I-TASSER results

I-TASSER results for job id Rv2430c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (194 residues)
MHFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSLMDAWAGPV
VMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILI
DNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIAHSTVLV
APVSPSTASSRTDT

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 \| \| \| \| \| \| \| \| \| MHFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSLMDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIAHSTVLVAPVSPSTASSRTDT
Prediction	CCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	98665885666655457999588999999999999999999999999999987544658999999999999999999999999999999999999999999799866777789999999997867665599999999999999999999999878888887758889999877788887766666666777899
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 \| \| \| \| \| \| \| \| \| MHFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSLMDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIAHSTVLVAPVSPSTASSRTDT
Prediction	56233320120102032242322023013203410440231042123101202431242002201420341241023003304422330421010332023322443413423420131333213211132024234414423241131033123202323442453443343344744444444446445678
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180

                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MHFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSLMDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIAHSTVLVAPVSPSTASSRTDT

2g38B

0.99

0.89

2.81

MUSTER

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSLMDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA--------------------

2g38B

0.99

0.89

2.47

dPPAS

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSLMDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA--------------------

2g38B

0.99

0.89

3.83

wdPPAS

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSLMDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA--------------------

2g38B

1.00

0.89

3.43

wMUSTER

--FEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSLMDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA--------------------

2g38B

0.99

0.89

5.37

wPPAS

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSLMDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA--------------------

2g38B

0.99

0.89

4.91

dPPAS2

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSLMDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA--------------------

2g38B

0.99

0.89

4.23

PPAS

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSLMDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA--------------------

2g38B

0.99

0.89

6.95

Env-PPAS

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSLMDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA--------------------

4ke2A

0.12

1.00

1.02

MUSTER

MNIDPAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAA

4ke2A

0.08

0.98

0.97

dPPAS

---MNIDPAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIA

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.29

Estimated TM-score = 0.68±0.12

Estimated RMSD = 5.9±3.7Å

Download Model 2

C-score=-0.62

Download Model 3

C-score=-0.33

Download Model 4

C-score=-1.60

Download Model 5

C-score=-2.12

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2g38B	0.872	0.81	0.988	0.892
2	4xwpA	0.686	2.06	0.118	0.773
3	4wj1A	0.665	2.49	0.143	0.783
4	4e40A	0.665	3.79	0.059	0.881
5	5ebzA	0.652	4.03	0.052	0.923
6	4iw0A3	0.651	3.95	0.053	0.907
7	4wpeA	0.647	3.61	0.054	0.856
8	1y2oA	0.641	3.79	0.094	0.881
9	4nqiA	0.637	3.89	0.104	0.881
10	2d4cB	0.637	3.91	0.065	0.892

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.17	3	1fbmA	RTL	Rep, Mult	78,85,88
2	0.10	2	2g38B	MN	Rep, Mult	148,151,152
3	0.06	2	4zzbA	XE	Rep, Mult	109,139,142,143
4	0.06	2	2zhzA	MG	Rep, Mult	113,136
5	0.03	1	2x7aI	MG	Rep, Mult	119,123
6	0.03	1	2h9dD	CA	Rep, Mult	138,141
7	0.03	1	5buoA	ZN	Rep, Mult	102,145
8	0.03	1	3o02B	JN3	Rep, Mult	24,28,82,85,86,89
9	0.03	1	5kayA	ZN	Rep, Mult	91,96,156
10	0.03	1	3r6yC	CA	Rep, Mult	108,112,135
11	0.03	1	2j9tA	BO3	Rep, Mult	52,53,56,60,61,64

