I-TASSER results

I-TASSER results for job id Rv2423

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (348 residues)
MDNLPIESAESTRLAKAAMTRRFYTRSVVKGEITLPAVPSMIDEYVTMCAGLFAGVGRKF
SDEELAHLRAVLQGQLAEAYAASQRSTIVISYNAPMGPTLHYQVRAQWRTVAQEYENWIA
TREPPLFGTEPDARVWALANEAADPTTHRVLEIGAGTGRNALALARRGHPVDVVEMTPKF
ADIIRSDAERDSLDVRVIMRDVFSTMDDLRQDYQLMVLSEVVPDFRTTQQLRNLFELAAQ
CLAPGARLVFNAFLANGDYAPDQAAREFGQQMYTGMCTRAEMSAAAAGLPLELVADDSVY
DYEKTHLPPGAWPPTSWYADWIRGLDVFTTNVESCPIEMRWLVFQRRR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MDNLPIESAESTRLAKAAMTRRFYTRSVVKGEITLPAVPSMIDEYVTMCAGLFAGVGRKFSDEELAHLRAVLQGQLAEAYAASQRSTIVISYNAPMGPTLHYQVRAQWRTVAQEYENWIATREPPLFGTEPDARVWALANEAADPTTHRVLEIGAGTGRNALALARRGHPVDVVEMTPKFADIIRSDAERDSLDVRVIMRDVFSTMDDLRQDYQLMVLSEVVPDFRTTQQLRNLFELAAQCLAPGARLVFNAFLANGDYAPDQAAREFGQQMYTGMCTRAEMSAAAAGLPLELVADDSVYDYEKTHLPPGAWPPTSWYADWIRGLDVFTTNVESCPIEMRWLVFQRRR
Prediction	CCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEEEEHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEHCCCCCHHHHHHHHHCCEEEEEHCCHHHHHHHHHHHHHHCCCCEEEHCCCCCCCCCCCCCEEEEEEHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEHCCCHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEHCC
Conf.Score	998898888867999999999999864345568756776899999999999999877888999999999999999998746888764788766888865788899999999999999987657766677755999999999688889858998689988999999989968999889999999999999989995899878555788888988999985654568999999999999999869995999997578998888667666666544567999999999986896898666455555555787778886788776467765445678898567888887669
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MDNLPIESAESTRLAKAAMTRRFYTRSVVKGEITLPAVPSMIDEYVTMCAGLFAGVGRKFSDEELAHLRAVLQGQLAEAYAASQRSTIVISYNAPMGPTLHYQVRAQWRTVAQEYENWIATREPPLFGTEPDARVWALANEAADPTTHRVLEIGAGTGRNALALARRGHPVDVVEMTPKFADIIRSDAERDSLDVRVIMRDVFSTMDDLRQDYQLMVLSEVVPDFRTTQQLRNLFELAAQCLAPGARLVFNAFLANGDYAPDQAAREFGQQMYTGMCTRAEMSAAAAGLPLELVADDSVYDYEKTHLPPGAWPPTSWYADWIRGLDVFTTNVESCPIEMRWLVFQRRR
Prediction	875442643444310240024203430314140302201300440052025004214451356315403510353036224344223011213343445034403520440053024214535352126301410230053047365240410042132200220422050100200450053026206746170420100013124536110000000000100234720340041014014243110000003334112462134202311000011500130046130220244302412563027531233520451141230031447523140101013458
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEEEEHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEHCCCCCHHHHHHHHHCCEEEEEHCCHHHHHHHHHHHHHHCCCCEEEHCCCCCCCCCCCCCEEEEEEHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEHCCCHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEHCC
MDNLPIESAESTRLAKAAMTRRFYTRSVVKGEITLPAVPSMIDEYVTMCAGLFAGVGRKFSDEELAHLRAVLQGQLAEAYAASQRSTIVISYNAPMGPTLHYQVRAQWRTVAQEYENWIATREPPLFGTEPDARVWALANEAADPTTHRVLEIGAGTGRNALALARRGHPVDVVEMTPKFADIIRSDAERDSLDVRVIMRDVFSTMDDLRQDYQLMVLSEVVPDFRTTQQLRNLFELAAQCLAPGARLVFNAFLANGDYAPDQAAREFGQQMYTGMCTRAEMSAAAAGLPLELVADDSVYDYEKTHLPPGAWPPTSWYADWIRGLDVFTTNVESCPIEMRWLVFQRRR

