I-TASSER results

I-TASSER results for job id Rv2425c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (480 residues)
MAARRIRAARPLAPHGLPGHLVGFVEALRGSGISVGPSETVDAGRVMATLGLGDREVLRE
GIACAVLRRPDHRDTYDAMFDLWFPAALGARAVITTEDESAGSGGLPPDDVEAMRQLLLD
LLANNQDLAGKDERLVEMIARIVEAYGKYSSSRGPSFSSYQALKAMALDELEGKLLAGLL
APYGDEPTATQEQIAKALAAQKIAQLRRMVDAETKRRTAEQLGREHVQMYGIPQLSENVE
FLRASGEQLRQMRRVVAPLARTLATRLAARRRRARAGSIDLRKTLRKSMSTGGVPIDLVL
HKPRPARPELVVLCDVSGSVAGFSHFTLLLVHALRQQFSRVRVFAFIDSTDEVTHMFGPE
SDLAIAIQRITREAGVYARDGHSDYGNAFVSFMQGFPNVLSPRSSLLVLGDGRTNYRNPA
TDVLADMVTASRHAHWLNPEPKHLWGSGDSAVPRYQEVITMHECRSAKQLATVIDQLLPV

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MAARRIRAARPLAPHGLPGHLVGFVEALRGSGISVGPSETVDAGRVMATLGLGDREVLREGIACAVLRRPDHRDTYDAMFDLWFPAALGARAVITTEDESAGSGGLPPDDVEAMRQLLLDLLANNQDLAGKDERLVEMIARIVEAYGKYSSSRGPSFSSYQALKAMALDELEGKLLAGLLAPYGDEPTATQEQIAKALAAQKIAQLRRMVDAETKRRTAEQLGREHVQMYGIPQLSENVEFLRASGEQLRQMRRVVAPLARTLATRLAARRRRARAGSIDLRKTLRKSMSTGGVPIDLVLHKPRPARPELVVLCDVSGSVAGFSHFTLLLVHALRQQFSRVRVFAFIDSTDEVTHMFGPESDLAIAIQRITREAGVYARDGHSDYGNAFVSFMQGFPNVLSPRSSLLVLGDGRTNYRNPATDVLADMVTASRHAHWLNPEPKHLWGSGDSAVPRYQEVITMHECRSAKQLATVIDQLLPV
Prediction	CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEHCCCCCCCCEEEEEHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEHCCEEEHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEHCCCCCCCCHHHHHHHHHHHHCCEEEEHCCCCHHHCCCCCHHHHHHHHHCCEEHCCCHHHHHHHHHHHCCC
Conf.Score	998888888888887578999999999999898778999999999999859999999999999998589999999999999997566677654455655555445554567788887777765544455556778889999888888776654554667666776565466776654555566777776544565555544456677766655555567776566776655677765565777999999999999999999998887764567777888889999999998995566676567778885899996998858999999999999999868579999878355556887678789999999998746666788876999999999987645788858999958877798779999999999889599858887665898755899999975456679899999999997689
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MAARRIRAARPLAPHGLPGHLVGFVEALRGSGISVGPSETVDAGRVMATLGLGDREVLREGIACAVLRRPDHRDTYDAMFDLWFPAALGARAVITTEDESAGSGGLPPDDVEAMRQLLLDLLANNQDLAGKDERLVEMIARIVEAYGKYSSSRGPSFSSYQALKAMALDELEGKLLAGLLAPYGDEPTATQEQIAKALAAQKIAQLRRMVDAETKRRTAEQLGREHVQMYGIPQLSENVEFLRASGEQLRQMRRVVAPLARTLATRLAARRRRARAGSIDLRKTLRKSMSTGGVPIDLVLHKPRPARPELVVLCDVSGSVAGFSHFTLLLVHALRQQFSRVRVFAFIDSTDEVTHMFGPESDLAIAIQRITREAGVYARDGHSDYGNAFVSFMQGFPNVLSPRSSLLVLGDGRTNYRNPATDVLADMVTASRHAHWLNPEPKHLWGSGDSAVPRYQEVITMHECRSAKQLATVIDQLLPV
Prediction	765643545634465302410120031027240100040011002004204143251012000000033460251033002100211222443222343334355223422422342135224443222423320231222212224313343344232332133122531342222222322343122244313432442423323432553443422542444323424354225434045034510530250043004304522432334343330213200020043201003022244454302000000000002100200010020024205401000001101200520356321330032014424223111111003003301530443032400000000011134540040032006103200100010363151020003102410300203206201500551177
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEHCCCCCCCCEEEEEHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEHCCEEEHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEHCCCCCCCCHHHHHHHHHHHHCCEEEEHCCCCHHHCCCCCHHHHHHHHHCCEEHCCCHHHHHHHHHHHCCC
MAARRIRAARPLAPHGLPGHLVGFVEALRGSGISVGPSETVDAGRVMATLGLGDREVLREGIACAVLRRPDHRDTYDAMFDLWFPAALGARAVITTEDESAGSGGLPPDDVEAMRQLLLDLLANNQDLAGKDERLVEMIARIVEAYGKYSSSRGPSFSSYQALKAMALDELEGKLLAGLLAPYGDEPTATQEQIAKALAAQKIAQLRRMVDAETKRRTAEQLGREHVQMYGIPQLSENVEFLRASGEQLRQMRRVVAPLARTLATRLAARRRRARAGSIDLRKTLRKSMSTGGVPIDLVLHKPRPARPELVVLCDVSGSVAGFSHFTLLLVHALRQQFSRVRVFAFIDSTDEVTHMFGPESDLAIAIQRITREAGVYARDGHSDYGNAFVSFMQGFPNVLSPRSSLLVLGDGRTNYRNPATDVLADMVTASRHAHWLNPEPKHLWGSGDSAVPRYQEVITMHECRSAKQLATVIDQLLPV

