I-TASSER results

I-TASSER results for job id Rv2337c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (372 residues)
MRAGRWGPGMTGLDPAEFLSLVEAAALAPSADNRREVQLEHAGRRVRLWGDQTWRSAPEH
RRIMSLVAIGAAVENVKLRAGRLGFETKVCWFPDSGNPGLVAEIDVDRLPQTRVDPIEGA
IERRRTNRRVRFRGPPLSQGELGALSAEATGIDGIQLHWFDSPETRKQILRLVRLAETER
FRSRELHEELFSAVRFDIGWTASSDDGLPPGSLEVEAWMRPMFRGLRHWRVLRLLRTVGM
HHALGLRAAYLPCRLAPHVGALTTSLDLASGALTAGAVFERIWLRTTLLGAELQPFAASA
VLSLPACEWVAPHVRAALVGGWNLLAPGHWPMMVFRIGHARAPSVRTMRQSVEAYCYAPA
ERSGSDSESRFA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRAGRWGPGMTGLDPAEFLSLVEAAALAPSADNRREVQLEHAGRRVRLWGDQTWRSAPEHRRIMSLVAIGAAVENVKLRAGRLGFETKVCWFPDSGNPGLVAEIDVDRLPQTRVDPIEGAIERRRTNRRVRFRGPPLSQGELGALSAEATGIDGIQLHWFDSPETRKQILRLVRLAETERFRSRELHEELFSAVRFDIGWTASSDDGLPPGSLEVEAWMRPMFRGLRHWRVLRLLRTVGMHHALGLRAAYLPCRLAPHVGALTTSLDLASGALTAGAVFERIWLRTTLLGAELQPFAASAVLSLPACEWVAPHVRAALVGGWNLLAPGHWPMMVFRIGHARAPSVRTMRQSVEAYCYAPAERSGSDSESRFA
Prediction	CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEHCCEEEEEHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHCCCCCCCCEEEEEEHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHCCCCCCCCCCCHHHHHCCCCEEEEEEHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCEEEEEEEHCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCC
Conf.Score	988777877678999999999999997898778888899997999999957877889995789999999999999999999989977568757999987589999758988765578888877546788898888999999999999997589869999789899999999999999999869999999999987887655667899886557888754566654567655666665567655455555666556887999995999999999999999999999999876554554677776666666557899999999987578997799999858999999999999889874566678888888889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRAGRWGPGMTGLDPAEFLSLVEAAALAPSADNRREVQLEHAGRRVRLWGDQTWRSAPEHRRIMSLVAIGAAVENVKLRAGRLGFETKVCWFPDSGNPGLVAEIDVDRLPQTRVDPIEGAIERRRTNRRVRFRGPPLSQGELGALSAEATGIDGIQLHWFDSPETRKQILRLVRLAETERFRSRELHEELFSAVRFDIGWTASSDDGLPPGSLEVEAWMRPMFRGLRHWRVLRLLRTVGMHHALGLRAAYLPCRLAPHVGALTTSLDLASGALTAGAVFERIWLRTTLLGAELQPFAASAVLSLPACEWVAPHVRAALVGGWNLLAPGHWPMMVFRIGHARAPSVRTMRQSVEAYCYAPAERSGSDSESRFA
Prediction	751443435445144720330040012011121100020214651020002233202123420110000000000000001112042323214357422100203044353344344242332234434431444202660043025103422000000033471042024002302221242440140023002234642543210022312413314322141024242242034242444243544343133000000000352324210300000010011003220010110111212332342424512540352253046530000000001047332302112033003223544345662427
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEHCCEEEEEHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHCCCCCCCCEEEEEEHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHCCCCCCCCCCCHHHHHCCCCEEEEEEHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCEEEEEEEHCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCC
MRAGRWGPGMTGLDPAEFLSLVEAAALAPSADNRREVQLEHAGRRVRLWGDQTWRSAPEHRRIMSLVAIGAAVENVKLRAGRLGFETKVCWFPDSGNPGLVAEIDVDRLPQTRVDPIEGAIERRRTNRRVRFRGPPLSQGELGALSAEATGIDGIQLHWFDSPETRKQILRLVRLAETERFRSRELHEELFSAVRFDIGWTASSDDGLPPGSLEVEAWMRPMFRGLRHWRVLRLLRTVGMHHALGLRAAYLPCRLAPHVGALTTSLDLASGALTAGAVFERIWLRTTLLGAELQPFAASAVLSLPACEWVAPHVRAALVGGWNLLAPGHWPMMVFRIGHARAPSVRTMRQSVEAYCYAPAERSGSDSESRFA

