I-TASSER results

I-TASSER results for job id Rv2415c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (297 residues)
MRTELPAERLQRRLGAVPDIDSHAASAHLDPEPHDPTDDGPDHDEPRDDPNSLLPRWLPD
TSRGQGWADRIRADPGRAGAVALAVIAALAVLVTVFTLIRDRTEPVMSAKLPPVEPVSPT
NPRSSASPGSPDRSGLPVVVSVVGLVHTPGLVTLAPGARIADALQAAGGAVDGADTVGLN
MARQLGDGEQIVVGLAPPSGQPRVLGSSVGAGTPGPAGTSGTATTGPKTAPKTAEVLDLN
TATVEQLDALPGIGPVTAAAIVAWRQRNGRFTSVDQLADVDGIGPARLDKRRNLVRV

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRTELPAERLQRRLGAVPDIDSHAASAHLDPEPHDPTDDGPDHDEPRDDPNSLLPRWLPDTSRGQGWADRIRADPGRAGAVALAVIAALAVLVTVFTLIRDRTEPVMSAKLPPVEPVSPTNPRSSASPGSPDRSGLPVVVSVVGLVHTPGLVTLAPGARIADALQAAGGAVDGADTVGLNMARQLGDGEQIVVGLAPPSGQPRVLGSSVGAGTPGPAGTSGTATTGPKTAPKTAEVLDLNTATVEQLDALPGIGPVTAAAIVAWRQRNGRFTSVDQLADVDGIGPARLDKRRNLVRV
Prediction	CCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCEEHCCCCCCCCEEEEEEEHHHHHHEEEEEHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEHCCCCCCCEEEHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEHCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHCCCCC
Conf.Score	987655799999975556666666666555555445665555455555555566776566789987534554567767568888755665444567774899975556667788888776544556677777777668999864557887799689986999999986669987656768878767996899867887666666666677654555445565566665566667775566899999987679889999999999999899999989985999788999999787879
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRTELPAERLQRRLGAVPDIDSHAASAHLDPEPHDPTDDGPDHDEPRDDPNSLLPRWLPDTSRGQGWADRIRADPGRAGAVALAVIAALAVLVTVFTLIRDRTEPVMSAKLPPVEPVSPTNPRSSASPGSPDRSGLPVVVSVVGLVHTPGLVTLAPGARIADALQAAGGAVDGADTVGLNMARQLGDGEQIVVGLAPPSGQPRVLGSSVGAGTPGPAGTSGTATTGPKTAPKTAEVLDLNTATVEQLDALPGIGPVTAAAIVAWRQRNGRFTSVDQLADVDGIGPARLDKRRNLVRV
Prediction	755644463045216554446554665544453445455445444445544431443145544253123203132422100000000020112111001345545445553543553455455555565456554330001014106532004046611023005304531551335114103405442201022435545453444435454345445444444444454456430200303360054035025510530051057435054162047055015300440373057
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCEEHCCCCCCCCEEEEEEEHHHHHHEEEEEHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEHCCCCCCCEEEHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEHCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHCCCCC
MRTELPAERLQRRLGAVPDIDSHAASAHLDPEPHDPTDDGPDHDEPRDDPNSLLPRWLPDTSRGQGWADRIRADPGRAGAVALAVIAALAVLVTVFTLIRDRTEPVMSAKLPPVEPVSPTNPRSSASPGSPDRSGLPVVVSVVGLVHTPGLVTLAPGARIADALQAAGGAVDGADTVGLNMARQLGDGEQIVVGLAPPSGQPRVLGSSVGAGTPGPAGTSGTATTGPKTAPKTAEVLDLNTATVEQLDALPGIGPVTAAAIVAWRQRNGRFTSVDQLADVDGIGPARLDKRRNLVRV

