I-TASSER results

I-TASSER results for job id Rv2366c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (435 residues)
MTGYYQLLGSIVLIGLGGLFAAIDAAISTVSPARVDELVRDQRPGAGSLRKVMADRPRYV
NLVVLLRTSCEITATALLVVFIRYHFSMVWGLYLAAGIMVLASFVVVGVGPRTLGRQNAY
SISLATALPLRLISWLLMPISRLLVLLGNALTPGRGFRNGPFASEIELREVVDLAQQRGV
VAADERRMIESVFELGDTPAREVMVPRTEMIWIESDKTAGQAMTLAVRSGHSRIPVIGEN
VDDIVGVVYLKDLVEQTFCSTNGGRETTVARVMRPAVFVPDSKPLDALLREMQRDRNHMA
LLVDEYGAIAGLVSIEDVLEEIVGEIADEYDQAETAPVEDLGDKRFRVSARLPIEDVGEL
YGVEFDDDLDVDTVGGLLALELGRVPLPGAEVISHGLRLHAEGGTDHRGRVRIGTVLLSP
AEPDGADDEEADHPG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTGYYQLLGSIVLIGLGGLFAAIDAAISTVSPARVDELVRDQRPGAGSLRKVMADRPRYVNLVVLLRTSCEITATALLVVFIRYHFSMVWGLYLAAGIMVLASFVVVGVGPRTLGRQNAYSISLATALPLRLISWLLMPISRLLVLLGNALTPGRGFRNGPFASEIELREVVDLAQQRGVVAADERRMIESVFELGDTPAREVMVPRTEMIWIESDKTAGQAMTLAVRSGHSRIPVIGENVDDIVGVVYLKDLVEQTFCSTNGGRETTVARVMRPAVFVPDSKPLDALLREMQRDRNHMALLVDEYGAIAGLVSIEDVLEEIVGEIADEYDQAETAPVEDLGDKRFRVSARLPIEDVGELYGVEFDDDLDVDTVGGLLALELGRVPLPGAEVISHGLRLHAEGGTDHRGRVRIGTVLLSPAEPDGADDEEADHPG
Prediction	CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEHCHCCCEEEEEHCCCCHHHHHHHHHHCCCCEEEEHCCCCCEEEEEEEHHHHHHHHHHHCCCCCCCCHHHHCCCCCEHCCCCCHHHHHHHHHHHCCEEEEEEHCCCCEEEEHCHHHHHHHHHCCCCCCCCCCCCCCEEEHCCCEEEEEHCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEHCCEEEEEEEHCCCCCCEEEEEEEEEHCCCCCCCCCCCCCCC
Conf.Score	979999999999999999999999888875899999999989979999999998867889999999999999999999999999975789999999999999999986667799998789999999799999999999999999999999999988998888999999999999998799999999999988645885686654568758999789999999999998699879975899874877775999999999756788889989975788655898899999999999898699999689985544349999999978888888998765558857998999856889999999899999999987779999999877899998999999999999965876544689999996899888766667789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTGYYQLLGSIVLIGLGGLFAAIDAAISTVSPARVDELVRDQRPGAGSLRKVMADRPRYVNLVVLLRTSCEITATALLVVFIRYHFSMVWGLYLAAGIMVLASFVVVGVGPRTLGRQNAYSISLATALPLRLISWLLMPISRLLVLLGNALTPGRGFRNGPFASEIELREVVDLAQQRGVVAADERRMIESVFELGDTPAREVMVPRTEMIWIESDKTAGQAMTLAVRSGHSRIPVIGENVDDIVGVVYLKDLVEQTFCSTNGGRETTVARVMRPAVFVPDSKPLDALLREMQRDRNHMALLVDEYGAIAGLVSIEDVLEEIVGEIADEYDQAETAPVEDLGDKRFRVSARLPIEDVGELYGVEFDDDLDVDTVGGLLALELGRVPLPGAEVISHGLRLHAEGGTDHRGRVRIGTVLLSPAEPDGADDEEADHPG
Prediction	331103010012012301210010000010344304400764352042024016305300000001102000201100000002211311010100222122002000110011023200200120033022102202220222023032002002045765223500330051037534137502500320040562405404011210100327330530152037260000001544201000000002003201444665551403400330000012130350054037542100000132441021001100200000004113166446404626621010203030520163070605674302000000031044015542403156030202204634442203303033356776655666678
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEHCHCCCEEEEEHCCCCHHHHHHHHHHCCCCEEEEHCCCCCEEEEEEEHHHHHHHHHHHCCCCCCCCHHHHCCCCCEHCCCCCHHHHHHHHHHHCCEEEEEEHCCCCEEEEHCHHHHHHHHHCCCCCCCCCCCCCCEEEHCCCEEEEEHCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEHCCEEEEEEEHCCCCCCEEEEEEEEEHCCCCCCCCCCCCCCC
MTGYYQLLGSIVLIGLGGLFAAIDAAISTVSPARVDELVRDQRPGAGSLRKVMADRPRYVNLVVLLRTSCEITATALLVVFIRYHFSMVWGLYLAAGIMVLASFVVVGVGPRTLGRQNAYSISLATALPLRLISWLLMPISRLLVLLGNALTPGRGFRNGPFASEIELREVVDLAQQRGVVAADERRMIESVFELGDTPAREVMVPRTEMIWIESDKTAGQAMTLAVRSGHSRIPVIGENVDDIVGVVYLKDLVEQTFCSTNGGRETTVARVMRPAVFVPDSKPLDALLREMQRDRNHMALLVDEYGAIAGLVSIEDVLEEIVGEIADEYDQAETAPVEDLGDKRFRVSARLPIEDVGELYGVEFDDDLDVDTVGGLLALELGRVPLPGAEVISHGLRLHAEGGTDHRGRVRIGTVLLSPAEPDGADDEEADHPG

