I-TASSER results

I-TASSER results for job id Rv2370c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (437 residues)
MVLPKPTPRGRELIRQAAKVALHPTPEWLDELDRATLAAHPSIAADPALATVVSRANRSH
LIHFATANLRKPGQPVPANLGPDPLRMARDLVRRGLDASALDVYRVGQNVAWQRWTEIAF
GLTTDPQELHELLTLPFRSASEFIDATLAGLAAQMQLEYDELTRDVHAEHRRIVELILDG
APISRQSAEAKLGYPLDRSHTAAIIWYDDPDDNQNHLDHTARAFGRALGCPQPLIAVASA
ATRWVWVSDAATLDTDRIHQVLDHAPHARIAVGTTARGIDGFRRSHRDALATQRMLARLR
SQQRLAFFADIHMIAVLTENPDSAADFITSTLGDLESASPQLLTTVLTYINEQCNASRAA
HVLHTHRNTLLRRLETAQRLLPRPLDHTIIQVAVAISALQWRGSQTSDPVETPVEGITSP
PPESLGRRRSRLAQLER

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MVLPKPTPRGRELIRQAAKVALHPTPEWLDELDRATLAAHPSIAADPALATVVSRANRSHLIHFATANLRKPGQPVPANLGPDPLRMARDLVRRGLDASALDVYRVGQNVAWQRWTEIAFGLTTDPQELHELLTLPFRSASEFIDATLAGLAAQMQLEYDELTRDVHAEHRRIVELILDGAPISRQSAEAKLGYPLDRSHTAAIIWYDDPDDNQNHLDHTARAFGRALGCPQPLIAVASAATRWVWVSDAATLDTDRIHQVLDHAPHARIAVGTTARGIDGFRRSHRDALATQRMLARLRSQQRLAFFADIHMIAVLTENPDSAADFITSTLGDLESASPQLLTTVLTYINEQCNASRAAHVLHTHRNTLLRRLETAQRLLPRPLDHTIIQVAVAISALQWRGSQTSDPVETPVEGITSPPPESLGRRRSRLAQLER
Prediction	CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEEEEHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEHCCCEEEEEHCCCCCCHHHHHHHHHHHCCCCEEEHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCC
Conf.Score	99989985799999999999998899999999999999857764675578999999999999999998756788887666689999999999989999999999999999999999999974899899999999999999999999999999999999999999999999999999997999999999999899999878999999689988667999999999999878886899857878999957888755899999987658977998677779999999999999999999986889985886556688998789899999999998756557889999999999989999999998899999999999999999899999868999999999999867778887788888888887655666555666569
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MVLPKPTPRGRELIRQAAKVALHPTPEWLDELDRATLAAHPSIAADPALATVVSRANRSHLIHFATANLRKPGQPVPANLGPDPLRMARDLVRRGLDASALDVYRVGQNVAWQRWTEIAFGLTTDPQELHELLTLPFRSASEFIDATLAGLAAQMQLEYDELTRDVHAEHRRIVELILDGAPISRQSAEAKLGYPLDRSHTAAIIWYDDPDDNQNHLDHTARAFGRALGCPQPLIAVASAATRWVWVSDAATLDTDRIHQVLDHAPHARIAVGTTARGIDGFRRSHRDALATQRMLARLRSQQRLAFFADIHMIAVLTENPDSAADFITSTLGDLESASPQLLTTVLTYINEQCNASRAAHVLHTHRNTLLRRLETAQRLLPRPLDHTIIQVAVAISALQWRGSQTSDPVETPVEGITSPPPESLGRRRSRLAQLER
Prediction	76344245403500330052036404400420041025204412513312520241013002200210033444224462252015101300234131500200110000003101310341135262023002100410130023003100310342143234523320230032015255222420142240305100000000013254222202300310131031220000002310000000333422242023002313401010000010021003004003300400442456410000000001000131262025004500430372353002001000435232430063041021002200510260072406332010100000010135443524643455444434543444453245158
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEEEEHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEHCCCEEEEEHCCCCCCHHHHHHHHHHHCCCCEEEHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCC
MVLPKPTPRGRELIRQAAKVALHPTPEWLDELDRATLAAHPSIAADPALATVVSRANRSHLIHFATANLRKPGQPVPANLGPDPLRMARDLVRRGLDASALDVYRVGQNVAWQRWTEIAFGLTTDPQELHELLTLPFRSASEFIDATLAGLAAQMQLEYDELTRDVHAEHRRIVELILDGAPISRQSAEAKLGYPLDRSHTAAIIWYDDPDDNQNHLDHTARAFGRALGCPQPLIAVASAATRWVWVSDAATLDTDRIHQVLDHAPHARIAVGTTARGIDGFRRSHRDALATQRMLARLRSQQRLAFFADIHMIAVLTENPDSAADFITSTLGDLESASPQLLTTVLTYINEQCNASRAAHVLHTHRNTLLRRLETAQRLLPRPLDHTIIQVAVAISALQWRGSQTSDPVETPVEGITSPPPESLGRRRSRLAQLER

