I-TASSER results

I-TASSER results for job id Rv2413c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (316 residues)
MHLVLGDEELLVERAVADVLRSARQRAGTADVPVSRMRAGDVGAYELAELLSPSLFAEER
IVVLGAAAEAGKDAAAVIESAAADLPAGTVLVVVHSGGGRAKSLANQLRSMGAQVHPCAR
ITKVSERADFIRSEFASLRVKVDDETVTALLDAVGSDVRELASACSQLVADTGGAVDAAA
VRRYHSGKAEVRGFDIADKAVAGDVAGAAEALRWAMMRGEPLVVLADALAEAVHTIGRVG
PQSGDPYRLAAQLGMPPWRVQKAQKQARRWSRDTVATAMRLVAELNANVKGAVADADYAL
ESAVRQVAELVADRGR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MHLVLGDEELLVERAVADVLRSARQRAGTADVPVSRMRAGDVGAYELAELLSPSLFAEERIVVLGAAAEAGKDAAAVIESAAADLPAGTVLVVVHSGGGRAKSLANQLRSMGAQVHPCARITKVSERADFIRSEFASLRVKVDDETVTALLDAVGSDVRELASACSQLVADTGGAVDAAAVRRYHSGKAEVRGFDIADKAVAGDVAGAAEALRWAMMRGEPLVVLADALAEAVHTIGRVGPQSGDPYRLAAQLGMPPWRVQKAQKQARRWSRDTVATAMRLVAELNANVKGAVADADYALESAVRQVAELVADRGR
Prediction	CEEEHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHCCCCCHHHHHHHHCCCCCCCCEEEEEHCCCCCCHHHHHHHHHHHHCCCCCEEEEEHCCCCCCCHHHHHHHHHHCCEEEEHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCC
Conf.Score	7999959899999999999999986678888569999878899999999985898888769999577789979999999999869998799999599875557999999989889986688999999999999999999999999999999998977999999999999889998899999999666655678999999998999999999999999899879999999999999999999899999999998999899999999998799999999999999999999768899999999999999999876589
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MHLVLGDEELLVERAVADVLRSARQRAGTADVPVSRMRAGDVGAYELAELLSPSLFAEERIVVLGAAAEAGKDAAAVIESAAADLPAGTVLVVVHSGGGRAKSLANQLRSMGAQVHPCARITKVSERADFIRSEFASLRVKVDDETVTALLDAVGSDVRELASACSQLVADTGGAVDAAAVRRYHSGKAEVRGFDIADKAVAGDVAGAAEALRWAMMRGEPLVVLADALAEAVHTIGRVGPQSGDPYRLAAQLGMPPWRVQKAQKQARRWSRDTVATAMRLVAELNANVKGAVADADYALESAVRQVAELVADRGR
Prediction	3400015243014400540164037666244122130314523341031003324425410100340751456005301600760374212030266655244004104624220120141452630151035105737151335003100420442043024003301023755022610361044333320030020015441630140044027553400300210041023002024454434400540714442043025104504272024005202500230243333120000200120042157668
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CEEEHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHCCCCCHHHHHHHHCCCCCCCCEEEEEHCCCCCCHHHHHHHHHHHHCCCCCEEEEEHCCCCCCCHHHHHHHHHHCCEEEEHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCC
MHLVLGDEELLVERAVADVLRSARQRAGTADVPVSRMRAGDVGAYELAELLSPSLFAEERIVVLGAAAEAGKDAAAVIESAAADLPAGTVLVVVHSGGGRAKSLANQLRSMGAQVHPCARITKVSERADFIRSEFASLRVKVDDETVTALLDAVGSDVRELASACSQLVADTGGAVDAAAVRRYHSGKAEVRGFDIADKAVAGDVAGAAEALRWAMMRGEPLVVLADALAEAVHTIGRVGPQSGDPYRLAAQLGMPPWRVQKAQKQARRWSRDTVATAMRLVAELNANVKGAVADADYALESAVRQVAELVADRGR

3zh9B

0.17

0.16

0.97

2.43

MUSTER

VYCLYGKETYLLQETVSRIRQTVV-DQETKDFNLSVFDLEEDPDQAIADAETFPFMGERRLVIVKNPKEKIEHNVSALESYIQSPAPYTVFVLLAEKLDERKKLTKALKKHA--FMMEAKELNAKETTDFTVNLAKTEQKTIGTEAAEHLVLLVNGHLSSIFQEIQKLCTFIGEEITLDDVKMLVARSLEQNIFELINKIVNRKRTESLQIFYDLLKQNEEPIKIMALISNQFRLILQTKYFAYGQKQIASNLKVHPFRVKLAMDQARLFSEEELRLIIEQLAVMDYEMKTGKKDKQLLLELFLLQLLKR------

