I-TASSER results

I-TASSER results for job id Rv2409c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (279 residues)
MWRTRVVHTTGYVYQSPVTASYNEARLTPRSSSRQNLVLNRVETIPATRSYRYIDYWGTA
VTAFDLHAPHTELTVTSSSVVETERPEPLAAKATWADLQSTAVIDRFDEVLRPTPHTPAS
ARVDAVGRRIRKCHEPSEAVVAAARWARSELDYIPGTTSVHSSGLDALEQGKGVCQDFVH
LSLMVLRSMGIPCRYVSGYLHPKRDAVVGKTVDGRSHAWVQAWTGGWWHYDPTNDNEITE
QYISVGVGRDYTDVSPLKGIYSGEGVTDLDVVVEITRLA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MWRTRVVHTTGYVYQSPVTASYNEARLTPRSSSRQNLVLNRVETIPATRSYRYIDYWGTAVTAFDLHAPHTELTVTSSSVVETERPEPLAAKATWADLQSTAVIDRFDEVLRPTPHTPASARVDAVGRRIRKCHEPSEAVVAAARWARSELDYIPGTTSVHSSGLDALEQGKGVCQDFVHLSLMVLRSMGIPCRYVSGYLHPKRDAVVGKTVDGRSHAWVQAWTGGWWHYDPTNDNEITEQYISVGVGRDYTDVSPLKGIYSGEGVTDLDVVVEITRLA
Prediction	CCEEEEEEEEEEEHCCCCCCCCEEEEEHCCCCCCEEEEEEEEEHCCCCCEEEEHCCCCCEEEEEEEHCCCCEEEEEEEEEEEEHCCCCCCCCCCCHHHCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCEEHCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEEEEHCCCCCCCCCCCCCCCCEEEEEEEHCCEEEEHCCCCCCCCCCEEEEEEHCCCCCCCCCCEEEHCCCEEEEEEEEEEEHCC
Conf.Score	968999999999858864447779999869999958999999986898589997899988999999689868999999999986789888788746656655555578887568899999999999999778999999999999999964567547788999999999989954458899999999998998588878766899998886678875689999979978884899999888868887658855689755588688756899999999879
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MWRTRVVHTTGYVYQSPVTASYNEARLTPRSSSRQNLVLNRVETIPATRSYRYIDYWGTAVTAFDLHAPHTELTVTSSSVVETERPEPLAAKATWADLQSTAVIDRFDEVLRPTPHTPASARVDAVGRRIRKCHEPSEAVVAAARWARSELDYIPGTTSVHSSGLDALEQGKGVCQDFVHLSLMVLRSMGIPCRYVSGYLHPKRDAVVGKTVDGRSHAWVQAWTGGWWHYDPTNDNEITEQYISVGVGRDYTDVSPLKGIYSGEGVTDLDVVVEITRLA
Prediction	744040404043436410320201000001427314414244605263432313223122001020344143020203020213424314252524513434225303400330421423510430053047464114103300520264041325325243212201443412011000000000211400000000000234443334223210000000103210000002412244300100201123001002111335444404040304538
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCEEEEEEEEEEEHCCCCCCCCEEEEEHCCCCCCEEEEEEEEEHCCCCCEEEEHCCCCCEEEEEEEHCCCCEEEEEEEEEEEEHCCCCCCCCCCCHHHCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCEEHCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEEEEHCCCCCCCCCCCCCCCCEEEEEEEHCCEEEEHCCCCCCCCCCEEEEEEHCCCCCCCCCCEEEHCCCEEEEEEEEEEEHCC
MWRTRVVHTTGYVYQSPVTASYNEARLTPRSSSRQNLVLNRVETIPATRSYRYIDYWGTAVTAFDLHAPHTELTVTSSSVVETERPEPLAAKATWADLQSTAVIDRFDEVLRPTPHTPASARVDAVGRRIRKCHEPSEAVVAAARWARSELDYIPGTTSVHSSGLDALEQGKGVCQDFVHLSLMVLRSMGIPCRYVSGYLHPKRDAVVGKTVDGRSHAWVQAWTGGWWHYDPTNDNEITEQYISVGVGRDYTDVSPLKGIYSGEGVTDLDVVVEITRLA