2ymvA

0.20

0.17

0.85

2.16

MUSTER

--------SDTRLDVATLANAVQLAARAPSLHNTQPWRLIAEDGELKLFLDPSRVVSTDRSSREA-VSCGVLLDHLRVALAAAGWDTEVQRFPNPNDRDHLATLSFRPLQFVTGHRKRADAILARRTDRLPS--AYVDWDAFETLLRARLG-DGPVHDTL-GEDVREEVAEAAALTESLRLYDAAYHSELAWWTT-----PFATEDGIPQTALISAEESERVAVSRD------------FPVAPHSSRRPALNNDAATIVVLSTDGYSREDALDAGEGLSKVLLECTS-GLATCPVTHVTEL------------HTSRDIIGRLIVRDACPQVLVRIGLAPAVPPPTPRRPVDAFLEVRPR-----------

2ymvA

0.20

0.17

0.86

2.60

dPPAS

--------SDTRLDVATLANAVQLAARAPSLHNTQPWRLIAEDGELKLFLDPSRVVRSTDRSSREAVSCGVLLDHLRVALAAAGWDTEVQRFPNPNDRDHLATLSFRPLQFVTEGRKRADAILARRTDRLPS--AYVDWDAFETLLRARLGDGPV--HDTLGEDVREEVAEAAALTESLRLYDAAYHSELAWWTT-----PFATEDGIPQTALI----SAEESERVAVSR--------DFPVAPHSSRRPALNNDAATIVVLSTDGYSREDALDAGEGLSKVLLECTS-GLATCPVTHVTEL------------HTSRDIIGRLIVRDACPQVLVRIGLAPAVPPPTPRRPVDAFLEVRPR-----------

2ymvA

0.20

0.17

0.85

4.51

wdPPAS

--------SDTRLDVATLANAVQLAARAPSLHNTQPWRLIAEDGELKLFLDPSRVVRSDRSSREA-VSCGVLLDHLRVALAAAGWDTEVQRFPNPNDRDHLATLSFRPLQFVTEGRKRADAILARRTDRLPS--AYVDWDAFETLLRARLG-DGPVHDTL-GEDVREEVAEAAALTESLRLYDAAYHSELAWWTTPFATE-----DGIPQTALISAEESERVAVSRD------------FPVAPHSSRRPALNNDAATIVVLSTDGYSREDALDAGEGLSKVLLECTS-GLATCPVTHVTEL------------HTSRDIIGRLIVRDACPQVLVRIGLAPAVPPPTPRRPVDAFLEVRPR-----------

2ymvA

0.20

0.17

0.85

2.65

wMUSTER

---------DTRLDVATLANAVQLAARAPSLHNTQPWRLIAEDGELKLFLDPSRVVSTDRSSREA-VSCGVLLDHLRVALAAAGWDTEVQRFPNPNDRDHLATLSFRPLQFVTGHRKRADAILARRTDRLPS--AYVDWDAFETLLRARLG-DGPVHDTL-GEDVREEVAEAAALTESLRLYDAAYHSELAWWTTPFATE-----DGIPQTALISAEESERVAVSRD------------FPVAPHSSRRPALNNDAATIVVLSTDGYSREDALDAGEGLSKVLLECTS-GLATCPVTHVTEL------------HTSRDIIGRLIVRDACPQVLVRIGLAPAVPPPTPRRPVDAFLEVRPR-----------

2ymvA

0.22

0.19

0.85

5.13

wPPAS

--------SDTRLDVATLANAVQLAARAPSLHNTQPWRLIAEDGELKLFLDPSRVVRSDRSSREA-VSCGVLLDHLRVALAAAGWDTEVQRFPNPNDRDHLATLSFRPLQFVTEGKRADAILARRTD-RLPS--AYVDWDAFETLLRARLG-DGPVHDTL-GEDVREEVAEAAALTESLRLYDAAYHSELAWWTTPF-----ATEDGIPQTALISAEESERVA-VSRDF-----------PVAPHSSRRPALNNDAATIVVLSTDGYSREDALDAGEGLSKVLLECTS-GLATCPVTHVTEL------------HTSRDIIGRLIVRDACPQVLVRIGLAPAVPPPTPRRPVDAFLEVRPR-----------

2ymvA

0.22

0.19

0.85

7.44

dPPAS2

--------SDTRLDVATLANAVQLAARAPSLHNTQPWRLIAEDGELKLFLDPSRVVRSDRSSREA-VSCGVLLDHLRVALAAAGWDTEVQRFPNPNDRDHLATLSFRPLQFVTEGKRADAILARRTDRLPS---AYVDWDAFETLLRARLG-DGPVHDTL-GEDVREEVAEAAALTESLRLYDAAYHSELAWWTT-----PFATEDGIPQTALISA---EESERVAVSRD---------FPVAPHSSRRPALNNDAATIVVLSTDGYSREDALDAGEGLSKVLLECTS-GLATCPVTHVTEL------------HTSRDIIGRLIVRDACPQVLVRIGLAPAVPPPTPRRPVDAFLEVRPR-----------