3zh9B

0.17

0.16

0.97

3.09

dPPAS

VYCLYGKETYLLQETVSRIRQTVV-DQETKDFNLSVFDLEEDPDQAIADAETFPFMGERRLVIVKNPKEKIEHNVSALESYIQSPAPYTVFVLLAPKLDERKKLTKALKKHA--FMMEAKELNAKETTDFTVNLAKTEQKTIGTEAAEHLVLLVNGHLSSIFQEIQKLCTFIGDRITLDDVKMLVARSLEQNIFELINKIVNRKRTESLQIFYDLLKQNEEPIKIMALISNQFRLILQTKYFAYGQKQIASNLKVHPFRVKLAMDQARLFSEEELRLIIEQLAVMDYEMKTGKKDKQLLLELFLLQLLKR------

3zh9B

0.17

0.16

0.97

3.69

wdPPAS

VYCLYGKETYLLQETVSRIRQTVV-DQETKDFNLSVFDLEEDPDQAIADAETFPFMGERRLVIVKNPKEKIEHNVSALESYIQSPAPYTVFVLLAPKLDERKKLTKALKKHA--FMMEAKELNAKETTDFTVNLAKTEQKTIGTEAAEHLVLLVNGHLSSIFQEIQKLCTFIGDRITLDDVKMLVARSLEQNIFELINKIVNRKRTESLQIFYDLLKQNEEPIKIMALISNQFRLILQTKYF-YGQKQIASNLKVHPFRVKLAMDQARLFSEEELRLIIEQLAVMDYEMKTGKKDKQLLLELFLLQLLKR------

3zh9B

0.17

0.16

0.97

3.18

wMUSTER

VYCLYGKETYLLQETVSRIRQTVV-DQETKDFNLSVFDLEEDPDQAIADAETFPFMGERRLVIVKNPKEKIEHNVSALESYIQSPAPYTVFVLLAEKLDERKKLTKALKKHA--FMMEAKELNAKETTDFTVNLAKTEQKTIGTEAAEHLVLLVNGHLSSIFQEIQKLCTFIREEITLDDVKMLVARSLEQNIFELINKIVNRKRTESLQIFYDLLKQNEEPIKIMALISNQFRLILQTKYFAYGQKQIASNLKVHPFRVKLAMDQARLFSEEELRLIIEQLAVMDYEMKTGKKDKQLLLELFLLQLLKR------

3zh9B

0.16

0.97

3.96

wPPAS

VYCLYGKETYLLQETVSRIRQTVV-DQETKDFNLSVFDLEEDPDQAIADAETFPFMGERRLVIVKNPYFLTEHNVSALESYIQSPAPYTVFVLLAPKLDERKKLTKALKKHA--FMMEAKELNAKETTDFTVNLAKTEQKTIGTEAAEHLVLLVNGHLSSIFQEIQKLCTFIREEITLDDVKMLVARSLEQNIFELINKIVNRKRTESLQIFYDLLKQNEEPIKIMALISNQFRLILQTKYF-YGQKQIASNLKVHPFRVKLAMDQARLFSEEELRLIIEQLAVMDYEMKTGKKDKQLLLELFLLQLLKR------

3zh9B

0.17

0.16

0.97

9.07

dPPAS2

VYCLYGKETYLLQETVSRIRQTVV-DQETKDFNLSVFDLEEDPDQAIADAETFPFMGERRLVIVKNPKEKIEHNVSALESYIQSPAPYTVFVLLAPKLDERKKLTKALKKHA--FMMEAKELNAKETTDFTVNLAKTEQKTIGTEAAEHLVLLVNGHLSSIFQEIQKLCTFIGDRITLDDVKMLVARSLEQNIFELINKIVNRKRTESLQIFYDLLKQNEEPIKIMALISNQFRLILQTKYFAYGQKQIASNLKVHPFRVKLAMDQARLFSEEELRLIIEQLAVMDYEMKTGKKDKQLLLELFLLQLLKR------

