I-TASSER results

I-TASSER results for job id Rv2529

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (463 residues)
MHLAHRVASSRDTPSSSATPNAVSGSASNAADRPCLVRPPTAPPWAHGPRLRRDPTGGGS
TPSIVLSRSTDRSKDGHRIVPAGARKSGVRASTGRLPSTRKTTRSPDCRPSASRTAFGTV
TCPFDVTMGSSECLLHRCRTPPVPSHSVELLVAANPAEDSRLPYLIRLPVGAGLVFATSD
VWPRTKALYCHRLDIADWPADPVVVDRVELRSCSRRGAAIDVVAARARENRSQLVHTMAR
GRQVVFWQSPKTRKQSRPGVRTPTARAAGIPELHIVVDAHERYPYTFADKPAKTTREALP
CGDYGLKVAGQLVAAVERKALADLTSGVLNGNLKYQLTELAALPRAAVVVEDRYSEIFAH
SFARPTAIADGLAELQIGFPNVPIVFCQTRKLAQEYTYRYLAAALTWFVDDADATTVFEP
AAAEPEPSSAELRAWAKSVGLPVSDRGRLRPQILQAWRAAHPR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MHLAHRVASSRDTPSSSATPNAVSGSASNAADRPCLVRPPTAPPWAHGPRLRRDPTGGGSTPSIVLSRSTDRSKDGHRIVPAGARKSGVRASTGRLPSTRKTTRSPDCRPSASRTAFGTVTCPFDVTMGSSECLLHRCRTPPVPSHSVELLVAANPAEDSRLPYLIRLPVGAGLVFATSDVWPRTKALYCHRLDIADWPADPVVVDRVELRSCSRRGAAIDVVAARARENRSQLVHTMARGRQVVFWQSPKTRKQSRPGVRTPTARAAGIPELHIVVDAHERYPYTFADKPAKTTREALPCGDYGLKVAGQLVAAVERKALADLTSGVLNGNLKYQLTELAALPRAAVVVEDRYSEIFAHSFARPTAIADGLAELQIGFPNVPIVFCQTRKLAQEYTYRYLAAALTWFVDDADATTVFEPAAAEPEPSSAELRAWAKSVGLPVSDRGRLRPQILQAWRAAHPR
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHCCCCCCCCCCCCHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHCCCCCCCCCEEEHCCCCCCEEEEHCCCCCCCCEEEEEHCCCCCCCCCHHHCCCHCCEEEEHCCCEEEEEHCCCCCCCEEEEEHCCCCCEEEHCCCCCHHHHCCCCCCCCCCCCCCCCCEEEEEHCCCCCHHHHHHHCCEEEEEHCCCCCEEHCCCCCCEEEEEHCCHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEHCCHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCC
Conf.Score	9866555567788888888865567777777888545788998877888767788888888747765788777777655567766567666678888777777888888877655555455776544687754344467899988766579997789998765788756788589998588887654677647876677774553444444554446645666534678866899864566544544676645545787777765456888769999789876678876599699986588758875789758999987999999998678599999999868998999968867754666789999999999999866996999879878999999999999987655666655555666677777668999999997987787788889999999998889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MHLAHRVASSRDTPSSSATPNAVSGSASNAADRPCLVRPPTAPPWAHGPRLRRDPTGGGSTPSIVLSRSTDRSKDGHRIVPAGARKSGVRASTGRLPSTRKTTRSPDCRPSASRTAFGTVTCPFDVTMGSSECLLHRCRTPPVPSHSVELLVAANPAEDSRLPYLIRLPVGAGLVFATSDVWPRTKALYCHRLDIADWPADPVVVDRVELRSCSRRGAAIDVVAARARENRSQLVHTMARGRQVVFWQSPKTRKQSRPGVRTPTARAAGIPELHIVVDAHERYPYTFADKPAKTTREALPCGDYGLKVAGQLVAAVERKALADLTSGVLNGNLKYQLTELAALPRAAVVVEDRYSEIFAHSFARPTAIADGLAELQIGFPNVPIVFCQTRKLAQEYTYRYLAAALTWFVDDADATTVFEPAAAEPEPSSAELRAWAKSVGLPVSDRGRLRPQILQAWRAAHPR
Prediction	5300331154443454433342142425422421010323412213313413432444341010002333543450231111114433142333413434533543514352432001101010202223230002105335344222100000224763300000104354200010334033131000131637414612410341303003344330301034335430210013342443222534543553455253554456537402000000052044057370511243040000001456410000001215200400254302500440461510000000215311525403131010000000031330000004445324422232112123433545434442544554555445302310353615036434125402500471358
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHCCCCCCCCCCCCHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHCCCCCCCCCEEEHCCCCCCEEEEHCCCCCCCCEEEEEHCCCCCCCCCHHHCCCHCCEEEEHCCCEEEEEHCCCCCCCEEEEEHCCCCCEEEHCCCCCHHHHCCCCCCCCCCCCCCCCCEEEEEHCCCCCHHHHHHHCCEEEEEHCCCCCEEHCCCCCCEEEEEHCCHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEHCCHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCC
MHLAHRVASSRDTPSSSATPNAVSGSASNAADRPCLVRPPTAPPWAHGPRLRRDPTGGGSTPSIVLSRSTDRSKDGHRIVPAGARKSGVRASTGRLPSTRKTTRSPDCRPSASRTAFGTVTCPFDVTMGSSECLLHRCRTPPVPSHSVELLVAANPAEDSRLPYLIRLPVGAGLVFATSDVWPRTKALYCHRLDIADWPADPVVVDRVELRSCSRRGAAIDVVAARARENRSQLVHTMARGRQVVFWQSPKTRKQSRPGVRTPTARAAGIPELHIVVDAHERYPYTFADKPAKTTREALPCGDYGLKVAGQLVAAVERKALADLTSGVLNGNLKYQLTELAALPRAAVVVEDRYSEIFAHSFARPTAIADGLAELQIGFPNVPIVFCQTRKLAQEYTYRYLAAALTWFVDDADATTVFEPAAAEPEPSSAELRAWAKSVGLPVSDRGRLRPQILQAWRAAHPR

