I-TASSER results

I-TASSER results for job id Rv2325c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (282 residues)
MTTTSAPARNGTRRPSRPIVLLIPVPGSSVIHDLWAGTKLLVVFGISVLLTFYPGWVTIG
MMAALVLAAARIAHIPRGALPSVPRWLWIVLAIGFLTAALAGGTPVVAVGGVQLGLGGAL
HFLRITALSVVLLALGAMVSWTTNVAEISPAVATLGRPFRVLRIPVDEWAVALALALRAF
PMLIDEFQVLYAARRLRPKRMPPSRKARRQRHARELIDLLAAAITVTLRRADEMGDAITA
RGGTGQLSAHPGRPKLADWVTLAITAMASGTAVAIESLILHS

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTTTSAPARNGTRRPSRPIVLLIPVPGSSVIHDLWAGTKLLVVFGISVLLTFYPGWVTIGMMAALVLAAARIAHIPRGALPSVPRWLWIVLAIGFLTAALAGGTPVVAVGGVQLGLGGALHFLRITALSVVLLALGAMVSWTTNVAEISPAVATLGRPFRVLRIPVDEWAVALALALRAFPMLIDEFQVLYAARRLRPKRMPPSRKARRQRHARELIDLLAAAITVTLRRADEMGDAITARGGTGQLSAHPGRPKLADWVTLAITAMASGTAVAIESLILHS
Prediction	CCCCCCCCCCCCCCCCCCEEEEEHCCCCCCEHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
Conf.Score	998877888888887776467776579985444787999999999999999869999999999999999999899777777778999999999999998479947999964787489999999999999999999999998499999999999996765543788799999999999999999999999999999989988888764567899999999999999999999999999999899998656655776789999999999999999999985589
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTTTSAPARNGTRRPSRPIVLLIPVPGSSVIHDLWAGTKLLVVFGISVLLTFYPGWVTIGMMAALVLAAARIAHIPRGALPSVPRWLWIVLAIGFLTAALAGGTPVVAVGGVQLGLGGALHFLRITALSVVLLALGAMVSWTTNVAEISPAVATLGRPFRVLRIPVDEWAVALALALRAFPMLIDEFQVLYAARRLRPKRMPPSRKARRQRHARELIDLLAAAITVTLRRADEMGDAITARGGTGQLSAHPGRPKLADWVTLAITAMASGTAVAIESLILHS
Prediction	744543455656554434010000134401001130101002113311210324333211212222221222132333223333322223233333223334332122113230132013102312333333333323203103232003002301310330402042002020333111310341053024014110242554433423430310000011011200430330030020112445142351403220100011222322222333333333
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCEEEEEHCCCCCCEHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
MTTTSAPARNGTRRPSRPIVLLIPVPGSSVIHDLWAGTKLLVVFGISVLLTFYPGWVTIGMMAALVLAAARIAHIPRGALPSVPRWLWIVLAIGFLTAALAGGTPVVAVGGVQLGLGGALHFLRITALSVVLLALGAMVSWTTNVAEISPAVATLGRPFRVLRIPVDEWAVALALALRAFPMLIDEFQVLYAARRLRPKRMPPSRKARRQRHARELIDLLAAAITVTLRRADEMGDAITARGGTGQLSAHPGRPKLADWVTLAITAMASGTAVAIESLILHS

5d3mD

0.17

0.15

0.90

2.52

MUSTER

--------------------IGRYLPGTTFVYRVDPRAKLLTTFYFIIMIFLANNWVSYLVISIFGLAYVFATGLKARVFWDGVKPMIWMIVFTSLLQTFAGGKVYWHWWIFTLSSEGLINGLYVFIRFAMIILVSTVMTVTTKPLEIADAMEWMLTPLKLFKVNVGMISLVISIALRFVPTLFDQTVKIMNAQRSRGADFNDGGL---VKRAKSVVPMLVPLFIDSLEVALDLSTAMESRGYKGRTRYRILEWSKVDLIPVAYCLLLTILMITTRK-----

5d3mD

0.17

0.15

0.90

2.76

dPPAS

--------------------IGRYLPGTTFVYRVDPRAKLLTTFYFIIMIFLANNWVSYLVISIFGLAYVFATGLKARVFWDGVKPMIWMIVFTSLLQTFFGGKVYWHWWIFTLSSEGLINGLYVFIRFAMIILVSTVMTVTTKPLEIADAMEWMLTPLKLFKVNVGMISLVISIALRFVPTLFDQTVKIMNAQRSRGADFNDGGL---VKRAKSVVPMLVPLFIDSLEVALDLSTAMESRGYKGRTRYRILEWSKVDLIPVAYCLLLTILMITTRK-----