3zh9B

0.17

0.16

0.97

3.50

PPAS

VYCLYGKETYLLQETVSRIRQTVV-DQETKDFNLSVFDLEEDPDQAIADAETFPFMGERRLVIVKNPKEKIEHNVSALESYIQSPAPYTVFVLLAPKLDERKKLTKALKKHA--FMMEAKELNAKETTDFTVNLAKTEQKTIGTEAAEHLVLLVNGHLSSIFQEIQKLCTFDREEITLDDVKMLVARSLEQNIFELINKIVNRKRTESLQIFYDLLKQNEEPIKIMALISNQFRLILQTKYFAYGQKQIASNLKVHPFRVKLAMDQARLFSEEELRLIIEQLAVMDYEMKTGKKDKQLLLELFLLQLLKR------

3zh9B

0.17

0.16

0.97

5.49

Env-PPAS

VYCLYGKETYLLQETVSRIRQTVV-DQETKDFNLSVFDLEEDPDQAIADAETFPFMGERRLVIVKNPKEKIEHNVSALESYIQSPAPYTVFVLLAEKLDERKKLTKALKKHA--FMMEAKELNAKETTDFTVNLAKTEQKTIGTEAAEHLVLLVNGHLSSIFQEIQKLCTFIREEITLDDVKMLVARSLEQNIFELINKIVNRKRTESLQIFYDLLKQNEEPIKIMALISNQFRLILQTKYFAYGQKQIASNLKVHPFRVKLAMDQARLFSEEELRLIIEQLAVMDYEMKTGKKDKQLLLELFLLQLLKR------

1xxhA

0.16

0.96

2.14

MUSTER

AYLLLGNDPLLLQESQDAVRQVAAA-QGFEEHHTFSID-PNTDWNAIFSLCQASLFASRQTLLLLLPENPNAAINEQLLTLTGLLHDDLLLIVRGNKLSKAAAWFTALANRS--VQVTCQTPEQAQLPRWVAARAKQLNLELDDAANQVLCYCYEGNLLALAQALERLSLLWPGKLTLPRVEQAVNDAAHFTPFHWVDALLG-KSKRALHILQQLRLEGSEPVILLRTLQRELLLLVNLKRQHTPLRALFDKHRVWQNR--RGGEALNRLSQTQLRQAVQLLTRTELTLKQDYQSVWAELEGLSLLLC------HK

1xxhA

0.15

0.97

2.66

dPPAS

AYLLLGNDPLLLQESQDAVRQVAAAQGFEE--HHTFSIDPNTDWNAIFSLCQASLFASRQTLLLLLPENPNAAINEQLLTLTGLLHDDLLLIVRGNKLSENAAWFTALANRS--VQVTCQTPEQAQLPRWVAARAKQLNLELDDAANQVLCYCYEGNLLALAQALERLSLLWPDGLTLPRVEQAVNDAAHFTPFHWVDALLG-KSKRALHILQQLRLEGSEPVILLRTLQRELLLLVNLKRQHTPLRALFDKHRVWQNRR--GGEALNRLSQTQLRQAVQLLTRTELTLKQDYGSVWAELEGLSLLLCHKPLAD--

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 2 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.51

Estimated TM-score = 0.92±0.06

Estimated RMSD = 3.3±2.3Å

Download Model 2

C-score=-3.42

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3zh9B	0.951	0.99	0.166	0.972
2	1xxhA	0.655	4.51	0.122	0.896
3	3glgG	0.611	5.02	0.113	0.861
4	1iqpA	0.539	5.21	0.095	0.797
5	3u5zB	0.492	5.68	0.086	0.763
6	2chvA	0.484	5.92	0.107	0.775
7	3cmuA	0.479	5.53	0.092	0.712
8	4xwhA	0.477	6.18	0.081	0.772
9	3qmzA	0.472	5.89	0.048	0.728
10	1sxjB	0.472	5.85	0.069	0.744

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.19	5	3glfA	NUC	Rep, Mult	190,223,224,227,231,259,290
2	0.12	3	3gliF	NUC	Rep, Mult	190,221,223,224,227,231,290
3	0.08	3	4dlsA	CA	Rep, Mult	238,239
4	0.06	2	4xk8L	CLA	Rep, Mult	281,310
5	0.03	1	1jql1	III	Rep, Mult	34,35,47,48,51,52,53,54,55,56
6	0.03	1	3gliI	III	Rep, Mult	272,273,276,277,280,314
7	0.03	1	2vs0B	ZN	Rep, Mult	227,286
8	0.03	1	3gliC	III	Rep, Mult	241,242,244,273,276,280,281,284
9	0.03	1	5c65A	37X	Rep, Mult	225,281

