I-TASSER results

I-TASSER results for job id Rv2426c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (291 residues)
MTVPARPTPLFADIADVSRRLAETGYLPDTATATAVFLADRLGKPLLVEGPAGVGKTELA
RAVAQATGSGLVRLQCYEGVDEARALYEWNHAKQILRIQAGSGDWEATKTDVFSEEFLLQ
RPLLTAIRRTEPTVLLIDETDKADIEIEGLLLEVLSDFAVTVPELGTLTATRAPFVLLTS
NATRELSEALKRRCLYLHIDFPTPELERRILLSRVPELPEHFAEELVRIIGVLRGMQLKK
VPSIAETIDWGRTVLALGLDTIDDAVVAATLGVVLKHQSDQQRATGELRLN

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTVPARPTPLFADIADVSRRLAETGYLPDTATATAVFLADRLGKPLLVEGPAGVGKTELARAVAQATGSGLVRLQCYEGVDEARALYEWNHAKQILRIQAGSGDWEATKTDVFSEEFLLQRPLLTAIRRTEPTVLLIDETDKADIEIEGLLLEVLSDFAVTVPELGTLTATRAPFVLLTSNATRELSEALKRRCLYLHIDFPTPELERRILLSRVPELPEHFAEELVRIIGVLRGMQLKKVPSIAETIDWGRTVLALGLDTIDDAVVAATLGVVLKHQSDQQRATGELRLN
Prediction	CCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEHCCCCCCHHHHHHHHHHHHCCCEEEEHCCCCCCHHHHCCCCCHHHHHHHCHCCCCCCCCCCCCCCCCCCEEHCHHHHHHHCCCCEEEEEHCCCCCCHHHHHHHHHHHHCCEEHCCCCCEEEHCCCCEEEEHCCCCCCCCHHHHHHHEEEEHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCC
Conf.Score	999989998889999999998746888899999999999997998899879999889999999999899969998689998888546455899998754555665444456776443455868887655998699997655698589999999987777875899979977898899995998888999988643676489999999999999857889999999999999999877655656999999999999989876898999999746657999999999998579
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTVPARPTPLFADIADVSRRLAETGYLPDTATATAVFLADRLGKPLLVEGPAGVGKTELARAVAQATGSGLVRLQCYEGVDEARALYEWNHAKQILRIQAGSGDWEATKTDVFSEEFLLQRPLLTAIRRTEPTVLLIDETDKADIEIEGLLLEVLSDFAVTVPELGTLTATRAPFVLLTSNATRELSEALKRRCLYLHIDFPTPELERRILLSRVPELPEHFAEELVRIIGVLRGMQLKKVPSIAETIDWGRTVLALGLDTIDDAVVAATLGVVLKHQSDQQRATGELRLN
Prediction	873466354334416403530575411246400200100132721000312331100200310042073410100022404244013322102102504344443543555224450025110030035651000000003303640361024103512031353432203430000000133450361024100312062144620340044315604650053015004403736164220002003003003425254135610350021004366015303630758
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEHCCCCCCHHHHHHHHHHHHCCCEEEEHCCCCCCHHHHCCCCCHHHHHHHCHCCCCCCCCCCCCCCCCCCEEHCHHHHHHHCCCCEEEEEHCCCCCCHHHHHHHHHHHHCCEEHCCCCCEEEHCCCCEEEEHCCCCCCCCHHHHHHHEEEEHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCC
MTVPARPTPLFADIADVSRRLAETGYLPDTATATAVFLADRLGKPLLVEGPAGVGKTELARAVAQATGSGLVRLQCYEGVDEARALYEWNHAKQILRIQAGSGDWEATKTDVFSEEFLLQRPLLTAIRRTEPTVLLIDETDKADIEIEGLLLEVLSDFAVTVPELGTLTATRAPFVLLTSNATRELSEALKRRCLYLHIDFPTPELERRILLSRVPELPEHFAEELVRIIGVLRGMQLKKVPSIAETIDWGRTVLALGLDTIDDAVVAATLGVVLKHQSDQQRATGELRLN

5c3cA

0.20

0.16

0.78

1.74

MUSTER

--------------------RKEPYYRAVQDEIELYRAGYEARIPMMLKGPTGCGKSRFVEHMAWKLNRPLITIACNEDMTASDLVGR-------------------------------DGPLTVAARI--GAICYLDEIVEARQDTIVVIHPLTDRRVLPLEKKGELVEAHPDQIVISYN--PDLKQSTKQRFGALDFDYPKPDIEAEIVSHE-AGVDKDTAEKLVQIAQKAR-----NGLSTRLLVYAGKLIAK-GVDA--RAACTMTLVNPITDDVDMRDALDTVVKT