4hg0A

0.35

0.18

0.51

1.95

MUSTER

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DEDTRDLEGVDIADQRVRD-IIPRSQI-TLKRNQTLDECLDVIIESAHSRFPVISEDKDHIEGILA-KDLLPF-----RSDAEAFSDKVLRQAVVVPESKRVDR-LKEFRSQR-YHAIVIDEFGGVSGLVTIEDILELIVGEIEDEYDEEDDIDFRQLSRHTWTVRALASIEDFNEAFGTHFSDE-EVDTIGGLVQAF-GHLPARGETIDIDGYQFKVA-ADSR----RIIQVHVKIP--------------

4hg0A

0.35

0.18

0.51

4.49

dPPAS

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DEDTRDLEGVDIADQRVRD-IIPRSQI-TLKRNQTLDECLDVIIESAHSRFPVISEDKDHIEGILA-KDLLP-----FRSDAEAFSDKVLRQAVVVPESKRVDR-LKEFRSQRY-HAIVIDEFGGVSGLVTIEDILELIVGEIEDEYDEEDDIDFRQLSRHTWTVRALASIEDFNEAFGTHFSDE-EVDTIGGLVQAF-GHLPARGETIDIDGYQFKVA-ADSRRII----QVHVKIP--------------

4hg0A

0.35

0.18

0.51

5.56

wdPPAS

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DEDTRDLEGVDIADQRVRD-IIPRSQI-TLKRNQTLDECLDVIIESAHSRFPVISEDKDHIEGILA-KDLLP-----FRSDAEAFSDKVLRQAVVVPESKRV-DRLKEFRSQRYH-AIVIDEFGGVSGLVTIEDILELIVGEIEDEYDEEDDIDFRQLSRHTWTVRALASIEDFNEAFGTHFSDE-EVDTIGGLVQA--GHLPARGETIDIDGYQFKVA-ADSR----RIIQVHVKIP--------------

4hg0A

0.35

0.18

0.51

2.57

wMUSTER

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DEDTRDLEGVDIADQRVRD-IIPRSQI-TLKRNQTLDECLDVIIESAHSRFPVISEDKDHIEGILA-KDLL-----PFRSDAEAFSDKVLRQAVVVPESKRVD-RLKEFRSQR-YHAIVIDEFGGVSGLVTIEDILELIVGEIEDEYDEEDDIDFRQLSRHTWTVRALASIEDFNEAFGTHFSDE-EVDTIGGLVQAF-GHLPARGETIDIDGYQFKVA-ADSR----RIIQVHVKIP--------------