3onqA

0.15

0.08

0.56

1.21

MUSTER

--------------------------------------------------------------------------------------------------------------------------------------------------------ADILDLLS--HTDDTTIERLAFECLLTNTD-DRVVSLNILGWQGDFNCFAIGGVP---SASLASTSLAIRKAVRDLGGEH-VVIGTYGTFLLALACQGAVTPEVTCTAVPAFSEDEPLYLSPVRSGVAGASHALRETFSLQAAPAL-STPSRPLRADELLPERALLGDDYAREELYRNVYQVLRGENPPTYLTVSTFLKYGSSLENTAKELNVHPNTVRYRLKRAAETTGWDATDPRDAYVLTTALAIGRRDR--------------------------------

3onqA

0.15

0.09

0.56

1.39

dPPAS

---------------------------------------------------------------------------------------------------------------------------------------------------------ADILDLLSGHTDDTTIERLAFECLLTNT-DDRVVSLNILGWQGDFNCFAIGGVPSA---SLASTSLAIRKAVRDLGGEHVVIGTYGT-FLLALACQGAVTPEVTCTAVPAFSEDEPLYLSPVRSGVAGASHALRETFSLQAAPAL-STPSRPLRADELLPERALLGDDYAREELYRNVYQVLRGENPPTYLTVSTFLKYGSSLENTAKELNVHPNTVRYRLKRAAETTGWDATDPRDAYVLTTALAIGRRDR--------------------------------

3onqA

0.15

0.09

0.56

2.59

wdPPAS

---------------------------------------------------------------------------------------------------------------------------------------------------------ADILDLLSGHTDDTTIERLAFECLLTNTD-DRVVSLNILGWQGDFNCFAIGGVPSA---SLASTSLAIRKAVRDLGGEHVVIGTYGT-FLLALACQGAVTPEVTCTAVPAFSEDEPLYLSPVRSGVAGASHALRETFSLQAAPAL-STPSRPLRADELLPERALLGDDYAREELYRNVYQVLRGENPPTYLTVSTFLKYGSSLENTAKELNVHPNTVRYRLKRAAETTGWDATDPRDAYVLTTALAIGRRDR--------------------------------

3onqA

0.16

0.09

0.56

1.62

wMUSTER

--------------------------------------------------------------------------------------------------------------------------------------------------------ADILDLLS--HTDDTTIERLAFECLLTNTD-DRVVSLNILGWQGDFNCFAIGGVP---SASLASTSLAIRKAVRDLGGEHVVIGTYGT-FLLALACQGAVTPEVTCTAVPAFSEDEPLYLSPVRSGVAGASHALRETFSLQAAPAL-STPSRPLRADELLPERALLGDDYAREELYRNVYQVLRGENPPTYLTVSTFLKYGSSLENTAKELNVHPNTVRYRLKRAAETTGWDATDPRDAYVLTTALAIGRRDR--------------------------------

3onqA

0.15

0.09

0.56

3.32

wPPAS

--------------------------------------------------------------------------------------------------------------------------------------------------------ADILDLLSG-HTDDTTIERLAFECLLTNTD-DRVVSLNILGWQGDFNCFAIGGVPS---ASLASTSLAIRKAVRDLGGEHVVIGTYGT-FLLALACQGAVTPEVTCTAVPAFSEDEPLYLSPVRSGVAGASHALRETFSLQAAPAL-STPSRPLRADELLPERALLGDDYAREELYRNVYQVLRGENPPTYLTVSTFLKYGSSLENTAKELNVHPNTVRYRLKRAAETTGWDATDPRDAYVLTTALAIGRRDR--------------------------------

