I-TASSER results

I-TASSER results for job id Rv2396

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (361 residues)
MSFLIASPEALAATATYLTGIGSAISAANAVAAAPTTEILAAGTDEVSTAISALFGAHAQ
AYQALSAHVAAFHDQFVHTLTAGAGSYMAAEAAAASPLQALQLELLNAINAPTLALLGRP
LIGDGTDAAPGSGGAGGAGGILIGNGGTGGASDLAGTGRGGVGGAGGAGGLFGIGGAGGG
CGSAVAIGGDGGAGGAGGVFSGGGAGGAGDAIGGSGGAGGTGGLLGGGGGAGGAGGAGGN
GGGASNSASIGGDGGSGGAGGMLYGAGGVGGNGGAAVAIGGDGGAGGRAGAIGNGGDGGN
GGTSNTPGGSGGDGGNGGNAGLIGNGGNGGNAEIVISGGSVAGTGGNGGLLLGFNGTNGL
P

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSFLIASPEALAATATYLTGIGSAISAANAVAAAPTTEILAAGTDEVSTAISALFGAHAQAYQALSAHVAAFHDQFVHTLTAGAGSYMAAEAAAASPLQALQLELLNAINAPTLALLGRPLIGDGTDAAPGSGGAGGAGGILIGNGGTGGASDLAGTGRGGVGGAGGAGGLFGIGGAGGGCGSAVAIGGDGGAGGAGGVFSGGGAGGAGDAIGGSGGAGGTGGLLGGGGGAGGAGGAGGNGGGASNSASIGGDGGSGGAGGMLYGAGGVGGNGGAAVAIGGDGGAGGRAGAIGNGGDGGNGGTSNTPGGSGGDGGNGGNAGLIGNGGNGGNAEIVISGGSVAGTGGNGGLLLGFNGTNGLP
Prediction	CCEEHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	9767644799999999999998899999988777666554566546889999999999999999999999999999999998788764555544555666677788887777888768888888889999999999998866789999999999999999999999988889999999888888899999999999999999999999999999999999988899999999998888999999988888899999999988899999999998888888999999889999999999988999999988999999888888998888999888888888888898888888889988999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSFLIASPEALAATATYLTGIGSAISAANAVAAAPTTEILAAGTDEVSTAISALFGAHAQAYQALSAHVAAFHDQFVHTLTAGAGSYMAAEAAAASPLQALQLELLNAINAPTLALLGRPLIGDGTDAAPGSGGAGGAGGILIGNGGTGGASDLAGTGRGGVGGAGGAGGLFGIGGAGGGCGSAVAIGGDGGAGGAGGVFSGGGAGGAGDAIGGSGGAGGTGGLLGGGGGAGGAGGAGGNGGGASNSASIGGDGGSGGAGGMLYGAGGVGGNGGAAVAIGGDGGAGGRAGAIGNGGDGGNGGTSNTPGGSGGDGGNGGNAGLIGNGGNGGNAEIVISGGSVAGTGGNGGLLLGFNGTNGLP
Prediction	4110202012021003203402200320120001100110200211001000000020032023003101300310030012002010323322232243334301310332022002241147635244143442110000002224133443234443343441133243342444444444435214334132323343444243344443424423424312324334443233343334444244335444244433342433444443334444142444553244344354243244644314334444344444424344255444444444345443443433345355438
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCEEHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MSFLIASPEALAATATYLTGIGSAISAANAVAAAPTTEILAAGTDEVSTAISALFGAHAQAYQALSAHVAAFHDQFVHTLTAGAGSYMAAEAAAASPLQALQLELLNAINAPTLALLGRPLIGDGTDAAPGSGGAGGAGGILIGNGGTGGASDLAGTGRGGVGGAGGAGGLFGIGGAGGGCGSAVAIGGDGGAGGAGGVFSGGGAGGAGDAIGGSGGAGGTGGLLGGGGGAGGAGGAGGNGGGASNSASIGGDGGSGGAGGMLYGAGGVGGNGGAAVAIGGDGGAGGRAGAIGNGGDGGNGGTSNTPGGSGGDGGNGGNAGLIGNGGNGGNAEIVISGGSVAGTGGNGGLLLGFNGTNGLP

