I-TASSER results

I-TASSER results for job id Rv2449c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (419 residues)
MTATPREFDIVLYGATGFVGKLTAEYLARAGGDARIALAGRSTQRVLAVREALGESAQTW
PILTADASLPSTLQAMAARAQVVVTTVGPYTRYGLPLVAACAAAGTDYADLTGEPMFMRN
SIDLYHKQAADTGARIVHACGFDSVPSDLSVYALYHAAREDGAGELTDTNCVVRSFKGGF
SGGTIASMLEVLSTASNDPDARRQLSDPYMLSPDRGAEPELGPQPDLPSRRGRRLAPELA
GVWTAGFIMAPTNTRIVRRSNALLDWAYGRRFRYSETMSVGSTVLAPVVSVVGGGVGNAM
FGLASRYIRLLPRGLVKRVVPKPGTGPSAAARERGYYRIETYTTTTTGARYLARMAQDGD
PGYKATSVLLGECGLALALDRDKLSDMRGVLTPAAAMGDALLERLPAAGVSLQTTRLAS

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTATPREFDIVLYGATGFVGKLTAEYLARAGGDARIALAGRSTQRVLAVREALGESAQTWPILTADASLPSTLQAMAARAQVVVTTVGPYTRYGLPLVAACAAAGTDYADLTGEPMFMRNSIDLYHKQAADTGARIVHACGFDSVPSDLSVYALYHAAREDGAGELTDTNCVVRSFKGGFSGGTIASMLEVLSTASNDPDARRQLSDPYMLSPDRGAEPELGPQPDLPSRRGRRLAPELAGVWTAGFIMAPTNTRIVRRSNALLDWAYGRRFRYSETMSVGSTVLAPVVSVVGGGVGNAMFGLASRYIRLLPRGLVKRVVPKPGTGPSAAARERGYYRIETYTTTTTGARYLARMAQDGDPGYKATSVLLGECGLALALDRDKLSDMRGVLTPAAAMGDALLERLPAAGVSLQTTRLAS
Prediction	CCCCCCCEEEEEHCCCCHHHHHHHHHHHHHCCCCEEEEHCCCHHHHHHHHHHHCCCCCCCCEEEEHCCCHHHHHHHHHCCCEEEEHCCCHHHHHHHHHHHHHHHCCCEEHCCCCCHHHHHHHHHHHHHHHHHCCEEEHCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEHCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHCCCCCEEEEEHCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEEHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHCCCEEEEEEEHCCCCCEEEEEEEHCCCCCHHHHHHHHHHHHHHHHHCHHCCCCCCCHCCHHHHCCHHHHHHHHHHCCEEEEEEHCC
Conf.Score	99889976799997997689999999999799968999679999999999997988777768998589999999999799789995796677879999999999998998789867999999999999999899899778887766889999999999987698657999998657888887579999999998766578888874775456777778877888776666665665666675887555788767899988888655567886689999858847899999999999999999877655555899999868889999998886558589999998699988999999889986789999999999999985654788997557667567899999998798899999679
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTATPREFDIVLYGATGFVGKLTAEYLARAGGDARIALAGRSTQRVLAVREALGESAQTWPILTADASLPSTLQAMAARAQVVVTTVGPYTRYGLPLVAACAAAGTDYADLTGEPMFMRNSIDLYHKQAADTGARIVHACGFDSVPSDLSVYALYHAAREDGAGELTDTNCVVRSFKGGFSGGTIASMLEVLSTASNDPDARRQLSDPYMLSPDRGAEPELGPQPDLPSRRGRRLAPELAGVWTAGFIMAPTNTRIVRRSNALLDWAYGRRFRYSETMSVGSTVLAPVVSVVGGGVGNAMFGLASRYIRLLPRGLVKRVVPKPGTGPSAAARERGYYRIETYTTTTTGARYLARMAQDGDPGYKATSVLLGECGLALALDRDKLSDMRGVLTPAAAMGDALLERLPAAGVSLQTTRLAS
Prediction	76557250100000002100010011006345502000001236004400652656245022020105336103400540300000000222102200200051403101111211112410440353047140100000000000000000000310475371403202020321310001000000020033134235113303412112234436263444243343211211341331220211203202100200110054533540201000102321102120322223130221011320331021003420255552144633640202010204245342000002044310010000000000000033356155400000000002440051057250403044258
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCEEEEEHCCCCHHHHHHHHHHHHHCCCCEEEEHCCCHHHHHHHHHHHCCCCCCCCEEEEHCCCHHHHHHHHHCCCEEEEHCCCHHHHHHHHHHHHHHHCCCEEHCCCCCHHHHHHHHHHHHHHHHHCCEEEHCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEHCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHCCCCCEEEEEHCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEEHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHCCCEEEEEEEHCCCCCEEEEEEEHCCCCCHHHHHHHHHHHHHHHHHCHHCCCCCCCHCCHHHHCCHHHHHHHHHHCCEEEEEEHCC
MTATPREFDIVLYGATGFVGKLTAEYLARAGGDARIALAGRSTQRVLAVREALGESAQTWPILTADASLPSTLQAMAARAQVVVTTVGPYTRYGLPLVAACAAAGTDYADLTGEPMFMRNSIDLYHKQAADTGARIVHACGFDSVPSDLSVYALYHAAREDGAGELTDTNCVVRSFKGGFSGGTIASMLEVLSTASNDPDARRQLSDPYMLSPDRGAEPELGPQPDLPSRRGRRLAPELAGVWTAGFIMAPTNTRIVRRSNALLDWAYGRRFRYSETMSVGSTVLAPVVSVVGGGVGNAMFGLASRYIRLLPRGLVKRVVPKPGTGPSAAARERGYYRIETYTTTTTGARYLARMAQDGDPGYKATSVLLGECGLALALDRDKLSDMRGVLTPAAAMGDALLERLPAAGVSLQTTRLAS