5a1uE

0.09

0.98

MUSTER

RGPAVRALCQITDSTML--QAVERYMKQAIVDKVPSVSSSALVSSLHLLKCSFDVVKRWVNEAQEAASSDNIMVQYHALGLLYHVRKNDRLAVSKMISKFTRHGLKSPFAYCMMIRVASKQLEEEDGSRDSPLFDFIESCLRNKHEMVVYEAASAIVNLPGCSAKLAPAVSVLQLFCSSPKAALRYAAVRTLNKVAMKHPSAVTACNLDLENLVTDSLAITTLLKTGSESSIDRL--MKQISSFMSEISDEFKVVVVQAISALCQKYPRKHAV--LMNF---LFTMLREEGGFEYKRAIVIISIIEENSESKETGL--SHLCEFIEDCEFTVLATRILHLPKTNNPSKYIRFIYNRVVLEHEEVRAGAVSALAKFGAQNEEMLILMDDDNEVRDRATFYLNVLEQKQKALNAGYILNGLTVSIPGLEKALQQYTLEPSQPEKVATRQEIFQEQLAAVPEFQGL

1j24A

0.26

0.07

0.28

1.33

dPPAS

-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVKVVVDSRELRVKRLKLLGVKLEVKTLDVGDYIISED----VAIERKSANDLIQSIIDGGLFDQVKRLKEASRPIMIVEGSL---YGIRNVHPNAIRGAIAAVTVDF-GVPIIFSSTPEETAQYIFLIAKREQEER-------------------------------------------------------

1j24A

0.26

0.07

0.28

2.42

wdPPAS

-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVKVVVDSRELRVKRLKLLGVKLEVKTLDVGDYIISED----VAIERKSANDLIQSIIDGGLFDQVKRLKEASRPIMIVEGS---LYGIRNVHPNAIRGAIAAVTVDF-GVPIIFSSTPEETAQYIFLIAKREQEER-------------------------------------------------------

