I-TASSER results

I-TASSER results for job id Rv2402

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (642 residues)
MALSSSSPLRNPFPPIADYAFLSDWETTCLISPAGSVEWLCVPRPDSPSVFGAILDRSAG
HFRLGPYGVSVPSARRYLPGSLIMETTWQTHTGWLIVRDALVMGKWHDIERRSRTHRRTP
MDWDAEHILLRTVRCVSGTVELMMSCEPAFDYHRLGATWEYSAEAYGEAIARANTEPDAH
PTLRLTTNLRIGLEGREARARTRMKEGDDVFVALSWTKHPPPQTYDEAADKMWQTTECWR
QWINIGNFPDHPWRAYLQRSALTLKGLTYSPTGALLAASTTSLPETPRGERNWDYRYAWI
RDSTFALWGLYTLGLDREADDFFAFIADVSGANNNERHPLQVMYGVGGERSLVEAELHHL
SGYDHARPVRIGNGAYNQRQHDIWGSILDSFYLHAKSREQVPENLWPVLKRQVEEAIKHW
REPDRGIWEVRGEPQHFTSSKVMCWVALDRGAKLAERQGEKSYAQQWRAIADEIKADILE
HGVDSRGVFTQRYGDEALDASLLLVVLTRFLPPDDPRVRNTVLAIADELTEDGLVLRYRV
HETDDGLSGEEGTFTICSFWLVSALVEIGEVGRAKRLCERLLSFASPLLLYAEEIEPRSG
RHLGNFPQAFTHLALINAVVHVIRAEEEADSSGMFQPANAPM

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MALSSSSPLRNPFPPIADYAFLSDWETTCLISPAGSVEWLCVPRPDSPSVFGAILDRSAGHFRLGPYGVSVPSARRYLPGSLIMETTWQTHTGWLIVRDALVMGKWHDIERRSRTHRRTPMDWDAEHILLRTVRCVSGTVELMMSCEPAFDYHRLGATWEYSAEAYGEAIARANTEPDAHPTLRLTTNLRIGLEGREARARTRMKEGDDVFVALSWTKHPPPQTYDEAADKMWQTTECWRQWINIGNFPDHPWRAYLQRSALTLKGLTYSPTGALLAASTTSLPETPRGERNWDYRYAWIRDSTFALWGLYTLGLDREADDFFAFIADVSGANNNERHPLQVMYGVGGERSLVEAELHHLSGYDHARPVRIGNGAYNQRQHDIWGSILDSFYLHAKSREQVPENLWPVLKRQVEEAIKHWREPDRGIWEVRGEPQHFTSSKVMCWVALDRGAKLAERQGEKSYAQQWRAIADEIKADILEHGVDSRGVFTQRYGDEALDASLLLVVLTRFLPPDDPRVRNTVLAIADELTEDGLVLRYRVHETDDGLSGEEGTFTICSFWLVSALVEIGEVGRAKRLCERLLSFASPLLLYAEEIEPRSGRHLGNFPQAFTHLALINAVVHVIRAEEEADSSGMFQPANAPM
Prediction	CCCCCCCCCCCCCCCHHHHHHCCCCCCEEEHCCCCCEEHCCCCCCCCHHHHHHHHCCCCCEEEHCCCCCCCCCCCCCCCCCEEEEEEEEHCCEEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEHCEEEEEEEEEEEHCCCCCCCCEEEEEHCCEEEEEEEHCCCCCCCCEEEEHCCCCEEHCCCCEEEEEHCCCCCEEEEEHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHCCCCCCCCCEHCCCCCCCCCCCCCEHCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEHCCCCCCCCCCCCCCCCCEHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
Conf.Score	999999999999998566544356565467669986565789999987787877568899699857899887655667997699998886997899998566788888754566678899877777569999999656899999999856888876579998498589999967999888579985897556668658999975789779999758999999988889999999899999999978999998679999999999865568866777555689999989988876554678999999999999798799999999999997689999898567765688666785346887888899875555577556545688889999998877578999789999999999999985899987555789988754577889999999999999979957899999999999999998788887876786798567889887687678999985799999999998668875765578888999999886435788999999999875999999999999875876554343478888888998556789999999999875444556788888888999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MALSSSSPLRNPFPPIADYAFLSDWETTCLISPAGSVEWLCVPRPDSPSVFGAILDRSAGHFRLGPYGVSVPSARRYLPGSLIMETTWQTHTGWLIVRDALVMGKWHDIERRSRTHRRTPMDWDAEHILLRTVRCVSGTVELMMSCEPAFDYHRLGATWEYSAEAYGEAIARANTEPDAHPTLRLTTNLRIGLEGREARARTRMKEGDDVFVALSWTKHPPPQTYDEAADKMWQTTECWRQWINIGNFPDHPWRAYLQRSALTLKGLTYSPTGALLAASTTSLPETPRGERNWDYRYAWIRDSTFALWGLYTLGLDREADDFFAFIADVSGANNNERHPLQVMYGVGGERSLVEAELHHLSGYDHARPVRIGNGAYNQRQHDIWGSILDSFYLHAKSREQVPENLWPVLKRQVEEAIKHWREPDRGIWEVRGEPQHFTSSKVMCWVALDRGAKLAERQGEKSYAQQWRAIADEIKADILEHGVDSRGVFTQRYGDEALDASLLLVVLTRFLPPDDPRVRNTVLAIADELTEDGLVLRYRVHETDDGLSGEEGTFTICSFWLVSALVEIGEVGRAKRLCERLLSFASPLLLYAEEIEPRSGRHLGNFPQAFTHLALINAVVHVIRAEEEADSSGMFQPANAPM
Prediction	443446425432100000000000000000002400000000001000000000012520100000441511010101340000001020550001000000002334465344434232443322000000021020303020202000101223030313262211000314433423010202040201043330202020434030000001161441242520251033003001200430404712111000000000000010000000000000110434241100000000000000000000000220041003000200213655410000000001124020420310411420200000010130200000000000000012123424640041023004101610431010000111432100000000000000002002414364316302400430121005301253200001141410000000001020011423201000200151013200010021641412041510000000000000001011262024002200210020000000111400111101000000100010001002024435553424246426
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560                 580                 600                 620                 640