3abiA

0.13

0.11

0.81

1.36

MUSTER

M-------KVLILGA-GNIGRAIAWDLKD---EFDVYIGDVNNENLEKVKE-------FATPLKVDASNFDKLVEVMKEFELVIGALP--GFLGFKSIKAAIKSKVDMVDVSFMPEN----PLELRDEAEKAQVTIVFDAGFAPGLSNILMGRIFQEL------DLKEGYIYVGGLKDPKPPLYYKITWSPRDLIEEYTRPARVIRN-------------GKVSKVDPLSEVKKVKIGKFEFEAFISDG-------LRSMLETINSE-----RLEEWTLRWPGHLEKIKVLRELGFFK-------PENLDFTLRVIEPLMRYETKDF---------SIMKVVGKGEEGEMEFFLYDEEDSSMSRVTGFTAAIISRIVAENT----CTFGVIPPEILG-RRIIDELKERGISIEG-----

3abiA

0.12

0.10

0.82

1.41

dPPAS

------HMKVLILGA-GNIGRAIAWDLK---DEFDVYIGDVNNENLEKVK-------EFATPLKVDASNFDKLVEVMKEFELVIGALP--GFLGFKSIKAAIKSKVDMVDVSFMPE----NPLELRDEAEKAQVTIVFDAGFAPGLSNILMGRIFQEL---DLKEGYIYVGGLPKDPKPPLY--YKITWSPRDLIEEYTRPARVIRN-------------GKVSKVDPLSEVKKVKIGKFEFEAFISDGLRSMLETI------------NSERLEEWTLRWPGHLEKIKVLRELGFFK-------PENLDFTLRVIEPLMRYETKD----------FSIMKVVGKGEEGEMEFFLYDEEDSMFSSMSRVTGFTAAIISRIVAENTCTFGVIPPEILGFRRIIDELKERGISIEG-----

