I-TASSER results

I-TASSER results for job id Rv2336

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (322 residues)
MDVPHEQPALSSSKSNRFTSQRQTTGVGTTTVERLEPRLSPASRHITEAKAFGTECHVSS
FTREQDPDRAVRVEQIHGEAYVAAGHVYESALDELGRLDNSNAEFILDKARGSTRETEVI
YLHAVPAEPLSGSQGEGGLRIVGISAVGSIDDLSAFKAAKPSMGLAHQRKLYDAIEDLGH
GGVKEIAALSVTADAPPTVSYSLIREVLRLYHRTGEKLIITFAMPAYAKMVMNFGRFAMP
QVGEPFYAHRNNDPRTSNDLLLVPSIVEPSNFLENISRGVVTADDGPTARRRFATLCYMT
DGLDDYFMPLTRQVLSEGIQDI

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MDVPHEQPALSSSKSNRFTSQRQTTGVGTTTVERLEPRLSPASRHITEAKAFGTECHVSSFTREQDPDRAVRVEQIHGEAYVAAGHVYESALDELGRLDNSNAEFILDKARGSTRETEVIYLHAVPAEPLSGSQGEGGLRIVGISAVGSIDDLSAFKAAKPSMGLAHQRKLYDAIEDLGHGGVKEIAALSVTADAPPTVSYSLIREVLRLYHRTGEKLIITFAMPAYAKMVMNFGRFAMPQVGEPFYAHRNNDPRTSNDLLLVPSIVEPSNFLENISRGVVTADDGPTARRRFATLCYMTDGLDDYFMPLTRQVLSEGIQDI
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHCCCCCCCCHHHHHHHHHHCCEEHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEHHHHHHHCCCCCCCHHHHHHHHCCCEEEEEEEEEEHCCCCCCCCCCCCCCEEEEEEEHCCCCCCHHHCCCCCCCHCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEHHHHHHHHHHHCCCCCCCCCCCCEEEHCCCCCCCCCEEEEEEHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCC
Conf.Score	9987666665567776544444456776545554356788655555666654664554444444578857888887766543345543677787768887655677776568657899999975787788888988756888865556765455555666555466666468887688867888877764688899854788999999999987987999974468999999866544677887655555488887775788866557578899877544567888754555666677776566654444677777765469
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MDVPHEQPALSSSKSNRFTSQRQTTGVGTTTVERLEPRLSPASRHITEAKAFGTECHVSSFTREQDPDRAVRVEQIHGEAYVAAGHVYESALDELGRLDNSNAEFILDKARGSTRETEVIYLHAVPAEPLSGSQGEGGLRIVGISAVGSIDDLSAFKAAKPSMGLAHQRKLYDAIEDLGHGGVKEIAALSVTADAPPTVSYSLIREVLRLYHRTGEKLIITFAMPAYAKMVMNFGRFAMPQVGEPFYAHRNNDPRTSNDLLLVPSIVEPSNFLENISRGVVTADDGPTARRRFATLCYMTDGLDDYFMPLTRQVLSEGIQDI
Prediction	8725464431555454413444433323333054044414434431350432234120331355444422220440334221122202341035224044741422144143442422101023145541546424200110203300436314404323332321345301520463233004301312423413231014003300400342432000000131134003301200033144412124155452342010000004044004302400232673340443011012004004402230134004431667
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320

