I-TASSER results

I-TASSER results for job id Rv2492

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (250 residues)
MSRRIINEFGVQIYGATIGDTWAGLVRAVLDLGSQCFDEDRERIALSNVRIKSSVQNYPD
LTIEEHCNSAQLKAMLDFMFNTDTMEDIDVVKSFSRGAKSYHRRIKEGRMIEFVIERLSL
IPESKKAVVVFPTYEDYAAVMRNHRDDYLPCLVSIQFRLLPDGKDYVFHTTFYSRSMDAW
QKGHGNLLSIAKLSDWVRENVSARIGRKIMLGPLDGMICDVHIYKETYAEACKRLANLDL
RRTQFDAVRN

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MSRRIINEFGVQIYGATIGDTWAGLVRAVLDLGSQCFDEDRERIALSNVRIKSSVQNYPDLTIEEHCNSAQLKAMLDFMFNTDTMEDIDVVKSFSRGAKSYHRRIKEGRMIEFVIERLSLIPESKKAVVVFPTYEDYAAVMRNHRDDYLPCLVSIQFRLLPDGKDYVFHTTFYSRSMDAWQKGHGNLLSIAKLSDWVRENVSARIGRKIMLGPLDGMICDVHIYKETYAEACKRLANLDLRRTQFDAVRN
Prediction	CCCHHHHCCCEEEEHCCHHHHHHHHHHHHHHHCCEHCCCCCCEEEEEEEEEHCCCCCCCCCCHHHHHHHHCCCCHHHHHHCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHCHHHCCCHHHHHCCCCCCCEEEEEEEEEHCCCCCEEEEEEEEEHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEHCCEEHCHHHHHHHHHHHHHCCCCCCCCCCCCC
Conf.Score	9754554566799867788999999999999795665788877899866764566777666644555554555545544346676666545666776667547788857999999999979866769999957566554555555689987468999998578998899999874456776457889999999999999989977766466568999865664478999999999977888766776789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MSRRIINEFGVQIYGATIGDTWAGLVRAVLDLGSQCFDEDRERIALSNVRIKSSVQNYPDLTIEEHCNSAQLKAMLDFMFNTDTMEDIDVVKSFSRGAKSYHRRIKEGRMIEFVIERLSLIPESKKAVVVFPTYEDYAAVMRNHRDDYLPCLVSIQFRLLPDGKDYVFHTTFYSRSMDAWQKGHGNLLSIAKLSDWVRENVSARIGRKIMLGPLDGMICDVHIYKETYAEACKRLANLDLRRTQFDAVRN
Prediction	7544214510230315204400240042016404624556433031320315423751351215523643415233421143631652433464453120125204625004300530473452210000011243234344636553100000000202346642201000001021003112100000130041005304353444042130202021000045116404610661625445154358
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCHHHHCCCEEEEHCCHHHHHHHHHHHHHHHCCEHCCCCCCEEEEEEEEEHCCCCCCCCCCHHHHHHHHCCCCHHHHHHCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHCHHHCCCHHHHHCCCCCCCEEEEEEEEEHCCCCCEEEEEEEEEHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEHCCEEHCHHHHHHHHHHHHHCCCCCCCCCCCCC
MSRRIINEFGVQIYGATIGDTWAGLVRAVLDLGSQCFDEDRERIALSNVRIKSSVQNYPDLTIEEHCNSAQLKAMLDFMFNTDTMEDIDVVKSFSRGAKSYHRRIKEGRMIEFVIERLSLIPESKKAVVVFPTYEDYAAVMRNHRDDYLPCLVSIQFRLLPDGKDYVFHTTFYSRSMDAWQKGHGNLLSIAKLSDWVRENVSARIGRKIMLGPLDGMICDVHIYKETYAEACKRLANLDLRRTQFDAVRN

3qj7A

0.16

0.13

0.85

1.86

MUSTER

------------------MTPYEDLLRFVLETGTPKSDRTGTTRSLFGQQMRYDLSAGFLWFLRGDSNIGWLHEHGVTIWDEWASDTGELGPIYGVQWRSWPPSGEHIDQISAALDLLRTDPDSRRIIVSAWNVGEIERM------ALPPCHAFFQFYVA-----GRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGL------SVGEFIWTGGDCHIYDNHVEQVRLQLSREPR---PYPKLAD