4rl6A

0.15

0.13

0.87

2.18

wdPPAS

-------SRLLVIGC-GGVAQVAISKICQDSETFTEIIASRTKSKCDDLKAKLEGKTSTIETAALDADKVEEVIALIGSPEAVLNVALPYQD---LTIDACLATGVHYIDTANYAYFDYSWQWAYQEKFKEAGLTALLGSGFDPGVTSVFSAYALKHYDEIHYIDILDCNGGDHGYPFATNF-NPEINLREVSAPGSYWEDGKWVEVEASIKRE-------------------YDFPQV---GQKDYLLHHEEIESLAKN---------PGVKRIRFFTFGQSYLTHKCLENVGLL-------TDTINFIVPIQFLKALLPDPASGPRTVGKTNIGCIFTGVKDGVE-KTIYIYNVCDHQEGSQAISYTTGVIGTKLVNGTWK---QAGVYNLEEL-DPDPFEALNEYGLPWVVVENPQ

4rl6A

0.15

0.13

0.87

1.68

wMUSTER

-------SRLLVIGC-GGVAQVAISKICQDSETFTEIIASRTKSKCDDLKAKLEGKTSTIETAALDADKVEEVIALIGSPEAVLNVALPYQDL---TIDACLATGVHYIDTANYEYFDYSWQWAYQEKFKEAGLTALLGSGFDPGVTSVFSAYALKHYDEIHYIDILDCNGGDHGYPFATNF-NPEINLREVSAPGSYWEDGKWVEVEASIKRE-------------------YDFPQV---GQKDYLLHHEEIESLAKNI--------PGVKRIRFFTFGQSYLTHKCLENVGLLRT-------TINFIVPIQFLKALLPDPASGPRTVGKTNIGCIFTGVKDGVE-KTIYIYNVCDHQEGSQAISYTTGVIGTKLVNGTWK---QAGVYNLEELDPDPF-EALNEYGLPWVVVENPQ

4rl6A

0.15

0.13

0.87

2.69

wPPAS

-------SRLLVIGC-GGVAQVAISKICQDSETFTEIIASRTKSKCDDLKAKLEGKTSTIETAALDADKVEEVIALIGSPEAVLNVALPYQD---LTIDACLATGVHYIDTANYAYFDYSWQWAYQEKFKEAGLTALLGSGFDPGVTSVFSAYALKHYDEIHYIDILDCNGGDHGYPFATNF-NPEINLREVSAPGSYWEDGKWVEVEASIKRE-------------------YDFPQVGQK----YLLHHEEIESLAKN---------PGVKRIRFFTFGQSYLTHKCLENVGLLRT-------TINFIVPIQFLKALLPDPASGPRTVGKTNIGCIFTGVKDG-VEKTIYIYNVCDHQEGSQAISYTTGVIGTKLVNGTWK---QAGVYNLEELDPDPF-EALNEYGLPWVVVENPQ

3abiA

0.12

0.10

0.81

2.84

dPPAS2

------HMKVLILGA-GNIGRAIAWDLK---DEFDVYIGDVNNENLEKVK-------EFATPLKVDASNFDKLVEVMKEFELVIGALP--GFLGFKSIKAAIKSKVDMVDVSFMPE----NPLELRDEAEKAQVTIVFDAGFAPGLSNILMGRIFQEL---DLKEGYIYVGGLPKDPKPPLY--YKITWSPRDLIEEYTRPARVIRN-------------GKVSKVDPLSEVKKVKIGKFEFEAFISDGLR----------SMLETINSE--RLEEWTLRWPGHLEKIKVLRELGFFK-------PENLDFTLRVIEPLMRYET---------KDFSIMKVVGKGEEGEMEFFLYDEEDSMFSRVTGFTAAIISRIVAENT----CTFGVIPPEILGFRRIIDELKERGISIEG-----