5d3mD

0.17

0.15

0.90

4.61

wdPPAS

--------------------IGRYLPGTTFVYRVDPRAKLLTTFYFIIMIFLANNWVSYLVISIFGLAYVFATGLKARVFWDGVKPMIWMIVFTSLLQTFFGGKVYWHWWIFTLSSEGLINGLYVFIRFAMIILVSTVMTVTTKPLEIADAMEWMLTPLKLFKVNVGMISLVISIALRFVPTLFDQTVKIMNAQRSRGADFNDGGLVK---RAKSVVPMLVPLFIDSLEVALDLSTAMESRGYKGRTRYRILEWSKVDLIPVAYCLLLTILMITTRK-----

5d3mD

0.17

0.15

0.90

3.42

wMUSTER

--------------------IGRYLPGTTFVYRVDPRAKLLTTFYFIIMIFLANNWVSYLVISIFGLAYVFATGLKARVFWDGVKPMIWMIVFTSLLQTFFGGKVYWHWWIFTLSSEGLINGLYVFIRFAMIILVSTVMTVTTKPLEIADAMEWMLTPLKLFKVNVGMISLVISIALRFVPTLFDQTVKIMNAQRSRGADFNDGGLVK---RAKSVVPMLVPLFIDSLEVALDLSTAMESRGYKGRTRYRILEWSKVDLIPVAYCLLLTILMITTRK-----

5d3mD

0.17

0.15

0.90

5.96

wPPAS

--------------------IGRYLPGTTFVYRVDPRAKLLTTFYFIIMIFLANNWVSYLVISIFGLAYVFATGLKARVFWDGVKPMIWMIVFTSLLQTFFGGKVYWHWWIFTLSSEGLINGLYVFIRFAMIILVSTVMTVTTKPLEIADAMEWMLTPLKLFKVNVGMISLVISIALRFVPTLFDQTVKIMNAQRSRGADFNDGGLVK---RAKSVVPMLVPLFIDSLEVALDLSTAMESRGYKGRTRYRILEWSKVDLIPVAYCLLLTILMITTRK-----

5d3mD

0.17

0.15

0.90

6.77

dPPAS2

--------------------IGRYLPGTTFVYRVDPRAKLLTTFYFIIMIFLANNWVSYLVISIFGLAYVFATGLKARVFWDGVKPMIWMIVFTSLLQTFFGGKVYWHWWIFTLSSEGLINGLYVFIRFAMIILVSTVMTVTTKPLEIADAMEWMLTPLKLFKVNVGMISLVISIALRFVPTLFDQTVKIMNAQRSRGADFNDGGL---VKRAKSVVPMLVPLFIDSLEVALDLSTAMESRGYKGRTRYRILEWSKVDLIPVAYCLLLTILMITTRK-----

5d3mD

0.17

0.15

0.90

4.49

PPAS

--------------------IGRYLPGTTFVYRVDPRAKLLTTFYFIIMIFLANNWVSYLVISIFGLAYVFATGLKARVFWDGVKPMIWMIVFTSLLQTFAGGKVYWHWWIFTLSSEGLINGLYVFIRFAMIILVSTVMTVTTKPLEIADAMEWMLTPLKLFKVNVGMISLVISIALRFVPTLFDQTVKIMNAQRSRGADFNDGGL---VKRAKSVVPMLVPLFIDSLEVALDLSTAMESRGYKGRTRYRILEWSKVDLIPVAYCLLLTILMITTRK-----

5d3mD

0.17

0.15

0.90

6.39

Env-PPAS

--------------------IGRYLPGTTFVYRVDPRAKLLTTFYFIIMIFLANNWVSYLVISIFGLAYVFATGLKARVFWDGVKPMIWMIVFTSLLQTFAGGKVYWHWWIFTLSSEGLINGLYVFIRFAMIILVSTVMTVTTKPLEIADAMEWMLTPLKLFKVNVGMISLVISIALRFVPTLFDQTVKIMNAQRSRGADFNDGGL---VKRAKSVVPMLVPLFIDSLEVALDLSTAMESRGYKGRTRYRILEWSKVDLIPVAYCLLLTILMITTRK-----

4huqT

0.21

0.18

0.86

2.47

MUSTER

--------------------FGRYLPLDSVVHRLDPRAKLMLSFCYIIVVFLANNIWSYAILIAFTVGAILSSKISLGFFLKGIRPLLWLIVFTVVLQLL---------FSINVTQDGLINAGYIFVRFLLIIMMSTLLTLSTQPLDIATGLASLMKPLRWVKVPVDTLAMMLSIALRFVPTLMDEATKIMNAQRARGVDFGEGG---LFKQAKSLIPLMVPLFMSAFNRAEDLSTAMEARGYQDRSQYRILTWQRRDTVTWLLFLLGFVAILI--------