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Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHCCCCCCCCHHHHHHHHHHCCEEHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEHHHHHHHCCCCCCCHHHHHHHHCCCEEEEEEEEEEHCCCCCCCCCCCCCCEEEEEEEHCCCCCCHHHCCCCCCCHCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEHHHHHHHHHHHCCCCCCCCCCCCEEEHCCCCCCCCCEEEEEEHCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCC
MDVPHEQPALSSSKSNRFTSQRQTTGVGTTTVERLEPRLSPASRHITEAKAFGTECHVSSFTREQDPDRAVRVEQIHGEAYVAAGHVYESALDELGRLDNSNAEFILDKARGSTRETEVIYLHAVPAEPLSGSQGEGGLRIVGISAVGSIDDLSAFKAAKPSMGLAHQRKLYDAIEDLGHGGVKEIAALSVTADAPPTVSYSLIREVLRLYHRTGEKLIITFAMPAYAKMVMNFGRFAMPQVGEPFYAHRNNDPRTSNDLLLVPSIVEPSNFLENISRGVVTADDGPTARRRFATLCYMTDGLDDYFMPLTRQVLSEGIQDI

4bqnA

0.12

0.11

0.89

0.59

MUSTER

------------SMAQR----KKYSVYGS---------APALAKMLNSCPTFARDWELVEMEPCFVAS-EEQIDRHLAETIPKLDLFLYQPVSEGYRGEKYSSVFLRNSMPPGGNALSVQYMHTVNSPYGLPPHPEGYVDALIAGAVVMDVDKETYLRHLEEIGASLRIDIDEIES----WCVDELKTREVGENDGKQIDISVTDFILANCR--QKRLFYTMNHPTAALMREIAARC-MLALGYTY---DISFDQNLDPLDVTKMSLYPI-YRDCFDFSELNRMNEYQVLYKKKAYEPYLLEQFEWFERSPKADVSAFFDRV

2r8cA

0.08

0.95

0.49

dPPAS

LDPDHPDLLQGFEEDGFIRSDKPIKSSNAHVIDVKGKTIMP-----------GLHVHVVAIEFNLPNVLVTLRAVPIMRAMLRRGFTTV---RDAGGAGYPFKQAVESGLVEGPRLFVSGRALSQTGGHADPRARSDYMPPDSPCGCCVRVGALGRVADGVDEVRRAVREELQMGADQIKIMASGGVASPTDPVGVFGYSEDEIRAIVAEAQGRGTYVLAHAYTPAAIARAVRCGVRTIEHGN--LIDDETARLVAEHGAYVVPTLVTYDALASEGEKYGLPPESIAKIADVHGAGLHSIEIMKRAGVKMGFGTDLLGEAQR

3zrpA

0.18

0.15

0.86

0.47

wdPPAS

GLENFTSKEVMGASKNYQP----IPGGGTSAME-LKPNL--GDRWEQIFKRYPVNVKVLRPSPGDYVKPGEVEEEVRKSEYVALTHVETSTVKDVINK-KYVELIVVD-SVGAE-EWNVDVYLTASQKALGS--AAG-LGLLLLSPKA----LSILDSQNSIAGLRNWLPVMRGAEEGKA----------AYFATPPVHVILQLAEAFRLIEKEG----IENRIKRHTMVASAI---GLEALGLEIVA---RRPESYSNT--VTGVILKQKVLAGTVN-EFAPGVHPTPNDAIIAISVIERTLRKLGEPAVEEVLFS-----

4bqnA

0.13

0.11

0.86

0.55

wMUSTER

M--A-QRKKYS---GS------QAPAL---------------AKMLNSCPTFARDWELVEMEPCFVAS-EEQIDRHLAETIPKLDLFLYQPVSEGYRGEKYSSVFLRNSMPPGGNALSVQYMTVNSPYGLPP--HPEGYVDALIAGAVVMDDKETYLRHLEEI-GASLRIDIDEIESWCVDELKTREVGENDGGKQIDIVTDFILANCR-----QKRLFYTMNHPT-AALMREIAARCMLALGYTYSDISFDQNLDPLDVTKMS--LYPI-YRDCF--DFSELNRMNEYQKKKAYEPYLLEQFEWFERPWVRTALRRAFE--