2ymvA

0.21

0.18

0.85

4.04

PPAS

--------SDTRLDVATLANAVQLAARAPSLHNTQPWRLIAEDGELKLFLDPSRVVRSDRSSREA-VSCGVLLDHLRVALAAAGWDTEVQRFPNPNDRDHLATLSFRPLQFVTEGKRADAILARRTDRLPS---AYVDWDAFETLLRARLG-DGPVHDTL-GEDVREEVAEAAALTESLRLYDAAYHSELAWWTTPF-----ATEDGIPQTALISA---EESERVAVSR---------DFPVAPHSSRRPALNNDAATIVVLSTDGYSREDALDAGEGLSKVLLECTS-GLATCPVTHVTEL------------HTSRDIIGRLIVRDACPQVLVRIGLAPEVPPPTPRRPVDAFLEVRPR-----------

2ymvA

0.22

0.19

0.85

6.26

Env-PPAS

--------SDTRLDVATLANAVQLAARAPSLHNTQPWRLIAEDGELKLFLDPSRVVRTDRSSRE-AVSCGVLLDHLRVALAAAGWDTEVQRFPNPNDRDHLATLSFRPLQFVTHRKRADAILARRTDRLPS---AYVDWDAFETLLRARLG-DGPVHDTL-GEDVREEVAEAAALTESLRLYDAAYHSELAWWTTPFATE-----DGIPQTALISAEESERVA-VSRDF-----------PVAPHSSRRPALNNDAATIVVLSTDGYSREDALDAGEGLSKVLLECTS-GLATCPVTHVTEL------------HTSRDIIGRLIVRDACPQVLVRIGLAPAVPPPTPRRPVDAFLEVRPR-----------

4gpaA

0.08

0.90

0.64

MUSTER

------FPSS-IRNTDQEYTAFRLAIF---LHNTSP---NASEAPFNLVPHVDNIETANSNAFCSQYSRGVSVHTLTSFCSALHISLITPSFPTEGESQFVLQL------RPSLRGALLSLLDHYEWNCFVFYDTDRGYSILQAIMEKAGQNGWHVSAICVENFNDVSYRQLLEELDRRQEKEIERLQNILEQIVKHVKGYHYIIANLGFKDISLERFIHGGANVLVDFNTPMVTKLMDRWKKLDQREYPGSETPPKY---------TSALTYDGVLVMAETFRSLRRQKIDISRRGNAGDC-LANPAAPWGQGIDMERTLKQVRIQGLTGNVQFD-GRRVNYT---------DVFELKSTGPRKNDMDKLV

3eo8A

0.11

0.06

0.55

0.73

dPPAS

------------------------------------------------------------------------------------------------------------------GELQDTIFKRQSVRK--FKNQDVSDEDILKIKAAGAAIQNWHFVVIKRRDLEKIADVITKKQQEILVEDVDKANRFRKFVKNFTLFYLKAPVLVLVFTKVYNPSGYYELELIDAPKETIDKLFIRNPG------------------------------QSLGAAIENFTLSAIELGYGSCWLTSQ---------NYAADEIEAVLEAETGFEKGEYFLGALALGVPEDNLKSPSKKPVEEICTFIK------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.21

Estimated TM-score = 0.74±0.11

Estimated RMSD = 6.2±3.8Å

Download Model 2

C-score=-1.24

Download Model 3

C-score=-1.07

Download Model 4

C-score=-2.10

Download Model 5

C-score=-2.10

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2ymvA	0.832	1.26	0.192	0.855
2	3eo7A	0.562	3.73	0.127	0.677
3	3gh8A	0.424	3.42	0.083	0.497
4	2iskA	0.415	3.39	0.126	0.487
5	3gr3A	0.411	4.23	0.112	0.513
6	2wzvA	0.407	3.95	0.146	0.500
7	5j62A	0.395	3.76	0.088	0.476
8	3eo8A	0.395	3.59	0.118	0.468
9	3ek3A	0.394	3.06	0.109	0.454
10	4xomA	0.394	3.81	0.125	0.470

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.53	35	3gh8G	FMN	Rep, Mult	29,30,31,32,33,64,67,68,71
2	0.05	3	2ymvA	FNR	Rep, Mult	29,30,31,33,64,67,125,126,127,129,208,226,240,294,295,296,297,347
3	0.02	2	2wqfA	FMN	Rep, Mult	125,126,128,280,283,295,296,297