2pffB

0.36

0.99

1.45

MUSTER

KNLVVSPPQSLYGLNLTLRKAKAKFSNRFLPVASP-SHLLVPASDLINKDLVKVYDTFGSDLRRIVDCIIRLPVKWETTTQFKATH-PGGASGLGVLTHRNKDGTGVRVIVAGTDDYGFKQGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG

1vt4I4

0.55

0.25

0.45

1.90

wdPPAS

----------------------------------------------------------------------------------------------------------------------------------------------------------GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG-------------------------------------------

2pffB

0.38

0.37

0.98

1.55

wMUSTER

KNLVVSGP------PQSLYGLNLTLRKAKAPSASP-SHLLVPASDLINKDLVKVYDTFGSDLRRIVDCIIRLPVKWETTTQFKATHILDFGPGGASGLGVLTHRNKDGTGVRVIVAGTLDINPDDDYGFKQGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG

5gaoE

0.19

0.18

0.92

2.15

wPPAS

------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA---------AAAAAAAAA-----AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA----------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFH

5gaoE

0.20

0.19

0.93

2.49

PPAS

-----AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA---------AAAAAAAAAAAAAAAAAAAAAAAAAAAAA-------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTK

5gaoE

0.16

0.12

0.78

2.88

dPPAS2

--------------------------------------------------------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATT

4cgkA

0.11

0.10

0.94

1.05

Env-PPAS

LT------AQQQEAQKQVDQIQEQVSAIQAEQSNLQAENDRLQAEKLEGEITELSKNIVSRNQSLEKQARSANGAVTSYINTIVNSKSITEAISVAAMSEIVSANNKMLEQQKADKKAISEKQVANNDAINT--------VIANQQKLADDAQALTTKQAELKAAELSLAAEKATAEGEKASLLEQKAAAEAEARAAAVAEAAYKEKRASQQQSVLASANTNLTAQVQAVSESAAAPVRAKVRPTYSTNASSYPIGECTWGVKTLAPWAGDYWGNGAQWATSAAAAGFR--TGSTPQVGAIACWND-------GGYGHVAVVTAVESTTRIQVSESNYAGNRTIGNHRGWFNPTTTSEGFA

1vt4I3

0.37

0.36

0.98

1.41

MUSTER

KTF-LIPPYL----QYFYSHIGHHLKNIEHPERMTLFRMVFLDFRFLEQKIR--TLQQLKFYKPYICDNDPKYERLVNAILDFLPKIEENLICSKIALMAEDEAIFEEAHKQVQR-GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG

1vt4I

0.38

0.99

1.26

MUSTER

ESTISI-PSIYLELKVKLALHRSIVDHYNIPKTFDSDDLIPPYLD---QYFYSHIGHHLKNIE-HPERMTLFRMVFLDFRFLEQKIRHDSTAWNASALMAEDEAIFEEAHKQVQRGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG

1pdiR

0.12

0.09

0.73

1.29

dPPAS

---------------------------------------------------------------------------------------LNGRGSTTSMRGVVK----------LTTTAGSQSGGDASSALAWNADVIHQRGGQTINGTLRINNTLTIASGGANITGTVNMTGGYIQGKRVVTQNEIDRTIPVGAIMMWAADSLPSDAWRFCHGGTVSASDCPLYASRIGTRYGGSSSNPGLPDMRGLFVRGSGRGSHTNPNVNGNDQFGKPRLGVGCTGGYVGEVQIQQMSYHKHAGGFGEHDDLGAFGNTRRSNFVGTRKGLDWDNRSYFTNDGYEIDPESQRNSKYTLNRPELIGNETRP

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.97

Estimated TM-score = 0.29±0.09

Estimated RMSD = 16.6±2.9Å

Download Model 2

C-score=-2.56

Download Model 3

C-score=-3.68

Download Model 4

C-score=-4.27

Download Model 5

C-score=-4.04

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5gaoE	0.560	4.94	0.168	0.745
2	5ganA	0.386	6.27	0.042	0.623
3	4hg6A	0.368	6.01	0.041	0.571
4	5cskA	0.365	7.37	0.063	0.654
5	3javA	0.362	6.48	0.018	0.593
6	2uvcG	0.360	6.56	0.060	0.604
7	5hb4B	0.360	6.18	0.039	0.571
8	3qmzA	0.352	6.13	0.040	0.557
9	1vt4I	0.350	6.10	0.086	0.540
10	4nh0A	0.349	6.43	0.043	0.562

