I-TASSER results

I-TASSER results for job id Rv2353c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (354 residues)
MPGRFRNFGSQNLGSGNIGSTNVGSGNIGSTNVGSGNIGDTNFGNGNNGNFNFGSGNTGS
NNIGFGNTGSGNFGFGNTGNNNIGIGLTGDGQIGIGGLNSGSGNIGFGNSGTGNVGLFNS
GTGNVGFGNSGTANTGFGNAGNVNTGFWNGGSTNTGLANAGAGNTGFFDAGNYNFGSLNA
GNINSSFGNSGDGNSGFLNAGDVNSGVGNAGDVNTGLGNSGNINTGGFNPGTLNTGFFSA
MTQAGPNSGFFNAGTGNSGFGHNDPAGSGNSGIQNSGFGNSGYVNTSTTSMFGGNSGVLN
TGYGNSGFYNAAVNNTGIFVTGVMSSGFFNFGTGNSGLLVSGNGLSGFFKNLFG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MPGRFRNFGSQNLGSGNIGSTNVGSGNIGSTNVGSGNIGDTNFGNGNNGNFNFGSGNTGSNNIGFGNTGSGNFGFGNTGNNNIGIGLTGDGQIGIGGLNSGSGNIGFGNSGTGNVGLFNSGTGNVGFGNSGTANTGFGNAGNVNTGFWNGGSTNTGLANAGAGNTGFFDAGNYNFGSLNAGNINSSFGNSGDGNSGFLNAGDVNSGVGNAGDVNTGLGNSGNINTGGFNPGTLNTGFFSAMTQAGPNSGFFNAGTGNSGFGHNDPAGSGNSGIQNSGFGNSGYVNTSTTSMFGGNSGVLNTGYGNSGFYNAAVNNTGIFVTGVMSSGFFNFGTGNSGLLVSGNGLSGFFKNLFG
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	998888888888888888888888888888888888888888888888888888888888888888888889988888889888888888888888899988888888888888888899999888889999888888899989888889988888888888888888999889988899988988889998898888999889888899989998889998898888999888888888888888998889988889988888888888888888888888888888888888888888888888888888888888888888888888888899888889899875567889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MPGRFRNFGSQNLGSGNIGSTNVGSGNIGSTNVGSGNIGDTNFGNGNNGNFNFGSGNTGSNNIGFGNTGSGNFGFGNTGNNNIGIGLTGDGQIGIGGLNSGSGNIGFGNSGTGNVGLFNSGTGNVGFGNSGTANTGFGNAGNVNTGFWNGGSTNTGLANAGAGNTGFFDAGNYNFGSLNAGNINSSFGNSGDGNSGFLNAGDVNSGVGNAGDVNTGLGNSGNINTGGFNPGTLNTGFFSAMTQAGPNSGFFNAGTGNSGFGHNDPAGSGNSGIQNSGFGNSGYVNTSTTSMFGGNSGVLNTGYGNSGFYNAAVNNTGIFVTGVMSSGFFNFGTGNSGLLVSGNGLSGFFKNLFG
Prediction	746544141441414314144241542414424143241443414314144242441414514143141442414413144342442434433341434414434143451544414323144140321415434042241543414334144241433415434143241541414314144341441414414043141432314323143341432414424043131432433334444444231432414212143334442443414424143141441414444143321331313422133131441313324143230432403423133241431112130245
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MPGRFRNFGSQNLGSGNIGSTNVGSGNIGSTNVGSGNIGDTNFGNGNNGNFNFGSGNTGSNNIGFGNTGSGNFGFGNTGNNNIGIGLTGDGQIGIGGLNSGSGNIGFGNSGTGNVGLFNSGTGNVGFGNSGTANTGFGNAGNVNTGFWNGGSTNTGLANAGAGNTGFFDAGNYNFGSLNAGNINSSFGNSGDGNSGFLNAGDVNSGVGNAGDVNTGLGNSGNINTGGFNPGTLNTGFFSAMTQAGPNSGFFNAGTGNSGFGHNDPAGSGNSGIQNSGFGNSGYVNTSTTSMFGGNSGVLNTGYGNSGFYNAAVNNTGIFVTGVMSSGFFNFGTGNSGLLVSGNGLSGFFKNLFG