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCHHHHHHCCCCCCEEEHCCCCCEEHCCCCCCCCHHHHHHHHCCCCCEEEHCCCCCCCCCCCCCCCCCEEEEEEEEHCCEEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEHCEEEEEEEEEEEHCCCCCCCCEEEEEHCCEEEEEEEHCCCCCCCCEEEEHCCCCEEHCCCCEEEEEHCCCCCEEEEEHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHCCCCCCCCCEHCCCCCCCCCCCCCEHCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEHCCCCCCCCCCCCCCCCCEHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
MALSSSSPLRNPFPPIADYAFLSDWETTCLISPAGSVEWLCVPRPDSPSVFGAILDRSAGHFRLGPYGVSVPSARRYLPGSLIMETTWQTHTGWLIVRDALVMGKWHDIERRSRTHRRTPMDWDAEHILLRTVRCVSGTVELMMSCEPAFDYHRLGATWEYSAEAYGEAIARANTEPDAHPTLRLTTNLRIGLEGREARARTRMKEGDDVFVALSWTKHPPPQTYDEAADKMWQTTECWRQWINIGNFPDHPWRAYLQRSALTLKGLTYSPTGALLAASTTSLPETPRGERNWDYRYAWIRDSTFALWGLYTLGLDREADDFFAFIADVSGANNNERHPLQVMYGVGGERSLVEAELHHLSGYDHARPVRIGNGAYNQRQHDIWGSILDSFYLHAKSREQVPENLWPVLKRQVEEAIKHWREPDRGIWEVRGEPQHFTSSKVMCWVALDRGAKLAERQGEKSYAQQWRAIADEIKADILEHGVDSRGVFTQRYGDEALDASLLLVVLTRFLPPDDPRVRNTVLAIADELTEDGLVLRYRVHETDDGLSGEEGTFTICSFWLVSALVEIGEVGRAKRLCERLLSFASPLLLYAEEIEPRSGRHLGNFPQAFTHLALINAVVHVIRAEEEADSSGMFQPANAPM