3zrpA

0.20

0.16

0.83

0.43

wPPAS

L-HV---PAGLGFTSKEFASKNYQPGGGTSAME-LKPNLVVSDRWEQIFKRYPVNVKVLRPSPGDYVKPGEVEEEVRKSEYVALTHVREP-VKDVINK-KYVELIVVD-G-----------VSSVGAEEVTASQAAG-LGLLLLSP------LSILDSQNSIAGLRNWLPVMRGAEEGKA----------AYFATPPVHVILQLAEAFRLIEKEGEN-----RIKRHTMVASAI---GLEALGEIV----ARRPESYSNT--VTGVILKQKVLAGTVN-EFAPGVHPAFKYRIGHM-----GVTPNDAIIAISVIERTLRKL

2r8cA

0.09

0.08

0.90

0.54

dPPAS2

LDPDHPDLLQGFEEDGFIRSDKPIKSSNAHVIDVKGKTIMP-----------GLHVHVVAIEFNLPNVLVTLRAVPIMRAMLRRGFTTV---RDAGGAGYPFKQAVESGLVEGPRLFVSGRALSQTGGHADPRARSDYMPPDSPCGCCVRVGALGRVADGVDEVRRAVREELQMGADQIKIMASGGVASPTDPVGVFGYSEDEIRAIVAEAQGRGTYVLAHAYTPAAIARAVRCG---VRTIGNLIDARLVAEHGA----YVVPTLVTYDALASEGEKYGLPPESIAKIADVHGAGLHSIEIMKRAGVKMG----------F

3zrpA

0.18

0.16

0.88

0.50

PPAS

GLENFTSKEVMGASKNYQP-----PGGGTSAME-LKPNLVVSDRWEQIFKRYPVNVKVLRPSPGDYVKPGEVEEEVRKSEYVALTHVETST----GVR--EPVKDVINKIRKYVELIVVDGVSSVGAEEVTASQSAAGLGLLLLSPKA----LSILDSQNSIAGLRNWLPVMRGAEEGKA----------AYFATPPVHVILQLAEAFRLIEKEGEN-----RIKRHTMVASAI-RAGLEALGLEIVA---RRPESYSNT--VTGVILKQKVLAGTVN-EFAPGVHPTPNDAIIAISVIERTLRKLGEPIRFGEGVKAVEEV

2g0bA

0.20

0.11

0.56

0.68

Env-PPAS

-------------------------GSMT-------PR-----KVARIL---------------VAPNERDAARRIVRTTYEAQGYAIDESFATFLEGPS---------------ATTFGLFNG---EVL--------YGTISIINDGAQG----LP-----MDSIYAVELAAWRGEGKK--LAEVVQFAMDHTLYEAEAASLFTMVLTYALETHDYLCISIN-PKHDTFYSLLG---FTQIGALHYG-TVN----------APAI------ARALYV--------PEWRSQT---------LLAQFM--------------

4yxzA

0.15

0.13

0.85

0.55

MUSTER

-----------ISVEELLKLAKAAYYSGTT-VEEAYKLALKLGISVEELLKLAEAAYYSGTTVEEAYKLALKLGISVEELLKL-----AKAAYYSGTTVEEAYKLALKL--GISVEELLKLAKAAYYSGTTVEEAYKLALKLG----ISVEELLKLAEAAYYSGTTVEEAYKLALK-LGIS-VEELLKLAKAAYYSGTTVEEAYKLALKLGISVEE-------LLKLAKAAYYSG-TTVEEAYK--LALKLGIS-----------VEELLKLAEAAYYSGTTVEEAYKLALKLISVEELLKLAKAAYYTTVEEAYKLALKL-

