I-TASSER results

I-TASSER results for job id Rv2410c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (325 residues)
MLARNAEALYWIGRYVERADDTARILDVAVHQLLEDSSVDPDQASRLLLRVLGIEPPDHE
LDVWSLTDLVAFSTNSQGGSSIVDAISAARENAKSAREVTSSETWECLNTTYNALPERER
AAKRLGPHEFLSFIEGRAAMFAGLADSTLLRDDGYRFMLLGRAIERVDMTVRLLLSRVGD
SASSPAWVTLLRSAGAHDTYLRTYRGVLDAGRVVEFMMLDRLFPRSVFHSLKLAEHNLAE
LMHNPHSRIGATTEAQRLLGQARSELEFVQPGVLLETLESRLAGLQTTCRDVGDALALQY
FHAAPWVAWSDAGQRGQLVGSQEES

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MLARNAEALYWIGRYVERADDTARILDVAVHQLLEDSSVDPDQASRLLLRVLGIEPPDHELDVWSLTDLVAFSTNSQGGSSIVDAISAARENAKSAREVTSSETWECLNTTYNALPERERAAKRLGPHEFLSFIEGRAAMFAGLADSTLLRDDGYRFMLLGRAIERVDMTVRLLLSRVGDSASSPAWVTLLRSAGAHDTYLRTYRGVLDAGRVVEFMMLDRLFPRSVFHSLKLAEHNLAELMHNPHSRIGATTEAQRLLGQARSELEFVQPGVLLETLESRLAGLQTTCRDVGDALALQYFHAAPWVAWSDAGQRGQLVGSQEES
Prediction	CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	8657899999999999999999999999999985788887558999999998988765555778899999999699998589999999999999998758889999999999999986567775569999999999999999999854666589999999889999999999999885888888999999999979999999977889999999999848999778999999999999985578777777666999999999999987999999999999999999999999999999984788877777654444444555679
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MLARNAEALYWIGRYVERADDTARILDVAVHQLLEDSSVDPDQASRLLLRVLGIEPPDHELDVWSLTDLVAFSTNSQGGSSIVDAISAARENAKSAREVTSSETWECLNTTYNALPERERAAKRLGPHEFLSFIEGRAAMFAGLADSTLLRDDGYRFMLLGRAIERVDMTVRLLLSRVGDSASSPAWVTLLRSAGAHDTYLRTYRGVLDAGRVVEFMMLDRLFPRSVFHSLKLAEHNLAELMHNPHSRIGATTEAQRLLGQARSELEFVQPGVLLETLESRLAGLQTTCRDVGDALALQYFHAAPWVAWSDAGQRGQLVGSQEES
Prediction	7313304000000100220320000010012101334554334003000200223333552544213201100214721100220041014002101530244003002301420452454444530240043014001101100331031410120030021001002001002032455143410210030120220012213450414200100012560000001004202610550273445544334402300440242044142540262025004300520350042006320424453544544444544456568
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
MLARNAEALYWIGRYVERADDTARILDVAVHQLLEDSSVDPDQASRLLLRVLGIEPPDHELDVWSLTDLVAFSTNSQGGSSIVDAISAARENAKSAREVTSSETWECLNTTYNALPERERAAKRLGPHEFLSFIEGRAAMFAGLADSTLLRDDGYRFMLLGRAIERVDMTVRLLLSRVGDSASSPAWVTLLRSAGAHDTYLRTYRGVLDAGRVVEFMMLDRLFPRSVFHSLKLAEHNLAELMHNPHSRIGATTEAQRLLGQARSELEFVQPGVLLETLESRLAGLQTTCRDVGDALALQYFHAAPWVAWSDAGQRGQLVGSQEES

5cwoA

0.12

0.08

0.67

1.50

dPPAS2

----------------------------------PELEEWIRRAKEVAKEVEKVAQRAEEEGNPDLRDSAKELR-----RAVEEAIEEAKKQGNPELVEWVARAAKVAAEVIKVAIQAEKEGNRDLFRAALELVRAVIEAIEEAVKQG------------------NPELVEWVARAAKVAAEVIKVAIQAEKEGNRDLFRAALELVRAVIEAIEEAVKQGN---------PELVERVARLA----------KKAAELIKRAIRAEKEGNRDERREALERVREVIERIEELVRQG------------------------------