2nvoA

0.14

0.12

0.82

1.08

wPPAS

LVQRD------------AALALRVTLDVVRGQRAPKADPALLVLALIAKTNAADRKAAWDALPEVA-RTGTMLLHFLAFADALWG--------------------------RLTRRGVANVYETAD------------VDKLALWAVKYKARDGWSQADALRKAHAARNAVLKFMVDGVLPKVDSPALRVIEGHLKATEAQTDAAAAALMQEYRLPLEAAEVYRAAMQTNGLTWLLRNGNLGRVTPNDSATVQAVIERLTDPAALKRGR--GQGVRGKGRVVDALEEAFTL--------FGNVQPANTRHLLALDVSGSM--PNMAAAAMSLIALRTEPDALTMGFAEQFRPL---ITPRDTLESAMQKAQSVS-----FGGTDCAQPILWAAQE-----LDVDTFVVYTDNETWGQVHPTVALDQYAQKMGKLIVVG-------ATEFSIADPQRR--DMLDVVGFAAAPNVMTAF-EV

4hqlA1

0.14

0.05

0.39

1.09

Env-PPAS

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DEVKYSEEVCN---EQVDLYLLVDGSGSIPNWITKVIPMLNGLINSLSNLYMNLFGSYTTELIR-LGSGIDKRQALSKVTELRKTYTPYGTTSMTAALDEVQKHLNDRVNREKLVILMTDGVPNSKYRALEVANKLKQRNVRLAVIGQGINHQFNRLIAGCRPREPNCKFYSYADWNEAVALIKPFIAK

5cwmA

0.12

0.06

0.47

1.18

dPPAS2

-----------------------------------DPEDELKRVEKLVKE----AEELLRQAKEKG-SEEDLEKALRTAEEAAREAKKVLEQAEKEGDPEVALRAVELVVRVAELLLRIAKESGSEEALERALRVAEEAARLAKRVLELAEKQGDPEVALRAVELVVRVAELLLRIAKESGSEEALERALRVAEEAARLAKRVLELAEKQGDPEVARRAVELVKRVAELLERIARESGSEEAKERAERVREEARELQERVKELRER----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

1yvpB

0.10

0.09

0.85

1.05

wPPAS

----TMDQTQPLNEKSDMNRLRRFLCFGSEGGTKLGQENAEALLRLIEDGKAKQEPTLFALAVCSQCSDIKTKQAAFRAVPEV----------------------RIPTHLFTFIQFKKDLKEGMKCGM---RALRKAVSDWYNTKDALNLA-ANEGLTMVAKYVSKGWKEVQEAYKEKELSPETEKVLKYLEATERVKRTKDELEIIHLIDEYRLVREHLLTIHLKSKEIWKSLLQDMPLGKMTADSVSEVSSVCERLTNEKLLKKAR--KKGHGNKLRWITSIVEALDN----FYKSFKLVEPTGKRFLLAIDVSASMNQASVVAAAMCMLVARTEKDSHMVAFSDEMLPCP--ITVNMLLHEVVEKMSDI-----TMGSTDCALPMLWAQKT-----TAADIFIVFTDCETNVEDVPATALKQYREKMGKLIVCAPDDR--FD--SGALDVIRNF--------TLDL----------