4hg0A

0.35

0.18

0.51

2.99

wPPAS

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DEDTRDLEGVDIADQRVRD-IIPRSQI-TLKRNQTLDECLDVIIESAHSRFPVISEDKDHIEGILA-KDLLPFR-----SDAEAFSDKVLRQAVVVPESKRV-DRLKEFRSQR-YHAIVIDEFGGVSGLVTIEDILELIVGEIEDEYDEEDDIDFRQLSRHTWTVRALASIEDFNEAFGTHFSDE-EVDTIGGLVQA--GHLPARGETIDIDGYQFKVA-ADSR----RIIQVHVKIP--------------

4hg0A

0.35

0.18

0.51

7.56

dPPAS2

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DEDTRDLEGVDIADQRVRD-IIPRSQI-TLKRNQTLDECLDVIIESAHSRFPVISEDKDHIEGILA-KDLLP-----FRSDAEAFSDKVLRQAVVVPESKRVDR-LKEFRSQRY-HAIVIDEFGGVSGLVTIEDILELIVGEIEDEYDEEDDIDFRQLSRHTWTVRALASIEDFNEAFGTHFSDE-EVDTIGGLVQAF-GHLPARGETIDIDGYQFKVA-ADSRRII----QVHVKIP--------------

4hg0A

0.35

0.18

0.51

2.80

PPAS

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DEDTRDLEGVDIADQRVRD-IIPRSQI-TLKRNQTLDECLDVIIESAHSRFPVISEDKDHIEGILA-KDLLP-----FRSDAEAFSDKVLRQAVVVPESKRV-DRLKEFRSQR-YHAIVIDEFGGVSGLVTIEDILELIVGEIEDEYDEEDDIDFRQLSRHTWTVRALASIEDFNEAFGTHFSDE-EVDTIGGLVQAF-GHLPARGETIDIDGYQFKVA-ADSR----RIIQVHVKIP--------------

4hg0A

0.35

0.18

0.51

4.09

Env-PPAS

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DEDTRDLEGVDIADQRVRD-IIPRSQI-TLKRNQTLDECLDVIIESAHSRFPVISEDKDHIEGILA-KDLLPF-----RSDAEAFSDKVLRQAVVVPESKRV-DRLKEFRSQR-YHAIVIDEFGGVSGLVTIEDILELIVGEIEDEYDEEDDIDFRQLSRHTWTVRALASIEDFNEAFGTHFSDE-EVDTIGGLVQAF-GHLPARGETIDIDGYQFKVA-ADSR----RIIQVHVKIP--------------

3oi8A

0.33

0.11

0.35

1.38

MUSTER

----------------------------------------------------------------------------------------------------------------------------------------------------------------SNASAEDVLNLLRQAHEQEVFDADTLLRLEKVLDFSDLEVRDAITRSRNV--LKENDSIERITAYVIDTAHSRFPVIGEDKDEVLGILHAKDLLKY-----FNPEQFHLKSILRPAVFVPEGKSLTALLKEFREQRNH-AIVIDEYGGTSGLVTFEDIIE-------------------------------------------------------------------------------------------------------------------

3oi8A

0.33

0.11

0.35

3.71

dPPAS

----------------------------------------------------------------------------------------------------------------------------------------------------------------SNASAEDVLNLLRQAHEQEVFDADTLLRLEKVLDFSDLEVRDAITRSRNV--LKENDSIERITAYVIDTAHSRFPVIGEDKDEVLGILHAKDLLKY-----FNPEQFHLKSILRPAVFVPEGKSLTALLKEFREQRNH-AIVIDEYGGTSGLVTFEDIIE-------------------------------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.76