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1sesA	0.423	4.72	0.039	0.644	6.1.1.11	94
2	0.060	3g61A	0.490	4.70	0.042	0.742	3.6.3.44	NA
3	0.060	3gzhA	0.463	4.39	0.056	0.649	4.3.2.2	NA
4	0.060	1fftA	0.458	4.76	0.064	0.701	1.10.3.-	NA
5	0.060	1y2mB	0.473	5.01	0.084	0.753	4.3.1.24	NA
6	0.060	1serB	0.416	3.95	0.033	0.583	6.1.1.11	37,44
7	0.060	3gtdA	0.481	3.90	0.053	0.665	4.2.1.2	86
8	0.060	1yfmA	0.512	4.20	0.076	0.711	4.2.1.2	NA
9	0.060	2pfmA	0.489	3.88	0.056	0.665	4.3.2.2	138
10	0.060	3e04D	0.483	4.36	0.065	0.696	4.2.1.2	60,67
11	0.060	2np0A	0.430	5.14	0.016	0.711	3.4.24.69	NA
12	0.060	1j3uA	0.488	4.23	0.059	0.691	4.3.1.1	NA
13	0.060	1wleB	0.480	4.46	0.066	0.696	6.1.1.11	116
14	0.060	1qd1B	0.221	5.79	0.022	0.402	2.1.2.5,4.3.1.4	NA
15	0.060	3i9wA	0.594	3.54	0.060	0.789	2.7.13.3	40
16	0.060	1occA	0.456	4.42	0.048	0.665	1.9.3.1	NA
17	0.060	2iw5A	0.449	4.28	0.037	0.644	1.-.-.-	NA
18	0.060	1dcnB	0.472	3.99	0.060	0.660	4.3.2.1	NA
19	0.060	3errA	0.508	4.18	0.083	0.732	6.1.1.11	113,115