3onqA

0.15

0.09

0.56

3.10

dPPAS2

---------------------------------------------------------------------------------------------------------------------------------------------------------ADILDLLSGHTDDTTIERLAFECLLTNT-DDRVVSLNILGWQGDFNCFAIGGVPSA---SLASTSLAIRKAVRDLGGEHVVIGTYGT-FLLALACQGAVTPEVTCTAVPAFSEDEPLYLSPVRSGVAGASHALRETFSLQAAPAL-STPSRPLRADELLPERALLGDDYAREELYRNVYQVLRGENPPTYLTVSTFLKYGSSLENTAKELNVHPNTVRYRLKRAAETTGWDATDPRDAYVLTTALAIGRRDR--------------------------------

3onqA

0.15

0.09

0.56

2.37

PPAS

--------------------------------------------------------------------------------------------------------------------------------------------------------ADILDLLSG-HTDDTTIERLAFECLLTNTD-DRVVSLNILGWQGDFNCFAIGGVPS---ASLASTSLAIRKAVRDLGGEHVVIGTYGT-FLLALACQGAVTPEVTCTAVPAFSEDEPLYLSPVRSGVAGASHALRETFSLQAAPAL-STPSRPLRADELLPERALLGDDYAREELYRNVYQVLRGENPPTYLTVSTFLKYGSSLENTAKELNVHPNTVRYRLKRAAETTGWDATDPRDAYVLTTALAIGRRDR--------------------------------

3onqA

0.15

0.08

0.56

3.76

Env-PPAS

--------------------------------------------------------------------------------------------------------------------------------------------------------ADILDLLSG-HTDDTTIERLAFECLLTNTD-DRVVSLNILGWQGDFNCFAIGGVPS---ASLASTSLAIRKAVRDLGGEH-VVIGTYGTFLLALACQGAVTPEVTCTAVPAFSEDEPLYLSPVRSGVAGASHALRETFSLQAAPAL-STPSRPLRADELLPERALLGDDYAREELYRNVYQVLRGENDPTYLTVSTFLKYGSSLENTAKELNVHPNTVRYRLKRAAETTGWDATDPRDAYVLTTALAIGRRDR--------------------------------

5ic0A

0.07

0.96

0.83

MUSTER

NPVQPINDMSYFGCLDSVMENSKVLGEAMTGISQNAKNNLPEFGDAATASKALCGFTEAAAQAAYLVGVSDPNSQAGQQGLQAIQMACQSLGEPGCTQAQVLSAATIVAKHTSALCNSCRLARTANPTAKRQFVQSAKEVANSTANLVKTIKALDGDFTEENRAQCRAATAPLLEAVDN-----LSAFASNPEFSSVPAQIS---GRAAMEPIVISAKTMLESAGGLIQTARALAVNPRDPPRWSVLAGHSRTVSDSIKKLITSMRDKAPGQLECETAIAALNSCLRDLDQASLAAVSQQLAPR---ISQEALHTQMLTAVQEISHLIEPLASAARAEASQLGHKVSQMAQYFEPLTLAAVGA-LSHPQQMALLDQTKTLA------ESALQLLYTAKEAGGNPKQAAHTQEALEEAVQMMTEAVEDLTTTLNEAAS

5ic0A

0.08

0.96

0.71

dPPAS

PVQPINDMSYFGCLDSVMENSKVLGEAMTGISQNAKNGNLPEFGDAATASKALCGFTEAAAQAAYLVGVSDPNSQAGQQGLVEPTQFARANQAIQMACQSLGEPGCTQAQVLSAATIVAKHTSALCNSCRLASARTAPTAKRQFVQSAKEVANSTANLVKTIKALDGDFTEENRAQCRAATAPLLEAVDNLSAFASNPEFSSVPAQISPEGRAVISAKTMLESAGGLIQTARALAVNPRDPPRWSVLAGHSRTVSDSIKKLITSMRDKAPGQ-LECETAIAALNSCLRDLDQASLAAVSQQLAPREGISQEALHTQMLTAVQEISHLIEPLASAARAEASQLGHKVSQMAQYFEPLTLAAVGAASK------------------TLSHPQQMALLDQTKTLAESALQLLYTAKEAGGNPKQAAHTQEALEEAVQMMT