1b5dA

0.11

0.10

0.94

3.05

dPPAS

-----------MISDSMTVEEIRLHLGLALKEKDFVVDKTGVTIEIIGASFVADEPFIFGALNDEYIQRELESLFVKDIPGETPKIWQQVASSKGEINSNYGWAIWEDNQYDMCLAELGQNPDSRRGIMIYTRPSMQ-FDYNKDGMSDFMCTNTVQYLIRD----KKINAVVNMRSNDVVFGFRNDYAWQKYVLDKLVSDLNADSTRQYKAGSIIWNVGSLHVYSRHFYLVDHWWKTGETHISKKDYVGK

1b5dA

0.10

0.09

0.90

3.91

wdPPAS

-----------MISDSMTVEEIRLHLGLALKEKDFVVDKTGVTIEIIGASFVADEPFLEWY-KSKSLFVKDIPGETPKIWQQVA-------SSKGEINSNYGWAIWEDNQYDMCLAELGQNPDSRRGIMIYTRPSMQF-DYNKDGMSDFMCTNTVQYLIRD----KKINAVVNMRSNDVVFGFRNDYAWQKYVLDKLVSDLNAGDSTRYKAGSIIWNVGSLHVYSRHFYLVDHWWKTGETHISKKDYVGK

3qj7A

0.16

0.14

0.86

2.38

wMUSTER

------------------MTPYEDLLRFVLETGTPKSDRTGTTRSLFGQQMRYDLSAGFLWFLRGDSNIGWLHEHGVTIWDEWASDTGELGPIYGVQWRSWPPSGEHIDQISAALDLLRTDPDSRRIIVSAWNVGE------IERMALPPCHAFFQFYVA-----GRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGL------SVGEFIWTGGDCHIYDNHVEQVRLQLSREPRPYPKLADRDS

1b5dA

0.11

0.10

0.90

4.03

wPPAS

MI------------SDSMVEEIRLHLGLALKEKDFVVDKTGVTIEIIGASFVADEPFLEWY-KSKSLFVKDIPGETPKIWQQVA-------SSKGEINSNYGWAIWEDNQYDMCLAELGQNPDSRRGIMIYTRPSMQF-DYNKDGMSDFMCTNTVQYLIR-----KKINAVVNMRSNDVVFGFRNDYAWQKYVLDKLVSDLNADSTRQYKAGSIIWNVGSLHVYSRHFYLVDHWWKTGETHISKKDYVGK

1b5dA

0.11

0.10

0.93

5.01

dPPAS2

------------MISDSMVEEIRLHLGLALKEKDFVVDKTGVTIEIIGASFVADEPFIFGALNDEYIQRELESLFVKDIPGETPKIWQQVASSKGEINSNYGWAIWEDNQYDMCLAELGQNPDSRRGIMIYTRPSMQ-FDYNKDGMSDFMCTNTVQYLIRD----KKINAVVNMRSNDVVFGFRNDYAWQKYVLDKLVSDLNADSTRQYKAGSIIWNVGSLHVYSRHFYLVDHWWKTGETHISKKDYVGK

3qj7A

0.15

0.12

0.84

3.06

PPAS

------------------MTPYEDLLRFVLETGTPKSDRTGTTRSLFGQQMRYDLSA--GFPLLTTKKVHFKSVAYELLW-IGWLHEDEWASDTGELGPIYGVQWRSWDQISAALDLLRTDPDSRRIIVSAWNVGEIERM------ALPPCHAFFQFYVA-----GRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGL------SVGEFIWTGGDCHIYDNHVEQVRLQLSREPR---PYPKLLA

3qj7A

0.15

0.12

0.84

4.54

Env-PPAS

------------------MTPYEDLLRFVLETGTPKSDRTGTTRSLFGQQMRYDLSA--GFPLLTTKKVHFKSVAYELLWFIGWLHEDEWASDTGELGPIYGVQWRSWDQISAALDLLRTDPDSRRIIVSAWNVGEIERMA------LPPCHAFFQFYVAD----GRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAG------LSVGEFIWTGGDCHIYDNHVEQVRLQLSREPR---PYPKLLA

1b5dA

0.09

0.08

0.92

1.78

MUSTER

MISDSMT-----------VEEIRLHLGLALKEKDFVVDKTGVTIEIIGASFVADEPFIFEWYKSKSLFVKDIPGETPKIWQQVASSKGEINSNYG--WAIWS--EDNYAQYDMCLAELGQNPDSRRGIMIYTRPSMQF-DYNKDGMSDFMCTNTVQYLIRD----KKINAVVNMRSNDVVFGFRNDYAWQKYVLDKLVSDLNADSTRQYKAGSIIWNVGSLHVYSRHFYLVDHWWKTGETHISKKDYVGK