2bgwA

0.17

0.07

0.41

1.02

wMUSTER

-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LEDPGGRPRVYVDVREEVPSILESLGVQVIPKQLPMGDYLVSDS----IIVERKTSSDFAKSLFDGRLFEQASRLAEHETVFIIVEGPPVPRRY--RGRERSLYAAMAALQLDY-GIRLMNTMDPKGTALVIESLARLSTREGGQRIVIHKKPRLSDVRPGIGRRTAERILERFGSKVEGIGEKREEIKKILMT--PK

1j24A

0.26

0.07

0.28

2.04

wPPAS

-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVKVVVDSRELVVKRLKLLGVKLEVKTLDVGDYIISED----VAIERKSANDLIQSIIDGGLFDQVKRLKEASRPIMIVEGSL---YGIRNVHPNAIRGAIAAVTVDF-GVPIIFSSTPEETAQYIFLIAKREQEER-------------------------------------------------------

1j24A

0.26

0.07

0.28

2.87

dPPAS2

-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVKVVVDSRELVVKRLKLLGVKLEVKTLDVGDYIISED----VAIERKSANDLIQSIIDGGLFDQVKRLKEASRPIMIVEGSL---YGIRNVHPNAIRGAIAAVTVDF-GVPIIFSSTPEETAQYIFLIAKREQEER-------------------------------------------------------

1j24A

0.26

0.07

0.28

1.36

PPAS

-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVKVVVDSRELVVKRLKLLGVKLEVKTLDVGDYIISED----VAIERKSANDLIQSIIDGGLFDQVKRLKEASRPIMIVEGSL---YGIRNVHPNAIRGAIAAVTVDF-GVPIIFSSTPEETAQYIFLIAKREQEER-------------------------------------------------------

1j24A

0.26

0.07

0.28

2.01

Env-PPAS

-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVKVVVDSRELVVKRLKLLGVKLEVKTLDVGDYIISED----VAIERKSANDLIQSIIDGGLFDQVKRLKEASRPIMIVEGSL---YGIRNVHPNAIRGAIAAVTVDF-GVPIIFSSTPEETAQYIFLIAKREQEER-------------------------------------------------------

5a1uG

0.10

0.98

0.97

MUSTER

MTIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMLVCDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVLAIYTIYRNEHLIPDAPELIHDFLVNEKDASCKRNAFMMLIHADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKV-----CHANPSERARFIRCIYNLLQSSSPAVKYE-AAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLIVLDRLVELKEHPAHERVLQDLVMDIPDLEVRKKTLQLALDLVSSRNVEELVIVLKTNNVSEHEDTDKYRQLLVRTLHSCSVRFMAANVIPVLMEFSNEAAAADVLEFVREAIQRFDNLRMLIVEKMLEVFAIKSVKIYILYCSTKEDIQSVMTEVRRSLGEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSALSSSRPTKK-EEDRPP

2bgwA

0.16

0.06

0.39

1.25

dPPAS

------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLEDPGGRPRVYVDVREERPSILESLGVQVIPKQLPMGDYLVSDS----IIVERKTSSDFAKSLFDGRLFEQASRLAEHETVFIIVEGPPVPR--RYRGRERSLYAAMAALQLDY-GIRLMNTMDPKGTALVIESLARLSTREGGQRI-------VIHKKPRLSDVREWQLYILQSFP-----GIGRRTAERILERFGS

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.54

Estimated TM-score = 0.64±0.13

Estimated RMSD = 8.4±4.5Å

Download Model 2

C-score=-1.80

Download Model 3

C-score=-1.72

Download Model 4

C-score=-2.14

Download Model 5

C-score=-2.74

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5a1uE	0.861	2.48	0.084	0.924
2	5dlqB	0.647	5.22	0.072	0.866
3	3ea5B	0.631	5.11	0.061	0.845
4	3icqT	0.625	5.17	0.051	0.847
5	2x19B	0.625	5.45	0.066	0.873
6	3w3tA	0.619	5.66	0.055	0.866
7	4fgvA	0.619	5.76	0.055	0.877
8	2vglB	0.616	5.78	0.085	0.866
9	3m1iC	0.605	5.78	0.036	0.855
10	3gjxA	0.598	5.81	0.062	0.858