3bzkA

0.19

0.18

0.96

2.41

MUSTER

SNQGRAADKWLAEVVR--WTWKVKLYTHLETDLFGELRDGAEDEAISVFARNLHDLLL---AAPAGPRATLGLDPGLRTGVKVAVVDATGKLLDTATVYPHAPKNQWDQTLAVLAALCAKHQVEAIGNGTASRETDKLAGELIKKYKLTKIMVSEAGASVYSASELAAKEFPELDRGAVSIARRLQDPLAELVKIEPKSIGVGQYQHDVSQLKLARSLDAVVEDCVNAVG------VDVNTASAALLARISGLNSTLAQNIVAHRDANGAFRTRDELKKVSRLGEKTFEQAAGFLRV

3bzkA3

0.18

0.08

0.46

1.45

dPPAS

----------------------------------------------------------------AGPRATLGLDPGLRTGVKVAVVDATGKLLDTATVYPHAPKNQWDQTLAVLAALCAKHQVEAIGNGTASRETDKLAGELIKKYKLTKIMVSEAGASVYSASELAAKEFPELDRGAVSIARRLQDPLAELVKIEPKSIGV-----------------------------------------------------------------------------------------------

3bzkA3

0.18

0.08

0.46

2.62

wdPPAS

----------------------------------------------------------------AGPRATLGLDPGLRTGVKVAVVDATGKLLDTATVYPHAPKNQWDQTLAVLAALCAKHQVEAIGNGTASRETDKLAGELIKKYKLTKIMVSEAGASVYSASELAAKEFPELDRGAVSIARRLQDPLAELVKIEPKSIGV-----------------------------------------------------------------------------------------------

3bzkA

0.19

0.18

0.96

2.95

wMUSTER

SNQGRAADKWLAEVVR--WTWKVKLYTHLETDLFGELRDGAEDEAISVFARNLHDLLLA---APAGPRATLGLDPGLRTGVKVAVVDATGKLLDTATVYPHAPKNQWDQTLAVLAALCAKHQVEAIGNGTASRETDKLAGELIKKYKLTKIMVSEAGASVYSASELAAKEFPELDRGAVSIARRLQDPLAELVKIEPKSIGVGQYQHDVSQLKLARSLDAVVEDCVNAVG------VDVNTASAALLARISGLNSTLAQNIVAHRDANGAFRTRDELKKVSRLGEKTFEQAAGFLRV

3bzkA3

0.18

0.08

0.46

2.60

wPPAS

----------------------------------------------------------------AGPRATLGLDPGLRTGVKVAVVDATGKLLDTATVYPHAPKNQWDQTLAVLAALCAKHQVEAIGNGTASRETDKLAGELIKKYKLTKIMVSEAGASVYSASELAAKEFPELDRGAVSIARRLQDPLAELVKIEPKSIGV-----------------------------------------------------------------------------------------------

3bzkA3

0.18

0.08

0.46

3.30

dPPAS2

----------------------------------------------------------------AGPRATLGLDPGLRTGVKVAVVDATGKLLDTATVYPHAPKNQWDQTLAVLAALCAKHQVEAIGNGTASRETDKLAGELIKKYKLTKIMVSEAGASVYSASELAAKEFPELDRGAVSIARRLQDPLAELVKIEPKSIGV-----------------------------------------------------------------------------------------------

3bzkA3

0.18

0.08

0.46

2.06

PPAS

----------------------------------------------------------------AGPRATLGLDPGLRTGVKVAVVDATGKLLDTATVYPHAPKNQWDQTLAVLAALCAKHQVEAIGNGTASRETDKLAGELIKKYKLTKIMVSEAGASVYSASELAAKEFPELDRGAVSIARRLQDPLAELVKIEPKSIGV-----------------------------------------------------------------------------------------------

3bzkA3

0.18

0.08

0.46

3.40

Env-PPAS

----------------------------------------------------------------AGPRATLGLDPGLRTGVKVAVVDATGKLLDTATVYPHAPKNQWDQTLAVLAALCAKHQVEAIGNGTASRETDKLAGELIKKYKLTKIMVSEAGASVYSASELAAKEFPELDRGAVSIARRLQDPLAELVKIEPKSIGV-----------------------------------------------------------------------------------------------