5c3cA

0.20

0.15

0.78

3.29

dPPAS

--------------------RKEPYYRAVQDEIELYRAGYEARIPMMLKGPTGCGKSRFVEHMAWKLNRPLITIACNEDMTASDLVGR-------------------------------DGPLTVAARIGA--ICYLDEIVEARQDTIVVIHPLTDHRVLPLEKKGELVEAHPDFQIVIS-YNPDLKQSTKQRFGALDFDYPKPDIEAEIVSHE-AGVDKDTAEKLVQIAQKAR-----NGLSTRLLVYAGKLIAK---GVDARAACTMTLVNPITDDVDMRDALDTVVKT

5c3cA

0.20

0.16

0.78

3.04

wdPPAS

--------------------RKEPYYRAVQDEIELYRAGYEARIPMMLKGPTGCGKSRFVEHMAWKLNRPLITIACNEDMTASDLVGR-------------------------------DGPLTVAARIGA--ICYLDEIVEARQDTIVVIHPLTDHRVLPLEKKGELVEAHPDQIVISYN--PDLKQSTKQRFGALDFDYPKPDIEAEIVSHE-AGVDKDTAEKLVQIAQKAR-----NGLSTRLLVYAGKLIAK-GVDA--RAACTMTLVNPITDDVDMRDALDTVVKT

5c3cA

0.20

0.16

0.78

2.03

wMUSTER

--------------------RKEPYYRAVQDEIELYRAGYEARIPMMLKGPTGCGKSRFVEHMAWKLNRPLITIACNEDMTASDLVGR-------------------------------DGPLTVAARI--GAICYLDEIVEARQDTIVVIHPLTDRRVLPLEKKGELVEAHPDQIVISYN--PDLKQSTKQRFGALDFDYPKPDIEAEIVSHE-AGVDKDTAEKLVQIAQKAR-----NGLSTRLLVYAGKLIAK-GVDA--RAACTMTLVNPITDDVDMRDALDTVVKT

5c3cA

0.20

0.16

0.78

2.76

wPPAS

--------------------RKEPYYRAVQDEIELYRAGYEARIPMMLKGPTGCGKSRFVEHMAWKLNRPLITIACNEDMTASDLVGR-------------------------------DGPLTVAARIGA--ICYLDEIVEARQDTIVVIHPLTDHRVLPLEKKGELVEAHPDQIVISYN--PDLKQSTKQRFGALDFDYPKPDIEAEIVSHE-AGVDKDTAEKLVQIAQKAR-----NGLSTRLLVYAGKLIAK-GVDA--RAACTMTLVNPITDDVDMRDALDTVVKT

5c3cA

0.21

0.16

0.78

9.10

dPPAS2

--------------------RKEPYYRAVQDEIELYRAGYEARIPMMLKGPTGCGKSRFVEHMAWKLNRPLITIACNEDMTASDLVGR-------------------------------DGPLTVAARIGA--ICYLDEIVEARQDTIVVIHPLTDHRVLPLEKKGELVEAHPDFQIVIS-YNPDLKQSTKQRFGALDFDYPKPDIEAEIVSHE-AGVDKDTAEKLVQIAQKAR-----NGLSTRLLVYAGKLIAK-GVDA--RAACTMTLVNPITDDVDMRDALDTVVKT

5c3cA

0.21

0.16

0.78

2.61

PPAS

--------------------RKEPYYRAVQDEIELYRAGYEARIPMMLKGPTGCGKSRFVEHMAWKLNRPLITIACNEDMTASDLVGR-------------------------------DGPLTVAARIGA--ICYLDEIVEARQDTIVVIHPLTDHRVLPLEKKGELVEAHPDFQIVISYN-PDLKQSTKQRFGALDFDYPKPDIEAEIVSHE-AGVDKDTAEKLVQIAQKAR-----NGLSTRLLVYAGKLIAK-GVDA--RAACTMTLVNPITDDVDMRDALDTVVKT

5c3cA

0.21

0.16

0.78

3.81

Env-PPAS

--------------------RKEPYYRAVQDEIELYRAGYEARIPMMLKGPTGCGKSRFVEHMAWKLNRPLITIACNEDMTASDLVGRD-------------------------------GPLTVAARIGA--ICYLDEIVEARQDTIVVIHPLTDHRVLPLEKKGELVEAHPDFQIVISYN-PDLKQSTKQRFGALDFDYPKPDIEAEIVSHE-AGVDKDTAEKLVQIAQKAR-----NGLSTRLLVYAGKLIAK-GVDA--RAACTMTLVNPITDDVDMRDALDTVVKT