1lf9A

0.17

0.15

0.86

1.91

MUSTER

DRFNNISAVNGP-ED---WAS-AQKQGTAN-NYVSKV-WFTLPTIDTADV------KEIKFIVTDGKSF-VPDETKKFDKSLGYKLVNTDKKGYRITKDIFT-----DVKR---------------NSLIMKAKFEAGSIKLYLAYDPHIKNQGSYNEGYVIKANNNEMLMAKRDN-----YTALSSNIGIGYYKVNEGAEIDLTKNSEFEIVLSFGQSDALETLGEYNNLKNNYIDEWTKYCNTLNNFNGKANSLYYNSMMILKASEKTNKGAYIASLSIPWGDGQRDDNTGGYHLVWSRDLYHVANAFIAAGDVDSANRSLDYLAKVVKDNGM----IPQNTWISGK-------------------------YWTGIQLDEQADPIILSYRLKRY-----DLYDSLVKPLADFIIKIGPKTGQERWEEIG--GYSPATMAAEVAGLTCAAYIAEQNKDYESAQKYQEKADNWQKLIDNLTYTENGLGNGQYQKEIVDPSFLELVRLGVKSADDPKILNTLKVVDSTIKVDTSWYRYEPSKTELYHGAGKGRWPLLTGERGMYEIAAGK--DATPYVKAMEKFANEGGIISEQVWEDTGLPTDSSPLNWAHAEYVILFASNIEH----------KVLDMPD

1lf9A

0.16

0.13

0.83

7.94

dPPAS

---------------------------------------------------------SIKIDRFAVNGPGEEDTWASLANGAISEVYYPTIDIKFIVTDG---KSFVPDETKDAISKVEKFTDKKRNSLIMKAKFEAHDYKLYLAYDPHIKNQGSYNEGYVIKANNNEMLMAKRDN----VYTALSSNIGIGYYKVNEGAEIDLTKNSEFEIVLSFGQSDLETLGEDYNNLKNNYIDEWTKYCNTLNNFNGKANSLYYNSMMILKASEKTNKGAYIASLSIPWGDGQRDDNTGGYHLVWSRDLYHVANAFIAAGDVDSANRSLDYLAKVVKDNGMIPQ----NTWISGK------------------------PYWTGIQLDEQADPIILSYRLKRY-----DLYDSLVKPLADFIIKIGPKTGQERWEEIGG--YSPATMAAEVAGLTCAAYIAEQNKDYESAQKYQEKADNWQKLIDNLTYTENGPGGVYDQKEIVDPSFLELVRLGVKSADDPKILNTLKVVDSTIKVDTSWYRYEPSKTELYHGAGKGRWPLLTGERGMYEIAAGK--DATPYVKAMEKFANEGGIISEQVWEDTGLPTDSSPLNWAHAEYVILFASNIEH----------KVLDMPD

1lf9A

0.17

0.14

0.81

6.10

wdPPAS

------------------------------------------------SI--RFNNISAN----GP-GEEDASAQK--YVSKV----WFT-NG--AISEV---KSFVPDETKDAISKVEKFTDKSRNSLIMKAKFEA-DYKLYLAYDPHIKNQGSYNEGYVIKANNNEMLMAKRDN-----YTALSSNIGIGYYKVNEGAEIDLTKNSEFEIVLSFGQSDS--LGEDYNNLKNNYIDEWTKYCNTLNNFNGKANSLYYNSMMILKASEKTNKGAYIASLSIPWGDGQRDDNTGGYHLVWSRDLYHVANAFIAAGDVDSANRSLDYLAKVVKDNGMIPQ----NTWISGK-------------------------YWTGIQLDEQADPIILSYRLKRY-----DLYDSLVKPLADFIIKIGPKTGQERWEEIGG--YSPATMAAEVAGLTCAAYIAEQNKDYESAQKYQEKADNWQKLIDNLTYTENGLGNGQYQKEIVDPSFLELVRLGVKSADDPKILNTLKVVDSTIKVDTSWYRYN-KTELYHGAGKGRLWPLLTGERGMYEIAAGK--DATPYVKAMEKFANEGGIISEQVWEDTGLPTDSSPLNWAHAEYVILFASNIEH----------KVLDMPD