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.01

Estimated TM-score = 0.47±0.15

Estimated RMSD = 11.8±4.5Å

Download Model 2

C-score=-3.20

Download Model 3

C-score=-1.78

Download Model 4

C-score=-4.09

Download Model 5

C-score=-4.01

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5ic0A	0.916	2.00	0.075	0.970
2	1st6A	0.410	5.89	0.086	0.584
3	4fhmB	0.392	7.28	0.048	0.654
4	2x0cA	0.382	3.87	0.051	0.446
5	3dyjA	0.380	5.62	0.066	0.526
6	3h7nA	0.379	6.89	0.037	0.611
7	3wajA	0.378	7.13	0.039	0.632
8	1vw1A	0.375	6.61	0.031	0.572
9	3dtpB1	0.372	7.09	0.050	0.613
10	3iydC	0.368	7.65	0.058	0.657

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.09	5	2gdcA	III	Rep, Mult	46,48,49,52,53,56,59,213,247,254,258,261,262,265
2	0.07	4	3qbgB	22B	Rep, Mult	324,328,331,346,349
3	0.07	4	1odbA	CU	Rep, Mult	364,366
4	0.04	2	4ogqA	8K6	Rep, Mult	285,289,360,377
5	0.04	2	1i5bA	MN	Rep, Mult	366,367,368
6	0.04	2	2y02A	2CV	Rep, Mult	370,373
7	0.04	2	3cc9A	GRG	Rep, Mult	368,371
8	0.04	2	5da5C	GOA	Rep, Mult	319,320,323,352
9	0.02	1	3ak1C	EDO	Rep, Mult	97,100
10	0.02	1	2ibfA	III	Rep, Mult	335,346,349,350,353,356,357,378
11	0.02	1	5l8gA	CA	Rep, Mult	327,352
12	0.02	1	2ppbC	STD	Rep, Mult	337,340,343,398