3isrB

0.18

0.16

0.94

3.09

MUSTER

LAKFKIHSDITYQVSP----TTFIFNVHALRTESQHILDESLIVTPPIEIEEFSYSGTSRFVRLKATENTTFSSYTATVDTQYKVIDQRQELETV---PVVDLDGDIIPFLFPSRYCQSDKLQKLAYKEFGKIENVYSKVLAITDWIYNNVEYISGSTNSQTSAFDTITERAGVCRDFAHLGIALCRALSIPARYFTGYAFKLNPP--------DFHACFEAYIGGWIIFDATRL-VPLNGLVKIATGRDAADAAV--ASIFGNASSTNHVECASLDTD

3isrB

0.18

0.17

0.94

5.61

dPPAS

NAKFKIHSDITYQV----SPTTFIFNVHALRTESQHILDESLIVTPPIEIEEFSYNSGTSFVRLKATENTTFSSYTATVDTQYKVIDQRQELETVPVV---DLDGDIIPFLFPSRYCQSDKLQKLAYKEFGKIENVYSKVLAITDWIYNNVEYISGSTNSQTSAFDTITERAGVCRDFAHLGIALCRALSIPARYFTGYAFKLNPP--------DFHACFEAYIGGWIIFDATRL-VPLNGLVKIATGRDAADAAV--ASIFGNASSTNHVECASLDTD

3isrB

0.17

0.16

0.94

7.17

wdPPAS

NAKFKIHSDITYQVSPTT----FIFNVHALRTESQHILDESLIVTPPIEIEEFSYNSTSRFVRLKATENTTFSSYTATVDTQYKVIDQRQELET---VPVVDLDGDIIPFLFPSRYCQSDKLQKLAYKEFGKIENVYSKVLAITDWIYNNVEYISGSTNSQTSAFDTITERAGVCRDFAHLGIALCRALSIPARYFTGYAFKLNPP--------DFHACFEAYIGGWIIFDATRL-VPLNGLVKIATGRDAADAAVASIFGNASSTNHVECASLDTDFT

3isrB

0.17

0.16

0.94

4.15

wMUSTER

NAKFKIHSDITYQVSP----TTFIFNVHALRTESQHILDESLIVTPPIEIEEFSYSGTSRFVRLKATENTTFSSYTATVDTQYKVIDQRQE---LETVPVVDLDGDIIPFLFPSRYCQSDKLQKLAYKEFGKIENVYSKVLAITDWIYNNVEYISGSTNSQTSAFDTITERAGVCRDFAHLGIALCRALSIPARYFTGYAFKLNPP--------DFHACFEAYIGGWIIFDATRL-VPLNGLVKIATGRDAADAAVASIFGNASSTNHVECASLDTDFT

3isrB

0.17

0.16

0.94

6.36

wPPAS

LAKFKIHSDITYQVSPTT----FIFNVHALRTESQHILDESLIVTPPIEIEEFSYSGTSRFVRLKATENTTFSSYTATVDTQYKVIDQRQ---ELETVPVVDLDGDIIPFLFPSRYCQSDKLQKLAYKEFGKIENVYSKVLAITDWIYNNVEYISGSTNSQTSAFDTITERAGVCRDFAHLGIALCRALSIPARYFTGYAFKLNPP--------DFHACFEAYIGGWIIFDATRL-VPLNGLVKIATGRDAADAAVASIFGNASSTNHVECASLDTDFT

3isrB

0.18

0.17

0.94

18.41

dPPAS2

NAKFKIHSDITYQV----SPTTFIFNVHALRTESQHILDESLIVTPPIEIEEFSYNSGSRFVRLKATENTTFSSYTATVDTQYKVIDQRQELETVPVV---DLDGDIIPFLFPSRYCQSDKLQKLAYKEFGKIENVYSKVLAITDWIYNNVEYISGSTNSQTSAFDTITERAGVCRDFAHLGIALCRALSIPARYFTGYAFKLNPP--------DFHACFEAYIGGWIIFDATRL-VPLNGLVKIATGRDAADAAV--ASIFGNASSTNHVECASLDTD