1pclA

0.11

0.10

0.97

1.64

MUSTER

VETDAATTGWATQNGGTTGGAKAAKKNISDFKKALNGTDSSAKIIKVTGPIDISGGKAYTSFDDQKARSQISIPSNTT----IGVG-SNGKFTNGSLVIKGVKNVNLYIETPVDVAPHYESGDGWNAEWDAAVIDNSTNVWVDHVTISDGSFTDDKYTTK-DGEKYVQHDGALDIKKGSDYVTISYSRFELHDK-TILIGHSDSNGSQDSGKLRVTFHNNVFDRVTERAP-RVRFGSIHAYNNVYLGDVKHSVYPYLYSFGLGTSGSILSES--NSFTLSNLKSIDGKNPECSIVKQFNSKVFSDKGSLVNGSTTTKLDTCGLTAYKPTLPYKYSAQTMTSSLATSINNNAGYG

1pclA

0.11

0.10

0.96

2.94

dPPAS

----AVETDAATTGWATQNGGTTGGAKAAKAVE-VKNISDFKKALNGTDSSAKIIKVTGPIDISGGKAYTSFDDQKARSQISIPSNGSNGKFTNGSLVIKGVKNVILRNLYIETPVDVAPHYESGDGWNAEWDAAVIDNSTNISDGSFTDDKYTTKDGEKYVQHDGALDIKKGSDYVTISYSRFELHDKTILIGHSDSNGSQDSGKLRVTFHNNVFDRVTERAPRVRFGSIHAYNNVYLGDVKHSVYPYLYSFGLGTSGSILSESNSFTLSNLKSIDGKNPECSIVKQFNSKVSDKGSLVNGSTTTKLDTCGLTAYKPTLPYKYSAQTMTSSLATSINNNAGYGKL--------

1pclA

0.14

0.12

0.92

2.63

wdPPAS

-------------------AVETDAATTGATQNGGTTGGAKAA-VKNISDFKKALNGTDSSAKIIKVTGPIDISGGKAYTSFDDQKARSQISIPSNTTIIGVGSNGKTNGSLVIKGVKNETPVDVAPHYESGDGWNAEWDAAVIDNSTN--TISDGSFTDDKYTTKDGEKYVQHDGALDIKKGSDYVTISELHDKTILIGHSDSNGSQDSGKLRVTFHNNVFDRVTERAP-RVRFGSIHAYNNVYLGDVKHSVYPYLYSFGLGTSGSILSESTLSNLKSIDGKNPECSIVKQFNSKVFSDKGSLVNGSTTTKLDTCGLTAYKPTLPYKYSAQTMTSSLATS------NNNAGYG

1yo8A

0.12

0.11

0.98

1.77

wMUSTER

FPDGS-PVG---LGNGTLVPDICFSTSKVPRPPR---RGNQPVGVGLEAAKTEKQENPCKDKTHNCHKHAECIYLGHFSDPQTGYAGDGLICGEDSDLDGWPNLNLVCATNATYHCIKDNCPHLPNSGQEDFDKDGIGDDDDDNDGVTDEKDNCQLLFNPRQADYDKDEVGDRDNCPYVHNPAQIDTDNNGEGSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDNCPLVHNPDQTDVDNDLVGDQCDNNEDIDDDGHQNNQDNCPYISNANQADHDRDGQGDADPDDDNDGVPDDRDNCRLVFNPDQEDLDGDGRGKDDFDNDNIPDVCPENNAISETDFRNFQVPLDPKG