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	3	1j24A	CA	Rep, Mult	303,317,318
2	0.06	3	1f59A	III	Rep, Mult	331,334,335,338,339,364,367,371
3	0.06	3	4ag5C	MG	Rep, Mult	370,374
4	0.04	2	4eneA	DMU	Rep, Mult	368,372
5	0.04	2	1g5bA	MN	Rep, Mult	278,280,303
6	0.04	2	1fbmD	RTL	Rep, Mult	372,379
7	0.04	2	2xquA	CVM	Rep, Mult	364,368
8	0.04	2	3melC	MG	Rep, Mult	278,303,323
9	0.02	1	2q5dB	III	Rep, Mult	323,326,358
10	0.02	1	2qvwB	MN	Rep, Mult	319,323
11	0.02	1	4lk3E	UGA	Rep, Mult	251,254
12	0.02	1	2bptA	III	Rep, Mult	319,322,323,347,349,350,351,352,354,355,382,384
13	0.02	1	4lmsC	M1V	Rep, Mult	372,375
14	0.02	1	3m3kC	ZN	Rep, Mult	280,281
15	0.02	1	2f7tA	MG	Rep, Mult	303,352

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3b9jJ	0.210	6.31	0.060	0.315	1.17.1.4,1.17.3.2	277
2	0.060	1ug9A	0.374	7.75	0.048	0.661	3.2.1.70	426
3	0.060	3ebgA	0.411	5.90	0.031	0.581	3.4.11.-	NA
4	0.060	3b9jC	0.273	7.19	0.033	0.445	1.17.3.2,1.17.1.4	NA
5	0.060	3dpyA	0.376	5.80	0.034	0.540	2.5.1.58,2.5.1.59	375
6	0.060	2olsA	0.361	7.21	0.044	0.598	2.7.9.2	NA
7	0.060	2fhbA	0.346	7.62	0.052	0.594	3.2.1.41	NA
8	0.060	3c5wA	0.326	4.17	0.026	0.404	3.1.3.16	NA
9	0.060	2rd0A	0.353	6.70	0.036	0.557	2.7.1.153	NA
10	0.060	2dqmA	0.362	6.91	0.057	0.568	3.4.11.2	NA
11	0.060	1fo4A	0.322	7.72	0.036	0.559	1.17.1.4	NA
12	0.060	2gtqA	0.381	6.60	0.045	0.577	3.4.11.2	NA
13	0.060	1dceA	0.509	6.26	0.057	0.758	2.5.1.60	145
14	0.060	2j62A	0.300	7.55	0.037	0.514	3.2.1.52	281,284,321
15	0.060	1i8qA	0.397	6.81	0.047	0.624	4.2.2.1	NA
16	0.060	1ouvA	0.366	5.63	0.062	0.514	3.5.2.6	365
17	0.060	3b9jI	0.152	5.57	0.038	0.212	1.17.1.4,1.17.3.2	371
18	0.060	1hn0A	0.412	7.08	0.040	0.678	4.2.2.20	280,285
19	0.060	1kc7A	0.386	7.23	0.047	0.646	2.7.9.1	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.24	0.598	5.81	0.06	0.86	3gjxA	GO:0000055 GO:0000056 GO:0000122 GO:0000776 GO:0003723 GO:0005487 GO:0005634 GO:0005642 GO:0005654 GO:0005730 GO:0005737 GO:0006611 GO:0006810 GO:0006886 GO:0008536 GO:0008565 GO:0010824 GO:0015030 GO:0015031 GO:0016020 GO:0019904 GO:0030529 GO:0031965 GO:0034504 GO:0042176 GO:0042493 GO:0043231 GO:0046825 GO:0051028
1	0.19	0.625	5.17	0.05	0.85	3icqT	GO:0000049 GO:0003723 GO:0005525 GO:0005634 GO:0005635 GO:0005643 GO:0005737 GO:0005829 GO:0006409 GO:0006605 GO:0006810 GO:0008033 GO:0008536 GO:0015932 GO:0016363 GO:0071528
2	0.18	0.861	2.48	0.08	0.92	5a1uE	GO:0000139 GO:0005198 GO:0005737 GO:0005794 GO:0005829 GO:0006810 GO:0006886 GO:0015031 GO:0016020 GO:0016192 GO:0030117 GO:0030126 GO:0030663 GO:0031410
3	0.18	0.569	5.75	0.05	0.81	1qgkA	GO:0000059 GO:0000060 GO:0005634 GO:0005635 GO:0005643 GO:0005654 GO:0005737 GO:0005829 GO:0006309 GO:0006606 GO:0006607 GO:0006610 GO:0006810 GO:0006886 GO:0007079 GO:0007080 GO:0008139 GO:0008270 GO:0008536 GO:0008565 GO:0015031 GO:0016020 GO:0016032 GO:0019054 GO:0019899 GO:0019904 GO:0030953 GO:0031291 GO:0031965 GO:0034399 GO:0040001 GO:0043234 GO:0044822 GO:0045184 GO:0051879 GO:0070062 GO:0071782 GO:0075733 GO:0090307
4	0.11	0.593	5.40	0.03	0.82	3gb8A	GO:0000055 GO:0000056 GO:0000122 GO:0000776 GO:0003723 GO:0005215 GO:0005487 GO:0005634 GO:0005635 GO:0005642 GO:0005654 GO:0005730 GO:0005737 GO:0005829 GO:0006611 GO:0006810 GO:0006886 GO:0007062 GO:0008536 GO:0008565 GO:0010824 GO:0015030 GO:0015031 GO:0016020 GO:0016032 GO:0019904 GO:0030529 GO:0031965 GO:0034504 GO:0042176 GO:0042493 GO:0043231 GO:0043488 GO:0046825 GO:0051028 GO:0075733