4huqT

0.21

0.18

0.86

2.75

dPPAS

--------------------FGRYLPLDSVVHRLDPRAKLMLSFCYIIVVFLANNIWSYAILIAFTVGAILSSKISLGFFLKGIRPLLWLIVFTVVLQLLFSI---------NVTQDGLINAGYIFVRFLLIIMMSTLLTLSTQPLDIATGLASLMKPLRWVKVPVDTLAMMLSIALRFVPTLMDEATKIMNAQRARGVDFGEGG---LFKQAKSLIPLMVPLFMSAFNRAEDLSTAMEARGYQDRSQYRILTWQRRDTVTWLLFLLGFVAILI--------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.27

Estimated TM-score = 0.68±0.12

Estimated RMSD = 6.6±4.0Å

Download Model 2

C-score=-0.03

Download Model 3

C-score=-0.16

Download Model 4

C-score=-1.03

Download Model 5

C-score=-2.56

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5d3mD	0.867	1.33	0.165	0.901
2	4huqT	0.805	1.70	0.215	0.858
3	3fvyA	0.459	5.85	0.061	0.738
4	2z1qB	0.423	6.22	0.076	0.720
5	3sqgA	0.420	5.95	0.047	0.670
6	3owaA	0.416	6.43	0.073	0.727
7	3abzA	0.413	6.52	0.045	0.723
8	4bqeA	0.412	6.05	0.068	0.677
9	5an8A	0.407	5.30	0.045	0.606
10	1w07B	0.407	6.84	0.079	0.755

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.08	4	4efcA	MG	Rep, Mult	232,236
2	0.06	3	2jj2G	QUE	Rep, Mult	237,240,241
3	0.04	2	1lghA	DET	Rep, Mult	172,179
4	0.04	2	2z1qB	FAD	Rep, Mult	73,75,78,81,134,135,136
5	0.04	2	4zzbA	XE	Rep, Mult	179,180,183
6	0.04	2	1hbnA	UUU	Rep, Mult	64,66,67,68,128,131,134
7	0.04	2	1bjeA	AZI	Rep, Mult	190,226
8	0.02	1	1diiA	HEM	Rep, Mult	155,159
9	0.02	1	2wse1	CLA	Rep, Mult	226,230
10	0.02	1	1xmeC	HAS	Rep, Mult	171,175
11	0.02	1	3hykA	A3P	Rep, Mult	230,234,241
12	0.02	1	1e6vA	UUU	Rep, Mult	42,43,132,135
13	0.02	1	2z1qA	FAD	Rep, Mult	156,158,159,167,170
14	0.02	1	3e6sE	FE	Rep, Mult	186,190
15	0.02	1	3gxqB	NUC	Rep, Mult	32,34
16	0.02	1	4zgmA	32M	Rep, Mult	220,224