3psfA

0.10

0.09

0.98

2.05

MUSTER

NTSDIAIEWNNFRKLAFNQAMDKIF-QDISQEVKDNLTKNCQKLVAKTVRHKFMTKLDQAPFIPPKIPKILSLTCGQADAIIAVYVNRKGDFIRDYKIVDNFDKTNPEKFEDTLDNIIQSCQPNAIGINGPNPKTQKFYKRLQEVLHKPIIYVEDEVAIRYQNSERAAQEFPNKPKYCIALARYMHSPLANLTSEEVRSLSIHPHQNLLSSEQLSWALETAFVDIVNLVS------VEVNKATASALKYISGFGKRKAIDFLQSLQRLEPLLARQQLITHNILHKTIFMNSAGFLYI

3psfA2

0.10

0.98

1.15

dPPAS

HSLVNKKDYVQRFYAELHIDDPIVTEYFKNQNSLQDIYDYLEFKMVAKTVRHKFMTKLDQAIPNVRDPLSLTCGQGRFGAIIAVYVNRKGDFIRDYKIVDNPDKTNPEKFEDTLDNIIQSCQPNAIGINGPNPKTQKFYKRLQQIVDSRGIYVEDEVAIRYQNSERAAQEFPNKPKYCIALARYMHSPLANLTSEEVRSLSIHPHQNLLSSEQLSWALET------AFVDIVNLVSVEVNKATASALKYISGFGKRKAIDFLQSLQRLEPLLARQQLITHNILHKTIFMNSAGFLYI

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.10

Estimated TM-score = 0.70±0.12

Estimated RMSD = 6.4±3.9Å

Download Model 2

C-score=-2.68

Download Model 3

C-score=-1.74

Download Model 4

C-score=-3.43

Download Model 5

C-score=-4.30

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3bzkA	0.912	1.72	0.185	0.963
2	3psfA	0.697	4.26	0.083	0.906
3	2o8cB	0.430	5.07	0.038	0.623
4	3sbgA	0.427	5.62	0.052	0.653
5	3mktA	0.412	6.06	0.067	0.667
6	2xn0A	0.409	6.24	0.069	0.694
7	1ldjA	0.408	4.85	0.056	0.589
8	2j37W	0.408	6.35	0.053	0.700
9	3a24A	0.406	6.31	0.047	0.677
10	2d73A	0.406	6.23	0.060	0.673

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.11	7	2wc9A	MN	Rep, Mult	74,75,129,181
2	0.06	4	1zbhA	MG	Rep, Mult	74,76,177
3	0.06	4	3e77A	PLP	Rep, Mult	240,241
4	0.05	3	3u3yA	CA	Rep, Mult	74,177
5	0.03	2	2x1lA	ADN	Rep, Mult	255,257,258,261,291,292
6	0.03	2	1hkbA	CA	Rep, Mult	277,280,282,284
7	0.02	1	2x1lA	MET	Rep, Mult	73,98,107,110,111,114
8	0.02	1	3o72C	OXY	Rep, Mult	175,265
9	0.02	1	2x1lB	MET	Rep, Mult	73,111,114,118,138,143
10	0.02	1	2oppA	MG	Rep, Mult	160,162,240
11	0.02	1	1qhaA	MG	Rep, Mult	162,167,171
12	0.02	1	3hdjB	IMD	Rep, Mult	263,265,266
13	0.02	1	2xn1A	TRS	Rep, Mult	70,72,74,126,128,153
14	0.02	1	1gljY	MG	Rep, Mult	74,289
15	0.02	1	2o8bB	ADP	Rep, Mult	105,129,132,133,134,135,136,137,138
16	0.02	1	3o80A	ANP	Rep, Mult	258,261,262,265
17	0.02	1	1czaN	ADP	Rep, Mult	176,180,184