5	0.09	0.542	6.45	0.04	0.82	2q5dB	GO:0000059 GO:0000060 GO:0005634 GO:0005635 GO:0005643 GO:0005654 GO:0005737 GO:0005829 GO:0006309 GO:0006606 GO:0006607 GO:0006610 GO:0006810 GO:0006886 GO:0007079 GO:0007080 GO:0008139 GO:0008270 GO:0008536 GO:0008565 GO:0015031 GO:0016020 GO:0016032 GO:0019054 GO:0019899 GO:0019904 GO:0030953 GO:0031291 GO:0031965 GO:0034399 GO:0040001 GO:0043234 GO:0044822 GO:0045184 GO:0051879 GO:0070062 GO:0071782 GO:0075733 GO:0090307
6	0.07	0.615	5.93	0.09	0.89	4uqiB	GO:0003279 GO:0003281 GO:0005048 GO:0005802 GO:0005829 GO:0005886 GO:0005905 GO:0006810 GO:0006886 GO:0006897 GO:0007018 GO:0007507 GO:0008565 GO:0015031 GO:0016020 GO:0016192 GO:0019886 GO:0030117 GO:0030118 GO:0030122 GO:0030131 GO:0030276 GO:0030666 GO:0030669 GO:0032403 GO:0035615 GO:0035904 GO:0036020 GO:0042059 GO:0043231 GO:0048013 GO:0048268 GO:0050690 GO:0060071 GO:0060976 GO:0072583
7	0.07	0.570	5.82	0.04	0.82	3nd2A	GO:0000059 GO:0000060 GO:0000176 GO:0005087 GO:0005634 GO:0005643 GO:0005737 GO:0006606 GO:0006607 GO:0006610 GO:0006612 GO:0006656 GO:0006810 GO:0006886 GO:0008139 GO:0008536 GO:0008565 GO:0015031 GO:0031965 GO:0034399 GO:0043547 GO:0051028 GO:0051292 GO:0060188
8	0.07	0.571	5.78	0.05	0.81	4xriA	GO:0005622 GO:0006886 GO:0008536
9	0.07	0.630	5.44	0.06	0.86	4bsmA	GO:0000055 GO:0000056 GO:0000122 GO:0000776 GO:0003723 GO:0005215 GO:0005487 GO:0005634 GO:0005635 GO:0005642 GO:0005654 GO:0005730 GO:0005737 GO:0005829 GO:0006611 GO:0006810 GO:0006886 GO:0007062 GO:0008536 GO:0008565 GO:0010824 GO:0015030 GO:0015031 GO:0016020 GO:0016032 GO:0019904 GO:0030529 GO:0031965 GO:0034504 GO:0042176 GO:0042493 GO:0043231 GO:0043488 GO:0046825 GO:0051028 GO:0075733
10	0.07	0.590	5.46	0.08	0.82	1w63A	GO:0005737 GO:0005794 GO:0005802 GO:0005829 GO:0006810 GO:0006886 GO:0008565 GO:0015031 GO:0016020 GO:0016192 GO:0017137 GO:0019894 GO:0030117 GO:0030131 GO:0030136 GO:0030665 GO:0030742 GO:0031410 GO:0035646 GO:0043231 GO:0043323 GO:0045954 GO:0048471 GO:0055037 GO:0090160
11	0.07	0.547	6.33	0.03	0.82	3a6pA	GO:0000049 GO:0003723 GO:0003729 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0006611 GO:0006810 GO:0006886 GO:0008536 GO:0008565 GO:0015031 GO:0031047 GO:0035281 GO:0042565 GO:0044822 GO:0070883 GO:0090631 GO:1900370
12	0.07	0.491	6.07	0.10	0.72	4uadA	GO:0005634 GO:0005643 GO:0005654 GO:0005737 GO:0005829 GO:0006606 GO:0006607 GO:0006810 GO:0008139 GO:0008565 GO:0015031 GO:0016020 GO:0045944 GO:0060135
13	0.07	0.482	5.83	0.05	0.70	1wa5B	GO:0000176 GO:0005634 GO:0005643 GO:0005654 GO:0005737 GO:0005829 GO:0006606 GO:0006607 GO:0006612 GO:0006810 GO:0008139 GO:0008565 GO:0015031 GO:0031144 GO:0048471
14	0.07	0.478	6.19	0.06	0.72	4rxhB	GO:0005634 GO:0005737 GO:0006606 GO:0006810 GO:0008565 GO:0015031
15	0.07	0.484	5.66	0.05	0.69	4b8jA	GO:0005634 GO:0005643 GO:0005654 GO:0005737 GO:0005829 GO:0006606 GO:0006607 GO:0006810 GO:0008139 GO:0008565 GO:0015031 GO:0016032 GO:0048471
16	0.06	0.263	7.52	0.04	0.44	3o8lA	GO:0000166 GO:0003824 GO:0003872 GO:0005524 GO:0005737 GO:0006002 GO:0006096 GO:0008022 GO:0008152 GO:0016301 GO:0016310 GO:0016740 GO:0046872 GO:0061615
17	0.06	0.254	7.60	0.04	0.43	4v81H	GO:0000166 GO:0005524 GO:0005737 GO:0005832 GO:0006457 GO:0051082
18	0.06	0.231	7.29	0.05	0.38	3a9vA	GO:0000166 GO:0003824 GO:0008152 GO:0016874