5cwqA

0.08

0.04

0.49

1.16

dPPAS2

------------------------------------EELERESEEAERRL----QEARKRSEEARERGDLKELAEALIEEARAVQELARVACERGNSEEAERASEKAQRVLEEARKVSEEAREQGDDEVLALALIAIALAVLALAEVACCRGNSEEAERASEKAQRVLEEARKVSEEAREQG-----DDEVLALALIAIALAVLALAEVACCRGNKEEAERAYEDARRVEEEARKVKESAEEQGDSEVKRLAEEAEQLAREARRHVQECRGGWLEHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

5a8jA1

0.13

0.04

0.32

1.09

Env-PPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGIHYVVMIDNSPSMKNKINLALSSASRLVQDIIFISIYLFSNDIETLYEGESGKQ----------IELKSIKMGYTTNLHKAITKVLEKFKSS-EIPVKIILLSDGKPTDKRYSRDYESLQVPKNVQLITI-----EDYN--EAIMKILADKGVFYHINDPSQLPTTLVE----

5cwiA

0.10

0.05

0.48

1.15

dPPAS2

---------------------------------------DIEKLCKKAESEAREARSKAEELRQRHPDSQAARDAQKLASQAEEAVKLACELAQEHPNADIAKLCIKAASEAAEAASKAAELAQRHPDSRDAIKLASQAAEAVKLACELAQEHPNADIAKLCIKAASEAAEAASKAAELAQRHPDSQAARDAIKLASQAAEAVKLACELAQEHPNADIAKKCIKAASEAAEEASKAAEEAQRHPDSQKARDEIKEASQKAEEVKERCER-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

1shuX

0.14

0.05

0.35

1.02

Env-PPAS

--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SCRRAFDLYFVLDKSGSVANNWIEIYNFVQQLAERFVRLSFIVFSSQATIILPLTGDRGKISKGLEDLKRV----SPVGETYIHEGLKLANEQIQKAGGLKTIIIALTDGKLDGLSYAEKEAKISRSLGASVYCV--------GVLDFEQAQLERIADVFPVGGFQALKGIINSILAQ

5cwoA

0.11

0.05

0.46

1.10

dPPAS2

-------------------------------------PELEEWIRRAKEVA---KEVEKVAQRAEEEGNPDLRDSAKELRRAVEEAIEEAKKQGN----PELVEWVARAAKVAAEVIKVAIQAEKEGNRDLFRAALELVRAVIEAIEEAVKQGNPELVEWVARAAKVAAEVIKVAIQAEKEGN------RDLFRAALELVRAVIEAIEEAVKQGNPELVERVARLAKKAAELIKRAIRA-EKEGNRDERREALERVREVIERIEELVRQG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

1yvpB

0.09

0.95

1.01

Env-PPAS

VSDMNRGSEGGTYYIEEKKLGQENAEALLRLIEDGKGCEVVQEIKTFSQEGRAQEPTLFALAVCSQCSDIKTKQAAFRAVPEVCRIPTHLFTFIQFKKDLKEGMKCG-MWGRALRKAVSDWYNTKDALNLAMAVTKYKQRSHKDLLRLSHIKPANEGLTMVAKYVSKGWKEVQEAYKEKELSPETEKVLKYLEATERVKRTKDELEIIHLIDEYRLVREHLLTIHLKSKEIWKSLLQDMPLTALLAPASSEVSSVCERLTNEKLLKKARIHKKGHGNKLRWITSIVEALDNA---FYKSFKLVEPTGKRFLLAIDVSASMNQASVVAAAMCMLVARTEKDSHMVAFSDEMLPCP--ITVNMLLHEVVEKMSDI-----TMGSTDCALPMLWAQKTN----TAADIFIVFTDCETNVEDVPATALKQYREKMGIVCAMTSNGFSIADPDDRGMLDICGFDS----GALDVIRNFTLDL---

