I-TASSER results

I-TASSER results for job id Rv2542

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (403 residues)
MLDAVSDARRDGFAVGEDYTVTDRSTGGSRQQRAARLGQAQGHADFIRHRVGALLATDRD
IATRVSAATQGLDELAFEDVPGVDTPAEDGVQAVDFRQAPPPGAPGGMSSGDIDAIDAAN
RALLQDMLAEYSRLPDGQVKTDRLADIAAIQEALRVPDSHLIYVARPDDPADMIPAVTAV
GDPFTADHVSVTVPGVSGTTRQTIATMTQETRGLREEARVIAHSVGESENVATIAWVGYQ
PPPVLASWNTVDDDLAQAGAPKLEAFLRDLQAGSHNPGHTTALFGHSYGSLLSGIALKDG
ASSLVDNAVLYGSPGFDATSPAKLGMNDHNFFVMTTPDDPIRYPARLAPLHGWGSDGADT
IGTVGRQGTPARVGIRPQRDHRRIPGPLPLHPSADRRGIHSAG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MLDAVSDARRDGFAVGEDYTVTDRSTGGSRQQRAARLGQAQGHADFIRHRVGALLATDRDIATRVSAATQGLDELAFEDVPGVDTPAEDGVQAVDFRQAPPPGAPGGMSSGDIDAIDAANRALLQDMLAEYSRLPDGQVKTDRLADIAAIQEALRVPDSHLIYVARPDDPADMIPAVTAVGDPFTADHVSVTVPGVSGTTRQTIATMTQETRGLREEARVIAHSVGESENVATIAWVGYQPPPVLASWNTVDDDLAQAGAPKLEAFLRDLQAGSHNPGHTTALFGHSYGSLLSGIALKDGASSLVDNAVLYGSPGFDATSPAKLGMNDHNFFVMTTPDDPIRYPARLAPLHGWGSDGADTIGTVGRQGTPARVGIRPQRDHRRIPGPLPLHPSADRRGIHSAG
Prediction	CHHHHHHHHHHCCEHCCCCEEHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEHCCCCCCCCEEEEEEHCCCCCCCEEEEEHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHCHHHHHHHHHHHHCCCCCCCEEEEHCCCCCCCCCHHHCCCCCCCEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	6679999999898456886577578889989999999999999999999999987778999998888756777777788888876544557777777656655457889999899999999999999999985566456689999999999987578986577655788889779999978854588699996899998877666646789999999999999868899858999968999999886445897899999799999999999866899984899998656899999998788876457999858999999988859999858996579986556777788888899998888765567888778888877766788888888777877766689
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MLDAVSDARRDGFAVGEDYTVTDRSTGGSRQQRAARLGQAQGHADFIRHRVGALLATDRDIATRVSAATQGLDELAFEDVPGVDTPAEDGVQAVDFRQAPPPGAPGGMSSGDIDAIDAANRALLQDMLAEYSRLPDGQVKTDRLADIAAIQEALRVPDSHLIYVARPDDPADMIPAVTAVGDPFTADHVSVTVPGVSGTTRQTIATMTQETRGLREEARVIAHSVGESENVATIAWVGYQPPPVLASWNTVDDDLAQAGAPKLEAFLRDLQAGSHNPGHTTALFGHSYGSLLSGIALKDGASSLVDNAVLYGSPGFDATSPAKLGMNDHNFFVMTTPDDPIRYPARLAPLHGWGSDGADTIGTVGRQGTPARVGIRPQRDHRRIPGPLPLHPSADRRGIHSAG
Prediction	6340053047221302341102134344424423423440451154035205504413450243034224414533343344444434421442423334233322404313142124222420441344254255454345315404523540654622112012345454201000000214304300000101103034314422420330252034125434564300000000000064143330134420450054034004103212546412000000000000002003424522000000000010105316405155310000303410032025132111103113312323432324132132233232412242213243444243458
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CHHHHHHHHHHCCEHCCCCEEHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEHCCCCCCCCEEEEEEHCCCCCCCEEEEEHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHCHHHHHHHHHHHHCCCCCCCEEEEHCCCCCCCCCHHHCCCCCCCEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MLDAVSDARRDGFAVGEDYTVTDRSTGGSRQQRAARLGQAQGHADFIRHRVGALLATDRDIATRVSAATQGLDELAFEDVPGVDTPAEDGVQAVDFRQAPPPGAPGGMSSGDIDAIDAANRALLQDMLAEYSRLPDGQVKTDRLADIAAIQEALRVPDSHLIYVARPDDPADMIPAVTAVGDPFTADHVSVTVPGVSGTTRQTIATMTQETRGLREEARVIAHSVGESENVATIAWVGYQPPPVLASWNTVDDDLAQAGAPKLEAFLRDLQAGSHNPGHTTALFGHSYGSLLSGIALKDGASSLVDNAVLYGSPGFDATSPAKLGMNDHNFFVMTTPDDPIRYPARLAPLHGWGSDGADTIGTVGRQGTPARVGIRPQRDHRRIPGPLPLHPSADRRGIHSAG