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1y2mB	0.347	6.83	0.050	0.542	4.3.1.24	NA
2	0.060	2pdaA	0.315	7.32	0.046	0.535	1.2.7.1	331
3	0.060	1reqA	0.303	7.57	0.041	0.524	5.4.99.2	NA
4	0.060	3b8cA	0.332	7.02	0.044	0.535	3.6.3.6	NA
5	0.060	1w27A	0.354	6.31	0.031	0.542	4.3.1.24	NA
6	0.060	1e1yA	0.254	7.95	0.031	0.465	2.4.1.1	NA
7	0.060	1ea0A	0.334	7.18	0.028	0.565	1.4.1.13	NA
8	0.060	1b0pA	0.325	7.39	0.058	0.556	1.2.7.1	NA
9	0.060	1fa9A	0.245	6.24	0.035	0.368	2.4.1.1	284
10	0.060	3eifA	0.357	6.94	0.066	0.577	3.4.21.110	NA
11	0.060	1br2A	0.325	7.46	0.050	0.556	3.6.1.32	NA
12	0.060	2vumB	0.339	6.91	0.047	0.540	2.7.7.6	NA
13	0.060	1pj6A	0.328	7.27	0.047	0.554	1.5.3.10	NA
14	0.060	3b8eA	0.334	7.03	0.047	0.545	3.6.3.9	NA
15	0.060	1ileA	0.317	6.53	0.047	0.476	6.1.1.5	278,286
16	0.060	3hkzJ	0.354	7.27	0.050	0.593	2.7.7.6	NA
17	0.060	1mhsA	0.359	7.52	0.036	0.629	3.6.3.6	NA
18	0.060	1mo7A	0.158	6.87	0.013	0.259	3.6.3.9	277
19	0.060	1fohC	0.338	7.07	0.045	0.547	1.14.13.7	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.30	0.916	2.00	0.07	0.97	5ic0A	GO:0001726 GO:0003779 GO:0005178 GO:0005200 GO:0005737 GO:0005815 GO:0005856 GO:0005886 GO:0005925 GO:0007016 GO:0007044 GO:0007155 GO:0009986 GO:0016020 GO:0017166 GO:0030054 GO:0030274 GO:0030866 GO:0032403 GO:0032587 GO:0042995 GO:0051015 GO:0070062 GO:0070527
1	0.06	0.410	5.89	0.09	0.58	1st6A	GO:0001725 GO:0002009 GO:0002162 GO:0003779 GO:0005198 GO:0005623 GO:0005737 GO:0005743 GO:0005856 GO:0005886 GO:0005903 GO:0005911 GO:0005912 GO:0005913 GO:0005915 GO:0005916 GO:0005925 GO:0005927 GO:0007155 GO:0008013 GO:0015629 GO:0016020 GO:0017166 GO:0030018 GO:0030032 GO:0030054 GO:0030334 GO:0030486 GO:0031594 GO:0031625 GO:0034333 GO:0034394 GO:0042383 GO:0042803 GO:0043034 GO:0043234 GO:0043297 GO:0045121 GO:0045294 GO:0045296 GO:0048675 GO:0051015 GO:0051371 GO:0051393 GO:0070062 GO:0070527 GO:0090136 GO:0090636 GO:0090637 GO:0097110 GO:0098723 GO:1903561 GO:1990357
2	0.06	0.392	7.28	0.05	0.65	4fhmB	GO:0005487 GO:0005634 GO:0005635 GO:0005643 GO:0006810 GO:0016973 GO:0031080 GO:0034399
3	0.06	0.268	6.78	0.02	0.42	4fhnD	GO:0005487 GO:0005634 GO:0005635 GO:0005643 GO:0006810 GO:0016973 GO:0031080 GO:0034399
4	0.06	0.388	3.97	0.06	0.47	3dyjA	GO:0001726 GO:0003779 GO:0005178 GO:0005200 GO:0005737 GO:0005815 GO:0005856 GO:0005886 GO:0005925 GO:0007016 GO:0007044 GO:0007155 GO:0009986 GO:0016020 GO:0017166 GO:0030054 GO:0030274 GO:0030866 GO:0032403 GO:0032587 GO:0042995 GO:0051015 GO:0070062 GO:0070527
5	0.06	0.247	4.41	0.06	0.31	4p9tA	GO:0005198 GO:0005634 GO:0005737 GO:0005856 GO:0005886 GO:0005912 GO:0005913 GO:0007155 GO:0007275 GO:0007409 GO:0015629 GO:0016020 GO:0016323 GO:0016337 GO:0021942 GO:0030027 GO:0030054 GO:0030154 GO:0030424 GO:0042995 GO:0045296 GO:0048813 GO:0048854 GO:0051015 GO:0051823 GO:0060134 GO:0097481
6	0.06	0.337	2.55	0.07	0.37	2l7nA	GO:0001726 GO:0003779 GO:0005178 GO:0005200 GO:0005737 GO:0005815 GO:0005856 GO:0005886 GO:0005925 GO:0007016 GO:0007044 GO:0007155 GO:0009986 GO:0016020 GO:0017166 GO:0030054 GO:0030274 GO:0030866 GO:0032403 GO:0032587 GO:0042995 GO:0051015 GO:0070062 GO:0070527
7	0.06	0.385	5.36	0.07	0.52	4iggB	GO:0001541 GO:0001669 GO:0005198 GO:0005737 GO:0005794 GO:0005829 GO:0005856 GO:0005886 GO:0005911 GO:0005912 GO:0005913 GO:0005915 GO:0005925 GO:0007015 GO:0007155 GO:0007163 GO:0007406 GO:0007568 GO:0008013 GO:0008584 GO:0014070 GO:0014704 GO:0015629 GO:0016020 GO:0016264 GO:0016342 GO:0016600 GO:0017166 GO:0030027 GO:0030054 GO:0031103 GO:0034332 GO:0034613 GO:0042127 GO:0042475 GO:0043066 GO:0043231 GO:0043297 GO:0043627 GO:0044822 GO:0045295 GO:0045296 GO:0045880 GO:0051015 GO:0051149 GO:0051291 GO:0071681 GO:0090136 GO:0098641 GO:2000146 GO:2001045 GO:2001240 GO:2001241
