I-TASSER results

I-TASSER results for job id Rv2434c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (481 residues)
MNLLDSTWFYWAVGIAIGLPAGLIVLTELHNILVRRNSHLARQASLLRNYLLPLGAVLLL
LVKASEVPAEDPTVRVLTTAFGFLVLVLLLSLLNATLFQGAPQQSWRKRLPAIFVDVARF
ALIGIGLAVILSYIWGVRVGGLFAALGVTSVVIGLMLQNSVGQIVSGLFMLFEQPFRIDD
WLETPTARGRVVEVNWRAVHIDTGSGLQIMPNSMLATTAFTNLSRPAGAHECSITTTFST
SDPPDKVCAMLNRAASALPHVKPGVVPATIARGAAEYRTTVRLTSPADEGPTQATFLRWV
WYAARREGLHLDEADDEFSTAERVESALRTVVGPELRLSSSDQQSLARYARLVRYGTDEI
VQHAGVVPMGITFVIAGSVRLTVTTDDGSVVAIATLKKGTFLGLTALTRQPDPAGAVALE
EVTALQIGREHLEQVVMNKPMLLQELGRVIDERQRKAQQAIRRDLHQSPAAAGEHRGPAR
R

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MNLLDSTWFYWAVGIAIGLPAGLIVLTELHNILVRRNSHLARQASLLRNYLLPLGAVLLLLVKASEVPAEDPTVRVLTTAFGFLVLVLLLSLLNATLFQGAPQQSWRKRLPAIFVDVARFALIGIGLAVILSYIWGVRVGGLFAALGVTSVVIGLMLQNSVGQIVSGLFMLFEQPFRIDDWLETPTARGRVVEVNWRAVHIDTGSGLQIMPNSMLATTAFTNLSRPAGAHECSITTTFSTSDPPDKVCAMLNRAASALPHVKPGVVPATIARGAAEYRTTVRLTSPADEGPTQATFLRWVWYAARREGLHLDEADDEFSTAERVESALRTVVGPELRLSSSDQQSLARYARLVRYGTDEIVQHAGVVPMGITFVIAGSVRLTVTTDDGSVVAIATLKKGTFLGLTALTRQPDPAGAVALEEVTALQIGREHLEQVVMNKPMLLQELGRVIDERQRKAQQAIRRDLHQSPAAAGEHRGPARR
Prediction	CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHCCEEEEEEEEEEEEEEEEHCCCEEEHCCHHHHCCCEEEHCCCCCEEEEEEEEEHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEHCCCEEEEEEEEEHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCEEEHCCCCEEEHCCCCCCCEEEEEEEEEEEEEHCCCCCEEEEEEHCCCCEHCHHHHCCCCCCEEEEEEEEEEEEEHCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
Conf.Score	9877765999999999999999999999999999855544567889999999999999999998755665579999999999999999999999999999887576656999999999999999999999999869865899999999999999999899999999999998488789889999998999999999999999799789977777636858985589985899999997799999999999999999899889997645555885789999998786777899999999999999999999999857999678766788876555556999999999998445676799689858988985899999899999976998579988748985334556468987579999864899998699999999987999999999999999999999998765567666566774549
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MNLLDSTWFYWAVGIAIGLPAGLIVLTELHNILVRRNSHLARQASLLRNYLLPLGAVLLLLVKASEVPAEDPTVRVLTTAFGFLVLVLLLSLLNATLFQGAPQQSWRKRLPAIFVDVARFALIGIGLAVILSYIWGVRVGGLFAALGVTSVVIGLMLQNSVGQIVSGLFMLFEQPFRIDDWLETPTARGRVVEVNWRAVHIDTGSGLQIMPNSMLATTAFTNLSRPAGAHECSITTTFSTSDPPDKVCAMLNRAASALPHVKPGVVPATIARGAAEYRTTVRLTSPADEGPTQATFLRWVWYAARREGLHLDEADDEFSTAERVESALRTVVGPELRLSSSDQQSLARYARLVRYGTDEIVQHAGVVPMGITFVIAGSVRLTVTTDDGSVVAIATLKKGTFLGLTALTRQPDPAGAVALEEVTALQIGREHLEQVVMNKPMLLQELGRVIDERQRKAQQAIRRDLHQSPAAAGEHRGPARR
Prediction	3313433013000102213322322222013102333331222122123122221222121111130223321011222222322232223201310131035451353024001200122122201101001134030010100202201000010132010210011013020030001030563403034010000102046320000013015430201025443000101010216330620150034006516513640203311320000101000231142130022004201510573607100010102145545531542352545145721540264033351454220132434120000001010201042773442303304311000000014221300020113010010336003400662250043005104502530451355446454455565542468
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHCCEEEEEEEEEEEEEEEEHCCCEEEHCCHHHHCCCEEEHCCCCCEEEEEEEEEHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEHCCCEEEEEEEEEHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCEEEHCCCCEEEHCCCCCCCEEEEEEEEEEEEEHCCCCCEEEEEEHCCCCEHCHHHHCCCCCCEEEEEEEEEEEEEHCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
MNLLDSTWFYWAVGIAIGLPAGLIVLTELHNILVRRNSHLARQASLLRNYLLPLGAVLLLLVKASEVPAEDPTVRVLTTAFGFLVLVLLLSLLNATLFQGAPQQSWRKRLPAIFVDVARFALIGIGLAVILSYIWGVRVGGLFAALGVTSVVIGLMLQNSVGQIVSGLFMLFEQPFRIDDWLETPTARGRVVEVNWRAVHIDTGSGLQIMPNSMLATTAFTNLSRPAGAHECSITTTFSTSDPPDKVCAMLNRAASALPHVKPGVVPATIARGAAEYRTTVRLTSPADEGPTQATFLRWVWYAARREGLHLDEADDEFSTAERVESALRTVVGPELRLSSSDQQSLARYARLVRYGTDEIVQHAGVVPMGITFVIAGSVRLTVTTDDGSVVAIATLKKGTFLGLTALTRQPDPAGAVALEEVTALQIGREHLEQVVMNKPMLLQELGRVIDERQRKAQQAIRRDLHQSPAAAGEHRGPARR