5gaoE

0.14

0.11

0.79

1.16

dPPAS2

----------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-----------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA---AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA--------------AAAAAAAAAAAAAAAAAA-------AAAAAAAAAAAAAAAAAA-----------AAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

5gaoE

0.13

0.11

0.83

1.21

PPAS

---------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA--AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK----------------

1gt6A

0.12

0.08

0.64

1.10

Env-PPAS

-------------------------------------------------------------------------------------------------------------EVSQDLFNQFNLFAQYSAAAYCGKNNDA-PAGTNITCTGNACPEVEKADATFLYSFE-DSGVGDVTGFLAL-D-NTNKLIVLSFRGSRS---------------IENWIGNLN-----------FDLKEINDICSGCRGHDGFTSSWRSVADTLRQKVEDAVREH--PDYRVVFTGHALGGALATVAGADLRGNGYDDVFSYGAPRVGNRAFAEFVQTGGTLYRITHTNDIVPRLPPREFGYSH---SSPEYWIKSGTLVPVTRNDIVKIEGIDATGGNNQPNIPDIPALWYFG

3mveA

0.11

0.10

0.90

0.83

MUSTER

---------------AKETSALTQYMPTSQSLLDEIKEKNGFSLRRLQWVWQGVPIEQEQVLARIASSKHSRTDEQWLDTVMGYHSGNWAYEWTRLGMEHQKRAG---EMTNEAASEALFSASLCYSIAGYPHLKSDNLAIQAQVLANSAYLEAAKKSKYIIKQLEIPFEKGKITAHLHLTNTDKPHPVVIVSAGLDSLQTD-----------MWRLFRDHLAKHD----IAMLTVDMPSVGYSSKYPLTED------YSRLHQAVLNELFSIPYVDHHRVGLIGFRFGGNAMVRLSFLEQE-KIKACVILGAPIHDIASPQKLQQMPKMYLDVLASRLGKSVVDIYSLSGQMAAWSLKVQGFLSSRKTKVPILAMSLEGDPVSPYSDNAFFSTYGKAKKSSK

5gaoE

0.13

0.11

0.79

0.80

dPPAS

----------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-----------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA---AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA--------------AAAAAAAAAAAAAAAAAA------AAAAAAAAAAAAAAAAAAA---------AAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTK

1gt6A

0.13

0.08

0.62

0.86

wdPPAS

-------------------------------------------------------------------------------------------------------------EVSQDLFNQFNLFAQYSAAA---GKNNDAPAGTNITCTGNACPEVEKADATFLYSFE-DSGVGDVTGFLAL---NTNKLIVLSFRGSRS------------IENWIGNLNFDLKEINDICSGCRGH--GF-------------TSSWRSVADTLRQKVEDAVREH--PDYRVVFTGHALGGALATVAGADLRGNGYDDVFSYGAPRVGNRAFAEFVQTGGTLYRITHTNDIVPRLPPREFGYSH--------SSPEYWIKSGTLVPVTRNDIVKIEGIDATGGNNQPNIPHLWG