4rl6A

0.13

0.12

0.87

2.16

PPAS

-------SRLLVIGC-GGVAQVAISKICQDSETFTEIIASRTKSKCDDLKAKLEGKTSTIETAALDADKVEEVIALIGSPEAVLNVALPYQDL---TIDACLATGVHYIDTANYEYFDYSWQWAYQEKFKEAGLTALLGSGFDPGVTSVFSAYALKHYDEIHYIDILDCNGGDHGYPFATNF-NPEINLREVSAPGSYWEDGKWVEVEASIKRE-------------------YDFPQV---GQKDYLLHHEEIESLAKN---------PGVKRIRFFTFGQSYLTHKCLENVGLLRT-------TINFIVPIQFLKALLPDPASGPRTVGKTNIGCIFTGVKDGVE-KTIYIYNVCDHQECYAEVAISYTTGVPAIGT-VNGTWKQAGVYNLEELDPDPF-EALNEYGLPWVVVENPQ

3abiA

0.12

0.10

0.81

2.55

Env-PPAS

M-------KVLILGA-GNIGRAIAWDLKD---EFDVYIGDVNNENLEKVK-------EFATPLKVDASNFDKLVEVMKEFELVIGALP--GFLGFKSIKAAIKSKVDMVDVSFMPEN----PLELRDEAEKAQVTIVFDAGFAPGLSNILMGRIFQEL------DLKEGYIYVGGLPKDPKPPLYKITWSPRDLIEEYTRPARVIRNGKVSK-------------VDPLSEVKKVKIGKFEFEAFISDG-------LRSMLETINSE-----RLEEWTLRWPGHLEKIKVLRELG-------FFKPENLDFTLRVIEPLMRY--ETKD-------FSIMKVVGKGEEGEMEFFLYDEEFSSMSRVTGFTAAIISRIVAEN--TCTFPPEILGMREDTFRRIIDELKERGISIEG-----

4inaA

0.16

0.14

0.87

1.36

MUSTER

-------AKVLQIGA-GGVGGVVAHKANREVFS-HITLASRTLSKCQEIAQSIKAGYGEIDITTVDADSIEELVALINEPQIVLNIALPYQDL---TIEACLRTGVPYLDTANYEHFEYKEQWAFHDRYKEKGVALL-GSGFDPGVTNVFCAYAQKHYDEIHEIDILDCNAGDHGYPFATNF-------NPEINLREVSSKGRYWENGEWIETEPEIQ--------------VWDYPEVGPKDSYLLYH--------EELESLVRNIKGLK-----RIRFFTFGQSYLTHRCLENVGLRIDEIEVNGCKVVPIQVLKALLPDPASLASRT---KGKTNIGCYIKGIKERTIYIYNVCDHESCYREVAISYTTGVPAIGAKLEGKWSGKGVFNE-ELDPDPF-DELNKQGLPWEVKE---

4rl6A

0.12

0.11

0.89

1.37

dPPAS

-------SRLLVIGC-GGVAQVAISKICQDSETFTEIIASRTKSKCDDLKAKLEGKTSTIETAALDADKVEEVIALIGSPEAVLNVALPYQDL---TIDACLATGVHYIDTANYEYFDYSWQWAYQEKFKEAGLTALLGSGFDPGVTSVFSAYALKHYFDEIHYIDILDCNGGDHGYPFATNFNPEINLREVSAPGSYWEDGKWVEVEASIKRE-------------------YDFPQV---GQKDYLLHHEEIESLAKNI--------PGVKRIRFFTFG------QSYLTHKCLENVGLLRTDTINFIVPIQFLKALLPDPASLGPRTVGKTNIGCIFTGVKDGVEKTIYIYNVCDHQECYAEVAISYTTGVPAIGTKLVNTWKQAGVYNLEELDPDPF-EALNEYGLPWVVVENPQ