2vv5A

0.16

0.08

0.52

1.74

MUSTER

---------------------------------------------------------------------LSYAVNIVAALAIIIVGLIIARMISNAVNRLMISRKIDATVADFLSALVRYGIIAFTLIAALGRV-GVQTASVIAVLGAAGLVVGLALQGSLSNLAAGVLLVMFRPFRAGEYVDLGGVAGTVLSVQIFSTTMRTADGIIVIPNGKIIAGNIINFSR-EPVRRNEFIIGVAYDSDIDQVKQILTNIIQSEDRILKDREMNELGASSINFVVRVWSNS-GDLQNVYWDVLERIKREFDAAGISFPYPQMDVNFKRV--------------------------------------------------------------------------------------------------------------------------------------------------------------

2vv5A

0.16

0.08

0.52

2.39

dPPAS

---------------------------------------------------------------------LSYAVNIVAALAIIIVGLIIARMISNAVNRLMISRKIDATVADFLSALVRYGIIAFTLIAALGRV-GVQTASVIAVLGAAGLVVGLALQGSLSNLAAGVLLVMFRPFRAGEYVDLGGVAGTVLSVQIFSTTMRTADGIIVIPNGKIIAGNIINFSR-EPVRRNEFIIGVAYDSDIDQVKQILTNIIQSEDRILKDREMNELGASSINFVVRVWSNS-GDLQNVYWDVLERIKREFDAAGISFPYPQMDVNFKRV--------------------------------------------------------------------------------------------------------------------------------------------------------------

2vv5A

0.16

0.08

0.52

4.26

wdPPAS

---------------------------------------------------------------------LSYAVNIVAALAIIIVGLIIARMISNAVNRLMISRKIDATVADFLSALVRYGIIAFTLIAALGRV-GVQTASVIAVLGAAGLVVGLALQGSLSNLAAGVLLVMFRPFRAGEYVDLGGVAGTVLSVQIFSTTMRTADGIIVIPNGKIIAGNIINFSR-EPVRRNEFIIGVAYDSDIDQVKQILTNIIQSEDRILKDREMNELGASSINFVVRVWSNS-GDLQNVYWDVLERIKREFDAAGISFPYPQMDVNFKRV--------------------------------------------------------------------------------------------------------------------------------------------------------------

2vv5A

0.16

0.08

0.52

2.38

wMUSTER

----------------------------------------------------------------------SYAVNIVAALAIIIVGLIIARMISNAVNRLMISRKIDATVADFLSALVRYGIIAFTLIAALGRV-GVQTASVIAVLGAAGLVVGLALQGSLSNLAAGVLLVMFRPFRAGEYVDLGGVAGTVLSVQIFSTTMRTADGIIVIPNGKIIAGNIINFSR-EPVRRNEFIIGVAYDSDIDQVKQILTNIIQSEDRILKDREMNELGASSINFVVRVWSNS-GDLQNVYWDVLERIKREFDAAGISFPYPQMDVNFKRV--------------------------------------------------------------------------------------------------------------------------------------------------------------