3qj7A

0.14

0.12

0.86

2.76

dPPAS

------------------MTPYEDLLRFVLETGTPKSDRTGTTRSLFGQQMRYDLSA--GFPLLTTKKVHFKSVAYELLWFIGWLHEDEWASDTGELGPIYGVQWRSWDQISAALDLLRTDPDSRRIIVSAWNVGEIERM------ALPPCHAFFQFYVAD----GRLSCQLYQRSADLFLGVPFNIASYALLTHMMAAQAGL------SVGEFIWTGGDCHIYDNHVEQVRLQLSREPRPYPKLADRDS

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.35

Estimated TM-score = 0.67±0.13

Estimated RMSD = 6.5±4.0Å

Download Model 2

C-score=-1.01

Download Model 3

C-score=-0.87

Download Model 4

C-score=-3.00

Download Model 5

C-score=-1.44

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1b5dA	0.807	2.34	0.108	0.904
2	2aazA	0.726	3.12	0.128	0.864
3	1ci7A	0.724	3.22	0.136	0.860
4	1qzfA	0.723	3.51	0.129	0.876
5	3k2hA	0.721	3.05	0.120	0.848
6	1j3iD	0.719	3.22	0.095	0.852
7	3ihhA	0.718	3.03	0.130	0.840
8	3jsuA	0.718	3.20	0.096	0.848
9	4eckA	0.717	3.11	0.120	0.852
10	4iswA	0.716	3.11	0.138	0.844

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.65	247	4g9uB	UMP	Rep, Mult	148,151,152,174,175,176,177,178,182,186,222,224
2	0.08	51	2kceA	D16	Rep, Mult	70,73,77,148,178,181,182,185,224
3	0.02	9	2onbA	7PA	Rep, Mult	39,175,176,224
4	0.02	11	1i00A	D16	Rep, Mult	66,178,181,182,185,224
5	0.02	13	1an5B	CB3	Rep, Mult	70,73,77,101,148,149,151,152,181,182,185,186
6	0.02	9	3k2hA	UMP	Rep, Mult	125,126
7	0.02	10	1f4gA	TP4	Rep, Mult	87,90,148,151,176,178,181,182,185,186,222,224
8	0.00	1	1f4eA	TPR	Rep, Mult	83,84,85
9	0.00	2	1kziA	CO3	Rep, Mult	68
10	0.00	2	2a9wA	GA9	Rep, Mult	70,73,181,182,185
11	0.00	1	3ejlC	UFP	Rep, Mult	113,125,126
12	0.00	1	1vzeA	CB3	Rep, Mult	39,40,178,181,186,224
13	0.00	1	3ihiB	SO4	Rep, Mult	148,175
14	0.00	1	2g8xB	CO3	Rep, Mult	133,135
15	0.00	1	3uwlB	FOZ	Rep, Mult	57,58,61,148,151,178,181,182,185,186
16	0.00	1	2g8xA	CO3	Rep, Mult	69,70
17	0.00	1	1b490	III	Rep, Mult	14,25,38,39,45,46,47,48,50,110,113,125,126,128,130,132,133,134,136,138,139,141,147,149,154,156,158,160,173,175,176,219,220,222,224
18	0.00	1	3n5eB	III	Rep, Mult	110,113,114,117,124,126,128,129,130,132,148,149,150,151
19	0.00	1	1b49A	PO4	Rep, Mult	175,176
20	0.00	1	3n5eA	III	Rep, Mult	130,132,137,140,148,149,150,151