1lf9A

0.18

0.15

0.86

1.97

wMUSTER

IKFNNISAVNGP-ED---WAS-AQ-KQTAN-NYVSKV-WFTLPTIDTADVK---------EIKFI-DGKSVPDETKKFDKSLGYKLVNTDKKGYRITKDIFT-----DVKR---------------NSLIMKAKFEAGSIKLYLAYDPHIKNQGSYNEGYVIKANNNEMLMAKRDN-----YTALSSNIGIGYYKVNEGAEIDLTKNSEFEIVLSFGQSDALETLGEYNNLKNNYIDEWTKYCNTLNNFNGKANSLYYNSMMILKASEKTNKGAYIASLSIPWGDGQRDDNTGGYHLVWSRDLYHVANAFIAAGDVDSANRSLDYLAKVVKDNGM----IPQNTWISGK-------------------------YWTGIQLDEQADPIILSYRLKRY-----DLYDSLVKPLADFIIKIGPKTGQERWEEIG--GYSPATMAAEVAGLTCAAYIAEQNKDYESAQKYQEKADNWQKLIDNLTYTENGLGNGQYQKEIVDPSFLELVRLGVKSADDPKILNTLKVVDSTIKVDTSWYRYEPSKTELYHGAGKGRWPLLTGERGMYEIAAGK--DATPYVKAMEKFANEGGIISEQVWEDTGLPTDSSPLNWAHAEYVILFASNIEH----------KVLDMPD

1lf9A

0.18

0.15

0.84

1.87

wPPAS

---------------------------------SIKIDRF-ISAVNGP---GE--DTSAQKQGVGANN---YVSK-YYP--TI--DTADVKEIKFIVTDG---KSFVPDETKDAISKKSLTDYDVKRSLIMKAKFEAGSIKLYLAYDPHIKNQGSYNEGYVIKANNNEMLMAKRDN-----YTALSSNIGIGYYKVNEGAEIDLTKNSEFEIVLSFGQSDALETLGEYNNLKNNYIDEWTKYCNTLNNFNGKANSLYYNSMMILKASEKTNKGAYIASLSIPWGDGQRDDNTGGYHLVWSRDLYHVANAFIAAGDVDSANRSLDYLAKVVKDNGM----IPQNTWISGK-------------------------YWTGIQLDEQADPIILSYRLKRY-----DLYDSLVKPLADFIIKIGPKTGQERWEEIGG--YSPATMAAEVAGLTCAAYIAEQNKDYESAQKYQEKADNWQKLIDNLTYTENGLGNGQYQKEIVDPSFLELVRLGVKSADDPKILNTLKVVDSTIKVDTSWYRYEPSKTELYHGAGKGRWPLLTGERGMYEIAAGK--DATPYVKAMEKFANEGGIISEQVWEDTGLPTDSSPLNWAHAEYVILFASNIEH----------KVLDMPD

1lf9A

0.16

0.13

0.81

9.47

dPPAS2

-------------------------------------------------------------------SIKIVNG----PGGAISEVYYPTIDIKFIVTDG---KSFVPDETKDAISKVEKFTDKKRNSLIMKAKFEAHDYKLYLAYDPHIKNQGSYNEGYVIKANNNEMLMAKRDN----VYTALSSNIGIGYYKVNEGAEIDLTKNSEFEIVLSFGQSDLETLGEDYNNLKNNYIDEWTKYCNTLNNFNGKANSLYYNSMMILKASEKTNKGAYIASLSIPWGDGQRDDNTGGYHLVWSRDLYHVANAFIAAGDVDSANRSLDYLAKVVKDNGMIPQ----NTWISGK------------------------PYWTGIQLDEQADPIILSYRLKRY-----DLYDSLVKPLADFIIKIGPKTGQERWEEIGG--YSPATMAAEVAGLTCAAYIAEQNKDYESAQKYQEKADNWQKLIDNLTYTENGPGGVYDQKEIVDPSFLELVRLGVKSADDPKILNTLKVVDSTIKVDTSWYRYEPSKTELYHGAGKGRWPLLTGERGMYEIAAGK--DATPYVKAMEKFANEGGIISEQVWEDTGLPTDSSPLNWAHAEYVILFASNIEH----------KVLDMPD

