHKFLTSSIIEKEATENVDRKIASVFYNRLAKDR-LQTDPTVLYALGEHKSKTTYKDLEVDSPYNTYKNNGLPPGPISNSG-DSSEAALYPEKSDYLYFLA----NKVYFSKTLEEHNKLKE------------

4iiwA

0.25

0.18

0.71

6.01

dPPAS2

-------------------------------------------------------------------------------SKEKITVEIPAGSSISDISTILEDKKVINNASIFSFYVKYNND-TNLKAGNYELSPAN-TDQIVKKQEGKTVAPAKLVIPEGYTLDQIADRIVAYQPKLKKADVLKTDD-------------------PEFVASIKAYPETVTNDVLN-KSIKHPLEGYLYPATYTFKGTDVSAEQIITEVKATDVNIAKYRDELTKQKS----VHKFLTSSIIEKEATENVDRKIASVFYNRLAKDR-LQTDPTVLYALGEHKSKTTYKDLEVDSPYNTYKNNGLPPGPISNSG-DSSEAALYPEKSDYLYFLA----NKVYFSKTLEEHNKLKE------------

4iiwA

0.25

0.18

0.71

3.94

PPAS

-------------------------------------------------------------------------------SKEKITVEIPAGSSISDISTILEDKKVINNASIFSFYVKYNND-TNLKAGNYELSPAN-TDQIVKKQEGKTVAPAKLVIPEGYTLDQIADRIVAYQ------------PKLKKADVLKTDDPEFVASIKA-------YPETVTNDVLN-KSIKHPLEGYLYPATYTFKGTDVSAEQIITEVKATDVNIAKYRDELTKQ----KSVHKFLTSSIIEKEATENVDRKIASVFYNRLAKDR-LQTDPTVLYALGEHKSKTTYKDLEVDSPYNTYKNNGLPPGPISNSG-DSSEAALYPEKSDYLYFLA----NKVYFSKTLEEHNKLKE------------

4iiwA

0.25

0.18

0.71

6.25

Env-PPAS

-------------------------------------------------------------------------------SKEKITVEIPAGSSISDISTILEDKKVINNASIFSFYVKYNN-DTNLKAGNYELSPAN-TDQIVKKQEGKTVAPAKLVIPEGYTLDQIADRIVAYQ------------PKLKKADVLKTDDPEFVASIKA-------YPETVTNDVLN-KSIKHPLEGYLYPATYTFKGTDVSAEQIITEVKATDVNIAKYRDELTKQ----KSVHKFLTSSIIEKEATENVDRKIASVFYNRLAKDR-LQTDPTVLYALGEHKSKTTYKDLEVDSPYNTYKNNGLPPGPISNSG-DSSEAALYPEKSDYLYFLA----NKVYFSKTLEEHNKLKE------------

2r1fA

0.26

0.16

0.60

2.26

dPPAS

----------------------------------------------------------------------------------------------------------------------------HFKAGTYRFTPQTV--RELKLLESGKEAQFPLRLVEGRLSDYLKQLREAPY-----------------------------------IKHTLSDDKYATVAQALELENPEWIEGWFWPDTWYT-ANTTDVALLKRAHKKVKAVDSAWEGR--ADGLPYKDKNQLVTASIIEKETAASERDQVASVFINRLRIGR-LQTDPTVIYGGERYNGKLSRADLETPTAYNTYTITGLPPGAIATPGADSLKAAAHPAKTPYLYFVAD-GKGGHTFNTNLASHNKSVQDYLKVLKEKNAQ

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.43

Estimated TM-score = 0.43±0.14

Estimated RMSD = 12.8±4.2Å

Download Model 2

C-score=-3.23

Download Model 3

C-score=-3.23

Download Model 4

C-score=-3.28

Download Model 5

C-score=-3.20

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4iiwA	0.682	1.44	0.241	0.705
2	2r1fA	0.491	3.26	0.232	0.561
3	2ebsB	0.457	7.11	0.060	0.767
4	3a0fA	0.454	6.97	0.061	0.748
5	4lgnA	0.436	7.09	0.060	0.734
6	5fkqA	0.434	7.18	0.057	0.731
7	5jwzA	0.428	7.21	0.074	0.727
8	2cn2A	0.416	7.11	0.074	0.693
9	3cskA	0.412	7.09	0.037	0.683
10	1bxrA	0.404	7.15	0.064	0.681

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.21	10	3wtgA	OXY	Rep, Mult	400,404
2	0.04	2	2f4aA	TOU	Rep, Mult	311,312
3	0.04	2	1jdbE	GLN	Rep, Mult	392,393,394,402,403
4	0.02	1	1g4pA	MG	Rep, Mult	301,322
5	0.02	1	2v3eB	UUU	Rep, Mult	348,349,350
6	0.02	1	2frdB	NAP	Rep, Mult	291,294
7	0.02	1	1yklG	DHB	Rep, Mult	237,241
8	0.02	1	1a9x2	III	Rep, Mult	298,303,304,307,373
9	0.02	1	1f8yB	5MD	Rep, Mult	348,381
10	0.02	1	1c3oA	GLN	Rep, Mult	324,344,345,356,358
11	0.02	1	2nrzB	MN	Rep, Mult	322,400
12	0.02	1	4ag5A	MG	Rep, Mult	138,160