2vv5A

0.16

0.08

0.52

3.55

wPPAS

---------------------------------------------------------------------LSYAVNIVAALAIIIVGLIIARMISNAVNRLMISRKIDATVADFLSALVRYGIIAFTLIAALGRV-GVQTASVIAVLGAAGLVVGLALQGSLSNLAAGVLLVMFRPFRAGEYVDLGGVAGTVLSVQIFSTTMRTADGIIVIPNGKIIAGNIINFSR-EPVRRNEFIIGVAYDSDIDQVKQILTNIIQSEDRILKDREMNELGASSINFVVRVWSNS-GDLQNVYWDVLERIKREFDAAGISFPYPQMDVNFKRV--------------------------------------------------------------------------------------------------------------------------------------------------------------

2vv5A

0.16

0.08

0.52

4.05

dPPAS2

---------------------------------------------------------------------LSYAVNIVAALAIIIVGLIIARMISNAVNRLMISRKIDATVADFLSALVRYGIIAFTLIAALGRV-GVQTASVIAVLGAAGLVVGLALQGSLSNLAAGVLLVMFRPFRAGEYVDLGGVAGTVLSVQIFSTTMRTADGIIVIPNGKIIAGNIINFSR-EPVRRNEFIIGVAYDSDIDQVKQILTNIIQSEDRILKDREMNELGASSINFVVRVWSNS-GDLQNVYWDVLERIKREFDAAGISFPYPQMDVNFKRV--------------------------------------------------------------------------------------------------------------------------------------------------------------

2vv5A

0.16

0.08

0.52

3.24

PPAS

---------------------------------------------------------------------LSYAVNIVAALAIIIVGLIIARMISNAVNRLMISRKIDATVADFLSALVRYGIIAFTLIAALGRV-GVQTASVIAVLGAAGLVVGLALQGSLSNLAAGVLLVMFRPFRAGEYVDLGGVAGTVLSVQIFSTTMRTADGIIVIPNGKIIAGNIINFSR-EPVRRNEFIIGVAYDSDIDQVKQILTNIIQSEDRILKDREMNELGASSINFVVRVWSNS-GDLQNVYWDVLERIKREFDAAGISFPYPQMDVNFKRV--------------------------------------------------------------------------------------------------------------------------------------------------------------

2vv5A

0.16

0.08

0.52

4.96

Env-PPAS

---------------------------------------------------------------------LSYAVNIVAALAIIIVGLIIARMISNAVNRLMISRKIDATVADFLSALVRYGIIAFTLIAALGRV-GVQTASVIAVLGAAGLVVGLALQGSLSNLAAGVLLVMFRPFRAGEYVDLGGVAGTVLSVQIFSTTMRTADGIIVIPNGKIIAGNIINFSR-EPVRRNEFIIGVAYDSDIDQVKQILTNIIQSEDRILKDREMNELGASSINFVVRVWSNS-GDLQNVYWDVLERIKREFDAAGISFPYPQMDVNFKRV--------------------------------------------------------------------------------------------------------------------------------------------------------------

4hw9A

0.12

0.06

0.51

1.69

MUSTER

-----------------------------------------------------------------------FGIILIKAVIVFCIGFYFSFFLRNKTMKLLS--KKDEILANFVAQVTFILILIITTIIALSTL--VQTTSIITVLGTVGIAVALALKDYLSSIAGGIILIILHPFKKGDIIEISGLEGKVEALNFFNTSLRLHDGLAVLPNRSVANSNIINSNN-TACRRIEWVCGVGYGSDIELVHKTIKDVIDTMEKIDKNMPTTDFGSSSLNFTIRVWAKIEDGIFNVRSELIERIKNALDANHIEIPFNKLDIAIKNQ--------------------------------------------------------------------------------------------------------------------------------------------------------------