1lf9A

0.17

0.15

0.85

2.20

PPAS

---------------------------------SIKIDRF-ISAVNGPGE-----DTSAQKQGVGANN---YVSKVWLANGAISEVYYPT-EIKFIVTDG---KSFVPDETKDAISKVEKFTYDVKRSLIMKAKFEAGSIKLYLAYDPHIKNQGSYNEGYVIKANNNEMLMAKRDN-----YTALSSNIGIGYYKVNEGAEIDLTKNSEFEIVLSFGQSDALETLGEYNNLKNNYIDEWTKYCNTLNNFNGKANSLYYNSMMILKASEKTNKGAYIASLSIPWGDGQRDDNTGGYHLVWSRDLYHVANAFIAAGDVDSANRSLDYLAKVVKDNGM----IPQNTWISGK------------------PYWTG------IQLDEQADPIILSYRLKRY-----DLYDSLVKPLADFIIKIGPKTGQERWEEIGG--YSPATMAAEVAGLTCAAYIAEQNKDYESAQKYQEKADNWQKLIDNLTYTENGLGNGQYQKEIVDPSFLELVRLGVKSADDPKILNTLKVVDSTIKVDTSWYRYEPSKTELYHGAGKGRWPLLTGERGMYEIAAGK--DATPYVKAMEKFANEGGIISEQVWEDTGLPTDSSPLNWAHAEYVILFASNIEH----------KVLDMPD

1lf9A

0.17

0.15

0.89

5.35

Env-PPAS

ISAVNGPGEEDTWASAQKQGVGTANNYVWFTLANGAISEVYYPTIDTADVK----E---IKFIVTDGKSFVPDETK----DAISKVEKFTDKGYKLVNT--------DKKGRYRITKDIFTDVK-RNSLIMKAKFEAGSIKLYLAYDPHIKNQGSYNEGYVIKANNNEMLMAKRDN----VYTALSSNIGIGYYKVNEGAEIDLTKNSEFEIVLSFGQSDALETLGEYNNLKNNYIDEWTKYCNTLNNFNGKANSLYYNSMMILKASEKTNKGAYIASLSIPWGDGQRDDNTGGYHLVWSRDLYHVANAFIAAGDVDSANRSLDYLAKVVKDNGM----IPQNTWISGK------------------PYWTG------IQLDEQADPIILSYRLKRY-----DLYDSLVKPLADFIIKIGPKTGQERWEEIGG--YSPATMAAEVAGLTCAAYIAEQNKDYESAQKYQEKADNWQKLIDNLTYTENGLGNGQYQKEIVDPSFLELVRLGVKSADDPKILNTLKVVDSTIKVDTSWYRYEPSKTELYHGAGKGRWPLLTGERGMYEIAAGK--DATPYVKAMEKFANEGGIISEQVWEDTGLPTDSSPLNWAHAEYVILFASNIEH----------KVLDMPD

1ulvA

0.19

0.17

0.89

1.21

MUSTER

TAEPPGSPGAAAWTKGDKEGV-----GTSL-NPASKV-WYTLPHADTPNTF-AVSD-GTSAQRESEQTTR--TVELADPKALSYRQTTTDNAGWRLTKTYVT-----------DPRR---------STVMLGVTFEVGDYQLFVLSDPSLAGTSGGDTGSVTDG---ALLASDLADAATPVATALVSSVGNGYVGTSQTGQIPLAAGGEFSLALGFGADTAKASLGTYKKVSKSYTGEWKKYLNSLDAPTGALRTQYDVSLMTVKSHEDKFPGAFIASLTIPWGQAASAETHREYHAVWARDMYQSVTALLAAGDEEAAARGVEWLFTYQ--QQPDGHFPQ---------------TSRVDGTIGQNGIQLDETAFPILLANQIG-------------RTDAGFYRNELKPAADYLVAAGPKTPQERWEETG--GYSTSTLASQIAALAAAADIAGKNGDAGSAAVYRATADEWQRSTEKWMFTTNGGATRDWGNAVLDGGFLEFVRLGVKAPADPYVADSLAETDASISQERMWHRYTYGEKADGSPWDGTG--IGRLWPLLSGERG-ALANALPYLETMHSAANAGYMIPEQVPTSYGHELGRSPLSWAMAQYVRLAAGVKAGAPVAARYAAGTPLSSPE