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.383	3kgbA	0.666	3.03	0.163	0.776	2.1.1.45	151,176,178,186,189,220,222
2	0.353	1aiqA	0.713	2.99	0.168	0.832	2.1.1.45	101,151,175,176,178,186,189,220,222
3	0.341	3ix6B	0.680	3.23	0.164	0.808	2.1.1.45	151,175,176,178,186,189,220,222
4	0.322	2aazA	0.726	3.12	0.128	0.864	2.1.1.45	151,176,178,186,220,222
5	0.319	1bo7A	0.715	3.04	0.157	0.840	2.1.1.45	151,176,178,186,189,220,222
6	0.259	1f28B	0.729	3.14	0.131	0.860	2.1.1.45	151,173,175,178,186,220,224
7	0.226	1tysA	0.714	3.03	0.163	0.836	2.1.1.45	173,175,186,220
8	0.090	1b02A	0.714	3.10	0.110	0.840	2.1.1.45	151,176,178,186,220,222
9	0.060	3c8yA	0.440	5.23	0.028	0.668	1.12.7.2	NA
10	0.060	3c0aA	0.703	3.23	0.166	0.836	2.1.1.45	151,176,178,186,189,220,222
11	0.060	1ypvA	0.661	3.56	0.121	0.800	2.1.1.45	176,178,186,220,222
12	0.060	3egyX	0.638	3.55	0.126	0.768	2.1.1.45	176,178,186,220,222
13	0.060	2ftyA	0.457	5.52	0.054	0.748	3.5.2.2	NA
14	0.060	3hhsA	0.428	5.85	0.062	0.724	1.14.18.1	NA
15	0.060	1dioA	0.429	5.08	0.045	0.660	4.2.1.28	NA
16	0.060	3e74B	0.432	5.85	0.048	0.724	3.5.2.5	NA
17	0.060	1f28A	0.728	3.13	0.131	0.864	2.1.1.45	151,176,178,220,222
18	0.060	3dc8A	0.449	5.60	0.051	0.740	3.5.2.2	66
19	0.060	1qzfA	0.723	3.51	0.129	0.876	2.1.1.45	151,176,178,186,220,222
20	0.060	1hvyA	0.717	3.11	0.128	0.848	2.1.1.45	151,176,178,186,189,220,222
21	0.060	1b5dA	0.807	2.34	0.108	0.904	2.1.2.8	101,151,175,178
22	0.060	1iwpA	0.427	5.24	0.050	0.672	4.2.1.30	181
23	0.060	1hfeL	0.437	5.00	0.026	0.664	1.12.7.2	NA
24	0.060	1lcbA	0.709	3.20	0.171	0.844	2.1.1.45	101,151,173,175,178,186,220,222
25	0.060	1j3iD	0.719	3.22	0.095	0.852	2.1.1.45,1.5.1.3	151,186,189
26	0.060	2ipyA	0.282	6.71	0.033	0.536	4.2.1.3	102
27	0.060	3d6nA	0.421	5.69	0.051	0.712	3.5.2.3	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.42	0.712	3.00	0.17	0.83	1an5A	GO:0003723 GO:0004799 GO:0005737 GO:0005829 GO:0006231 GO:0006235 GO:0006417 GO:0008168 GO:0009165 GO:0016740 GO:0032259
1	0.40	0.721	3.27	0.12	0.86	3irmA	GO:0003824 GO:0004146 GO:0004799 GO:0006231 GO:0006545 GO:0006730 GO:0008152 GO:0008168 GO:0009165 GO:0016491 GO:0016740 GO:0032259 GO:0046654 GO:0055114
2	0.40	0.715	3.04	0.16	0.84	1bo7A	GO:0004799 GO:0005737 GO:0006231 GO:0006235 GO:0008168 GO:0009165 GO:0016740 GO:0032259
3	0.40	0.718	3.26	0.10	0.85	3qg2A	GO:0000166 GO:0004146 GO:0004799 GO:0006231 GO:0006545 GO:0006730 GO:0008168 GO:0009165 GO:0016491 GO:0016740 GO:0032259 GO:0046654 GO:0055114
4	0.36	0.728	3.13	0.13	0.86	1f28A	GO:0004799 GO:0006231 GO:0006235 GO:0008168 GO:0009165 GO:0016740 GO:0032259
5	0.35	0.807	2.34	0.11	0.90	1b5dA	GO:0016740 GO:0047153
6	0.35	0.723	3.51	0.13	0.88	1qzfA
7	0.35	0.703	3.23	0.17	0.84	3c0aA	GO:0004799 GO:0005737 GO:0006231 GO:0006235 GO:0008168 GO:0009165 GO:0016740 GO:0032259
8	0.35	0.726	3.12	0.13	0.86	2aazA	GO:0004799 GO:0006231 GO:0006235 GO:0008168 GO:0009165 GO:0016740 GO:0032259
9	0.34	0.705	3.25	0.17	0.84	4h0rB	GO:0004799 GO:0005737 GO:0006231 GO:0006235 GO:0008168 GO:0009165 GO:0016740 GO:0032259
10	0.32	0.721	3.05	0.12	0.85	3k2hA	GO:0000166 GO:0004146 GO:0004799 GO:0006231 GO:0006545 GO:0006730 GO:0008168 GO:0009165 GO:0016491 GO:0016740 GO:0032259 GO:0046654 GO:0055114