3isrB

0.18

0.17

0.94

4.74

PPAS

LAKFKIHSDITYQVS-PT---TFIFNVHALRTESQHILDESLIVTPPIEIEEFSNSGTSRFVRLKATENTTFSSYTATVDTQYKVIDQRQELETVPVV---DLDGDIIPFLFPSRYCQSDKLQKLAYKEFGKIENVYSKVLAITDWIYNNVEYISGSTNSQTSAFDTITERAGVCRDFAHLGIALCRALSIPARYFTGYAFKLNPP--------DFHACFEAYIGGWIIFDATRL-VPLNGLVKIATGRDAADAAV--ASIFGNASSTNHVECASLDTD

3isrB

0.18

0.17

0.94

5.89

Env-PPAS

LAKFKIHSDITYQVS-PT---TFIFNVHALRTESQHILDESLIVTPPIEIEEFSNSGTSRFVRLKATENTTFSSYTATVDTQYKVIDQRQELETVPVVD---LDGDIIPFLFPSRYCQSDKLQKLAYKEFGKIENVYSKVLAITDWIYNNVEYISGSTNSQTSAFDTITERAGVCRDFAHLGIALCRALSIPARYFTGYAFKLNPP--------DFHACFEAYIGGWIIFDATRL-VPLNGLVKIATGRDAADAAV--ASIFGNASSTNHVECASLDTD

4xz7A

0.12

0.11

0.91

1.03

MUSTER

FPHILVMNKGDVIYHNQMRELRFSGNGDLHNSMEPKRIHALFKIELDSNKRQLLNAAGLGTAENSLKN-INGMTIYSHGLTVDNKY--YEDYSKYTHNSVKNINVTKERFIA------NDDLIHKLIESSEKQSSERDKVKAFVQYVANHTTYDDINYYLGSDLFAVTERQKAMCVGFSTTAARAFNMLGLPAYVVVGKN-----------AEGVPHATARVYYDKWHTIDGTGFITKYSEKHFSTIGEDSYD-----VVEAGQEPKAERNYMIIDSNY

4xz7A2

0.15

0.09

0.56

1.70

dPPAS

---------------------------------------------------------------------------------------------------------------TKERFIANDDLIHKLIESSEKQSSERDKVKAFVQYVANHTTYADINYYLGSDLFAVTERQKAMCVGFSTTAARAFNMLGLPAYVVVGKN-----------AEGVPHATARVYYDKWHTIDGTGFITKYSEKHFSTIGEDSYDVVEAG-QEPKAERNYMIIDSNYESWA

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.43

Estimated TM-score = 0.91±0.06

Estimated RMSD = 3.2±2.2Å

Download Model 2

C-score=-3.29

Download Model 3

C-score=-2.98

Download Model 4

C-score=-3.51

Download Model 5

C-score=-3.54

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3isrB	0.899	1.34	0.176	0.935
2	1g0dA	0.515	3.91	0.097	0.627
3	1l9mB	0.511	3.85	0.091	0.627
4	1f13A	0.508	3.86	0.097	0.624
5	2q3zA4	0.478	3.60	0.153	0.566
6	3kd4A	0.457	4.75	0.090	0.609
7	3cf4A	0.427	6.02	0.052	0.706
8	3d9wA	0.422	4.19	0.099	0.545
9	4guzA	0.420	4.11	0.099	0.534
10	1w4tA	0.412	3.78	0.093	0.520