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1bxrA	0.415	6.68	0.050	0.722	6.3.5.5	131
2	0.060	2bf4A	0.416	6.44	0.054	0.706	1.6.2.4	NA
3	0.060	2qr5A	0.385	7.06	0.053	0.709	3.4.19.1	NA
4	0.060	2vr5A	0.452	6.14	0.035	0.715	3.2.1.-	NA
5	0.060	1u22A	0.433	6.30	0.043	0.718	2.1.1.14	NA
6	0.060	1uaaA	0.409	5.96	0.090	0.652	3.6.4.12	NA
7	0.060	1rtkA	0.320	6.99	0.045	0.573	3.4.21.47	NA
8	0.060	1ixsB	0.445	5.59	0.089	0.677	3.6.4.12	NA
9	0.060	1xxiA	0.651	4.57	0.108	0.899	2.7.7.7	11,168
10	0.060	1t7lA	0.431	6.34	0.044	0.709	2.1.1.14	126
11	0.060	3fvyA	0.419	6.36	0.082	0.699	3.4.14.4	NA
12	0.060	1in5A	0.454	5.42	0.105	0.677	3.6.4.12	NA
13	0.060	2pdaA	0.425	6.23	0.080	0.699	1.2.7.1	NA
14	0.060	2wanA	0.430	6.50	0.052	0.731	3.2.1.41	NA
15	0.060	1a5tA	0.445	4.43	0.081	0.573	2.7.7.7	134,167
16	0.060	1m7xB	0.411	6.16	0.023	0.671	2.4.1.18	NA
17	0.060	2e8yA	0.430	6.49	0.074	0.718	3.2.1.41	159
18	0.060	3bq5A	0.416	6.52	0.032	0.699	2.1.1.14	126
19	0.060	3glfG	0.607	5.07	0.110	0.864	2.7.7.7	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.40	0.951	0.99	0.17	0.97	3zh9B	GO:0003677 GO:0003887 GO:0006260 GO:0009360 GO:0071897
1	0.27	0.710	3.88	0.13	0.91	1jr3D	GO:0003677 GO:0003887 GO:0006260 GO:0006261 GO:0009360 GO:0016740 GO:0016779 GO:0071897
2	0.17	0.607	5.07	0.11	0.86	3glfG	GO:0000166 GO:0003677 GO:0003689 GO:0003887 GO:0005524 GO:0005663 GO:0006260 GO:0006261 GO:0009360 GO:0016740 GO:0016779 GO:0016887 GO:0017111 GO:0030337 GO:0042802 GO:0043846 GO:0071897
3	0.07	0.539	5.21	0.10	0.80	1iqpA	GO:0000166 GO:0003677 GO:0004519 GO:0005524 GO:0006260 GO:0006281 GO:0006310 GO:0009378 GO:0016539 GO:0032508 GO:0090305
4	0.07	0.488	5.04	0.11	0.72	2chqA	GO:0000166 GO:0003677 GO:0003689 GO:0005524 GO:0005663 GO:0006260
5	0.07	0.492	5.68	0.09	0.76	3u5zB	GO:0000166 GO:0003677 GO:0005524 GO:0006260 GO:0039686
6	0.07	0.472	5.85	0.07	0.74	1sxjB	GO:0000166 GO:0003677 GO:0003689 GO:0005524 GO:0005634 GO:0005663 GO:0005829 GO:0006260 GO:0006272 GO:0006298 GO:0007049 GO:0007062 GO:0031389 GO:0031390 GO:0031391
7	0.07	0.468	5.91	0.08	0.75	1sxjC	GO:0000166 GO:0003677 GO:0003689 GO:0005524 GO:0005634 GO:0005663 GO:0005829 GO:0006260 GO:0006272 GO:0006298 GO:0007049 GO:0007062 GO:0016887 GO:0031389 GO:0031390 GO:0031391
8	0.07	0.457	4.57	0.09	0.62	3pfiA	GO:0000166 GO:0003677 GO:0004386 GO:0005524 GO:0006281 GO:0006310 GO:0006974 GO:0009378 GO:0009432 GO:0016787 GO:0032508
9	0.07	0.445	5.59	0.09	0.68	1ixsB	GO:0000166 GO:0003677 GO:0004386 GO:0005524 GO:0006281 GO:0006310 GO:0006974 GO:0009378 GO:0009432 GO:0016787 GO:0032508