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2ct8B	0.384	5.72	0.044	0.596	6.1.1.10	NA
2	0.060	3l4uA	0.397	6.78	0.060	0.717	3.2.1.20,3.2.1.3	NA
3	0.060	2iirA	0.382	5.76	0.047	0.606	2.7.2.1	267
4	0.060	2g3mF	0.390	6.40	0.034	0.680	3.2.1.20	NA
5	0.060	1fohC	0.340	6.68	0.046	0.603	1.14.13.7	NA
6	0.060	2vtfA	0.379	6.33	0.056	0.657	3.2.1.96	168,187
7	0.060	1hkgA	0.394	5.46	0.031	0.586	2.7.1.1	194
8	0.060	2iirJ	0.381	5.69	0.042	0.603	2.7.2.1	240
9	0.060	1ig8A	0.403	5.32	0.053	0.596	2.7.1.1	265
10	0.060	3hm8A	0.390	5.93	0.065	0.616	2.7.1.1	NA
11	0.060	1v4tA	0.403	6.03	0.044	0.643	2.7.1.2,2.7.1.1	NA
12	0.060	2ct8A	0.391	5.83	0.045	0.606	6.1.1.10	NA
13	0.060	1pn0C	0.381	5.80	0.081	0.609	1.14.13.7	NA
14	0.060	2iz1B	0.378	6.12	0.072	0.633	1.1.1.44	NA
15	0.060	3f9mA	0.397	5.66	0.068	0.613	2.7.1.2	NA
16	0.060	1g5aA	0.377	6.02	0.045	0.593	2.4.1.4	182
17	0.060	3cf4A	0.382	6.76	0.057	0.690	1.2.99.2	NA
18	0.060	3hz3A	0.376	5.82	0.053	0.593	2.4.1.5	NA
19	0.060	3czkA	0.380	5.85	0.047	0.599	3.2.1.48	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.17	0.816	2.90	0.18	0.96	3bzcA	GO:0003676 GO:0006139
1	0.11	0.697	4.26	0.08	0.91	3psfA	GO:0000122 GO:0000414 GO:0000433 GO:0000991 GO:0001073 GO:0001178 GO:0003676 GO:0003677 GO:0005634 GO:0006139 GO:0006325 GO:0006334 GO:0006338 GO:0006351 GO:0006355 GO:0006357 GO:0016973 GO:0031440 GO:0031491 GO:0031564 GO:0032784 GO:0032968 GO:0034728 GO:0035327 GO:0042393 GO:0043618 GO:0045944 GO:0060303 GO:0070827 GO:0071931
2	0.11	0.714	4.18	0.09	0.94	3psiA	GO:0000122 GO:0000414 GO:0000433 GO:0000991 GO:0001073 GO:0001178 GO:0003676 GO:0003677 GO:0005634 GO:0006139 GO:0006325 GO:0006334 GO:0006338 GO:0006351 GO:0006355 GO:0006357 GO:0016973 GO:0031440 GO:0031491 GO:0031564 GO:0032784 GO:0032968 GO:0034728 GO:0035327 GO:0042393 GO:0043618 GO:0045944 GO:0060303 GO:0070827 GO:0071931
3	0.06	0.339	5.42	0.07	0.52	2dt8A	GO:0008289
4	0.06	0.342	5.89	0.06	0.55	3cvrA	GO:0004842 GO:0005576 GO:0009405 GO:0016567 GO:0016874 GO:0030430
5	0.06	0.318	6.10	0.04	0.53	3obwA	GO:0004518 GO:0004519 GO:0005737 GO:0016787 GO:0046872 GO:0070481 GO:0070966 GO:0071025 GO:0090305
6	0.06	0.303	6.00	0.05	0.48	1nu5A	GO:0003824 GO:0008152 GO:0009063 GO:0016853 GO:0018849 GO:0018850 GO:0019439 GO:0030145 GO:0046300 GO:0046872
7	0.06	0.277	5.89	0.04	0.44	3ckdC	GO:0004842 GO:0005576 GO:0009405 GO:0016567 GO:0016874 GO:0030430
8	0.06	0.275	6.02	0.05	0.45	3ckdB	GO:0004842 GO:0005576 GO:0009405 GO:0016567 GO:0016874 GO:0030430