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.07	4	3mbgA	ZN	Rep, Mult	176,180
2	0.05	3	5ajbB	FUC	Rep, Mult	223,227
3	0.05	3	2f4oA	III	Rep, Mult	153,162,174,175,176,217,218
4	0.04	2	3np2X	PLL	Rep, Mult	187,192,193
5	0.04	2	5d63A	III	Rep, Mult	153,174,175,176,216,217,245
6	0.04	2	2h8pC	GOA	Rep, Mult	198,199
7	0.04	2	4ej7A	CA	Rep, Mult	234,250
8	0.04	2	1x3zA	SUC	Rep, Mult	152,216,217,234
9	0.02	1	2y04B	2CV	Rep, Mult	183,184
10	0.02	1	1l9nA	CA	Rep, Mult	167,172,173,174,177
11	0.02	1	1btgB	ZN	Rep, Mult	217,231
12	0.02	1	3hiaC	PC	Rep, Mult	219,227
13	0.02	1	1g0dA	SO4	Rep, Mult	106,194,227
14	0.02	1	1l9nB	CA	Rep, Mult	196,216,217,254
15	0.02	1	1ea0A	F3S	Rep, Mult	164,165,166,167,170,171,174,179
16	0.02	1	2vdcA	F3S	Rep, Mult	157,158,159,160,161,162,174,175

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1ahpA	0.370	6.40	0.037	0.642	2.4.1.1	NA
2	0.060	3cf4A	0.427	6.02	0.052	0.706	1.2.99.2	166
3	0.060	1e1yA	0.338	6.91	0.061	0.656	2.4.1.1	NA
4	0.060	2w68C	0.229	6.14	0.047	0.380	3.2.1.18	72
5	0.060	2z8yD	0.401	6.29	0.046	0.692	1.2.7.4,1.2.99.2	NA
6	0.060	1jqkF	0.391	6.14	0.061	0.663	1.2.99.2	143,147
7	0.060	1myrA	0.370	5.97	0.050	0.617	3.2.1.147	NA
8	0.060	1gx3A	0.405	3.89	0.096	0.509	2.3.1.5	175,217
9	0.060	1ea0A	0.337	6.23	0.053	0.566	1.4.1.13	NA
10	0.060	2ijaA	0.402	4.23	0.124	0.516	2.3.1.5	175,217,231
11	0.060	2c4mC	0.366	6.65	0.055	0.656	2.4.1.1	252
12	0.060	2v4wD	0.365	6.12	0.036	0.620	2.3.3.10	174
13	0.060	3gpbA	0.367	6.51	0.041	0.645	2.4.1.1	NA
14	0.060	2azdB	0.367	6.57	0.036	0.652	2.4.1.1	NA
15	0.060	1jqnA	0.377	6.20	0.055	0.645	4.1.1.31	NA
16	0.060	1g0dA	0.515	3.91	0.097	0.627	2.3.2.13	175,217,231
17	0.060	2vdcF	0.398	5.95	0.024	0.656	1.4.1.13	NA
18	0.060	1ileA	0.375	5.79	0.028	0.602	6.1.1.5	173
19	0.060	2jf6B	0.366	5.82	0.035	0.595	3.2.1.105	150