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.84	0.853	1.26	0.99	0.90	4kxrB	GO:0005576 GO:0009405 GO:0009986
1	0.19	0.699	2.33	0.12	0.81	3j83A	GO:0005576 GO:0009405 GO:0044315
2	0.17	0.630	4.05	0.07	0.90	4wpeA	GO:0000142 GO:0000144 GO:0000281 GO:0000917 GO:0005737 GO:0005856 GO:0005935 GO:0007049 GO:0007067 GO:0008092 GO:0044697 GO:0051301 GO:0090339
3	0.17	0.694	2.06	0.12	0.79	4xxxA	GO:0005576 GO:0009405 GO:0044315
4	0.11	0.667	3.62	0.06	0.87	5jdoA	GO:0016020 GO:0016021
5	0.07	0.644	3.80	0.10	0.88	4iw0A	GO:0000166 GO:0002218 GO:0002376 GO:0003676 GO:0004672 GO:0004674 GO:0005524 GO:0005737 GO:0005829 GO:0006468 GO:0006954 GO:0007249 GO:0009615 GO:0010008 GO:0010629 GO:0016032 GO:0016301 GO:0016310 GO:0016740 GO:0018105 GO:0032480 GO:0032481 GO:0032606 GO:0032727 GO:0032728 GO:0033138 GO:0035666 GO:0043123 GO:0044565 GO:0045087 GO:0045359 GO:0045944 GO:0050830 GO:0051219 GO:0051607 GO:1901214 GO:1904417
6	0.07	0.629	3.98	0.07	0.88	4kikB	GO:0000166 GO:0002223 GO:0003009 GO:0004672 GO:0004674 GO:0005524 GO:0005634 GO:0005737 GO:0005829 GO:0006468 GO:0006954 GO:0007249 GO:0007252 GO:0008284 GO:0008384 GO:0008385 GO:0009615 GO:0009636 GO:0009898 GO:0010803 GO:0010976 GO:0016020 GO:0016301 GO:0016310 GO:0016740 GO:0019901 GO:0030866 GO:0031175 GO:0032496 GO:0033209 GO:0035509 GO:0035631 GO:0035666 GO:0038095 GO:0042325 GO:0042493 GO:0042501 GO:0042803 GO:0043066 GO:0043123 GO:0043231 GO:0045087 GO:0045121 GO:0045893 GO:0045944 GO:0046982 GO:0050852 GO:0051092 GO:0051403 GO:0070423 GO:0070498 GO:0070542 GO:0071356 GO:0090002 GO:0097110 GO:1901216 GO:1903140 GO:1903347
7	0.07	0.602	4.33	0.06	0.89	5c1fA	GO:0001786 GO:0005547 GO:0005737 GO:0005826 GO:0005829 GO:0005856 GO:0007049 GO:0007067 GO:0051301 GO:0070273 GO:1903475
8	0.07	0.635	4.25	0.05	0.92	4iwoA	GO:0000166 GO:0002218 GO:0002376 GO:0003676 GO:0004672 GO:0004674 GO:0005524 GO:0005737 GO:0005829 GO:0006468 GO:0006954 GO:0007249 GO:0009615 GO:0010008 GO:0010629 GO:0016032 GO:0016301 GO:0016310 GO:0016740 GO:0018105 GO:0032480 GO:0032481 GO:0032606 GO:0032727 GO:0032728 GO:0033138 GO:0035666 GO:0043123 GO:0044565 GO:0045087 GO:0045359 GO:0045944 GO:0050830 GO:0051219 GO:0051607 GO:1901214 GO:1904417
9	0.07	0.539	4.81	0.07	0.84	3qa8A	GO:0004672 GO:0005524 GO:0005622 GO:0006468 GO:0007252 GO:0008384
10	0.07	0.475	4.52	0.07	0.72	3qa8G	GO:0004672 GO:0005524 GO:0005622 GO:0006468 GO:0007252 GO:0008384
11	0.06	0.387	4.58	0.04	0.54	3hztA	GO:0000166 GO:0004672 GO:0004674 GO:0005509 GO:0005524 GO:0006468 GO:0016301 GO:0016310 GO:0046872
12	0.06	0.364	5.16	0.06	0.60	4ci6B	GO:0004672 GO:0004674 GO:0005524 GO:0006468 GO:0016301 GO:0016310 GO:0016740
13	0.06	0.350	4.50	0.04	0.49	4bwpA	GO:0000166 GO:0000288 GO:0000289 GO:0000932 GO:0004672 GO:0005524 GO:0005737 GO:0006397 GO:0006468 GO:0010606 GO:0031251 GO:0044822
14	0.06	0.330	5.51	0.01	0.57	4btfA	GO:0000166 GO:0004672 GO:0005524 GO:0005737 GO:0005886 GO:0006468 GO:0012501 GO:0016020 GO:0019901 GO:0032403 GO:0070207 GO:0070266
15	0.06	0.269	4.99	0.02	0.42	4nifA	GO:0000166 GO:0000287 GO:0004672 GO:0004674 GO:0004712 GO:0005524 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0006468 GO:0006915 GO:0007049 GO:0007165 GO:0016301 GO:0016310 GO:0016740 GO:0030307 GO:0035556 GO:0043027 GO:0043066 GO:0043154 GO:0043555 GO:0043620 GO:0045597 GO:0045944 GO:0046872 GO:0072574 GO:2000491
16	0.06	0.267	4.97	0.06	0.42	1blxA	GO:0000082 GO:0000166 GO:0000307 GO:0001726 GO:0001954 GO:0002244 GO:0003323 GO:0004672 GO:0004674 GO:0004693 GO:0005524 GO:0005634 GO:0005654 GO:0005737 GO:0005813 GO:0005815 GO:0005829 GO:0005856 GO:0006468 GO:0007049 GO:0007050 GO:0007219 GO:0008285 GO:0009615 GO:0010468 GO:0010628 GO:0014002 GO:0016301 GO:0016310 GO:0016740 GO:0021542 GO:0021670 GO:0030097 GO:0030154 GO:0030332 GO:0033077 GO:0042063 GO:0042127 GO:0042995 GO:0043697 GO:0045596 GO:0045638 GO:0045646 GO:0045656 GO:0045668 GO:0045786 GO:0048146 GO:0048699 GO:0050680 GO:0051301 GO:0060218 GO:1904628 GO:2000145 GO:2000773
17	0.06	0.325	4.91	0.06	0.49	2j51A	GO:0000166 GO:0004672 GO:0004674 GO:0004702 GO:0005524 GO:0005737 GO:0005913 GO:0006468 GO:0006915 GO:0016301 GO:0016310 GO:0016740 GO:0023014 GO:0030334 GO:0031122 GO:0031252 GO:0042802 GO:0042803 GO:0042981 GO:0046777 GO:0051893 GO:0070062 GO:0098609 GO:0098641
18	0.06	0.265	5.00	0.03	0.42	4d9uA	GO:0000166 GO:0000287 GO:0001501 GO:0002224 GO:0004672 GO:0004674 GO:0005524 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0006468 GO:0006915 GO:0007049 GO:0007165 GO:0007417 GO:0016301 GO:0016310 GO:0016740 GO:0019901 GO:0030307 GO:0032496 GO:0035556 GO:0043027 GO:0043066 GO:0043154 GO:0043555 GO:0043620 GO:0045597 GO:0045944 GO:0046872

Consensus prediction of GO terms

Molecular Function	GO:0005515
GO-Score	0.35
Biological Processes	GO:0009405	GO:1902410	GO:0000280	GO:0090337	GO:0090529	GO:0032232	GO:0044315
GO-Score	0.90	0.35	0.35	0.35	0.35	0.35	0.33
Cellular Component	GO:0005576	GO:0009986	GO:0043234	GO:0000399	GO:0005940	GO:0032161	GO:0005826
GO-Score	0.90	0.84	0.35	0.35	0.35	0.35	0.35

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.