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1fa9A	0.325	6.55	0.060	0.578	2.4.1.1	142
2	0.060	2azdB	0.404	6.07	0.063	0.663	2.4.1.1	NA
3	0.060	2ztgA	0.382	6.56	0.086	0.681	6.1.1.7	64,68,122
4	0.060	3gpbA	0.393	6.03	0.027	0.652	2.4.1.1	142
5	0.060	2fonB	0.411	6.56	0.058	0.727	1.3.3.6	42
6	0.060	2z1qB	0.423	6.22	0.076	0.720	1.3.99.3	94
7	0.060	1is2A	0.397	6.73	0.037	0.727	1.3.3.6	180
8	0.060	2zxqA	0.389	6.63	0.050	0.692	3.2.1.97	65,70
9	0.060	1mhsA	0.376	6.36	0.039	0.649	3.6.3.6	NA
10	0.060	1e6vA	0.405	5.87	0.048	0.649	2.8.4.1	NA
11	0.060	1kqfA	0.363	6.50	0.066	0.638	1.2.1.2	NA
12	0.060	2hpiA	0.316	6.61	0.036	0.560	2.7.7.7	185
13	0.060	1a0eA	0.370	5.87	0.085	0.589	5.3.1.5	NA
14	0.060	3fvyA	0.459	5.85	0.061	0.738	3.4.14.4	36,151
15	0.060	3eqlM	0.362	6.48	0.041	0.642	2.7.7.6	72,75
16	0.060	2vumB	0.291	7.02	0.015	0.553	2.7.7.6	NA
17	0.060	1de5A	0.375	5.89	0.074	0.599	5.3.1.14	NA
18	0.060	1e6yA	0.387	6.35	0.046	0.660	2.8.4.1	NA
19	0.060	1t3tA	0.372	5.89	0.027	0.610	6.3.5.3	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.42	0.805	1.70	0.21	0.86	4huqT	GO:0005215 GO:0005886 GO:0006810 GO:0016020 GO:0016021
1	0.41	0.867	1.33	0.17	0.90	5d3mD	GO:0005215 GO:0005886 GO:0006810 GO:0016020 GO:0016021
2	0.07	0.350	6.58	0.03	0.61	3cskA	GO:0004177 GO:0005737 GO:0006508 GO:0008233 GO:0008237 GO:0008239 GO:0016787 GO:0046872
3	0.06	0.423	6.22	0.08	0.72	2z1qB	GO:0000166 GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
4	0.06	0.282	5.88	0.08	0.45	2uxwA	GO:0000062 GO:0001659 GO:0003995 GO:0004466 GO:0005634 GO:0005730 GO:0005737 GO:0005739 GO:0005743 GO:0005759 GO:0006629 GO:0006631 GO:0006635 GO:0008152 GO:0009055 GO:0015980 GO:0016020 GO:0016491 GO:0016627 GO:0017099 GO:0030855 GO:0033539 GO:0036498 GO:0042645 GO:0042760 GO:0045717 GO:0046322 GO:0050660 GO:0052890 GO:0055088 GO:0055114 GO:0090181
5	0.06	0.331	6.39	0.06	0.59	5e2qA	GO:0004177 GO:0005654 GO:0005737 GO:0005886 GO:0006508 GO:0008233 GO:0008237 GO:0008239 GO:0008270 GO:0016787 GO:0046872 GO:0070062
6	0.06	0.297	6.56	0.07	0.52	3mxlB	GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
7	0.06	0.261	6.20	0.06	0.43	3r7kA	GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
8	0.06	0.393	6.05	0.07	0.64	3u33A	GO:0000062 GO:0003677 GO:0003995 GO:0005737 GO:0006974 GO:0008152 GO:0008470 GO:0009055 GO:0016491 GO:0016627 GO:0033539 GO:0043565 GO:0045892 GO:0050660 GO:0052890 GO:0055088 GO:0055114
9	0.06	0.290	6.23	0.03	0.48	3afeA	GO:0000062 GO:0003995 GO:0004497 GO:0005886 GO:0006629 GO:0006694 GO:0006707 GO:0008152 GO:0008202 GO:0009055 GO:0016042 GO:0016491 GO:0016627 GO:0016712 GO:0019439 GO:0033539 GO:0036383 GO:0044117 GO:0050660 GO:0052890 GO:0055088 GO:0055114
10	0.06	0.267	6.77	0.04	0.49	2ix4A	GO:0003824 GO:0004315 GO:0005739 GO:0006629 GO:0006631 GO:0006633 GO:0008152 GO:0016740 GO:0016746 GO:0016747
11	0.06	0.425	6.46	0.07	0.74	3owaC	GO:0000166 GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
12	0.06	0.299	6.54	0.06	0.53	4kcfA	GO:0000166 GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
13	0.06	0.397	6.73	0.04	0.73	1is2A	GO:0000062 GO:0003995 GO:0003997 GO:0005504 GO:0005777 GO:0006091 GO:0006629 GO:0006631 GO:0006635 GO:0006693 GO:0008152 GO:0009055 GO:0016401 GO:0016491 GO:0016627 GO:0019395 GO:0033539 GO:0033540 GO:0050660 GO:0052890 GO:0055088 GO:0055114
14	0.06	0.278	6.47	0.05	0.48	4n5fA	GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
15	0.06	0.284	5.97	0.05	0.47	3d9dA	GO:0000166 GO:0003995 GO:0006807 GO:0008152 GO:0016491 GO:0016627 GO:0050141 GO:0050660 GO:0052664 GO:0055114 GO:0071949
16	0.06	0.288	6.27	0.03	0.48	2rfqA	GO:0004497 GO:0006629 GO:0006694 GO:0008152 GO:0008202 GO:0016042 GO:0016491 GO:0016627 GO:0019439 GO:0036383 GO:0050660 GO:0055114
17	0.06	0.285	6.87	0.04	0.51	3affA	GO:0000062 GO:0003995 GO:0004497 GO:0005886 GO:0006629 GO:0006694 GO:0006707 GO:0008152 GO:0008202 GO:0009055 GO:0016042 GO:0016491 GO:0016627 GO:0016712 GO:0019439 GO:0033539 GO:0036383 GO:0044117 GO:0050660 GO:0052890 GO:0055088 GO:0055114
18	0.06	0.269	6.81	0.03	0.49	2pg0A	GO:0000166 GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0005215
GO-Score	0.66
Biological Processes	GO:0006810
GO-Score	0.66
Cellular Component	GO:0016021	GO:0005886
GO-Score	0.66	0.66

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
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