3mveA

0.13

0.11

0.87

0.82

wMUSTER

--------------AKETSALT-QYMPTSQSLLDEIKEKNGFNLRRLQWVWQGVPIEQEQVLARIASSKHSRTDEQWLDT-VMGYHSGNWAYEWTRLGMEHQKRAG--EMTNEAASEALFSASLCYSIAG---KSDNLAIQAQVLANSAYLEAAKKSKYIIKQLEIPFE-KGKITAHLHLTNTDKPHPVVIVSAGLDSLQTD-----------MWRLFRDHLAKHD----IAMLTV-SVYSSKYPLTEDY---------SRLHQAVLNELFSIPYVDHHRVGLIGFRFGGNAMVRLSFLEQE-KIKACVILGAPIHDIASPQKLQMPKMYLDVLKSVVDIYSLSGQMAAWS------LKVQGFLSSRKTKVPILAMSLEGDPVSPYSDNAFFSTYGKAKKSSK

1gt6A

0.14

0.09

0.61

0.92

wPPAS

----------------------------------------------------------------------------------------------------------EVS------QDLFNQFNLFAQYSAAAGKNNDAPAGTNITCTGNACPEVEKADATFLYSFE-DSGVGDVTGFLAL-D-NTNKLIVLSFRGSRS------------IENWIGNLNFDLKEINDICSGCRGH--GF-------------TSSWRSVADTLRQKVEDAVREH--PDYRVVFTGHALGGALATVAGADLRGNGYDDVFSYGAPRVGNRAFAEFVQTGGTLYRITHTNDIVPRL------------PPREFGYSHSSPKSGTLVPVTRNDIVKIEGIDATGGNNQPNIPHL-G

5cwqA

0.14

0.08

0.54

0.84

dPPAS2

ARKRSEEARERG----------DLKELAEALIEEARAVQELARVACERGNSEEAERASEKAQRVLEEARKVSEEAREQGDDEVLALALIAIALAVLALAEVACCRGNSEEAERASEKAQRVLEEARKVSEEAREQGDDEVLALALIAIALAVLALA------------------EVACCRGNKEEAERA------------------YEDARRVEEEARKVKESAEEQGDSEV----------------KRLAEEAEQLAREARRHVQECRGGWLEHHH----------------------------------------------------------------------------------------------------------------------------

5bx9A

0.10

0.08

0.88

0.83

PPAS

YNKQIDRLQDLGLWVRLDLHWDRLETAEDQ-------------LASLDQLVKDLEARQLKSVFYLVGSARFITTAPFYSPFQDQYPPRDPEVFARRMAMLSQRYPSVA---AWQVWNEPN------LIGFWRPKADPEGYAKLLQASTIALRMVDPEKPVVSAGMAFFSEMPDGRTMFALGHLGVESLGTIATYHPYTQLPEGNYPWNLDFVSHANQINRALRNAGVPA-----IWSTWGWSAYKGPKELQDIIGVEGQADYVLRRLALMSALDSDLDQRASVRDRDYG--PVYLALQRFLKVTGPKLRPADPPVTEDLP------DGSFSIGWTREDGRNVWL--FWSARGGNVRLPKLKEATLHDPLSGKVTPLSGSDGLEVPVKSSLQ--WE--------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.69

Estimated TM-score = 0.41±0.14

Estimated RMSD = 13.3±4.1Å

Download Model 2

C-score=-4.12

Download Model 3

C-score=-4.45

Download Model 4

C-score=-5.00

Download Model 5

C-score=-3.58

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3mveA	0.867	1.59	0.102	0.901
2	2jbwB	0.686	2.40	0.092	0.752
3	3fnbA	0.671	3.14	0.082	0.769
4	4ywfA	0.640	2.78	0.132	0.710
5	3azoA	0.566	4.67	0.057	0.727
6	1ve6A	0.564	4.41	0.079	0.707
7	2xe4A	0.555	5.18	0.075	0.740
8	5l8sA	0.554	5.06	0.080	0.730
9	2bklB	0.554	4.34	0.064	0.697
10	3g0bB	0.553	4.95	0.059	0.735