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.85

Estimated TM-score = 0.39±0.13

Estimated RMSD = 14.2±3.8Å

Download Model 2

C-score=-2.14

Download Model 3

C-score=-2.67

Download Model 4

C-score=-2.81

Download Model 5

C-score=-3.37

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1yvpB	0.790	3.56	0.085	0.898
2	2nvoA	0.615	5.19	0.065	0.812
3	3s4wB	0.440	6.39	0.037	0.650
4	3s4wA	0.426	6.84	0.051	0.669
5	1djnA	0.423	6.87	0.057	0.650
6	3k30A	0.416	7.05	0.049	0.648
7	2ebsB	0.410	7.52	0.057	0.685
8	5cskA	0.406	6.28	0.060	0.594
9	4i2wA	0.403	7.21	0.035	0.662
10	2x42A	0.403	6.50	0.055	0.608

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.45	22	3eobJ	ZN	Rep, Mult	315,317,319,411
2	0.04	2	1gt8C	SF4	Rep, Mult	314,315,316,320,321,322,326,327,329
3	0.02	1	1ps9A	SF4	Rep, Mult	326,409,410,437,438,452
4	0.02	1	1o94B	SF4	Rep, Mult	314,316,348,349,350,351,352,353,377,378
5	0.02	1	3k30A	ADP	Rep, Mult	312,313,330,344,345,407,408,409,437