1ulvA

0.16

0.14

0.84

5.23

dPPAS

----------------------------------------------------------------TAEPPGSPGAASLNPEGTMSEVYYPHADLQFAVSD----GTSAQRESEQTTRTVELADPKARSTVMLGVTFEVGDYQLFVLSDPSLAGTSGGDTGSVTDG---ALLASDLADAATPVATALVSSVGNGYVGTSQTGQIPLAAGGKTEFSLALGFGADTAEGTGYKKVSKSYTGEWKKYLNSLDAPTGALRTQYDVSLMTVKSHEKTFPGAFIASLTIPWGQAASAETHREYHAVWARDMYQSVTALLAAGDEEAAARGVEWLFTYQQQPDGHFPQ-----------------TSRVDGTIGQNGI-------------QLDETAFPILLANQIGRTDAGFYRNELKPAADYLVAAGPKTPQERWEETGG--YSTSTLASQIAALAAAADIAGKNGDAGSAAVYRATADEWQRSTEKWMFTTNGATRDWGNGAVLDGGFLEFVRLGVKAPADPYVADSLAETDASIPGGRMWHRYTYDEKADGSPWDGTGIGRPLLSGERGEYALANGQDALPYLETMHSAANAGYMIPEQVWDRDEPTSYGHPLSWAMAQYVRLAAGVKAGAPVETPQAAGTPLSSPE

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 3 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.34

Estimated TM-score = 0.76±0.10

Estimated RMSD = 7.1±4.2Å

Download Model 2

C-score=-0.01

Download Model 3

C-score=-4.18

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1lf9A	0.830	2.79	0.143	0.891
2	1ulvA	0.816	2.79	0.163	0.880
3	5h3zA	0.727	4.54	0.062	0.871
4	2cqtA	0.707	4.50	0.116	0.846
5	3qdeA	0.699	4.49	0.082	0.838
6	1v7vA	0.688	5.12	0.082	0.860
7	4zleA	0.684	4.53	0.083	0.826
8	4ktpA	0.677	4.72	0.078	0.822
9	3wiqA	0.674	4.77	0.075	0.822
10	1h54B	0.670	4.64	0.075	0.813

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.51	6	1ulvA	ACR	Rep, Mult	277,295,299,301,302,342,427,428,429,430,546,608,610
2	0.07	1	3c67A	GLC	Rep, Mult	78,80,121

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.447	1lf6A	0.832	2.71	0.145	0.889	3.2.1.3	429,593
2	0.066	1ayxA	0.507	3.01	0.135	0.551	3.2.1.3	429,593
3	0.066	2f6dA	0.505	3.14	0.135	0.551	3.2.1.3	49,148,193
4	0.066	1gaiA	0.483	2.91	0.149	0.525	3.2.1.3	429,593
5	0.060	2jg0A	0.455	4.30	0.108	0.536	3.2.1.28	294
6	0.060	1fo2A	0.431	5.38	0.069	0.550	3.2.1.113	NA
7	0.060	1is9A	0.399	4.29	0.083	0.477	3.2.1.4	NA
8	0.060	1tnzL	0.382	4.81	0.094	0.470	2.5.1.59	320
9	0.060	1fp3A	0.421	4.20	0.073	0.498	5.1.3.8	NA
10	0.060	1h54B	0.670	4.64	0.075	0.813	2.4.1.8	NA
11	0.060	2cqsA	0.706	4.53	0.118	0.846	2.4.1.20	206
12	0.060	1fmiA	0.430	5.37	0.067	0.550	3.2.1.113	NA
13	0.060	1g87B	0.395	4.97	0.078	0.489	3.2.1.4	NA
14	0.060	1hcuB	0.432	5.47	0.054	0.556	3.2.1.113	151
15	0.060	1rw9A	0.360	5.46	0.057	0.463	4.2.2.5	NA
16	0.060	1z1wA	0.351	7.98	0.042	0.567	3.4.11.-	38
17	0.060	1clcA	0.370	6.25	0.057	0.511	3.2.1.4	NA
18	0.060	1ks8A	0.390	4.49	0.080	0.470	3.2.1.4	NA
19	0.060	1ia7A	0.394	4.52	0.068	0.475	3.2.1.4	NA
20	0.060	1dceB	0.371	4.48	0.089	0.446	2.5.1.60,2.5.1.-	NA
21	0.060	2drsA	0.398	4.43	0.067	0.480	3.2.1.156	303
22	0.060	2sqcA	0.399	4.80	0.082	0.486	5.4.99.17	NA
23	0.060	2vn4A	0.484	2.92	0.140	0.526	3.2.1.3	429,593