5cwmA

0.10

0.07

0.69

1.47

dPPAS2

-------------------------------------------------------------DPEDELKRVEKLV-----KEAEELLRQAKEKGEEDLEKALRTAEEAAREAKKVLEQAEKEGDPEVALRAVELVVRVAELLLRIAKESGSEEALERALRVAEEAARLAKRVLELAEKQGDPEVALRAVELVVRVAELLLRIAKESGS---EEALERALR-----VAEEAARLAKRVLELAEKQGDPEVARRAVELVKRVAELLERIARESGSEEAKERAERVREEARELQERVKELRER--------------------------

5j1iA

0.11

0.94

0.78

MUSTER

--SRCQRCISELKDIRLQLEACETRTVHRLRL--PLDKEPARECAQRIAEQQKAQAEVEGLGARLSAEAEKVLALSPAAPTLRSELELTLGKLEQVRSLSAQGAEEVLRAHEEQLKEAQAVPATASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHEVERWRERVAQLLERWQAVLADVRQRELEQLGRQLRYYRESADPLGAQDARRRQEQIQAMDSQAVREQLRQEQALLEEIE----RHGEKVEECQRFAKQYINAIKDYQLVTYKAQLESGSESVIQEYVDLRTHYSELT------------TLTSQYIKFISET

5cwmA

0.10

0.07

0.69

0.88

dPPAS

-------------------------------------------------------------DPEDELKRVEKLV-----KEAEELLRQAKEKGEEDLEKALRTAEEAAREAKKVLEQAEKEGDPEVALRAVELVVRVAELLLRIAKESGSEEALERALRVAEEAARLAKRVLELAEKQGDPEVALRAVELVVRVAELLLRIAKESGS---EEALERALR-----VAEEAARLAKRVLELAEKQGDPEVARRAVELVKRVAELLERIARESGSEEAKERAERVREEARELQERVKELRER--------------------------

5j1iA

0.09

0.08

0.88

0.78

wdPPAS

--SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPRECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALSPAAPTLRSELELTLGKLEQVRSLSAQGAEEVLRAHEEQLKEAQAVPATEAQQPTFDALRDELRGAQEVGERL-HGERDVEVERWRERVAQLLERWQAVLAQT-----DVRQRELEQLGRQLRYYRESADPAMDSQAVREQLRQ-----QALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEKVQVIQEYVDLRTHYSELTTLTSQYIKFISET--------------------------

5j1iA

0.14

0.13

0.92

0.80

wMUSTER

--SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKE--PARECAQRIAEQQKAQAEVEGLGARLSAEAEKVLALSPAAPTLRSELELTLGKLEQVRSLSAQGAEEVLRAHEEQLKEAQAVPATASLKKLRAQAEAQQPTFDALRDEL-AQEVGERLQQRHGEVERWRERVAQLLERWQAVLADVRQRELEQLGRQLRYYRESADP--DARRRQEQIQAMDS--QAVREQLRQEQALLEEIE----RHGEKVEECQRFAKQYINAIKDYQLVTYKAQLESGSESVIQEYVDLRTHYSELT------------TLTSQYIKFISET

5i1uA

0.11

0.10

0.85

0.73

wPPAS

M----SDSLEF--RHQTEAADRHLEWLQRHRELAAVVSGSTGWDITELASLVYPESSAEDLALAADLMGFYFLFDGRRPEQVALICERLSAIAHGTLTAVTSPSERAFADLWRRITL---GMTDRWRARAACNWEYYFACHPAEAAGRPP--DREGYLTLRRGTAAMESIFDMIERLGHFEVHHPLFRQLRQLAADIPSFTNDVRSFAQEANLVMIVRRDRCC--STAEACAVVWDEAQRMA----------DRFCDLRDQLPDACRSMSLPAQRLAAERYADGMALWLAGYLHWESHT--------------------------

5cwjA

0.16

0.07

0.42

1.47

dPPAS2

SLRQAIEDVAQLAKKSQDSEVLEEAIRVILRIAKESGSEEALRQAIRAVAEIAKEAQDSEVLEEAIRVILRIAKESGSEEALRQAIRAVAEIAKEAQDP--RVLEEAIRVIRQIAEESGSEEARRQAERAEEEIRRRAQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

5cwmA

0.14

0.10

0.69

0.86

PPAS

-------------------------------------------------------------DPEDELKRVEKLV-----KEAEELLRQAKEKGEEDLEKALRTAEEAAREAKKVLEQAEKEGDPEVALRAVELVVRVAELLLRIAKESGSEEALERALRVAEEAARLAKRVLELAEKQGDPEVALRAVELVVRVAELLLRIAKESGS-------EEALERAL--RVAEEAARLAKRVLELAEKQGDPE--VARRAVELVKRVAELLERIARESGSEEAKERAERVREEARELQERVKELRER-----------------------