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.09	5	3tdcA	0EU	Rep, Mult	23,27,28,30,31,32
2	0.06	3	1g9kA	CA	Rep, Mult	283,284,285,286,288,306,313
3	0.04	2	1g9kA	CA	Rep, Mult	278,279,280,282,290,291,292,295
4	0.04	2	1g9kA	CA	Rep, Mult	266,267,268,270,283,284,285,288
5	0.04	2	4jolC	III	Rep, Mult	243,247,250
6	0.02	1	4ca5A	FUC	Rep, Mult	47,48,148
7	0.02	1	2xqtB	DCW	Rep, Mult	55,62
8	0.02	1	3adcA	MG	Rep, Mult	26,159
9	0.02	1	2q6qA	CO	Rep, Mult	249,253
10	0.02	1	1hq3A	CL	Rep, Mult	231,233,234
11	0.02	1	1o0tA	CA	Rep, Mult	284,285,286,288,299,301,304
12	0.02	1	1zaxA	III	Rep, Mult	97,101,108
13	0.02	1	2a69F	MG	Rep, Mult	44,46
14	0.02	1	2xqtD	CVM	Rep, Mult	241,244,248
15	0.02	1	1u94A	CA	Rep, Mult	38,42,45
16	0.02	1	3p4gA	CA	Rep, Mult	293,294,295,297,308,309,310,313
17	0.02	1	3wmgA	DMU	Rep, Mult	238,242
18	0.02	1	2x24A	X24	Rep, Mult	109,114,116,117