4uxeA

0.15

0.14

0.91

1.96

wPPAS

IQTVNGSLTLTQQTNLSAPLVSSSTGEFGGSLAANRTFTIRNTGAPTSIVFEKG--PASGANPAQSSIRVWGNQFGGGSDTT-------STVFEVG--DDTSHHFYSQRNKDGNIAFNINGTVPININASGLNVNGTATFGR---SVTANGEFISKSANAINGDYGF-NDASN-----AAGD-QTGGFNG-NNQSGQITIGE---GLIIAKGVTIN--SGGLTVNSRIRSQGTKTSDLYTRAPTSDTVGFWSIDINDSATYNQFPG-KVEKTNEVTGLPYLERGEEVKSPGTLTQFGNTLDSLYQDWITYPTTPEARTT-TWQKTKNSWSGGNPPQPS---GAPSDNATGNLTG

1vt4I4

0.25

0.12

0.46

3.94

dPPAS2

---------------------------------------------------------------------------------------------------------------------------------------------------------------GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG-GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG------------------------------

5gaoE

0.05

0.95

2.29

PPAS

-AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK--------------

3sf4A

0.11

0.10

0.92

0.75

Env-PPAS

LE--LALEGERLCKSGDCSFFEAAVQVGTEDLKTLSAI-YSQLGNFYLHDYAKALEYHHHDLTLARTIG-DQLGEAKA-SGNLGNKVLGNFDEAIVCCQRHDISRELNDKVGEARALYNLGNVYHAKGKSFGGEFPEEVRDALQAAVDFYEENLSLVTALGD-RAAQGRA-FGNLGNYLLGNFRDAVIAHEQRLLIAKEFG-DKAAERRA-YSNLGNIFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNT----------------YTLLQDYEKAIDYHLKHLAIAQELN-DRIGEGRA-CWSLGNA---YTALGNHDQAMHSREVGDKSGELTARLNLSDLQMVLG

5fmwA

0.08

1.00

1.38

MUSTER

IEVFGQFNGKRCTDAVGDRRQCVPTEPCECGNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESEPPCRDRVVEESELARTAGYGINILGMDPLSTPFDNEFYNGLCNRDRGNTLTYYRRPWNVASLIYETKGEKNFRTEHYEEQIEAFKSIIQEKTSNFNAAISLKFT-PGKGSFRFSYSKNETYQLFLSYSSKKEKMFLHVKGEIHLGTYEKGEYFSSGSLGGLYELIYVDKASMKRKGVELKDIKRCLGYHLDVSLAFSEISVGAEFNKDDCVKRGEGRAVNITSENLIDDVVSLIRGGTRKYAFELKEKLLRGTVIDVTDFVNASSINDAPVLISQKSPIYNLVPVKMK

2xd8A

0.08

0.99

2.66

dPPAS

----MANANQVALGRSNLSTGTGYGGATDKYALYLKLFSGEMFKGFQHETIARDLVTKNGKSLQFIYTGRMTSSFHTPGTPILGNADKAPPVAEKTIVMDDLLISSAFVYDLDETLAHYELRGEISKKIGYALAEKYDRLIFRSITRGARSASPVSATNFVEPGGTQIRVGSGTNESDAFTASALVNAFYDAAAAMDEKGVSSQGRCAVLNPRQYYALIQDIGSNGLVNRDVQGSALQSGNGVIEIAHIYKSMNIPFLGKYGVKYGGTTGETSPGNLGSHIGPTPENANATGGVNNDYGTNAELGAKSCGLIFQKEAAGVVEAIGPQVQVT-NGDVSVIYQGDVILGRMAMGAD

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.60

Estimated TM-score = 0.41±0.14

Estimated RMSD = 12.8±4.2Å

Download Model 2

C-score=-1.99

Download Model 3

C-score=-2.72

Download Model 4

C-score=-3.38

Download Model 5

C-score=-3.48

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1pclA	0.903	1.85	0.100	0.963
2	1jtaA	0.878	2.29	0.097	0.955
3	4hwvA	0.867	2.74	0.097	0.969
4	3krgA	0.861	2.35	0.116	0.946
5	1vblA	0.860	2.42	0.092	0.949
6	3zscA	0.727	3.25	0.094	0.839
7	3vmvA	0.725	3.10	0.108	0.825
8	1pxzA	0.716	2.81	0.082	0.808
9	2qy1A	0.713	3.17	0.094	0.819
10	2eweA	0.704	3.66	0.092	0.836