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2qr5A	0.377	7.31	0.050	0.643	3.4.19.1	NA
2	0.060	1is2A	0.369	6.83	0.036	0.602	1.3.3.6	293
3	0.060	2eabA	0.371	7.39	0.042	0.638	3.2.1.63	NA
4	0.060	3gm8A	0.370	7.15	0.028	0.624	3.2.1.-	NA
5	0.060	1t7lA	0.370	7.19	0.041	0.616	2.1.1.14	379
6	0.060	2epoB	0.353	7.57	0.052	0.619	3.2.1.52	NA
7	0.060	1ps9A	0.370	7.46	0.044	0.652	1.3.1.34	310
8	0.060	1djnA	0.376	7.60	0.030	0.667	1.5.8.2,1.5.99.7	NA
9	0.060	1bxrA	0.404	7.15	0.064	0.681	6.3.5.5	NA
10	0.060	3fvyA	0.398	6.99	0.051	0.657	3.4.14.4	309,333,357,369
11	0.060	1yiqA	0.369	7.53	0.060	0.643	1.1.99.-	NA
12	0.060	1yr2A	0.395	7.32	0.064	0.686	3.4.21.26	301
13	0.060	3g0bB	0.389	6.96	0.025	0.643	3.4.14.5	319,365
14	0.060	2nq5A	0.374	7.37	0.090	0.645	2.1.1.14	NA
15	0.060	1kc7A	0.378	7.23	0.038	0.635	2.7.9.1	301
16	0.060	1kb0A	0.367	7.74	0.054	0.662	1.1.99.-	NA
17	0.060	2epoA	0.369	7.31	0.039	0.626	3.2.1.52	NA
18	0.060	1yrzA	0.371	7.47	0.058	0.659	3.2.1.37	283,312
19	0.060	3bq5A	0.373	7.13	0.044	0.614	2.1.1.14	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.34	0.570	2.73	0.20	0.62	4iiwB	GO:0003676 GO:0016020 GO:0016021
1	0.24	0.501	3.32	0.23	0.57	2r1fA	GO:0003676
2	0.07	0.457	7.11	0.06	0.77	2ebsB	GO:0000272 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0030245 GO:0033945
3	0.07	0.436	7.09	0.06	0.73	4lgnA	GO:0004553 GO:0005975 GO:0030246 GO:0030247 GO:0030248
4	0.07	0.420	7.14	0.07	0.71	2cn2A	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0030245 GO:0033946 GO:0043263 GO:2000899
5	0.07	0.434	7.18	0.06	0.73	5fkqA	GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0030246 GO:0030247 GO:0030248
6	0.06	0.431	7.18	0.07	0.73	5jwzA	GO:0004553 GO:0005975 GO:0030246 GO:0030247
7	0.06	0.431	6.98	0.05	0.71	2cn3A	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0030245 GO:0033946 GO:0043263 GO:2000899
8	0.06	0.295	7.29	0.04	0.50	3b69A	GO:0004308 GO:0009405 GO:0016020 GO:0016021
9	0.06	0.270	8.02	0.04	0.50	4q6kA	GO:0004308 GO:0009405
10	0.06	0.297	7.43	0.04	0.52	4dg8A	GO:0000166 GO:0003824 GO:0008152
11	0.06	0.287	6.65	0.04	0.46	3b7fA	GO:0016787
12	0.06	0.277	7.03	0.04	0.46	1r6tA	GO:0000166 GO:0001525 GO:0004812 GO:0004830 GO:0005524 GO:0005634 GO:0005737 GO:0005829 GO:0006412 GO:0006418 GO:0006436 GO:0008285 GO:0016874 GO:0045765 GO:0070062
13	0.06	0.264	6.54	0.04	0.41	3jvuA	GO:0000166 GO:0005524 GO:0005737 GO:0006810 GO:0043107 GO:0043108 GO:0044096
14	0.06	0.268	6.35	0.03	0.41	3pymA	GO:0003723 GO:0004365 GO:0005737 GO:0005739 GO:0005811 GO:0006006 GO:0006094 GO:0006096 GO:0006915 GO:0009277 GO:0016491 GO:0016620 GO:0050661 GO:0051287 GO:0055114 GO:0072593
15	0.06	0.229	7.48	0.06	0.40	4r6hA	GO:0005215 GO:0005886 GO:0006810 GO:0016020
16	0.06	0.242	6.67	0.03	0.39	4chiA	GO:0003824 GO:0008152 GO:0008483 GO:0016740
17	0.06	0.205	6.74	0.07	0.33	3b12A	GO:0003824 GO:0016787 GO:0018785
18	0.06	0.240	5.93	0.04	0.35	3rh7A	GO:0000166 GO:0010181 GO:0016491 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0003676
GO-Score	0.50
Biological Processes	GO:0044238
GO-Score	0.32
Cellular Component	GO:0016021
GO-Score	0.34

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.