8	0.06	0.300	4.33	0.08	0.38	1dowA	GO:0001541 GO:0001669 GO:0005198 GO:0005737 GO:0005794 GO:0005829 GO:0005856 GO:0005886 GO:0005911 GO:0005912 GO:0005913 GO:0005915 GO:0005925 GO:0007015 GO:0007155 GO:0007163 GO:0007406 GO:0007568 GO:0008013 GO:0008584 GO:0014070 GO:0014704 GO:0015629 GO:0016020 GO:0016264 GO:0016342 GO:0016600 GO:0017166 GO:0030027 GO:0030054 GO:0031103 GO:0034613 GO:0042127 GO:0042475 GO:0043066 GO:0043231 GO:0043297 GO:0043627 GO:0044822 GO:0045295 GO:0045296 GO:0045880 GO:0046982 GO:0051015 GO:0051291 GO:0071681 GO:0090136 GO:2000146 GO:2001045 GO:2001240 GO:2001241
9	0.06	0.316	3.11	0.08	0.35	1sj8A	GO:0001726 GO:0003779 GO:0005178 GO:0005200 GO:0005737 GO:0005815 GO:0005856 GO:0005886 GO:0005925 GO:0007016 GO:0007044 GO:0007155 GO:0009986 GO:0016020 GO:0017166 GO:0030054 GO:0030274 GO:0030866 GO:0032403 GO:0032587 GO:0042995 GO:0051015 GO:0070062 GO:0070527
10	0.06	0.318	2.10	0.05	0.34	3fyqA	GO:0001726 GO:0003779 GO:0005158 GO:0005178 GO:0005200 GO:0005856 GO:0005925 GO:0006909 GO:0007016 GO:0007155 GO:0007298 GO:0007390 GO:0007430 GO:0007475 GO:0007526 GO:0008360 GO:0016203 GO:0033627 GO:0035160 GO:0045214 GO:0045892 GO:0051015 GO:0060439 GO:0086042
11	0.06	0.243	7.36	0.02	0.41	4oc9D	GO:0003824 GO:0003961 GO:0006520 GO:0016740 GO:0016765 GO:0016829 GO:0030170 GO:0071266
12	0.06	0.340	7.25	0.05	0.56	4fhnB	GO:0005487 GO:0005634 GO:0005635 GO:0005643 GO:0006810 GO:0016973 GO:0031080 GO:0034399
13	0.06	0.269	4.54	0.02	0.34	4k1nA	GO:0001541 GO:0001669 GO:0005198 GO:0005737 GO:0005794 GO:0005829 GO:0005856 GO:0005886 GO:0005911 GO:0005912 GO:0005913 GO:0005915 GO:0005925 GO:0007015 GO:0007155 GO:0007163 GO:0007406 GO:0007568 GO:0008013 GO:0008584 GO:0014070 GO:0014704 GO:0015629 GO:0016020 GO:0016264 GO:0016342 GO:0016600 GO:0017166 GO:0030027 GO:0030054 GO:0031103 GO:0034613 GO:0042127 GO:0042475 GO:0043066 GO:0043231 GO:0043297 GO:0043627 GO:0044822 GO:0045295 GO:0045296 GO:0045880 GO:0046982 GO:0051015 GO:0051291 GO:0071681 GO:0090136 GO:2000146 GO:2001045 GO:2001240 GO:2001241
14	0.06	0.276	3.52	0.10	0.32	4k1oA	GO:0005198 GO:0005634 GO:0005737 GO:0005856 GO:0005886 GO:0005912 GO:0005913 GO:0007155 GO:0007275 GO:0007409 GO:0015629 GO:0016020 GO:0016323 GO:0016337 GO:0021942 GO:0030027 GO:0030054 GO:0030154 GO:0030424 GO:0042995 GO:0045296 GO:0048813 GO:0048854 GO:0051015 GO:0051823 GO:0060134 GO:0097481
15	0.06	0.209	6.38	0.03	0.32	3zwlD	GO:0001731 GO:0002183 GO:0002188 GO:0003743 GO:0005737 GO:0005852 GO:0006412 GO:0006413 GO:0006446 GO:0016282 GO:0033290 GO:0043614
16	0.06	0.228	4.91	0.04	0.30	4wnlC	GO:0003723 GO:0003729 GO:0005634 GO:0005737 GO:0005789 GO:0005934 GO:0006810 GO:0007533 GO:0008289 GO:0008298 GO:0051028
17	0.06	0.207	5.54	0.08	0.29	2fncA	GO:0004175 GO:0005363 GO:0006511 GO:0015768 GO:0019773
18	0.06	0.209	6.27	0.06	0.31	5hbgA	GO:0004124 GO:0006535 GO:0008652 GO:0016740 GO:0019344

Consensus prediction of GO terms

Molecular Function	GO:0017166	GO:0051015	GO:0030274	GO:0005200	GO:0005178
GO-Score	0.38	0.38	0.34	0.34	0.34
Biological Processes	GO:0070527	GO:0007016	GO:0007044	GO:0030866
GO-Score	0.38	0.34	0.34	0.34
Cellular Component	GO:0005737	GO:0005925	GO:0070062	GO:0009986	GO:0032587	GO:0005815
GO-Score	0.38	0.38	0.38	0.34	0.34	0.34

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.