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2ri9B	0.370	7.19	0.031	0.598	3.2.1.113	353,426
2	0.060	3ffzA	0.370	7.84	0.030	0.654	3.4.24.69	403
3	0.060	2jfdA	0.215	7.37	0.043	0.360	2.3.1.85	370
4	0.060	1gthA	0.407	7.43	0.048	0.677	1.3.1.2	NA
5	0.060	1dl2A	0.370	7.18	0.046	0.598	3.2.1.113	NA
6	0.060	1kktA	0.369	7.21	0.036	0.596	3.2.1.113	NA
7	0.060	1js4A	0.379	7.28	0.066	0.621	3.2.1.4	NA
8	0.060	1jqoA	0.399	6.94	0.049	0.625	4.1.1.31	NA
9	0.060	1nxcA	0.357	7.28	0.042	0.581	3.2.1.113	NA
10	0.060	1fmiA	0.354	7.09	0.067	0.565	3.2.1.113	411
11	0.060	2ebsB	0.410	7.52	0.057	0.685	3.2.1.150	NA
12	0.060	1ayxA	0.361	7.23	0.063	0.594	3.2.1.3	NA
13	0.060	1jqnA	0.378	7.19	0.062	0.623	4.1.1.31	NA
14	0.060	1n8zC	0.359	7.70	0.055	0.613	2.7.10.1	336,342,473
15	0.060	1g87B	0.377	7.49	0.049	0.627	3.2.1.4	NA
16	0.060	2tmdA	0.422	6.80	0.044	0.646	1.5.8.2	437,440,441
17	0.060	2zxqA	0.373	7.65	0.049	0.637	3.2.1.97	263
18	0.060	3ebgA	0.390	6.76	0.042	0.602	3.4.11.-	NA
19	0.060	3la4A	0.366	7.79	0.053	0.631	3.5.1.5	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.45	0.790	3.56	0.09	0.90	1yvpB	GO:0003723 GO:0005737 GO:0030030 GO:0030529 GO:0034336 GO:0046872
1	0.28	0.615	5.19	0.07	0.81	2nvoA	GO:0003723 GO:0005737 GO:0030529 GO:0046872
2	0.06	0.325	7.36	0.06	0.53	5ahkA	GO:0000287 GO:0003824 GO:0030976
3	0.06	0.394	7.09	0.03	0.62	3s51A	GO:0005634 GO:0005654 GO:0005737 GO:0006281 GO:0006974 GO:0007049 GO:0007095 GO:0016020 GO:0031398 GO:0043240 GO:0070182
4	0.06	0.426	6.84	0.05	0.67	3s4wA	GO:0005634 GO:0005654 GO:0005737 GO:0006281 GO:0006974 GO:0007049 GO:0007095 GO:0016020 GO:0031398 GO:0043240 GO:0070182
5	0.06	0.440	6.39	0.04	0.65	3s4wB	GO:0000793 GO:0005634 GO:0005730 GO:0005737 GO:0006281 GO:0006974 GO:0007049 GO:0007129 GO:0007275 GO:0007276 GO:0010332 GO:0034599 GO:0045589 GO:0048854 GO:0050727 GO:0051090 GO:0070182 GO:0097150 GO:2000348
6	0.06	0.270	6.87	0.06	0.43	4mlcA	GO:0006865
7	0.06	0.257	6.23	0.06	0.38	2qb5A	GO:0000166 GO:0000287 GO:0003824 GO:0005524 GO:0005622 GO:0005829 GO:0007165 GO:0007596 GO:0016301 GO:0016310 GO:0016311 GO:0016324 GO:0016740 GO:0016787 GO:0016853 GO:0021915 GO:0032957 GO:0043647 GO:0046872 GO:0047325 GO:0052659 GO:0052725 GO:0052726 GO:0052825 GO:0052830 GO:0052831 GO:0052835
8	0.06	0.247	5.75	0.03	0.34	4lliA	GO:0000146 GO:0000166 GO:0001726 GO:0001750 GO:0003774 GO:0003779 GO:0005509 GO:0005516 GO:0005524 GO:0005737 GO:0005764 GO:0005769 GO:0005770 GO:0005777 GO:0005783 GO:0005794 GO:0005829 GO:0005882 GO:0005884 GO:0006582 GO:0006810 GO:0006887 GO:0006892 GO:0007268 GO:0007601 GO:0015031 GO:0016020 GO:0016192 GO:0016459 GO:0017137 GO:0030048 GO:0030050 GO:0030073 GO:0030141 GO:0030318 GO:0030426 GO:0031585 GO:0031982 GO:0031987 GO:0032252 GO:0032400 GO:0032402 GO:0032433 GO:0032593 GO:0032869 GO:0035371 GO:0042438 GO:0042470 GO:0042476 GO:0042552 GO:0042641 GO:0042759 GO:0043005 GO:0043025 GO:0043473 GO:0044822 GO:0048066 GO:0050808 GO:0051643 GO:0055037 GO:0070062 GO:0072659 GO:1903358
9	0.06	0.248	6.87	0.06	0.40	1i60A	GO:0016853 GO:0046872
10	0.06	0.205	6.11	0.07	0.30	3ps0A	GO:0003723 GO:0051607
11	0.06	0.218	7.35	0.04	0.36	3f3fA	GO:0005634 GO:0005643 GO:0005773 GO:0005774 GO:0006810 GO:0006913 GO:0015031 GO:0016020 GO:0017056 GO:0031080 GO:0031965 GO:0035859 GO:0051028 GO:0097042 GO:1904263
12	0.06	0.210	7.32	0.03	0.34	4bqqA	GO:0000150 GO:0003677 GO:0006310 GO:0006508 GO:0008233
13	0.06	0.211	7.37	0.03	0.35	4gyiA	GO:0000166 GO:0004672 GO:0004674 GO:0005524 GO:0006468
14	0.06	0.189	7.22	0.03	0.31	1kvpA	GO:0005198 GO:0019012 GO:0019028 GO:0030430 GO:0039615
15	0.06	0.207	6.62	0.04	0.32	4wbsB	GO:0000166 GO:0005524 GO:0016887 GO:0043190 GO:0055085
16	0.06	0.216	5.66	0.06	0.30	5ahoA	GO:0000075 GO:0000723 GO:0000781 GO:0000784 GO:0003684 GO:0004518 GO:0004527 GO:0005634 GO:0005694 GO:0005737 GO:0005813 GO:0005815 GO:0005856 GO:0006281 GO:0006303 GO:0006974 GO:0008409 GO:0016787 GO:0031627 GO:0031848 GO:0031860 GO:0035312 GO:0036297 GO:0090305
17	0.06	0.218	6.55	0.03	0.33	2bpa1	GO:0005198 GO:0019012 GO:0019028 GO:0030430 GO:0039615
18	0.06	0.196	6.24	0.05	0.29	4io0A	GO:0003824 GO:0008152 GO:0016787 GO:0016798 GO:0047405

Consensus prediction of GO terms

Molecular Function	GO:0046872	GO:0034336
GO-Score	0.60	0.45
Biological Processes	GO:0030030
GO-Score	0.45
Cellular Component	GO:0005737	GO:0030529
GO-Score	0.65	0.60

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.