Estimated TM-score = 0.31±0.10

Estimated RMSD = 16.5±3.0Å

Download Model 2

C-score=-3.58

Download Model 3

C-score=-4.03

Download Model 4

C-score=-4.01

Download Model 5

C-score=-4.29

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4hg0A	0.493	1.45	0.357	0.508
2	2vz8B	0.404	7.63	0.066	0.715
3	4i43B	0.380	7.60	0.051	0.667
4	2okxA	0.377	6.93	0.061	0.605
5	4zhjA	0.377	7.72	0.041	0.676
6	5ganA	0.371	7.30	0.042	0.630
7	4xqkA	0.364	6.71	0.058	0.575
8	3czjA	0.363	7.11	0.028	0.595
9	3poyA	0.356	7.45	0.054	0.616
10	3orgA	0.355	4.48	0.087	0.444

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.35	16	3lfrA	AMP	Rep, Mult	205,209,210,211,231,232,233,235,299,312,314,317
2	0.06	3	2ckjC	FES	Rep, Mult	22,26,28,31,34,35,36
3	0.04	2	1ea0A	F3S	Rep, Mult	62,63,64,67,68,69,98,99
4	0.02	1	2ckjA	FES	Rep, Mult	20,22,25,27,31
5	0.02	1	3eubS	FES	Rep, Mult	101,102,103,105,106,107,108
6	0.02	1	2ckjB	FES	Rep, Mult	234,235,236,245,246,277
7	0.02	1	1jz6A	MG	Rep, Mult	390,392,399

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3hhsB	0.328	6.72	0.032	0.517	1.14.18.1	NA
2	0.060	3k1dA	0.329	7.23	0.046	0.554	2.4.1.18	305
3	0.060	2jfdA	0.239	7.29	0.036	0.407	2.3.1.85	166
4	0.060	2vdcA	0.350	7.30	0.056	0.595	1.4.1.13	NA
5	0.060	1h16A	0.328	7.62	0.043	0.584	2.3.1.54	NA
6	0.060	1ea0A	0.319	7.05	0.040	0.529	1.4.1.13	227
7	0.060	1bhgA	0.330	7.10	0.046	0.542	3.2.1.31	167
8	0.060	3ffzA	0.333	7.26	0.057	0.568	3.4.24.69	NA
9	0.060	3b9jI	0.164	5.88	0.014	0.241	1.17.1.4,1.17.3.2	NA
10	0.060	2qf7B	0.350	7.14	0.042	0.584	6.4.1.1	NA
11	0.060	2aryA	0.220	6.78	0.044	0.356	3.4.22.52	NA
12	0.060	2c6fA	0.336	6.81	0.050	0.529	3.4.15.1	321
13	0.060	1t3tA	0.345	7.80	0.071	0.625	6.3.5.3	NA
14	0.060	2ckjA	0.346	6.55	0.051	0.536	1.17.1.4,1.17.3.2	NA
15	0.060	1ofdA	0.333	7.10	0.049	0.554	1.4.7.1	NA
16	0.060	2pdaA	0.282	7.31	0.034	0.474	1.2.7.1	NA
17	0.060	1d8yA	0.291	7.98	0.058	0.531	2.7.7.7	152,190
18	0.060	2je8B	0.329	6.84	0.027	0.533	3.2.1.25	325
19	0.060	2vdcF	0.349	7.38	0.056	0.600	1.4.1.13	237