4e0tA

0.11

0.10

0.98

0.72

Env-PPAS

HVAPMLAKMLVDGKYIHQQYEYLCLFAQLVAPVLGPYPSPGRDVYRCTLGGNMTVELSQNFQRSGSTPVRYQASVGHDRFNRTSVNAFFSQLQLLVKS-VNIELHHLLSEHLTLTAKDERNLNEEQLTKYLTNFQVKTQYVVAL---DLRKTGEY-FFPGIKCAATGQTGSNACFGAIRAVDKDGHLDSLCQLIEAHFQQSKIDDPLVTLARAEEHWTLGRLTDEDAAVGLEIIRGLWSELGIIQGPLEPSAMMEKGLLPEMKAGLTGIPETKIARIMTAFFQRHMPEQAEVFMENLQAYYEGKNLEEATRYQAWLSFAYTKEKG

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.96

Estimated TM-score = 0.38±0.13

Estimated RMSD = 13.5±4.0Å

Download Model 2

C-score=-3.78

Download Model 3

C-score=-4.00

Download Model 4

C-score=-3.72

Download Model 5

C-score=-4.54

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4okmA	0.769	3.10	0.091	0.908
2	3kb9A	0.732	3.79	0.081	0.895
3	5i1uA	0.725	3.27	0.107	0.859
4	1hm7B	0.722	3.19	0.118	0.852
5	3v1vA	0.714	3.46	0.074	0.862
6	5a0iA	0.711	2.92	0.092	0.828
7	5dw7A	0.707	3.40	0.082	0.852
8	4zq8A	0.706	3.49	0.075	0.852
9	4mc0A	0.698	3.24	0.105	0.831
10	2oa6D	0.694	3.60	0.076	0.849

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.22	11	1yyuA	RAZ	Rep, Mult	45,48,68,71,72,161,166,199,292,295
2	0.04	2	2ongB	MN	Rep, Mult	166,194,198
3	0.04	2	4ea0A	MG	Rep, Mult	14,17,21
4	0.02	1	1dxoA	DQN	Rep, Mult	105,143
5	0.02	1	1iw7P	MG	Rep, Mult	227,231
6	0.02	1	3b6aD	ZCT	Rep, Mult	164,165
7	0.02	1	2a01B	AC9	Rep, Mult	274,275,278
8	0.02	1	2q9yB	MG	Rep, Mult	75,209,300
9	0.02	1	4ecgA	CA	Rep, Mult	58,60
10	0.02	1	4f6xA	MG	Rep, Mult	97,157
11	0.02	1	3hykB	A3P	Rep, Mult	4,18
12	0.02	1	3bnxD	POP	Rep, Mult	199,207,299,300
13	0.02	1	4f8bB	MG	Rep, Mult	20,24