4hw9A

0.12

0.06

0.52

2.32

dPPAS

-----------------------------------------------------------------------FGIILIKAVIVFCIGFYFSFFLRNKTMKLLS--KKDEILANFVAQVTFILILIITTIIALSTLG-VQTTSIITVLGTVGIAVALALKDYLSSIAGGIILIILHPFKKGDIIEISGLEGKVEALNFFNTSLRLHDGLAVLPNRSVANSNIINSNN-TACRRIEWVCGVGYGSDIELVHKTIKDVIDTMEKIDKNMPTTDFGSSSLNFTIRVWAKIEDGIFNVRSELIERIKNALDANHIEIPFNKLDIAIKNQ--------------------------------------------------------------------------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.72

Estimated TM-score = 0.40±0.14

Estimated RMSD = 13.9±3.9Å

Download Model 2

C-score=-3.02

Download Model 3

C-score=-1.30

Download Model 4

C-score=-1.87

Download Model 5

C-score=-1.52

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2vv5A	0.509	1.29	0.151	0.522
2	4hw9A	0.414	3.33	0.133	0.470
3	2pffB	0.412	7.58	0.050	0.697
4	3t9nA	0.400	3.91	0.164	0.474
5	2uvcG	0.377	7.82	0.043	0.655
6	3hmjG	0.371	7.40	0.049	0.615
7	4bedB	0.368	7.65	0.068	0.620
8	2hyeC	0.350	7.43	0.049	0.580
9	5ganA	0.346	7.42	0.034	0.576
10	5f0oA	0.342	7.40	0.051	0.568

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.07	4	1c9iA	III	Rep, Mult	183,201,202,203,208,210
2	0.06	3	1cgpA	CMP	Rep, Mult	381,393,394,396,401,402,403,404,405,412,413,414,416,453,457
3	0.04	2	1mz9B	VDY	Rep, Mult	86,89,93
4	0.04	2	1kflB	PHE	Rep, Mult	179,180,191
5	0.04	2	1c9iB	III	Rep, Mult	201,203,208,210,212
6	0.04	2	2ajdB	UUU	Rep, Mult	193,195,212
7	0.04	2	4z10A	RCO	Rep, Mult	158,161,165
8	0.02	1	4ukeK	MG	Rep, Mult	202,206
9	0.02	1	1lshB	UPL	Rep, Mult	234,279
10	0.02	1	3sfzA	GBL	Rep, Mult	127,128,142,145
11	0.02	1	3shfA	GBL	Rep, Mult	170,196,215
12	0.02	1	3idbB	ANP	Rep, Mult	305,307,308
13	0.02	1	1i1eA	DM2	Rep, Mult	234,235,271,276,278
14	0.02	1	3c9iC	XE	Rep, Mult	300,303
15	0.02	1	4xk8L	CLA	Rep, Mult	93,125
16	0.02	1	1sxgA	171	Rep, Mult	153,156
17	0.02	1	3asoA	DMU	Rep, Mult	81,84