4bqnA

0.09

0.08

0.89

0.48

dPPAS

-----------------------SMAQRKKYSVYGSCQAPALAKMLNSCPTFARDWELVEMEPCFVASEEQIDRHLAETIPKLD-LFLYQPVSEGYRGEKYSSVFLRNSMPPGGNALSVQYMHWEGYHPTVNSPYGLP------PHPEGYVDALIAGAVVMDVDKETYLRHLEEIGASLRIDIDEIESWCVDGENDGGKQIDISVTDFILANCRQKRLFYTMNHPT-AALMREIAARCMLALGYT--YSDISFDQNLDPLDVTKMSLYPI-YRDCFDFSELNRMNEYQVLYKKKAYEPYLLEQFEWFERSPKADVSAFFDRV

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.88

Estimated TM-score = 0.30±0.10

Estimated RMSD = 16.0±3.2Å

Download Model 2

C-score=-4.32

Download Model 3

C-score=-5.00

Download Model 4

C-score=-5.00

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2r8cA	0.854	2.71	0.075	0.957
2	3feqN	0.825	2.83	0.080	0.935
3	4c5yA	0.792	3.39	0.082	0.944
4	3be7A	0.789	3.18	0.091	0.925
5	3gnhA	0.785	3.16	0.108	0.922
6	2qs8A	0.766	3.39	0.096	0.910
7	4wgxA	0.710	4.41	0.096	0.913
8	4whbE	0.707	4.40	0.103	0.910
9	2p9bA	0.669	3.86	0.089	0.839
10	3giqA	0.626	4.50	0.067	0.835

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.18	9	3n2cB	LWY	Rep, Mult	58,129,154,180,187,188,221,223,242,268,269
2	0.04	2	3be7E	ARG	Rep, Mult	9,46,47,50
3	0.04	2	4faiA	ZN	Rep, Mult	99,128,249
4	0.04	2	3mdwC	NFQ	Rep, Mult	7,41,44
5	0.02	1	3r4iB	CA	Rep, Mult	136,152
6	0.02	1	1j7lA	MG	Rep, Mult	258,285
7	0.02	1	3mkvF	CO3	Rep, Mult	129,187,188,223
8	0.02	1	3r4iA	CA	Rep, Mult	72,136,152
9	0.02	1	3jpyA	ZN	Rep, Mult	123,268
10	0.02	1	1z1nX	UUU	Rep, Mult	256,258
11	0.02	1	3igh0	III	Rep, Mult	205,208,212
12	0.02	1	3be7A	ARG	Rep, Mult	2,3,16,43,46,319
13	0.02	1	3mkvA	ZN	Rep, Mult	45,57,184,321
14	0.02	1	2p53A	NNG	Rep, Mult	3,44,88,91,310,313
15	0.02	1	1frvB	SF4	Rep, Mult	34,180
16	0.02	1	3rszC	III	Rep, Mult	96,97