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.118	1hm7A	0.684	3.26	0.113	0.809	4.2.3.7,4.6.1.5	302
2	0.109	2oa6D	0.694	3.60	0.076	0.849	4.2.3.9	NA
3	0.104	1di1A	0.650	3.96	0.066	0.831	4.2.3.9	16
4	0.067	1kizA	0.665	4.08	0.063	0.849	4.2.3.6	NA
5	0.067	2azjA	0.566	4.11	0.039	0.732	2.5.1.1	NA
6	0.067	2azkA	0.565	4.14	0.039	0.735	2.5.1.1,2.5.1.29,2.5.1.10	NA
7	0.067	1rqiA	0.573	4.18	0.101	0.745	2.5.1.10	NA
8	0.066	3npkA	0.525	4.03	0.064	0.677	2.5.1.10	209,212,299
9	0.066	2j1pB	0.537	4.34	0.081	0.714	2.5.1.1,2.5.1.10,2.5.1.29	NA
10	0.060	1mhyD	0.435	6.59	0.043	0.739	1.14.13.25	NA
11	0.060	2h8oA	0.560	4.11	0.088	0.726	2.5.1.10	NA
12	0.060	1ezfB	0.560	4.58	0.091	0.763	2.5.1.21	167,195,205
13	0.060	2f8zF	0.597	3.94	0.073	0.754	2.5.1.10,2.5.1.1	NA
14	0.060	1wmwA	0.580	4.20	0.099	0.757	2.5.1.-	NA
15	0.060	3ckeD	0.656	4.00	0.081	0.834	4.2.3.9	NA
16	0.060	3lk5A	0.569	4.23	0.086	0.745	2.5.1.1	33,66,82,84,108,136
17	0.060	3kb9A	0.732	3.79	0.081	0.895	4.2.3.37	72
18	0.060	1hm7B	0.722	3.19	0.118	0.852	4.2.3.7,4.6.1.5	NA
19	0.060	1kv9A	0.446	6.40	0.061	0.739	1.1.99.-	36
20	0.060	3lomA	0.554	4.46	0.078	0.739	2.5.1.10	166
21	0.060	1dgpA	0.649	4.14	0.062	0.840	4.2.3.9,4.1.99.7	141
22	0.060	3g4dA	0.665	4.08	0.061	0.862	4.2.3.13	NA
23	0.060	2f89F	0.586	4.00	0.072	0.754	2.5.1.1,2.5.1.10	NA
24	0.060	2q80A	0.521	4.09	0.063	0.671	2.5.1.29,2.5.1.10,2.5.1.1	191
25	0.060	2j5cB	0.683	4.02	0.052	0.862	4.2.3.-	228
26	0.060	1hxgA	0.680	3.85	0.065	0.859	4.2.3.9,4.1.99.7	NA
27	0.060	1fpsA	0.579	4.12	0.073	0.754	2.5.1.1,2.5.1.10	NA
28	0.060	1v4eA	0.515	4.05	0.074	0.652	2.5.1.11	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.24	0.732	3.79	0.08	0.90	3kb9A	GO:0016829 GO:0046872 GO:0052680
1	0.14	0.746	3.10	0.08	0.88	5dz2A	GO:0016829 GO:0034004 GO:0046872 GO:0052577
2	0.14	0.769	3.10	0.09	0.91	4okmA	GO:0046872
3	0.12	0.724	3.37	0.07	0.87	4la6A	GO:0010333 GO:0016829 GO:0042214 GO:0046872
4	0.12	0.700	3.38	0.10	0.85	4mc8A	GO:0016829
5	0.12	0.714	3.41	0.09	0.86	4okmD	GO:0046872
6	0.12	0.722	3.19	0.12	0.85	1hm7B	GO:0016829 GO:0017000 GO:0046872 GO:0050467
7	0.11	0.697	3.43	0.08	0.85	5imiA	GO:0016829 GO:0045483 GO:0046872
8	0.11	0.649	4.14	0.06	0.84	1dgpA	GO:0005737 GO:0016829 GO:0045483 GO:0046872
9	0.10	0.684	3.26	0.11	0.81	1hm7A	GO:0016829 GO:0017000 GO:0046872 GO:0050467
10	0.09	0.368	6.09	0.06	0.59	3jruA	GO:0004177 GO:0005622 GO:0005737 GO:0006508 GO:0008233 GO:0008235 GO:0016787 GO:0019538 GO:0030145 GO:0046872
11	0.09	0.656	4.00	0.08	0.83	3ckeD	GO:0016829 GO:0045483 GO:0046872
12	0.07	0.634	3.69	0.07	0.79	5ermB	GO:0003824 GO:0004311 GO:0008152 GO:0008299 GO:0016740 GO:0016829 GO:0046872
13	0.07	0.604	3.60	0.07	0.75	5er8A	GO:0003824 GO:0004311 GO:0008152 GO:0008299 GO:0016740 GO:0016829 GO:0046872
14	0.06	0.366	6.67	0.05	0.63	3qwtA	GO:0003824
15	0.06	0.367	6.89	0.04	0.65	3pmmA	GO:0003824
16	0.06	0.358	6.35	0.08	0.60	4mivA	GO:0003824 GO:0005764 GO:0006027 GO:0008152 GO:0008484 GO:0016250 GO:0016787 GO:0030200 GO:0043202 GO:0046872 GO:0070062
17	0.06	0.332	6.15	0.05	0.53	2d09A	GO:0004497 GO:0005506 GO:0016491 GO:0016705 GO:0020037 GO:0042440 GO:0046872 GO:0055114
18	0.06	0.332	6.33	0.04	0.54	3v1hA	GO:0004436 GO:0005576 GO:0006629 GO:0008081 GO:0009405 GO:0016042 GO:0016829
19	0.06	0.284	6.45	0.06	0.48	3mz2A	GO:0006629 GO:0008081 GO:0008889

Consensus prediction of GO terms

Molecular Function	GO:0046872	GO:0016838
GO-Score	0.51	0.49
Biological Processes	GO:0042214
GO-Score	0.12
Cellular Component
GO-Score

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.