11	0.27	0.680	3.23	0.16	0.81	3ix6B	GO:0004799 GO:0005737 GO:0006231 GO:0006235 GO:0008168 GO:0009165 GO:0016740 GO:0032259
12	0.25	0.721	3.06	0.12	0.85	4eilA	GO:0003824 GO:0004146 GO:0004799 GO:0006231 GO:0006545 GO:0006730 GO:0008152 GO:0008168 GO:0009165 GO:0016491 GO:0016740 GO:0032259 GO:0046654 GO:0055114
13	0.23	0.666	3.51	0.13	0.80	3ef9A	GO:0000082 GO:0000083 GO:0000166 GO:0003729 GO:0004799 GO:0005542 GO:0005634 GO:0005654 GO:0005730 GO:0005737 GO:0005739 GO:0005743 GO:0005759 GO:0005829 GO:0006139 GO:0006206 GO:0006231 GO:0006235 GO:0007568 GO:0007623 GO:0008144 GO:0008168 GO:0008283 GO:0009157 GO:0009165 GO:0009636 GO:0014070 GO:0016020 GO:0016049 GO:0016740 GO:0019088 GO:0019860 GO:0031100 GO:0032259 GO:0032570 GO:0033189 GO:0034097 GO:0035999 GO:0042493 GO:0042803 GO:0045471 GO:0046078 GO:0046134 GO:0046653 GO:0046683 GO:0048037 GO:0048589 GO:0051216 GO:0051384 GO:0051593 GO:0060574 GO:0071897
14	0.22	0.714	3.21	0.14	0.85	4irrA	GO:0004799 GO:0006231 GO:0008168 GO:0016740 GO:0032259
15	0.22	0.704	3.23	0.17	0.84	3uwlA	GO:0004799 GO:0005737 GO:0006231 GO:0006235 GO:0008168 GO:0009165 GO:0016740 GO:0032259
16	0.20	0.704	3.04	0.14	0.83	3v8hA	GO:0004799 GO:0005737 GO:0006231 GO:0006235 GO:0008168 GO:0009165 GO:0016740 GO:0032259
17	0.20	0.706	3.39	0.17	0.85	4dq1A	GO:0004799 GO:0005737 GO:0006231 GO:0006235 GO:0008168 GO:0009165 GO:0016740 GO:0032259
18	0.12	0.727	3.09	0.12	0.86	4eb4B	GO:0000166 GO:0003729 GO:0004799 GO:0005542 GO:0005634 GO:0005730 GO:0005737 GO:0005739 GO:0005743 GO:0005759 GO:0006206 GO:0006231 GO:0006235 GO:0007568 GO:0007623 GO:0008144 GO:0008168 GO:0009165 GO:0009636 GO:0014070 GO:0016020 GO:0016740 GO:0019088 GO:0019860 GO:0031100 GO:0032259 GO:0032570 GO:0033189 GO:0034097 GO:0035999 GO:0042493 GO:0042803 GO:0045471 GO:0046078 GO:0046653 GO:0046683 GO:0048037 GO:0048589 GO:0051216 GO:0051384 GO:0051593 GO:0060574
19	0.12	0.718	3.20	0.15	0.85	4xscB	GO:0004799 GO:0006231 GO:0006235 GO:0008168 GO:0009165 GO:0016740 GO:0032259
20	0.12	0.713	3.05	0.17	0.84	4fogD	GO:0004799 GO:0005737 GO:0006231 GO:0006235 GO:0008168 GO:0009165 GO:0016740 GO:0032259 GO:0046079
21	0.12	0.715	3.06	0.15	0.84	4o7uB	GO:0004799 GO:0005737 GO:0006231 GO:0006235 GO:0008168 GO:0009165 GO:0016740 GO:0032259
22	0.11	0.718	3.14	0.12	0.85	5by6B	GO:0004799 GO:0006231 GO:0008168 GO:0016740 GO:0032259
23	0.11	0.702	3.13	0.17	0.83	4o7uC	GO:0004799 GO:0005737 GO:0006231 GO:0006235 GO:0008168 GO:0009165 GO:0016740 GO:0032259
24	0.11	0.714	3.10	0.11	0.84	1b02A	GO:0004799 GO:0005737 GO:0006231 GO:0006235 GO:0008168 GO:0009165 GO:0016740 GO:0032259
25	0.09	0.666	3.03	0.16	0.78	3kgbA	GO:0004799 GO:0006231 GO:0006235 GO:0008168 GO:0009165 GO:0016740 GO:0032259
26	0.07	0.695	3.38	0.16	0.84	1tisA	GO:0004799 GO:0006231 GO:0006235 GO:0008168 GO:0009165 GO:0016740 GO:0032259

Consensus prediction of GO terms

Molecular Function	GO:0004799	GO:0004146	GO:0003723	GO:0000166
GO-Score	0.92	0.64	0.42	0.40
Biological Processes	GO:0006231	GO:0032259	GO:0006235	GO:0006730	GO:0046654	GO:0055114	GO:0006545	GO:0006417
GO-Score	0.92	0.92	0.78	0.64	0.64	0.64	0.64	0.42
Cellular Component	GO:0005829
GO-Score	0.42

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.