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.53

Estimated TM-score = 0.65±0.13

Estimated RMSD = 8.1±4.4Å

Download Model 2

C-score=-1.21

Download Model 3

C-score=-2.06

Download Model 4

C-score=-0.67

Download Model 5

C-score=-2.71

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1e5qA	0.795	2.79	0.108	0.888
2	3abiA	0.793	1.48	0.119	0.821
3	4rl6A	0.778	2.78	0.121	0.869
4	4inaA	0.750	2.96	0.138	0.850
5	4plpA	0.749	3.83	0.102	0.897
6	2axqA	0.738	3.87	0.116	0.885
7	2ph5A	0.736	3.89	0.077	0.885
8	2ixaA	0.528	4.90	0.086	0.687
9	3wybA	0.513	4.58	0.090	0.640
10	3mtjA	0.510	5.02	0.118	0.661

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.35	12	3abiA	NAD	Rep, Mult	16,18,19,40,41,45,65,66,67,86,87,88,91,93,111,112,113,141,142,143,144,189,190,193,366,370
2	0.09	4	2o4uX	PO4	Rep, Mult	14,15,40,41,45
3	0.07	3	1dapB	NDP	Rep, Mult	14,16,17,18,19,40,41,42,86,87,111,113,140,141,142,143,144,366,370
4	0.02	1	1e5qA	SHR	Rep, Mult	91,112,113,143,170,171,172,189,230,244,246
5	0.02	1	2c4wA	IMD	Rep, Mult	141,142
6	0.02	1	3abiB	SO4	Rep, Mult	81,105,106,107
7	0.02	1	3fl8A	CA	Rep, Mult	108,110