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.22	11	3d5eA	DEP	Rep, Mult	195,196,286,287,288,314,381
2	0.12	6	2ripA	UUU	Rep, Mult	177,178,179,234,235,236
3	0.04	2	1yahB	EEE	Rep, Mult	238,287
4	0.02	1	1htwA	MG	Rep, Mult	181,182
5	0.02	1	3proC	AES	Rep, Mult	323,324
6	0.02	1	2o01H	CLA	Rep, Mult	285,292
7	0.02	1	1r3nF	BIB	Rep, Mult	201,294
8	0.02	1	3jskM	FE2	Rep, Mult	339,340
9	0.02	1	2vn4A	MAN	Rep, Mult	369,370

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.117	2jbwD	0.690	2.70	0.090	0.769	3.7.1.-	287
2	0.066	1jjiA	0.505	4.29	0.074	0.630	3.1.1.1	NA
3	0.060	2o7rA	0.491	3.82	0.107	0.593	3.1.1.1	NA
4	0.060	2c7bA	0.480	3.93	0.102	0.576	3.1.1.1	197,291
5	0.060	2bklB	0.554	4.34	0.064	0.697	3.4.21.26	NA
6	0.060	1ivyA	0.472	4.53	0.067	0.588	3.4.16.5	NA
7	0.060	2o7vA	0.492	3.81	0.107	0.593	3.4.23.16	195,241,287
8	0.060	1z68A	0.546	4.93	0.068	0.722	3.4.21.-	NA
9	0.060	2qr5A	0.561	4.22	0.083	0.695	3.4.19.1	NA
10	0.060	1crlA	0.462	5.01	0.107	0.603	3.1.1.3	NA
11	0.060	2veoB	0.495	4.46	0.077	0.625	3.1.1.3	297
12	0.060	1orvA	0.545	5.04	0.065	0.727	3.4.14.5	197
13	0.060	1yr2A	0.531	5.18	0.077	0.697	3.4.21.26	287,380
14	0.060	1ac5A	0.474	4.40	0.044	0.586	3.4.16.6	NA
15	0.060	1lnsA	0.473	3.55	0.075	0.556	3.4.14.11	NA
16	0.060	3fcyA	0.467	3.62	0.075	0.553	3.1.1.41	NA
17	0.060	1l7aA	0.471	3.88	0.089	0.563	3.1.1.72,3.1.1.41	NA
18	0.060	1qz3A	0.494	4.28	0.083	0.610	3.1.1.1	NA
19	0.060	3ga7A	0.483	4.28	0.069	0.603	3.1.1.-	NA
20	0.060	3fakA	0.468	4.44	0.107	0.593	3.1.1.-	NA
21	0.060	3fvrA	0.471	3.88	0.100	0.563	3.1.1.6	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.20	0.704	2.35	0.08	0.77	2jbwB	GO:0009820 GO:0016787 GO:0019608
1	0.12	0.458	3.77	0.09	0.54	3hjuA	GO:0004622 GO:0005654 GO:0005737 GO:0005789 GO:0005829 GO:0005886 GO:0006629 GO:0006631 GO:0006633 GO:0006954 GO:0009966 GO:0016020 GO:0016042 GO:0016787 GO:0019369 GO:0019433 GO:0019898 GO:0036155 GO:0042803 GO:0046464 GO:0047372 GO:0050727 GO:0051930 GO:0052689 GO:2000124
2	0.09	0.686	3.03	0.07	0.78	3fnbA	GO:0004252 GO:0006508
3	0.07	0.552	4.48	0.05	0.70	4hxgF	GO:0006508 GO:0008236 GO:0046872
4	0.07	0.537	5.00	0.07	0.71	4wjlB	GO:0005886 GO:0006508 GO:0008236 GO:0008239 GO:0015459 GO:0016020 GO:0016021 GO:0072659 GO:0090004 GO:1901379
5	0.07	0.533	4.82	0.06	0.70	2d5lA	GO:0004177 GO:0006508 GO:0008233 GO:0008236 GO:0016787