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.43	0.909	1.28	0.17	0.94	3isrB	GO:0006508 GO:0008233
1	0.11	0.508	3.86	0.10	0.62	1f13A	GO:0002576 GO:0003810 GO:0005576 GO:0005737 GO:0007596 GO:0007599 GO:0016740 GO:0016746 GO:0018149 GO:0031093 GO:0042060 GO:0046872 GO:0072562
2	0.07	0.511	3.85	0.09	0.63	1l9mB	GO:0003810 GO:0003824 GO:0005509 GO:0005737 GO:0006464 GO:0016740 GO:0016746 GO:0018149 GO:0030216 GO:0031069 GO:0031234 GO:0031424 GO:0043163 GO:0046872 GO:0051262 GO:0070062
3	0.07	0.515	3.91	0.10	0.63	1g0dA	GO:0003810 GO:0016740 GO:0016746 GO:0018149 GO:0046872
4	0.07	0.306	5.88	0.05	0.49	2q3zA	GO:0003810 GO:0005737 GO:0005739 GO:0005783 GO:0005829 GO:0005925 GO:0007200 GO:0016740 GO:0016746 GO:0018149 GO:0031012 GO:0031226 GO:0032471 GO:0043065 GO:0043277 GO:0045785 GO:0046872 GO:0051561 GO:0060445 GO:0060662 GO:0070062
5	0.07	0.449	4.20	0.10	0.56	3s3sA	GO:0003810 GO:0005737 GO:0005739 GO:0005783 GO:0005829 GO:0005925 GO:0007200 GO:0016740 GO:0016746 GO:0018149 GO:0031012 GO:0031226 GO:0032471 GO:0043065 GO:0043277 GO:0045785 GO:0046872 GO:0051561 GO:0060445 GO:0060662 GO:0070062
6	0.06	0.255	6.51	0.06	0.44	3jct4	GO:0000055 GO:0005634 GO:0005654 GO:0005730 GO:0005737 GO:0006508 GO:0008233 GO:0008237 GO:0016787 GO:0022625 GO:0030687 GO:0046872
7	0.06	0.319	6.24	0.06	0.55	4r2bA	GO:0005215 GO:0006810
8	0.06	0.311	6.92	0.06	0.59	4pygA	GO:0003810 GO:0005737 GO:0005739 GO:0005783 GO:0005829 GO:0005925 GO:0007200 GO:0016740 GO:0016746 GO:0018149 GO:0031012 GO:0031226 GO:0032471 GO:0043065 GO:0043277 GO:0045785 GO:0046872 GO:0051561 GO:0060445 GO:0060662 GO:0070062
9	0.06	0.282	6.68	0.02	0.52	4aw6A	GO:0004222 GO:0005634 GO:0005637 GO:0005783 GO:0005789 GO:0006508 GO:0006998 GO:0008233 GO:0008235 GO:0008237 GO:0016020 GO:0016021 GO:0016787 GO:0030327 GO:0046872 GO:0070062 GO:0071586
10	0.06	0.267	6.67	0.04	0.48	3czmB	GO:0003824 GO:0004459 GO:0005975 GO:0016491 GO:0016616 GO:0019752 GO:0055114
11	0.06	0.263	6.20	0.07	0.45	2p1gB	GO:0008152 GO:0016787 GO:0016798 GO:0045493
12	0.06	0.264	5.28	0.04	0.41	2jzxA	GO:0000398 GO:0002376 GO:0003676 GO:0003677 GO:0003723 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0005925 GO:0010467 GO:0016020 GO:0016071 GO:0019899 GO:0030529 GO:0031625 GO:0032480 GO:0039694 GO:0043161 GO:0044822 GO:0045087 GO:0050687 GO:0051607 GO:0070062 GO:0075522
13	0.06	0.267	6.45	0.06	0.47	4mwaF	GO:0003824 GO:0005506 GO:0008299 GO:0016114 GO:0016491 GO:0019288 GO:0044237 GO:0046429 GO:0046872 GO:0051536 GO:0051539 GO:0055114
14	0.06	0.268	6.04	0.05	0.44	2xu2A	GO:0003824 GO:0005975
15	0.06	0.254	5.58	0.08	0.39	2r01A	GO:0000166 GO:0016491 GO:0046872 GO:0055114
16	0.06	0.219	5.25	0.04	0.33	2l9cA	GO:0000772 GO:0005009 GO:0005186 GO:0005215 GO:0005550 GO:0005576 GO:0005615 GO:0005634 GO:0005829 GO:0006112 GO:0006810 GO:0008286 GO:0008355 GO:0009060 GO:0010628 GO:0010888 GO:0010907 GO:0031649 GO:0036094 GO:0042593 GO:0045475 GO:0045721 GO:0045834 GO:0045892 GO:0051055 GO:0051897 GO:0061179 GO:0070584 GO:0071396
17	0.06	0.221	5.35	0.04	0.34	2vj5A	GO:0005576 GO:0006810 GO:0009306 GO:0009405 GO:0009986 GO:0019867 GO:0030254 GO:0043657 GO:0046903 GO:0050709
18	0.06	0.205	4.91	0.03	0.30	3pu6A	GO:0006508 GO:0008047 GO:0008233 GO:0043085

Consensus prediction of GO terms

Molecular Function	GO:0016755	GO:0043169	GO:0008233
GO-Score	0.56	0.56	0.43
Biological Processes	GO:0006464	GO:0006508
GO-Score	0.56	0.43
Cellular Component	GO:0044424
GO-Score	0.46

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.