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.278	1e5qA	0.795	2.79	0.108	0.888	1.5.1.10	18,89,91,112
2	0.200	3ijpB	0.453	4.64	0.104	0.578	1.3.1.26	21
3	0.128	1e5lA	0.765	3.25	0.108	0.885	1.5.1.10	143
4	0.067	2dc1A	0.453	3.93	0.136	0.546	1.4.1.21	111
5	0.060	3euwD	0.491	4.72	0.088	0.630	1.1.1.18	97
6	0.060	1i33C	0.481	4.57	0.066	0.611	1.2.1.12	NA
7	0.060	1cf2O	0.481	4.49	0.109	0.613	1.2.1.59,1.2.1.12	NA
8	0.060	2nqtA	0.475	4.82	0.125	0.618	1.2.1.38	20
9	0.060	1dapA	0.503	4.05	0.071	0.609	1.4.1.16	14,28,88,376
10	0.060	2o4uX	0.492	4.74	0.071	0.637	1.3.1.20	17
11	0.060	1ebfA	0.486	5.15	0.101	0.647	1.1.1.3	NA
12	0.060	2ixaA	0.528	4.90	0.086	0.687	3.2.1.49	15,17,39,89,100
13	0.060	2yyyB	0.484	4.51	0.108	0.618	1.2.1.59	355
14	0.060	3mtjA	0.510	5.02	0.118	0.661	1.1.1.3	105
15	0.060	2glxA	0.481	4.70	0.086	0.618	1.1.1.292	15,116
16	0.060	2ejwA	0.494	4.59	0.123	0.625	1.1.1.3	NA
17	0.060	2q49B	0.486	4.70	0.106	0.623	1.2.1.38	14,111
18	0.060	2yyyA	0.484	4.52	0.104	0.621	1.2.1.59	NA
19	0.060	2glxE	0.483	4.54	0.087	0.613	1.1.1.263	39
20	0.060	3idsC	0.482	4.55	0.081	0.611	1.2.1.12	84
21	0.060	2qz9A	0.487	4.21	0.128	0.601	1.2.1.11	NA
22	0.060	2axqA	0.738	3.87	0.116	0.885	1.5.1.10	143
23	0.060	2o48X	0.493	4.73	0.071	0.637	1.1.1.179,1.3.1.20	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.33	0.765	3.25	0.11	0.89	1e5lA	GO:0004755 GO:0008652 GO:0009085 GO:0016491 GO:0019878 GO:0055114
1	0.31	0.793	1.48	0.12	0.82	3abiA	GO:0000166 GO:0016491 GO:0055114
2	0.31	0.786	2.83	0.14	0.88	4inaB	GO:0016491 GO:0055114
3	0.16	0.796	2.74	0.12	0.89	4rl6A	GO:0004754 GO:0016491 GO:0055114
4	0.13	0.738	3.87	0.12	0.89	2axqA	GO:0004755 GO:0008652 GO:0009085 GO:0016491 GO:0019878 GO:0055114
5	0.10	0.432	3.67	0.12	0.51	1j5pA	GO:0006742 GO:0009435 GO:0016491 GO:0016639 GO:0019363 GO:0033735 GO:0050661 GO:0051287 GO:0055114
6	0.07	0.483	4.77	0.06	0.63	3db2A	GO:0008152 GO:0016491 GO:0055114
7	0.06	0.431	5.91	0.10	0.61	4g65A	GO:0005886 GO:0006813 GO:0008324 GO:0015079 GO:0071805 GO:0098655
8	0.06	0.377	4.02	0.12	0.46	1ulsB	GO:0016491 GO:0055114
9	0.06	0.323	6.95	0.03	0.54	2xvgA	GO:0003824 GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0030246
10	0.06	0.377	5.29	0.06	0.51	2plaA	GO:0002027 GO:0004367 GO:0005737 GO:0005829 GO:0005886 GO:0005975 GO:0006072 GO:0006654 GO:0006734 GO:0009331 GO:0010765 GO:0016020 GO:0016491 GO:0016616 GO:0017080 GO:0019432 GO:0019674 GO:0033137 GO:0042803 GO:0044325 GO:0046168 GO:0051287 GO:0055114 GO:0060373 GO:0070062 GO:0086005 GO:0090038 GO:2000010 GO:2000649
11	0.06	0.388	3.86	0.08	0.47	4pvcA	GO:0003854 GO:0005634 GO:0005737 GO:0006694 GO:0008204 GO:0016491 GO:0016616 GO:0030447 GO:0043892 GO:0046568 GO:0055114
12	0.06	0.385	3.86	0.10	0.46	4pvdC	GO:0003854 GO:0005634 GO:0005737 GO:0006694 GO:0008204 GO:0016491 GO:0016616 GO:0030447 GO:0043892 GO:0046568 GO:0055114
13	0.06	0.341	5.63	0.05	0.48	2hk7A	GO:0004764 GO:0008652 GO:0009073 GO:0009423 GO:0016491 GO:0019632 GO:0050661 GO:0055114
14	0.06	0.313	6.85	0.05	0.50	5e9hB	GO:0003824 GO:0004451 GO:0005777 GO:0006097 GO:0006099 GO:0008152 GO:0009514 GO:0016829 GO:0019752 GO:0046421 GO:0046872
15	0.06	0.311	4.91	0.11	0.40	1zejA	GO:0003857 GO:0006631 GO:0016491 GO:0055114 GO:0070403
16	0.06	0.268	5.39	0.05	0.37	2rarA	GO:0005737 GO:0016311 GO:0016787 GO:0016791 GO:0044283 GO:0046872
17	0.06	0.271	6.76	0.08	0.44	1gpjA	GO:0006779 GO:0006782 GO:0008883 GO:0016491 GO:0033014 GO:0050661 GO:0055114
18	0.06	0.258	3.80	0.10	0.31	1o4vA	GO:0006164 GO:0006189 GO:0016853 GO:0034023

Consensus prediction of GO terms

Molecular Function	GO:0004755	GO:0000166
GO-Score	0.42	0.31
Biological Processes	GO:0055114	GO:0019878
GO-Score	0.77	0.42
Cellular Component
GO-Score

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.