6	0.07	0.531	5.07	0.06	0.71	4q1vA	GO:0006508 GO:0008236 GO:0016787 GO:0046872
7	0.07	0.460	4.48	0.04	0.58	1cqzB	GO:0000287 GO:0003824 GO:0004301 GO:0005102 GO:0005737 GO:0005777 GO:0005829 GO:0006629 GO:0008152 GO:0009636 GO:0010628 GO:0015643 GO:0016311 GO:0016787 GO:0016791 GO:0019439 GO:0033885 GO:0042577 GO:0042632 GO:0042803 GO:0046272 GO:0046839 GO:0046872 GO:0070062 GO:0090181
8	0.07	0.460	4.48	0.05	0.58	4haiA	GO:0000287 GO:0003824 GO:0004301 GO:0005102 GO:0005737 GO:0005777 GO:0005829 GO:0006629 GO:0006805 GO:0006874 GO:0006954 GO:0008152 GO:0008217 GO:0009636 GO:0010628 GO:0015643 GO:0016311 GO:0016787 GO:0016791 GO:0017144 GO:0019373 GO:0019439 GO:0033885 GO:0042577 GO:0042632 GO:0042803 GO:0045909 GO:0046272 GO:0046839 GO:0046872 GO:0070062 GO:0072593 GO:0090181
9	0.07	0.453	4.55	0.05	0.57	5aljA	GO:0000287 GO:0003824 GO:0004301 GO:0005102 GO:0005737 GO:0005777 GO:0005829 GO:0006629 GO:0006805 GO:0006874 GO:0006954 GO:0008152 GO:0008217 GO:0009636 GO:0010628 GO:0015643 GO:0016311 GO:0016787 GO:0016791 GO:0017144 GO:0019373 GO:0019439 GO:0033885 GO:0042577 GO:0042632 GO:0042803 GO:0045909 GO:0046272 GO:0046839 GO:0046872 GO:0070062 GO:0072593 GO:0090181
10	0.07	0.451	3.72	0.11	0.53	2vf2A	GO:0005618 GO:0005886 GO:0006629 GO:0006694 GO:0016042 GO:0016787 GO:0018774 GO:0019439 GO:0034820 GO:0044117 GO:0102296
11	0.07	0.467	3.62	0.07	0.55	3fcyA
12	0.06	0.448	3.45	0.11	0.52	2ocgA	GO:0005739 GO:0005741 GO:0006520 GO:0006805 GO:0009636 GO:0016787 GO:0047658 GO:0070062
13	0.06	0.419	3.49	0.12	0.48	1j1iA	GO:0016787
14	0.06	0.392	2.91	0.13	0.44	3trdA	GO:0016787
15	0.06	0.372	2.71	0.13	0.41	4eb0A	GO:0003847 GO:0016042 GO:0016787 GO:0050525
16	0.06	0.325	5.74	0.06	0.48	3bv6B	GO:0046872
17	0.06	0.319	6.88	0.06	0.53	1bzlA	GO:0005737 GO:0015036 GO:0015042 GO:0016491 GO:0016668 GO:0045454 GO:0050660 GO:0055114
18	0.06	0.290	6.70	0.03	0.48	3f70A	GO:0005634 GO:0005654 GO:0006351 GO:0006355 GO:0008270 GO:0016568 GO:0016925 GO:0035064 GO:0042393 GO:0046872

Consensus prediction of GO terms

Molecular Function	GO:0003824
GO-Score	0.42
Biological Processes	GO:0019538	GO:0072526	GO:0018933	GO:0009822
GO-Score	0.42	0.41	0.41	0.41
Cellular Component	GO:0071944
GO-Score	0.36

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.