2qbyB1

0.14

0.12

0.82

1.00

MUSTER

-----KNPKVFIDPLSV-------KEIPFRDAAIAIRYFVKNEVKNLFLGLTGTGKTFVSKYIFNEIEEKQAYVNCREGGTPQAV-----LSSLAGKLT----GFSVPKHGINLGEYID--KIKNGTR-NIRAIIYLDEVDTKRRGGDIVLYQLLR-------------SDANISVIMISNDINYMEPRVLSSLGSVIFKPYDAEQLKFILSKYAEYIKGTYDDEILSYIAAISA---KEHGDARKAVNLLFRAAQLASGGGI-------------RKEHVDKAIVDYEQE

5c3cA1

0.18

0.09

0.49

2.04

dPPAS

--------------------RKEPYYRAVQDEIELYRAGYEARIPMMLKGPTGCGKSRFVEHMAWKLNRPLITIACNEDMTASDLVGR-------------------------------DGPLTVAARIGA--ICYLDEIVEARQDTIVVIHPLTDHRVLPLEKKGELVEAHPDQIVISYN--PDLKQSTKQRFGALDF--------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.24

Estimated TM-score = 0.68±0.12

Estimated RMSD = 6.6±4.0Å

Download Model 2

C-score=-1.07

Download Model 3

C-score=-3.12

Download Model 4

C-score=-2.29

Download Model 5

C-score=-2.43

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5c3cA	0.743	1.54	0.203	0.780
2	1fnnA	0.651	4.45	0.110	0.859
3	3k1jA	0.647	3.69	0.117	0.808
4	1w5tB	0.639	4.60	0.089	0.856
5	4wvyA	0.624	3.95	0.165	0.780
6	2c9oA	0.622	4.02	0.184	0.780
7	1ny5B	0.620	3.39	0.139	0.746
8	2qbyA	0.619	4.38	0.127	0.804
9	4wvyB	0.619	3.84	0.165	0.770
10	2qenA	0.617	4.37	0.124	0.821

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.42	61	4lzzM	08T	Rep, Mult	25,52,55,56,57,58,138,139,181,214,244,245,248
2	0.07	10	2qbyB	MG	Rep, Mult	57,138,181
3	0.03	5	3u60E	MG	Rep, Mult	57,138,139,245
4	0.01	1	1r6bX	MG	Rep, Mult	56,57,179
5	0.01	1	2awb6	III	Rep, Mult	59,60,61,62,63,64,65,69

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.189	3b9pA	0.567	3.65	0.187	0.708	3.6.4.3	55,57,138,181,211
2	0.117	1in5A	0.606	3.79	0.180	0.753	3.6.4.12	NA
3	0.067	1nsfA	0.545	4.26	0.156	0.718	3.6.4.6	56
4	0.066	2c9oC	0.623	4.05	0.175	0.780	3.6.1.-	NA
5	0.060	2db3A	0.430	5.77	0.053	0.677	3.6.4.13	NA
6	0.060	2hyiI	0.430	5.53	0.096	0.646	3.6.4.13	57
7	0.060	1jbwA	0.417	5.41	0.061	0.622	6.3.2.17	NA
8	0.060	2tmdA	0.409	5.75	0.074	0.636	1.5.8.2	53,148,177
9	0.060	2uv8G	0.418	5.47	0.071	0.632	2.3.1.86	NA
10	0.060	3kx2B	0.461	4.92	0.081	0.636	3.6.4.13	53,57,95
11	0.060	1hv8A	0.453	5.56	0.093	0.673	3.6.4.13	57,99,139,244
12	0.060	3i62A	0.426	5.47	0.075	0.629	3.6.4.13	NA
13	0.060	2w00B	0.446	5.80	0.075	0.684	3.1.21.3	125
14	0.060	3etcB	0.418	5.65	0.082	0.656	6.2.1.-	NA
15	0.060	2c9oA	0.622	4.02	0.184	0.780	3.6.4.12	NA
16	0.060	3fccA	0.416	5.64	0.060	0.636	6.1.1.13	NA
17	0.060	1a5tA	0.526	4.29	0.117	0.705	2.7.7.7	26,53,202,217
18	0.060	1q16A	0.388	5.93	0.046	0.632	1.7.99.4	NA
19	0.060	2vkzG	0.417	5.52	0.067	0.636	2.3.1.38,3.1.2.14	NA
20	0.060	3e7wA	0.379	6.39	0.035	0.653	6.1.1.13	NA
21	0.060	1ixsB	0.617	3.90	0.189	0.773	3.6.4.12	NA
22	0.060	3hz3A	0.416	6.43	0.047	0.711	2.4.1.5	63,196
23	0.060	1njgA	0.550	3.80	0.203	0.694	2.7.7.7	55,61,139,198