Consensus prediction of GO terms

Molecular Function	GO:0008536	GO:0003723	GO:0019904	GO:0008565	GO:0022891	GO:0032550	GO:0035639	GO:0032561	GO:0046914	GO:0005048	GO:0031072	GO:0005487
GO-Score	0.55	0.45	0.44	0.44	0.38	0.38	0.38	0.38	0.36	0.36	0.36	0.32
Biological Processes	GO:1902583	GO:0046794	GO:0019058	GO:0034470	GO:0006399	GO:0006409	GO:0051310	GO:0006606	GO:0044068	GO:0019048	GO:0000070	GO:0043623	GO:0051305	GO:0000737	GO:0007265	GO:0051225	GO:0030262	GO:0031122	GO:1902850	GO:0051293	GO:0000122	GO:0000056	GO:0042176	GO:0046825	GO:0010824	GO:0000055	GO:0042493	GO:0051028
GO-Score	0.53	0.53	0.53	0.38	0.38	0.38	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32
Cellular Component	GO:0005829	GO:0031965	GO:0034399	GO:0030120	GO:0030663	GO:1903561	GO:0098827	GO:0005643	GO:0015030	GO:0005730	GO:0030529	GO:0000776	GO:0005642
GO-Score	0.52	0.44	0.38	0.37	0.37	0.36	0.36	0.33	0.32	0.32	0.32	0.32	0.32

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.