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1ynyB	0.580	4.82	0.050	0.798	3.5.2.2	43
2	0.060	3hm7B	0.589	4.29	0.052	0.767	3.5.2.5	NA
3	0.060	3gipA	0.624	4.57	0.074	0.839	3.5.1.82	NA
4	0.060	3iv8D	0.551	5.30	0.071	0.807	3.5.1.25	244
5	0.060	3giqA	0.626	4.50	0.067	0.835	3.5.1.82	42,49,53,87
6	0.060	1xrtA	0.569	4.10	0.085	0.733	3.5.2.3	NA
7	0.060	2i9uA	0.595	4.58	0.074	0.814	3.5.4.3	NA
8	0.060	3e0lA	0.605	3.98	0.060	0.773	3.5.4.3	NA
9	0.060	1c7sA	0.553	5.37	0.072	0.795	3.2.1.52	NA
10	0.060	2g3fA	0.620	3.93	0.063	0.789	3.5.2.7	4,10
11	0.060	2oodA	0.599	3.90	0.089	0.767	3.5.4.3	NA
12	0.060	2gokA	0.623	3.88	0.106	0.786	3.5.2.7	NA
13	0.060	2ftyA	0.578	4.83	0.065	0.798	3.5.2.2	NA
14	0.060	1qbaA	0.551	5.32	0.057	0.792	3.2.1.52	NA
15	0.060	2z00A	0.577	4.41	0.081	0.761	3.5.2.3	NA
16	0.060	1a5lC	0.492	5.29	0.045	0.733	3.5.1.5	284
17	0.060	1m7jA	0.622	4.59	0.092	0.839	3.5.1.81	NA
18	0.060	1p1mA	0.566	4.63	0.039	0.776	3.5.4.28	88
19	0.060	1k1dA	0.576	4.94	0.050	0.801	3.5.2.-	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.37	0.617	3.93	0.09	0.78	2oofA	GO:0005506 GO:0005737 GO:0006547 GO:0006548 GO:0008270 GO:0016787 GO:0016810 GO:0016812 GO:0019556 GO:0019557 GO:0046872 GO:0050480
1	0.19	0.853	2.72	0.07	0.96	3mkvA	GO:0016787 GO:0016810 GO:0046872
2	0.18	0.833	2.87	0.08	0.95	3n2cA
3	0.17	0.788	3.15	0.11	0.93	3mtwA	GO:0016787 GO:0016810 GO:0046872
4	0.16	0.780	3.53	0.10	0.93	2qs8A	GO:0016787 GO:0016810 GO:0046872
5	0.16	0.789	3.18	0.09	0.93	3be7A
6	0.16	0.773	3.79	0.08	0.94	4c60A	GO:0006508 GO:0016787 GO:0016805 GO:0016810 GO:0046872 GO:0102009 GO:1900817
7	0.12	0.710	4.41	0.10	0.91	4ub9A	GO:0016787 GO:0016810
8	0.11	0.687	3.84	0.09	0.86	2p9bA	GO:0016787 GO:0016810
9	0.11	0.704	4.43	0.10	0.91	4whbA	GO:0016787 GO:0016810
10	0.08	0.622	4.59	0.09	0.84	1m7jA	GO:0016787 GO:0016810 GO:0016811 GO:0046872 GO:0047420
11	0.07	0.623	3.88	0.11	0.79	2gokA	GO:0005506 GO:0005737 GO:0006547 GO:0006548 GO:0008270 GO:0016787 GO:0016810 GO:0016812 GO:0019556 GO:0019557 GO:0046872 GO:0050480
12	0.07	0.620	3.93	0.06	0.79	2g3fA	GO:0005506 GO:0005737 GO:0006547 GO:0006548 GO:0008270 GO:0016787 GO:0016810 GO:0016812 GO:0019556 GO:0019557 GO:0046872 GO:0050480
13	0.07	0.595	4.58	0.07	0.81	2i9uA	GO:0006147 GO:0008270 GO:0008892 GO:0016787 GO:0016810 GO:0046872
14	0.07	0.617	3.79	0.07	0.77	4v1xE	GO:0005737 GO:0016787 GO:0016810 GO:0018788 GO:0019381 GO:0046872
15	0.07	0.578	4.69	0.04	0.80	3lnpA	GO:0016787 GO:0016810 GO:0019239 GO:0046872 GO:0050270 GO:0090614
16	0.07	0.606	3.75	0.08	0.77	2oodA	GO:0006147 GO:0008270 GO:0008892 GO:0016787 GO:0016810 GO:0046098 GO:0046872
17	0.07	0.579	4.81	0.06	0.80	1nfgA	GO:0005737 GO:0016787 GO:0016810 GO:0046872
18	0.07	0.597	4.36	0.09	0.78	4bjhA	GO:0004151 GO:0006221 GO:0008270 GO:0016787 GO:0016810 GO:0016812 GO:0044205 GO:0046872

Consensus prediction of GO terms

Molecular Function	GO:0008270	GO:0050480	GO:0005506
GO-Score	0.37	0.37	0.37
Biological Processes	GO:0019556	GO:0019557
GO-Score	0.37	0.37
Cellular Component	GO:0005737
GO-Score	0.37

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.