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1ej6A	0.334	7.04	0.041	0.576	2.7.7.50	NA
2	0.060	2rhqB	0.328	6.70	0.055	0.546	6.1.1.20	NA
3	0.060	2cseW	0.306	6.53	0.044	0.501	3.6.4.13	NA
4	0.060	3ffzA	0.319	6.67	0.036	0.535	3.4.24.69	NA
5	0.060	3btaA	0.307	7.16	0.026	0.546	3.4.24.69	NA
6	0.060	2np0A	0.312	6.84	0.042	0.523	3.4.24.69	NA
7	0.060	1od2A	0.331	6.49	0.061	0.537	6.3.4.14,6.4.1.2	147
8	0.060	2z8yD	0.340	5.94	0.042	0.512	1.2.7.4,1.2.99.2	NA
9	0.060	2uv8G	0.298	6.93	0.034	0.512	2.3.1.86	NA
10	0.060	1r1jA	0.283	6.59	0.063	0.465	3.4.24.11	NA
11	0.060	2vz8A	0.323	6.88	0.028	0.562	2.3.1.85	NA
12	0.060	1ygeA	0.228	7.37	0.029	0.421	1.13.11.12	29
13	0.060	2je8B	0.317	6.27	0.043	0.507	3.2.1.25	NA
14	0.060	2vumB	0.311	7.08	0.046	0.551	2.7.7.6	16
15	0.060	1bf2A	0.304	6.79	0.090	0.510	3.2.1.68	NA
16	0.060	1dmtA	0.286	6.65	0.050	0.474	3.4.24.11	91
17	0.060	2jfdA	0.237	6.96	0.046	0.404	2.3.1.85	25
18	0.060	3ff6A	0.331	6.25	0.012	0.529	6.4.1.2,6.3.4.14	51
19	0.060	2gtqA	0.314	6.63	0.067	0.507	3.4.11.2	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.08	0.560	4.94	0.17	0.75	5gaoE	GO:0000387 GO:0000398 GO:0000481 GO:0005634 GO:0005681 GO:0006397 GO:0008380 GO:0030529 GO:0045292 GO:0046540
1	0.06	0.368	6.01	0.04	0.57	4hg6A	GO:0000166 GO:0006011 GO:0016020 GO:0016021 GO:0016740 GO:0016757 GO:0016759 GO:0016760 GO:0030244 GO:0035438
2	0.06	0.295	7.00	0.02	0.51	3zefE	GO:0000244 GO:0000350 GO:0000386 GO:0000389 GO:0000398 GO:0003676 GO:0003723 GO:0005634 GO:0005681 GO:0005682 GO:0006397 GO:0008380 GO:0017070 GO:0030529 GO:0030619 GO:0030620 GO:0030623 GO:0046540 GO:0071013 GO:0097157
3	0.06	0.298	7.05	0.03	0.51	5gapA	GO:0000244 GO:0000350 GO:0000386 GO:0000389 GO:0000398 GO:0003676 GO:0003723 GO:0005634 GO:0005681 GO:0005682 GO:0006397 GO:0008380 GO:0017070 GO:0030529 GO:0030619 GO:0030620 GO:0030623 GO:0046540 GO:0071013 GO:0097157
4	0.06	0.243	5.75	0.05	0.37	1pjaA	GO:0005764 GO:0008474 GO:0016787 GO:0016790 GO:0035338 GO:0043202 GO:0043231 GO:0070062 GO:0098599 GO:0098734
5	0.06	0.225	7.14	0.05	0.40	3c75H	GO:0016491 GO:0030058 GO:0030416 GO:0042597 GO:0052876 GO:0055114
6	0.06	0.187	7.07	0.04	0.32	1yxaA	GO:0004867 GO:0005576 GO:0005615 GO:0006953 GO:0010466 GO:0010951 GO:0030414 GO:0034097 GO:0043434 GO:0070062 GO:0072562
7	0.06	0.218	6.08	0.03	0.34	4kitC	GO:0000244 GO:0000375 GO:0000386 GO:0000398 GO:0003676 GO:0003723 GO:0005634 GO:0005654 GO:0005681 GO:0005682 GO:0006397 GO:0008380 GO:0016020 GO:0016607 GO:0017070 GO:0030529 GO:0030532 GO:0030619 GO:0030620 GO:0030623 GO:0044822 GO:0070530 GO:0071013 GO:0071222 GO:0071356 GO:0097157
8	0.06	0.252	5.70	0.09	0.37	2uvnA	GO:0004497 GO:0005506 GO:0005618 GO:0016491 GO:0016705 GO:0020037 GO:0046872 GO:0055114
9	0.06	0.216	5.68	0.05	0.32	1cydA	GO:0004090 GO:0005739 GO:0005759 GO:0006116 GO:0016491 GO:0043621 GO:0051262 GO:0055114
10	0.06	0.217	6.40	0.04	0.35	5bwkE	GO:0005737 GO:0006620 GO:0006810 GO:0016192 GO:0045048 GO:0071818 GO:0072380
11	0.06	0.194	7.03	0.06	0.33	1pciA	GO:0006508 GO:0008233 GO:0008234 GO:0016787
12	0.06	0.240	6.85	0.06	0.39	5gamA	GO:0000244 GO:0000350 GO:0000386 GO:0000389 GO:0000398 GO:0003676 GO:0003723 GO:0005634 GO:0005681 GO:0005682 GO:0006397 GO:0008380 GO:0017070 GO:0030529 GO:0030619 GO:0030620 GO:0030623 GO:0046540 GO:0071013 GO:0097157
13	0.06	0.224	5.62	0.06	0.34	2hpsA	GO:0005509 GO:0046872
14	0.06	0.221	6.11	0.07	0.34	4ztkA	GO:0008658 GO:0016020 GO:0016021 GO:0051301
15	0.06	0.191	6.48	0.03	0.31	2qe7G	GO:0005524 GO:0005886 GO:0006754 GO:0006810 GO:0006811 GO:0015986 GO:0015992 GO:0016020 GO:0042777 GO:0045261 GO:0046933 GO:0046961
16	0.06	0.202	6.58	0.07	0.34	1r4qL	GO:0016787 GO:0017148 GO:0030598
17	0.06	0.190	6.81	0.07	0.33	3wtcA	GO:0016491 GO:0019152 GO:0045150 GO:0055114
18	0.06	0.199	5.51	0.04	0.29	3nibA	GO:0008146

Consensus prediction of GO terms

Molecular Function	GO:0000386	GO:0030619	GO:0030623	GO:0030620	GO:0017070	GO:0097157	GO:0016760	GO:0035438	GO:0008474
GO-Score	0.12	0.12	0.12	0.12	0.12	0.12	0.06	0.06	0.06
Biological Processes	GO:0016071	GO:0000377
GO-Score	0.39	0.39
Cellular Component	GO:0097526
GO-Score	0.39

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.