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2qf7B	0.225	7.70	0.031	0.389	6.4.1.1	NA
2	0.060	2qf7A	0.258	7.59	0.039	0.432	6.4.1.1	NA
3	0.060	1g87B	0.277	5.92	0.048	0.393	3.2.1.4	NA
4	0.060	1ej6A	0.310	7.17	0.044	0.499	2.7.7.50	246
5	0.060	3btaA	0.335	7.43	0.038	0.559	3.4.24.69	NA
6	0.060	1jkyA	0.282	7.15	0.055	0.457	3.4.24.83	NA
7	0.060	1yq2A	0.266	7.36	0.060	0.437	3.2.1.23	NA
8	0.060	1ynnD	0.305	7.83	0.048	0.532	2.7.7.6	264,268
9	0.060	2q1fA	0.299	7.87	0.064	0.524	4.2.2.21	NA
10	0.060	2pffD	0.287	7.64	0.007	0.491	2.3.1.86	236
11	0.060	1ynnJ	0.144	6.52	0.031	0.223	2.7.7.6	148,158,161
12	0.060	2vuaA	0.200	6.09	0.033	0.293	3.4.24.69	NA
13	0.060	3ecqB	0.285	7.78	0.045	0.493	3.2.1.97	NA
14	0.060	1tj7A	0.260	6.76	0.042	0.399	4.3.2.1	NA
15	0.060	1eulA	0.265	7.12	0.044	0.434	3.6.3.8	NA
16	0.060	2o36A	0.259	6.55	0.041	0.389	3.4.24.15	114
17	0.060	1mc0A	0.190	6.67	0.044	0.291	3.1.4.17	NA
18	0.060	3hmjA	0.294	7.94	0.044	0.516	2.3.1.86	NA
19	0.060	2zy4F	0.261	6.79	0.053	0.407	4.1.1.12	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.22	0.519	1.55	0.14	0.54	5ajiA	GO:0005886 GO:0006810 GO:0006811 GO:0008381 GO:0009992 GO:0016020 GO:0016021 GO:0034220 GO:0055085
1	0.20	0.400	3.91	0.17	0.47	3udcA	GO:0005886 GO:0006810 GO:0006811 GO:0008381 GO:0009992 GO:0016020 GO:0016021 GO:0034220 GO:0055085
2	0.19	0.414	3.33	0.13	0.47	4hw9A	GO:0016020 GO:0016021 GO:0055085
3	0.06	0.246	7.10	0.02	0.40	5flmA	GO:0001047 GO:0001055 GO:0003677 GO:0003899 GO:0005665 GO:0005719 GO:0006351 GO:0006366 GO:0016740 GO:0016779
4	0.06	0.299	6.82	0.04	0.46	5iy6A	GO:0000398 GO:0000974 GO:0001055 GO:0001172 GO:0003677 GO:0003899 GO:0003968 GO:0005634 GO:0005654 GO:0005665 GO:0005730 GO:0006283 GO:0006351 GO:0006353 GO:0006355 GO:0006366 GO:0006367 GO:0006368 GO:0006370 GO:0008543 GO:0010467 GO:0016740 GO:0016779 GO:0031047 GO:0031625 GO:0033120 GO:0035019 GO:0042795 GO:0044822 GO:0046872 GO:0050434
5	0.06	0.231	7.87	0.03	0.40	4mz0A	GO:0003824 GO:0008152 GO:0016740 GO:0031177 GO:0046872
6	0.06	0.206	8.25	0.03	0.38	4mz0B	GO:0003824 GO:0008152 GO:0016740 GO:0031177 GO:0046872
7	0.06	0.209	7.54	0.04	0.35	2pffB	GO:0003824 GO:0004312 GO:0004313 GO:0004314 GO:0004318 GO:0004319 GO:0004320 GO:0004321 GO:0005811 GO:0005829 GO:0005835 GO:0006629 GO:0006631 GO:0006633 GO:0008152 GO:0016295 GO:0016296 GO:0016297 GO:0016409 GO:0016491 GO:0016740 GO:0016787 GO:0016829 GO:0019171 GO:0042759 GO:0047451 GO:0055114
8	0.06	0.167	7.55	0.02	0.28	1pxyB	GO:0003779 GO:0005737 GO:0005856 GO:0007623 GO:0046872
9	0.06	0.181	6.32	0.04	0.27	3keaA
10	0.06	0.134	5.79	0.05	0.19	3h0pB	GO:0003824 GO:0004314 GO:0006629 GO:0006631 GO:0006633 GO:0008152 GO:0016740 GO:0016746
11	0.06	0.170	5.92	0.05	0.24	3ptwA	GO:0003824 GO:0004314 GO:0008152 GO:0016740 GO:0016746
12	0.06	0.141	6.12	0.07	0.20	3qatA	GO:0003824 GO:0004314 GO:0008152 GO:0016740 GO:0016746
13	0.06	0.134	6.55	0.03	0.21	2cuyA	GO:0003824 GO:0004314 GO:0008152 GO:0016740 GO:0016746
14	0.06	0.134	5.06	0.04	0.17	3im9A	GO:0003824 GO:0004314 GO:0006629 GO:0006631 GO:0006633 GO:0008152 GO:0016740 GO:0016746
15	0.06	0.133	6.65	0.03	0.21	2h1yB	GO:0003824 GO:0004314 GO:0008152 GO:0016740 GO:0016746
16	0.06	0.157	6.25	0.05	0.23	3k89A	GO:0003824 GO:0004314 GO:0008152 GO:0016740 GO:0016746
17	0.06	0.158	6.35	0.05	0.23	3hjvA	GO:0003824 GO:0004314 GO:0006633 GO:0008152 GO:0016740 GO:0016746
18	0.06	0.155	5.48	0.06	0.21	3rgiA	GO:0003824 GO:0004314 GO:0008152 GO:0016740

Consensus prediction of GO terms

Molecular Function	GO:0008381
GO-Score	0.38
Biological Processes	GO:0009992	GO:0034220
GO-Score	0.38	0.38
Cellular Component	GO:0016021	GO:0005886
GO-Score	0.50	0.38

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.