4krhA

0.11

0.10

0.95

1.19

MUSTER

LSNQALDEEINDSEKLDKFITAALRSLRTDGVLIL-DLS---KALTDYFDVFRLEEGNGNVGFQFYAVNEVLDSVYVHQNWLDFIWTLKKPFPK-------VVSFRDFLDRTQYTDTGIFAYGNNFISPGGWNQNLAILKRFGPKTG-QRLDIGVGIGGGARQAASE-LQVHGVDLSTNLAVALERVHKEKDARVTYAVCDACE-YEFEPNSFDYVFSRDCIQHIKD---TDKLFSRIYRALKPGGKVLITYGVGHGTL--SESFKEYVSQRQYYLKNLEQIEEIAKKTGFIDIEVENTPRFKEILLEERERFSQNAYDGLVSGWKSKLQYIADDNHNWNFFAAVKPQ

4necA

0.16

0.10

0.64

1.39

dPPAS

---------------------------------------------------------------------------------------------------------HMTEVFDAVYRGESPFGKRPPWDIGAPQPAYVALEKAGLIQG-AVLDAGCGTGEDALHLAGLGYAVTGLDLSPTAISVARDKADARGLGAVFEVADALDL-TGWEERFDTVIDSGLAHTF-EGDRLRAYATALHRACRPGAVAHILSISDRGS----AEMQARLAEAIDEIPA---------PLPDDDPTLKRSADHLRDGFAEGWT-----IESIDESLMRGVIPTTSELLDVHAWLGRFRR

4qnuA

0.11

0.10

0.90

1.12

MUSTER

MID------------FGNFYSLIAK----------NHLSHWLETLPAQIANWQREQQHG----LFKQWSNAVEF--IKPYRLDLLHSVTAESEEPLSAGQIKRIETLMRNL-MPWRKGPFSLYGVNIDTESDWKWDRVLPHLSDLTGRTILDVGCGSGYHMWRMIGAGALAVGIDPTQLFLCQFEAVRKLLGNRAHLLPLGIEQL--PALKAFDTVFSMGVLYHRRS---PLEHLWQLKDQLVNEGELVLETLVIDGDENTVLVPGDRYAQMVYFIPSALALKNWLKKCGFVDIRIADVSVTTTEEQRRTEWMVTESLADFLDPHDPGKTVEGYPAPKRAVLIARKP-

4necA

0.17

0.11

0.66

1.87

wdPPAS

------------------------------------------------------------------------------------------------------HMTEVFDAVYRGESP--FGKRPPWDIGAPQPAYVALEKA---LIQGAVLDAGCGTGEDALHLAGLGYAVTGLDLSPTAISVARDKADARGLGAVFEVADALD-LTGWEERFDTVIDSGLAHTFE-GDRLRAYATALHRACRPGAVAHILSISDRGSAEMQARLAEAPDDDPTLKRSADHLRDGFAE-GWTIESIDESLMRGVIPTTSELLDVHAWLGRFRRDWNSSSVDKLAAALEH---------

4qnuA

0.13

0.11

0.88

1.45

wMUSTER

ID-----------------FGNFYSLIA-------NHLSHWLETLPAQIANWQREQQHG----LFKQWSNAVEF-----EIKPYRLDLLHSVTAESEEPLSAGQIKRIETLMRNLMPW-RKGPFSLYG-RSDWKWDRVLPHLSDLTGRTILDVGCGSGYHMWRMIGAGALAVGIDPTQLFLCQFEAVRKLLGNRAHLLPLGIEQL--PALKAFDTVFSMGVLYHRRS---PLEHLWQLKDQLVNEGELVLETLVIDGDENTVLVPGDRYAQMVYFIPSALALKNWLKKCGFVDIRIADVSVTTTEEQRRTEWMVTESLADFLDPHDPGKTVEGYPAPKRAVLIARKP-

4pneA

0.13

0.09

0.71

1.45

wMUSTER

----------------------------------------------------------------------------RSGIPAPTSQQVGQMY------DLVTPLLNSVAGGPCAIH-YWENDGRASWQQAADRLTDLVAERTVLDGGVRLLDVGCGTGQPALRVARDAIQITGITVSQVQVAIAADCARERGLSVDFSCVDAMSL-PYPDNAFDAAWAMQSLLEMSE---PDRAIREILRVLKPGGILGVTEVVKREAGGDRWPT-------GLRICLAEQLLESLRAAGFEILDWEDVSSR--------RYFMPQFAEELAAHQHGIACDYEKYAHDMGYAILTARK

5f8cA

0.12

0.11

0.90

1.05

MUSTER

METAAIDSAGLAILVSVGHQTGLLDTMAGLPPATSMEIERYVREWLGGMTTG-AHRAGMLTRAAGPDNLAVIAQFVSLLGEVEQK--VIRCFREGGG--VPYSEYPRFHKLMAEMSGMVFD---AALIDVVLPLVDGLPDRL--RSGADVADFGCGSGRAVKLMAQAASRFTGIDFSDEAVAAGTEEAARLGLAATFERHDLAEL--DKVGAYDVITVFDAIHDQAQ---PARVLQNIYRALRPGGVLLMVDIKASSQ-----------LEDNVGVPLSTYLYTTSLMH--------MTVSLALDGAGLGTVWGRQLATSMLAGFTDVTVAEIESDVLNNYYIARKLE