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3a2pA	0.337	6.88	0.049	0.567	3.5.2.12	NA
2	0.060	1v5yA	0.375	3.11	0.125	0.430	1.6.99.-	NA
3	0.060	2c6fA	0.361	6.83	0.041	0.597	3.4.15.1	31,188
4	0.060	2q5lA	0.344	7.08	0.079	0.594	4.1.1.74,4.1.1.43	275
5	0.060	1q16A	0.335	7.22	0.025	0.594	1.7.99.4	NA
6	0.060	1dgjA	0.352	6.70	0.068	0.583	1.2.-.-	47
7	0.060	3dy5A	0.353	6.18	0.043	0.556	1.13.11.40,4.2.1.92	NA
8	0.060	1vlbA	0.356	6.77	0.043	0.600	1.2.99.7	54,269
9	0.060	3hznH	0.365	3.31	0.121	0.422	1.-.-.-	NA
10	0.060	1xjjA	0.335	7.24	0.038	0.594	1.17.4.1	72,157
11	0.060	2vdcA	0.359	7.05	0.067	0.624	1.4.1.13	NA
12	0.060	3hq2B	0.336	7.03	0.049	0.570	3.4.24.-	NA
13	0.060	2fugU	0.288	6.68	0.039	0.476	1.6.99.5	49
14	0.060	2wghB	0.343	7.20	0.030	0.589	1.17.4.1	59
15	0.060	2vdcF	0.369	6.85	0.035	0.613	1.4.1.13	NA
16	0.060	1ds7A	0.368	3.38	0.125	0.430	1.5.1.34,1.6.99.7	189
17	0.060	2cf2C	0.337	6.63	0.048	0.543	2.3.1.85	73
18	0.060	2zxcA	0.380	7.22	0.052	0.675	3.5.1.23	203,210
19	0.060	2iukA	0.389	6.18	0.052	0.602	1.13.11.12	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.39	0.841	1.29	0.19	0.87	2ymvA	GO:0016491 GO:0055114
1	0.26	0.406	3.18	0.11	0.47	3gfaA	GO:0000166 GO:0016491 GO:0055114
2	0.19	0.405	3.39	0.12	0.47	3eo8A	GO:0000166 GO:0016491 GO:0055114
3	0.15	0.367	3.08	0.08	0.42	3gbhB	GO:0016491 GO:0055114
4	0.15	0.376	3.91	0.11	0.45	4eo3A	GO:0000166 GO:0016209 GO:0016491 GO:0055114 GO:0098869
5	0.13	0.414	3.43	0.13	0.49	2isjA	GO:0000166 GO:0009236 GO:0016491 GO:0016705 GO:0055114
6	0.08	0.426	3.42	0.09	0.50	3tnzA	GO:0004447 GO:0016020 GO:0016021 GO:0016491 GO:0055114 GO:0098869
7	0.07	0.385	3.07	0.09	0.44	4ttbA	GO:0004447 GO:0005886 GO:0006590 GO:0016020 GO:0016021 GO:0016491 GO:0055114 GO:0098869
8	0.07	0.382	3.49	0.13	0.45	2i7hA	GO:0000166 GO:0016491 GO:0055114
9	0.07	0.568	3.66	0.13	0.68	3eo7A	GO:0000166 GO:0016491 GO:0055114
10	0.06	0.426	4.05	0.13	0.52	2wzvB	GO:0000166 GO:0010181 GO:0016491 GO:0042802 GO:0042803 GO:0050661 GO:0055114 GO:2001039
11	0.06	0.426	4.16	0.10	0.53	3gr3A	GO:0016491 GO:0055114
12	0.06	0.425	3.39	0.08	0.50	4ttcA	GO:0004447 GO:0005886 GO:0006590 GO:0016020 GO:0016021 GO:0016491 GO:0055114 GO:0098869
13	0.06	0.399	3.05	0.11	0.46	3ek3A	GO:0000166 GO:0016491 GO:0055114
14	0.06	0.392	3.38	0.06	0.45	1vkwA	GO:0016491 GO:0055114
15	0.06	0.382	3.08	0.10	0.44	3gb5A	GO:0004447 GO:0016020 GO:0016021 GO:0016491 GO:0055114 GO:0098869
16	0.06	0.366	3.18	0.13	0.42	3gagA	GO:0000166 GO:0016491 GO:0055114
17	0.06	0.373	3.00	0.11	0.43	3bemB	GO:0005737 GO:0009636 GO:0016491 GO:0019439 GO:0055114
18	0.06	0.375	3.11	0.12	0.43	1v5yA	GO:0008218 GO:0016491 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0016491	GO:0000166
GO-Score	0.74	0.49
Biological Processes	GO:0055114
GO-Score	0.74
Cellular Component
GO-Score

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.