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.10	5	2nzmA	ADA	Rep, Mult	129,165,189,192,227
2	0.06	3	5amvA	ADA	Rep, Mult	127,222,225,289
3	0.06	3	1af0A	CA	Rep, Mult	254,255,256,266,267,268,271
4	0.04	2	2quaA	CA	Rep, Mult	279,280,281,282,285,297,302,303,306
5	0.04	2	1af0A	CA	Rep, Mult	267,268,269,271,277,280,281,284
6	0.02	1	2z8xA	CA	Rep, Mult	322,333,335,336
7	0.02	1	2iq7E	UUU	Rep, Mult	255,256,257,258,288,289,290
8	0.02	1	1rmgA	MAN	Rep, Mult	86,88
9	0.02	1	5amvA	ADA	Rep, Mult	159,221,289
10	0.02	1	2o0vA	CA	Rep, Mult	133,165,166,169
11	0.02	1	2o04A	ADA	Rep, Mult	221,225,289
12	0.02	1	2nzmA	ADA	Rep, Mult	76,138,172
13	0.02	1	3s6lA	IOD	Rep, Mult	231,232,246
14	0.02	1	3krgA	ADA	Rep, Mult	138,172,200
15	0.02	1	2iq7A	UUU	Rep, Mult	175,179,208,210,230