4necA

0.17

0.11

0.65

1.99

wPPAS

------------------------------------------------------------------------------------------------------HMTEVFDAVYRGESPFG--KRPPWDIGAPQPAYVALEKA---LIQGAVLDAGCGTGEDALHLAGLGYAVTGLDLSPTAISVARDKADARGLGAVFEVADALD-LTGWEERFDTVIDSGLAHTFE-GDRLRAYATALHRACRPGAVAHILSISDRGSAEMQARLAEAPDDDPTLKRSADHLRDGFAE-GWTIESIDES--LMRGVIPTTSELLDAWLGRFRRDWNSSSVDKLAAALEH---------

4necA

0.18

0.11

0.61

2.23

dPPAS2

------------------------------------------------------------------------------------------------------HMTEVFDAVYRGES--PFGKRPPWDIGAPQPAYVALEKAGLIQ--GAVLDAGCGTGEDALHLAGLGYAVTGLDLSPTAISVARDKADARGLGAVFEVADALDL-TGWEERFDTVIDSGLAHTF-EGDRLRAYATALHRACRPGAVAHILSISDRGSAEMQARLAEAPDDDPTLKRSADHLRDGFAEGWTIESIDESLM--------------------------RGVIPTTSELLDVHAWLGRFRR

4necA

0.17

0.11

0.66

1.70

PPAS

------------------------------------------------------------------------------------------------------HMTEVFDAVYRGESPFG--KRPPWDIGAPQPAYVALEKAG--LIQGAVLDAGCGTGEDALHLAGLGYAVTGLDLSPTAISVARDKADARGLGAVFEVADALDL-TGWEERFDTVIDSGLAHTFE-GDRLRAYATALHRACRPGAVAHILSISDRGSAEMQARLAEAPDDDPTLKRSADHLRDGFAE-GWTIESIDESLMRGVIPTTSELLDVHAWLGRFRRDWNSSSVDKLAAALEH---------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.70

Estimated TM-score = 0.40±0.14

Estimated RMSD = 13.0±4.2Å

Download Model 2

C-score=-3.13

Download Model 3

C-score=-3.99

Download Model 4

C-score=-4.30

Download Model 5

C-score=-4.21

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4qnuA	0.761	3.07	0.105	0.879
2	4p7cA	0.723	3.24	0.121	0.856
3	4ineA	0.625	4.34	0.096	0.779
4	4krhA	0.613	4.48	0.116	0.767
5	4iv0A	0.566	3.35	0.117	0.658
6	3uj6A	0.558	3.40	0.095	0.652
7	2o57A	0.557	3.52	0.123	0.658
8	3vc1A	0.555	3.38	0.149	0.652
9	3ha3A	0.553	3.71	0.124	0.664
10	3hemA	0.549	3.95	0.092	0.664

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.36	25	4qnuH	GEK	Rep, Mult	134,153,154,156,175,176,177,180,201,202,203,219,220,221,223,225,339
2	0.11	8	1kiaA	SAM	Rep, Mult	118,122,154,159,175,176,202,219,221,224
3	0.04	3	1kpgB	CO3	Rep, Mult	220,223,251,252,253,302,339
4	0.01	1	3e7p0	III	Rep, Mult	138,141,142,256,257,278,280,283,284,287,292,294,295,296,297,298

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.136	3lccA	0.473	3.29	0.089	0.552	2.1.1.-	154
2	0.120	3bgdA	0.491	3.40	0.089	0.578	2.1.1.67	NA
3	0.067	1xxlA	0.506	3.55	0.163	0.595	2.1.1.-	NA
4	0.067	2ex4A	0.484	3.36	0.126	0.563	2.1.1.-	229
5	0.060	1ky8A	0.499	4.98	0.050	0.675	1.2.1.9	NA
6	0.060	3fg0C	0.488	5.18	0.063	0.667	1.2.1.8	NA
7	0.060	3ifgA	0.485	5.25	0.099	0.667	1.2.1.16	NA
8	0.060	1l1eA	0.550	3.49	0.110	0.649	2.1.1.79	NA
9	0.060	2o2pA	0.497	5.25	0.064	0.681	1.5.1.6	NA
10	0.060	1uxvA	0.501	5.21	0.053	0.687	1.2.1.9	NA
11	0.060	2hg2A	0.479	5.15	0.054	0.658	1.2.1.21,1.2.1.22	NA
12	0.060	2opbB	0.485	3.55	0.106	0.578	2.1.1.28	154,156,197
13	0.060	1t90A	0.486	5.01	0.062	0.652	1.2.1.18,1.2.1.27	215
14	0.060	2fk8A	0.555	3.66	0.120	0.664	2.1.1.-	NA
15	0.060	2ve5A	0.488	4.86	0.072	0.652	1.2.1.8	NA
16	0.060	3ifh6	0.485	5.20	0.099	0.667	1.2.1.16	NA
17	0.060	2okcB	0.513	4.92	0.090	0.695	2.1.1.72	NA
18	0.060	2ve5H	0.489	4.94	0.079	0.658	1.2.1.8	154
19	0.060	2h11B	0.494	3.34	0.086	0.578	2.1.1.67	121
20	0.060	2a14A	0.491	3.56	0.130	0.581	2.1.1.49	154,156,197,202
21	0.060	1o9jA	0.483	5.24	0.076	0.661	1.2.1.3	NA
22	0.060	1kpiA	0.549	4.03	0.096	0.667	2.1.1.79	NA
23	0.060	1ej6A	0.505	4.85	0.079	0.687	2.7.7.50	154,156,178