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.34	0.816	2.79	0.16	0.88	1ug9A	GO:0003824 GO:0004339 GO:0004553 GO:0005975 GO:0005976 GO:0016052 GO:0030246 GO:0046872
1	0.17	0.832	2.71	0.14	0.89	1lf6A	GO:0003824 GO:0004339 GO:0005975 GO:0005976 GO:0008152 GO:0016787 GO:0016798 GO:0030246
2	0.11	0.707	4.54	0.11	0.85	3rrsA	GO:0003824 GO:0005975 GO:0016740 GO:0016757 GO:0030246 GO:0047738
3	0.10	0.699	4.49	0.08	0.84	3qdeA	GO:0003824 GO:0005975 GO:0016740 GO:0016757 GO:0030246 GO:0047738
4	0.10	0.707	4.47	0.12	0.84	3acsA	GO:0003824 GO:0005975 GO:0030246
5	0.10	0.683	4.52	0.08	0.82	4zlfA	GO:0003824 GO:0005975 GO:0030246
6	0.10	0.688	5.12	0.08	0.86	1v7vA	GO:0003824 GO:0005975 GO:0016740 GO:0030246 GO:0046872
7	0.07	0.507	3.01	0.14	0.55	1ayxA	GO:0000272 GO:0003824 GO:0004339 GO:0005975 GO:0005976 GO:0008152 GO:0016787 GO:0016798
8	0.06	0.398	5.40	0.04	0.51	2a73B	GO:0001798 GO:0001934 GO:0001970 GO:0002376 GO:0002507 GO:0004252 GO:0004866 GO:0005102 GO:0005576 GO:0005615 GO:0005886 GO:0006508 GO:0006629 GO:0006631 GO:0006954 GO:0006955 GO:0006956 GO:0006957 GO:0006958 GO:0007165 GO:0007186 GO:0007596 GO:0008289 GO:0010575 GO:0010828 GO:0010866 GO:0010884 GO:0010951 GO:0030449 GO:0031715 GO:0032026 GO:0032355 GO:0032570 GO:0043627 GO:0045087 GO:0045745 GO:0045766 GO:0048037 GO:0048639 GO:0050766 GO:0050776 GO:0051384 GO:0070062 GO:0070374 GO:0072562 GO:2000427
9	0.06	0.316	4.47	0.08	0.38	1qqfA	GO:0001934 GO:0002376 GO:0002507 GO:0004866 GO:0005576 GO:0005615 GO:0006629 GO:0006631 GO:0006935 GO:0006954 GO:0006956 GO:0006957 GO:0006958 GO:0007596 GO:0008289 GO:0010828 GO:0010866 GO:0010884 GO:0010951 GO:0031715 GO:0032026 GO:0032355 GO:0032570 GO:0043627 GO:0045087 GO:0045745 GO:0048037 GO:0048639 GO:0051384 GO:0070374
10	0.06	0.237	7.68	0.04	0.37	4za4A	GO:0005737 GO:0010181 GO:0016491 GO:0016829 GO:0016831 GO:0033494 GO:0046281 GO:0046872 GO:0055114
11	0.06	0.220	7.62	0.04	0.35	2guwB	GO:0003824 GO:0008152 GO:0008714 GO:0009116 GO:0016787 GO:0016798 GO:0044209 GO:0046033
12	0.06	0.230	7.78	0.08	0.37	4impA	GO:0000166 GO:0003824 GO:0008152 GO:0016740 GO:0031177 GO:0048037
13	0.06	0.181	6.58	0.04	0.26	4mboA	GO:0005576 GO:0005618 GO:0007155 GO:0009986 GO:0030260 GO:1990254
14	0.06	0.196	6.76	0.03	0.28	2xwxA	GO:0004568 GO:0005576 GO:0006032 GO:0008061
15	0.06	0.196	6.90	0.08	0.29	2rdxA	GO:0003824 GO:0008152 GO:0046872
16	0.06	0.183	6.70	0.05	0.26	4wsnF	GO:0000715 GO:0005634 GO:0005654 GO:0005737 GO:0006283 GO:0008180 GO:0010388 GO:0016032 GO:0070062
17	0.06	0.198	6.70	0.06	0.29	2j0rA	GO:0006810 GO:0006811 GO:0006826 GO:0055072
18	0.06	0.178	6.34	0.07	0.25	2ffiA	GO:0016787 GO:0047554

Consensus prediction of GO terms

Molecular Function	GO:0030246	GO:0004339	GO:0004645	GO:0046872
GO-Score	0.60	0.45	0.40	0.34
Biological Processes	GO:0005976	GO:0016052
GO-Score	0.45	0.34
Cellular Component
GO-Score

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.