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.120	2qx3A	0.712	3.18	0.091	0.819	4.2.2.2	NA
2	0.111	1idjA	0.697	3.06	0.106	0.794	4.2.2.10	NA
3	0.107	2pecA	0.707	3.61	0.092	0.839	4.2.2.2	NA
4	0.105	1qcxA	0.696	3.03	0.089	0.794	4.2.2.10	NA
5	0.067	1xg2A	0.565	3.58	0.050	0.678	3.1.1.11	212
6	0.066	1qjvA	0.552	3.97	0.083	0.672	3.1.1.11	NA
7	0.066	1nhcA	0.509	4.45	0.075	0.658	3.2.1.15	NA
8	0.066	1ib4A	0.525	4.14	0.096	0.652	3.2.1.15	NA
9	0.066	1ia5A	0.514	4.49	0.071	0.661	3.2.1.15	NA
10	0.066	1rmgA	0.575	4.05	0.051	0.726	3.2.1.-	NA
11	0.066	1czfA	0.519	4.24	0.101	0.652	3.2.1.15	NA
12	0.066	1hg8A	0.530	4.42	0.080	0.681	3.2.1.15	NA
13	0.060	1airA	0.707	3.62	0.092	0.839	4.2.2.2	NA
14	0.060	2z8gB	0.543	4.58	0.077	0.712	3.2.1.57	NA
15	0.060	1nhcE	0.522	4.12	0.101	0.650	3.2.1.15	172,195
16	0.060	1ogoX	0.547	5.15	0.076	0.751	3.2.1.11	102,177
17	0.060	1pclA	0.903	1.85	0.100	0.963	4.2.2.2	NA
18	0.060	2ntqB	0.546	4.27	0.044	0.698	3.1.1.11	192
19	0.060	1kcdA	0.531	4.40	0.060	0.678	3.2.1.15	256,288
20	0.060	1k5cA	0.531	4.46	0.056	0.681	3.2.1.15	NA
21	0.060	1bn8A	0.862	2.34	0.119	0.946	4.2.2.2	NA
22	0.060	1vblA	0.860	2.42	0.092	0.949	4.2.2.2	NA
23	0.060	2o1dA	0.860	2.37	0.119	0.946	4.2.2.2	150
24	0.060	1ru4A	0.604	4.21	0.065	0.777	4.2.2.2	NA
25	0.060	3jurD	0.589	3.77	0.063	0.723	3.2.1.15	NA
26	0.060	2iq7A	0.522	4.18	0.097	0.652	3.2.1.15	NA
27	0.060	1dboA	0.626	4.35	0.104	0.785	4.2.2.19	226
28	0.060	1oocB	0.884	2.22	0.097	0.955	4.2.2.2	NA
29	0.060	1ofdA	0.420	5.06	0.083	0.588	1.4.7.1	NA
30	0.060	3eqoA	0.576	4.30	0.060	0.720	3.2.1.58	NA
31	0.060	1jtaA	0.878	2.29	0.097	0.955	4.2.2.2	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.31	0.860	2.42	0.09	0.95	1vblA	GO:0000272 GO:0005576 GO:0005975 GO:0016829 GO:0046872
1	0.25	0.860	2.33	0.12	0.94	5amvA	GO:0005576 GO:0016829 GO:0030570 GO:0045490 GO:0046872
2	0.25	0.867	2.74	0.10	0.97	4hwvA	GO:0000272 GO:0005576 GO:0005975 GO:0016829 GO:0046872
3	0.22	0.903	1.85	0.10	0.96	1pclA	GO:0005576 GO:0016829 GO:0030570 GO:0045490 GO:0046872
4	0.21	0.697	3.06	0.11	0.79	1idjA	GO:0000272 GO:0005576 GO:0005975 GO:0016829 GO:0047490 GO:0071555
5	0.21	0.878	2.29	0.10	0.95	1jtaA	GO:0005576 GO:0016829 GO:0030570 GO:0045490 GO:0046872
6	0.13	0.725	3.10	0.11	0.82	3vmvA	GO:0000272 GO:0005576 GO:0005975 GO:0016829
7	0.12	0.727	3.25	0.09	0.84	3zscA	GO:0000272 GO:0005576 GO:0005615 GO:0005975 GO:0016829 GO:0046872 GO:0071555
8	0.11	0.716	2.81	0.08	0.81	1pxzA	GO:0016829 GO:0030570 GO:0045490 GO:0046872
9	0.11	0.712	3.18	0.09	0.82	2qx3A	GO:0000272 GO:0005576 GO:0005975 GO:0016829
10	0.11	0.696	3.03	0.09	0.79	1qcxA	GO:0000272 GO:0005576 GO:0005975 GO:0016829 GO:0047490 GO:0071555
11	0.11	0.707	3.62	0.09	0.84	1airA	GO:0005576 GO:0009405 GO:0016829 GO:0030570 GO:0045490 GO:0046872
12	0.06	0.357	6.19	0.07	0.57	1cm5A	GO:0003824 GO:0005737 GO:0005829 GO:0005975 GO:0006006 GO:0006567 GO:0008152 GO:0008861 GO:0016020 GO:0016740 GO:0016746
13	0.06	0.301	6.88	0.03	0.51	3hhsA	GO:0004497 GO:0004503 GO:0005507 GO:0005576 GO:0006583 GO:0006952 GO:0008152 GO:0016491 GO:0031404 GO:0035008 GO:0042438 GO:0046872 GO:0055114
14	0.06	0.249	6.02	0.06	0.39	3b7mA	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0008810 GO:0016787 GO:0016798
15	0.06	0.244	6.96	0.03	0.42	1gpjA	GO:0006779 GO:0006782 GO:0008883 GO:0016491 GO:0033014 GO:0050661 GO:0055114
16	0.06	0.238	6.83	0.04	0.41	1xhcA	GO:0000166 GO:0005623 GO:0016491 GO:0045454 GO:0050660 GO:0055114
17	0.06	0.236	6.66	0.05	0.40	3nreA	GO:0003824 GO:0005975 GO:0006974 GO:0016853 GO:0030246
18	0.06	0.202	5.88	0.02	0.31	1iybA	GO:0003723 GO:0033897 GO:0090502

Consensus prediction of GO terms

Molecular Function	GO:0046872	GO:0030570
GO-Score	0.70	0.42
Biological Processes	GO:0045229	GO:0071554	GO:0045490
GO-Score	0.43	0.43	0.42
Cellular Component	GO:0005576
GO-Score	0.76

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.