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.26	0.761	3.07	0.10	0.88	4qnuA	GO:0002098 GO:0006400 GO:0008033 GO:0016300 GO:0016740 GO:0016765 GO:0030488
1	0.25	0.744	3.28	0.12	0.88	4p7cA	GO:0002098 GO:0006400 GO:0008033 GO:0016300 GO:0016740 GO:0016765 GO:0030488
2	0.14	0.550	3.49	0.11	0.65	1l1eA	GO:0005737 GO:0006629 GO:0008168 GO:0008610 GO:0008825 GO:0009405 GO:0016740 GO:0032259 GO:0042783 GO:0046500 GO:0052167 GO:0071768
3	0.14	0.626	4.51	0.11	0.78	4krhA	GO:0008152 GO:0008168 GO:0032259 GO:0046872 GO:0051536 GO:0051539
4	0.11	0.549	3.98	0.12	0.66	1tpyA	GO:0005618 GO:0005737 GO:0005886 GO:0006629 GO:0008168 GO:0008610 GO:0008825 GO:0016740 GO:0032259 GO:0071768
5	0.11	0.472	2.83	0.15	0.53	3e23A	GO:0008152 GO:0008168 GO:0032259 GO:0046872 GO:0051536 GO:0051539
6	0.11	0.537	3.91	0.13	0.66	3kkzA	GO:0046872 GO:0051536 GO:0051539
7	0.10	0.486	3.82	0.11	0.59	3mggB	GO:0008168 GO:0016740 GO:0032259
8	0.09	0.492	3.77	0.15	0.59	4rsrA	GO:0008168 GO:0016740 GO:0032259 GO:0046872 GO:0051536 GO:0051539
9	0.09	0.499	3.78	0.14	0.59	5je1A	GO:0008168 GO:0016740 GO:0032259
10	0.09	0.484	2.93	0.14	0.55	3d2lC	GO:0008168 GO:0016740 GO:0032259
11	0.08	0.472	3.54	0.10	0.55	3ccfB	GO:0008152 GO:0008168 GO:0016740 GO:0030798 GO:0032259
12	0.07	0.554	3.57	0.13	0.66	4pneB	GO:0008152 GO:0008168 GO:0016740 GO:0032259
13	0.07	0.550	4.10	0.12	0.67	1kpgA	GO:0005737 GO:0005886 GO:0006629 GO:0008168 GO:0008610 GO:0008825 GO:0016740 GO:0032259 GO:0046500 GO:0071768
14	0.07	0.499	4.37	0.09	0.63	1p91A	GO:0005737 GO:0006364 GO:0008168 GO:0008270 GO:0008989 GO:0016740 GO:0032259 GO:0046872 GO:0052911 GO:0070475
15	0.07	0.484	2.83	0.11	0.55	4uw0A	GO:0004672 GO:0005524 GO:0006468
16	0.07	0.476	4.34	0.14	0.61	1nkvC	GO:0005737 GO:0008757 GO:0016020 GO:0016021 GO:0032259
17	0.07	0.482	3.30	0.15	0.55	4kdcA	GO:0005829 GO:0006744 GO:0008168 GO:0008425 GO:0008689 GO:0008757 GO:0016740 GO:0032259 GO:0043431 GO:0061542 GO:0102004
18	0.07	0.484	3.76	0.13	0.59	5bp9A	GO:0008168 GO:0016740 GO:0032259

Consensus prediction of GO terms

Molecular Function	GO:0008757	GO:0016765	GO:0016300
GO-Score	0.47	0.45	0.45
Biological Processes	GO:0044038	GO:0071767	GO:0006633	GO:0071766	GO:0002098	GO:0030488
GO-Score	0.47	0.47	0.47	0.47	0.45	0.45
Cellular Component	GO:0044424
GO-Score	0.47

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
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