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.43	0.576	4.52	0.13	0.77	1ofhA	GO:0000166 GO:0005524 GO:0005737 GO:0006508 GO:0009376 GO:0016887 GO:0043335 GO:0070011
1	0.39	0.602	4.41	0.11	0.78	2qbyB	GO:0000166 GO:0003677 GO:0005524 GO:0006260
2	0.38	0.733	1.76	0.19	0.78	5c3cB	GO:0005524 GO:0016887
3	0.26	0.588	3.44	0.20	0.71	3whkA	GO:0000166 GO:0000502 GO:0005524 GO:0005634 GO:0005737 GO:0006511 GO:0008540 GO:0010498 GO:0016787 GO:0016887 GO:0017025 GO:0022623 GO:0030163 GO:0030433 GO:0031595 GO:0031597 GO:0036402 GO:0043335 GO:0045899 GO:0070682 GO:1901800
4	0.25	0.571	3.57	0.15	0.70	1ksfX	GO:0000166 GO:0004176 GO:0005524 GO:0005829 GO:0006508 GO:0006979 GO:0016887 GO:0019538 GO:0043335
5	0.24	0.623	4.01	0.21	0.78	3uk6F	GO:0000166 GO:0000812 GO:0000979 GO:0000980 GO:0001094 GO:0003678 GO:0004003 GO:0004386 GO:0005524 GO:0005622 GO:0005634 GO:0005654 GO:0005719 GO:0005737 GO:0006281 GO:0006310 GO:0006338 GO:0006351 GO:0006355 GO:0006457 GO:0006974 GO:0016020 GO:0016363 GO:0016568 GO:0016787 GO:0016887 GO:0030529 GO:0031011 GO:0031490 GO:0032508 GO:0034644 GO:0035066 GO:0035267 GO:0040008 GO:0042802 GO:0042803 GO:0043141 GO:0043531 GO:0043967 GO:0043968 GO:0045944 GO:0051082 GO:0051117 GO:0070062 GO:0071169 GO:0071339 GO:0071392 GO:0071733 GO:0071899 GO:0097255 GO:1904874
6	0.24	0.628	4.49	0.10	0.84	1w5sB	GO:0000166 GO:0003677 GO:0005524 GO:0006260
7	0.24	0.631	4.08	0.17	0.79	2xszC	GO:0000166 GO:0000812 GO:0003678 GO:0004386 GO:0005524 GO:0005634 GO:0005654 GO:0005737 GO:0005794 GO:0005815 GO:0005856 GO:0005913 GO:0006281 GO:0006310 GO:0006351 GO:0006355 GO:0006357 GO:0006974 GO:0007049 GO:0007067 GO:0007283 GO:0016020 GO:0016363 GO:0016568 GO:0016787 GO:0016887 GO:0031011 GO:0032508 GO:0034080 GO:0035267 GO:0040008 GO:0043231 GO:0043967 GO:0043968 GO:0051301 GO:0070062 GO:0071339 GO:0097255 GO:0098609 GO:0098641 GO:1903146 GO:1903955 GO:1904837 GO:1904874
8	0.23	0.603	3.40	0.15	0.73	4l4uA	GO:0000160 GO:0000166 GO:0003677 GO:0005524 GO:0005622 GO:0006351 GO:0006355 GO:0008134 GO:0043565
9	0.22	0.651	4.45	0.11	0.86	1fnnA	GO:0000166 GO:0005524 GO:0006260 GO:0051301
10	0.21	0.604	4.40	0.14	0.80	2v1uA	GO:0000166 GO:0003677 GO:0005524 GO:0006260
11	0.21	0.619	4.38	0.13	0.80	2qbyA	GO:0000166 GO:0003677 GO:0005524 GO:0006260
12	0.21	0.623	3.87	0.18	0.78	3uk6G	GO:0000166 GO:0000812 GO:0000979 GO:0000980 GO:0001094 GO:0003678 GO:0004003 GO:0004386 GO:0005524 GO:0005622 GO:0005634 GO:0005654 GO:0005719 GO:0005737 GO:0006281 GO:0006310 GO:0006338 GO:0006351 GO:0006355 GO:0006457 GO:0006974 GO:0016020 GO:0016363 GO:0016568 GO:0016787 GO:0016887 GO:0030529 GO:0031011 GO:0031490 GO:0032508 GO:0034644 GO:0035066 GO:0035267 GO:0040008 GO:0042802 GO:0042803 GO:0043141 GO:0043531 GO:0043967 GO:0043968 GO:0045944 GO:0051082 GO:0051117 GO:0070062 GO:0071169 GO:0071339 GO:0071392 GO:0071733 GO:0071899 GO:0097255 GO:1904874