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.37	0.513	1.52	0.35	0.53	4hg0A	GO:0003824 GO:0006810 GO:0016614 GO:0050660 GO:0055114
1	0.22	0.295	2.34	0.29	0.31	3oi8A	GO:0003824 GO:0016614 GO:0046872 GO:0050660 GO:0055114
2	0.18	0.289	2.70	0.27	0.32	4iysA	GO:0005886 GO:0006810 GO:0006811 GO:0010960 GO:0015693 GO:0016020 GO:0016021 GO:0016323
3	0.09	0.305	2.79	0.31	0.34	3ocmA	GO:0000166 GO:0003824 GO:0016020 GO:0016021 GO:0016614 GO:0050660 GO:0055114
4	0.06	0.240	7.38	0.06	0.41	5bp4L	GO:0003824 GO:0008152 GO:0016491 GO:0016740 GO:0016746 GO:0031177 GO:0050111 GO:0055114
5	0.06	0.333	7.85	0.07	0.60	5bp4A	GO:0003824 GO:0008152 GO:0016491 GO:0016740 GO:0016746 GO:0031177 GO:0050111 GO:0055114
6	0.06	0.247	7.51	0.05	0.43	2z5lA	GO:0003824 GO:0008152 GO:0016740 GO:0031177
7	0.06	0.302	7.01	0.04	0.49	5d2eA	GO:0003824 GO:0008152 GO:0031177
8	0.06	0.295	7.42	0.04	0.50	4difA	GO:0000166 GO:0003824 GO:0008152 GO:0016740 GO:0031177 GO:0048037
9	0.06	0.300	6.80	0.05	0.48	2fr0A	GO:0003824 GO:0008152 GO:0016740 GO:0016746 GO:0017000 GO:0031177 GO:0033068 GO:0047879
10	0.06	0.297	7.30	0.03	0.50	4impA	GO:0000166 GO:0003824 GO:0008152 GO:0016740 GO:0031177 GO:0048037
11	0.06	0.288	7.05	0.04	0.47	3qp9A	GO:0003824 GO:0008152 GO:0008270 GO:0016491 GO:0016740 GO:0016746 GO:0016747 GO:0017000 GO:0031177 GO:0033068 GO:0048037 GO:0055114
12	0.06	0.301	7.36	0.03	0.51	2et6A	GO:0003824 GO:0005777 GO:0006629 GO:0006631 GO:0006635 GO:0008152 GO:0016491 GO:0016616 GO:0016829 GO:0016853 GO:0055114
13	0.06	0.235	6.60	0.03	0.37	4opfA	GO:0003824 GO:0008152 GO:0016874 GO:0031177
14	0.06	0.264	7.58	0.04	0.47	4oqjA	GO:0003824 GO:0008152 GO:0031177
15	0.06	0.297	6.77	0.05	0.47	2zkmX	GO:0004435 GO:0004629 GO:0004871 GO:0005509 GO:0005737 GO:0005829 GO:0006629 GO:0006644 GO:0007165 GO:0007202 GO:0007223 GO:0008081 GO:0016042 GO:0016787 GO:0035556 GO:0043647 GO:0046872 GO:0050913
16	0.06	0.275	6.69	0.04	0.44	4j1qA	GO:0003824 GO:0005737 GO:0008152 GO:0016740 GO:0016746 GO:0016874 GO:0017000 GO:0031177
17	0.06	0.267	7.66	0.04	0.47	3hhdC	GO:0001649 GO:0003824 GO:0004312 GO:0004313 GO:0004314 GO:0004315 GO:0004316 GO:0004317 GO:0004319 GO:0004320 GO:0005737 GO:0005739 GO:0005794 GO:0005829 GO:0005886 GO:0005913 GO:0006084 GO:0006629 GO:0006631 GO:0006633 GO:0008144 GO:0008152 GO:0009058 GO:0015939 GO:0016020 GO:0016295 GO:0016296 GO:0016297 GO:0016491 GO:0016740 GO:0016787 GO:0016788 GO:0016829 GO:0019171 GO:0030879 GO:0031177 GO:0031325 GO:0035338 GO:0042470 GO:0042587 GO:0042802 GO:0042803 GO:0044822 GO:0047117 GO:0047451 GO:0055114 GO:0070062 GO:0070402 GO:0071353 GO:0098609 GO:0098641 GO:0102132
18	0.06	0.268	7.57	0.03	0.47	4z37A	GO:0003824 GO:0008152 GO:0031177

Consensus prediction of GO terms

Molecular Function	GO:0016614	GO:0050660	GO:0043169
GO-Score	0.55	0.55	0.43
Biological Processes	GO:0055114	GO:0070838	GO:0055065	GO:0072507
GO-Score	0.58	0.37	0.37	0.37
Cellular Component	GO:0031224	GO:0098590
GO-Score	0.41	0.37

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.