10	0.07	0.454	5.42	0.10	0.68	1in5A	GO:0000166 GO:0003677 GO:0004386 GO:0005524 GO:0006281 GO:0006310 GO:0006974 GO:0009378 GO:0009432 GO:0016787 GO:0032508
11	0.07	0.460	5.43	0.09	0.69	2gnoA	GO:0003677 GO:0003689 GO:0005663 GO:0006260 GO:0006261
12	0.07	0.438	6.52	0.11	0.74	1sxjD	GO:0000076 GO:0000166 GO:0003677 GO:0003689 GO:0005524 GO:0005634 GO:0005663 GO:0006260 GO:0006272 GO:0006298 GO:0007049 GO:0007062 GO:0017076 GO:0031389 GO:0031390 GO:0031391
13	0.07	0.431	6.04	0.06	0.70	1ksfX	GO:0000166 GO:0004176 GO:0005524 GO:0005829 GO:0006508 GO:0006979 GO:0016887 GO:0019538 GO:0043335
14	0.06	0.428	6.06	0.10	0.68	4d2qA	GO:0000166 GO:0005524 GO:0005737 GO:0005829 GO:0006986 GO:0009408 GO:0016020 GO:0016485 GO:0019538 GO:0042623 GO:0042802
15	0.06	0.429	5.42	0.07	0.64	1sxjE	GO:0000166 GO:0003677 GO:0003689 GO:0005524 GO:0005634 GO:0005663 GO:0006260 GO:0006272 GO:0007049 GO:0007062 GO:0031389 GO:0031390 GO:0031391
16	0.06	0.437	4.30	0.07	0.56	3glfE	GO:0003677 GO:0003689 GO:0003887 GO:0005663 GO:0006260 GO:0006261 GO:0008408 GO:0009360 GO:0016740 GO:0016779 GO:0071897 GO:0090305
17	0.06	0.350	5.85	0.08	0.53	3uk6F	GO:0000166 GO:0000812 GO:0000979 GO:0000980 GO:0001094 GO:0003678 GO:0004003 GO:0004386 GO:0005524 GO:0005622 GO:0005634 GO:0005654 GO:0005719 GO:0005737 GO:0006281 GO:0006310 GO:0006338 GO:0006351 GO:0006355 GO:0006457 GO:0006974 GO:0016020 GO:0016363 GO:0016568 GO:0016787 GO:0016887 GO:0030529 GO:0031011 GO:0031490 GO:0032508 GO:0034644 GO:0035066 GO:0035267 GO:0040008 GO:0042802 GO:0042803 GO:0043141 GO:0043531 GO:0043967 GO:0043968 GO:0045944 GO:0051082 GO:0051117 GO:0070062 GO:0071169 GO:0071339 GO:0071392 GO:0071733 GO:0071899 GO:0097255 GO:1904874
18	0.06	0.346	5.80	0.06	0.53	3uk6G	GO:0000166 GO:0000812 GO:0000979 GO:0000980 GO:0001094 GO:0003678 GO:0004003 GO:0004386 GO:0005524 GO:0005622 GO:0005634 GO:0005654 GO:0005719 GO:0005737 GO:0006281 GO:0006310 GO:0006338 GO:0006351 GO:0006355 GO:0006457 GO:0006974 GO:0016020 GO:0016363 GO:0016568 GO:0016787 GO:0016887 GO:0030529 GO:0031011 GO:0031490 GO:0032508 GO:0034644 GO:0035066 GO:0035267 GO:0040008 GO:0042802 GO:0042803 GO:0043141 GO:0043531 GO:0043967 GO:0043968 GO:0045944 GO:0051082 GO:0051117 GO:0070062 GO:0071169 GO:0071339 GO:0071392 GO:0071733 GO:0071899 GO:0097255 GO:1904874

Consensus prediction of GO terms

Molecular Function	GO:0003677	GO:0003887	GO:0032559	GO:0035639	GO:0032550	GO:0033170	GO:0005515	GO:0030234
GO-Score	0.68	0.64	0.55	0.55	0.55	0.45	0.34	0.34
Biological Processes	GO:0071897	GO:0006261
GO-Score	0.64	0.40
Cellular Component	GO:0009360	GO:0005657
GO-Score	0.64	0.45

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.