13	0.21	0.617	3.90	0.19	0.77	1ixsB	GO:0000166 GO:0003677 GO:0004386 GO:0005524 GO:0006281 GO:0006310 GO:0006974 GO:0009378 GO:0009432 GO:0016787 GO:0032508
14	0.20	0.564	3.32	0.22	0.68	2qz4A	GO:0000166 GO:0004176 GO:0004222 GO:0005524 GO:0005739 GO:0006508 GO:0007005 GO:0007155 GO:0007399 GO:0008089 GO:0008233 GO:0008237 GO:0008270 GO:0016020 GO:0016021 GO:0016787 GO:0031966 GO:0046872 GO:0051082 GO:1904115
15	0.18	0.569	4.56	0.14	0.76	1g3iA	GO:0000166 GO:0005524 GO:0005737 GO:0006508 GO:0009376 GO:0016887 GO:0043335 GO:0070011
16	0.15	0.605	3.25	0.14	0.73	5exxA	GO:0000160 GO:0000166 GO:0003677 GO:0005524 GO:0005622 GO:0006351 GO:0006355 GO:0008134 GO:0043565 GO:0044212 GO:0045785 GO:2000155
17	0.09	0.647	3.69	0.12	0.81	3k1jA	GO:0000166 GO:0004176 GO:0004252 GO:0005524 GO:0006355 GO:0006508 GO:0008134 GO:0008233 GO:0016020 GO:0016021 GO:0030163
18	0.07	0.630	4.05	0.16	0.79	4ww4B	GO:0000166 GO:0003678 GO:0004386 GO:0005524 GO:0005634 GO:0006281 GO:0006351 GO:0006355 GO:0006974 GO:0016568 GO:0016787 GO:0032508 GO:0043141
19	0.07	0.606	3.79	0.18	0.75	1in5A	GO:0000166 GO:0003677 GO:0004386 GO:0005524 GO:0006281 GO:0006310 GO:0006974 GO:0009378 GO:0009432 GO:0016787 GO:0032508
20	0.07	0.622	4.02	0.18	0.78	2c9oA	GO:0000166 GO:0000812 GO:0003678 GO:0004386 GO:0005524 GO:0005634 GO:0005654 GO:0005737 GO:0005794 GO:0005815 GO:0005856 GO:0005913 GO:0006281 GO:0006310 GO:0006351 GO:0006355 GO:0006357 GO:0006974 GO:0007049 GO:0007067 GO:0007283 GO:0016020 GO:0016363 GO:0016568 GO:0016787 GO:0016887 GO:0031011 GO:0032508 GO:0034080 GO:0035267 GO:0040008 GO:0043231 GO:0043967 GO:0043968 GO:0051301 GO:0070062 GO:0071339 GO:0097255 GO:0098609 GO:0098641 GO:1903146 GO:1903955 GO:1904837 GO:1904874
21	0.07	0.624	3.95	0.17	0.78	4wvyA	GO:0000166 GO:0003678 GO:0004386 GO:0005524 GO:0005634 GO:0006281 GO:0006351 GO:0006355 GO:0006974 GO:0016568 GO:0016787 GO:0032508 GO:0043141
22	0.07	0.614	4.06	0.13	0.79	4fw9A	GO:0004176 GO:0004252 GO:0005524 GO:0006508 GO:0030163

Consensus prediction of GO terms

Molecular Function	GO:0005524	GO:0042623	GO:0008134	GO:0070011	GO:0003677
GO-Score	0.88	0.53	0.53	0.43	0.39
Biological Processes	GO:0043335	GO:0060261	GO:0036503	GO:0045898	GO:0061136	GO:0043161	GO:1903052	GO:0043248	GO:0006260
GO-Score	0.68	0.53	0.53	0.53	0.53	0.53	0.53	0.53	0.39
Cellular Component	GO:0031981	GO:0005838	GO:0009376
GO-Score	0.53	0.53	0.43

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.