9	0.06	0.285	5.89	0.04	0.46	3fwyA	GO:0000166 GO:0005524 GO:0015979 GO:0015995 GO:0016491 GO:0016636 GO:0016730 GO:0019685 GO:0030494 GO:0036070 GO:0046148 GO:0046872 GO:0051536 GO:0051539 GO:0055114
10	0.06	0.279	6.15	0.02	0.46	2ynmB	GO:0000166 GO:0005524 GO:0015979 GO:0015995 GO:0016491 GO:0016636 GO:0016730 GO:0019685 GO:0036068 GO:0046148 GO:0046872 GO:0051536 GO:0051539 GO:0055114
11	0.06	0.267	6.88	0.04	0.48	4iliA	GO:0000244 GO:0005634 GO:0005682 GO:0005737 GO:0006397 GO:0008380
12	0.06	0.300	5.88	0.04	0.47	4aimA	GO:0000175 GO:0000287 GO:0003676 GO:0003723 GO:0004654 GO:0005737 GO:0006396 GO:0006402 GO:0016740 GO:0016779 GO:0046872 GO:0090503
13	0.06	0.239	6.56	0.03	0.42	3sahB	GO:0000166 GO:0000175 GO:0000176 GO:0000178 GO:0000184 GO:0000460 GO:0000956 GO:0003676 GO:0003723 GO:0003824 GO:0004518 GO:0004527 GO:0004532 GO:0005622 GO:0005634 GO:0005654 GO:0005730 GO:0005737 GO:0006139 GO:0006364 GO:0006396 GO:0008408 GO:0009048 GO:0016020 GO:0016787 GO:0035327 GO:0044237 GO:0044822 GO:0071028 GO:0071034 GO:0071035 GO:0071044 GO:0071048 GO:0090305 GO:0090503
14	0.06	0.251	6.21	0.06	0.40	2ba0B	GO:0000178 GO:0003676 GO:0003723 GO:0005737 GO:0006401 GO:0008143
15	0.06	0.239	6.07	0.04	0.39	2wrhH	GO:0016020 GO:0016021 GO:0016032 GO:0019012 GO:0019031 GO:0019062 GO:0019064 GO:0019065 GO:0020002 GO:0033644 GO:0039654 GO:0039663 GO:0046718 GO:0046789 GO:0055036 GO:0075509 GO:0075512
16	0.06	0.235	6.95	0.04	0.43	1q8kA	GO:0002230 GO:0003676 GO:0003723 GO:0003743 GO:0005634 GO:0005737 GO:0005829 GO:0005840 GO:0005844 GO:0005850 GO:0005851 GO:0006412 GO:0006413 GO:0006417 GO:0007568 GO:0010494 GO:0016020 GO:0032057 GO:0033290 GO:0034198 GO:0034605 GO:0034644 GO:0034976 GO:0036499 GO:0043022 GO:0043558 GO:0043614 GO:0044207 GO:0044822 GO:0046777 GO:0055085 GO:0070062 GO:0097451 GO:0098779 GO:0098792 GO:1901216 GO:1990737 GO:2000676
17	0.06	0.217	5.85	0.04	0.35	2hpsA	GO:0005509 GO:0046872
18	0.06	0.262	4.79	0.05	0.37	3fncB	GO:0008080

Consensus prediction of GO terms

Molecular Function	GO:0003682	GO:0003700	GO:0032403	GO:0000990	GO:0003676
GO-Score	0.42	0.42	0.42	0.42	0.34
Biological Processes	GO:0045014	GO:0032786	GO:0065008	GO:0031497	GO:0065004	GO:0000437	GO:0050684	GO:0031124	GO:0010452	GO:0000430	GO:0043620	GO:0045944	GO:0043954	GO:0001174	GO:0034243	GO:0034728	GO:0031060	GO:0000083	GO:0060260	GO:0006406	GO:0031555
GO-Score	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42
Cellular Component	GO:0000785	GO:0043231
GO-Score	0.42	0.42

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.