I-TASSER results

I-TASSER results for job id Rv2323c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (302 residues)
MENTQRPSFDCEIRAKYRWFMTDSYVAAARLGSPARRTPRTRRYAMTPPAFFAVAYAINP
WMDVTAPVDVQVAQAQWEHLHQTYLRLGHSVDLIEPISGLPDMVYTANGGFIAHDIAVVA
RFRFPERAGESRAYASWMSSVGYRPVTTRHVNEGQGDLLMVGERVLAGYGFRTDQRAHAE
IAAVLGLPVVSLELVDPRFYHLDTALAVLDDHTIAYYPPAFSTAAQEQLSALFPDAIVVG
SADAFVFGLNAVSDGLNVVLPVAAMGFAAQLRAAGFEPVGVDLSELLKGGGSVKCCTLEI
HP

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MENTQRPSFDCEIRAKYRWFMTDSYVAAARLGSPARRTPRTRRYAMTPPAFFAVAYAINPWMDVTAPVDVQVAQAQWEHLHQTYLRLGHSVDLIEPISGLPDMVYTANGGFIAHDIAVVARFRFPERAGESRAYASWMSSVGYRPVTTRHVNEGQGDLLMVGERVLAGYGFRTDQRAHAEIAAVLGLPVVSLELVDPRFYHLDTALAVLDDHTIAYYPPAFSTAAQEQLSALFPDAIVVGSADAFVFGLNAVSDGLNVVLPVAAMGFAAQLRAAGFEPVGVDLSELLKGGGSVKCCTLEIHP
Prediction	CCCCCCCCCCCCCCCHHHHHCHHHHHHCCCCCCCCCCCCCCCEEEEHCCCCCCCHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEHCCCCCCCCEEHCCCCEEEHCCEEEHCCCCCHHHHHHHHHHHHHHHHHCCEEHCCCCCCCCCCEEEEHCCEEEEEHCCCCCHHHHHHHHHHHCCEEEEEHCCCCCCEEHCEEEEEHCCCEEEHCCCCCCHHHHHHHHHHCCCEEHCCHHHHHHHCCCEEEHCCCEEHCCCCHHHHHHHHHHCCEEEEHCHHHHHHCCCCCCEEEEHCCC
Conf.Score	98766776445455444443444455546777766667777779997897765444456555788888899999999999999999899999968999999756657858998999999589877888899999999998599787588877788759998999999977889999999999997996899985898655544578886699899967658989999999989987987999999876869998896897898889999999999989997778887759986446887699
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MENTQRPSFDCEIRAKYRWFMTDSYVAAARLGSPARRTPRTRRYAMTPPAFFAVAYAINPWMDVTAPVDVQVAQAQWEHLHQTYLRLGHSVDLIEPISGLPDMVYTANGGFIAHDIAVVARFRFPERAGESRAYASWMSSVGYRPVTTRHVNEGQGDLLMVGERVLAGYGFRTDQRAHAEIAAVLGLPVVSLELVDPRFYHLDTALAVLDDHTIAYYPPAFSTAAQEQLSALFPDAIVVGSADAFVFGLNAVSDGLNVVLPVAAMGFAAQLRAAGFEPVGVDLSELLKGGGSVKCCTLEIHP
Prediction	86536424341544351342035322534634444543441310000204304143321421556542326303500540151047250403304236520100000000001441000010223103200400240057270431446321012000010441000010310134004201720724200040255400000000000153000001420467025204732551040345202300000010473000143054015204726041130423102301400130003138
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCHHHHHCHHHHHHCCCCCCCCCCCCCCCEEEEHCCCCCCCHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEHCCCCCCCCEEHCCCCEEEHCCEEEHCCCCCHHHHHHHHHHHHHHHHHCCEEHCCCCCCCCCCEEEEHCCEEEEEHCCCCCHHHHHHHHHHHCCEEEEEHCCCCCCEEHCEEEEEHCCCEEEHCCCCCCHHHHHHHHHHCCCEEHCCHHHHHHHCCCEEEHCCCEEHCCCCHHHHHHHHHHCCEEEEHCHHHHHHCCCCCCEEEEHCCC
MENTQRPSFDCEIRAKYRWFMTDSYVAAARLGSPARRTPRTRRYAMTPPAFFAVAYAINPWMDVTAPVDVQVAQAQWEHLHQTYLRLGHSVDLIEPISGLPDMVYTANGGFIAHDIAVVARFRFPERAGESRAYASWMSSVGYRPVTTRHVNEGQGDLLMVGERVLAGYGFRTDQRAHAEIAAVLGLPVVSLELVDPRFYHLDTALAVLDDHTIAYYPPAFSTAAQEQLSALFPDAIVVGSADAFVFGLNAVSDGLNVVLPVAAMGFAAQLRAAGFEPVGVDLSELLKGGGSVKCCTLEIHP

3bpbA

0.19

0.16

0.83

2.50

MUSTER

---------------------------------------MFKHIIARTPARSLVDGLT---SSHLGKPDYAKALEQHNAYIRALQTCDVDITLLPPDERFPDSVFVEDPVLCTSRCAIITRPGAESRRGETEIIEETVQRFKVERIEAPGTVEAG-DIMMVGDHFYIGESARTNAEGARQMIAILEKHGLSGSVVREKVLGLKTGLAYLEHNNLLAAGEFVSKPEFQ-----DFNIIEIP--EEESYAANCIWVNERVIMPAGYPRTREKIARLGYRVIEVDTSEYRKIDGGVSCMSLRF--

3bpbA

0.19

0.16

0.83

5.04

dPPAS

---------------------------------------MFKHIIARTPARSLVDGLT---SSHLGKPDYAKALEQHNAYIRALQTCDVDITLLPPDERFPDSVFVEDPVLCTSRCAIITRPGAESRRGETEIIEETVQRFGKVERIEAPGTVEAGDIMMVGDHFYIGESARTNAEGARQMIAILEKHGLSGSVVLEKVLGLKTGLAYLEHNNLLAAGE-----FVSKPEFQDFNIIEIP--EEESYAANCIWVNERVIMPAGYPRTREKIARLGYRVIEVDTSEYRKIDGGVSCMSLRF--

3bpbA

0.19

0.16

0.83

4.92

wdPPAS

---------------------------------------MFKHIIARTPARSLVDGLTS---SHLGKPDYAKALEQHNAYIRALQTCDVDITLLPPDERFPDSVFVEDPVLCTSRCAIITRPGAESRRGETEIIEETVQRFYPERIEAPGTVEAG-DIMMVGDHFYIGESARTNAEGARQMIAILEKHGLSGSVVREKVLGLKTGLAYLEHNNLLAAGEFVSKPEFQ-----DFNIIEIP--EEESYAANCIWVNERVIMPAGYPRTREKIARLGYRVIEVDTSEYRKIDGGVSCMSLRF--

3bpbA

0.19

0.16

0.82

2.87

wMUSTER

----------------------------------------FKHIIARTPARSLVDGLTS---SHLGKPDYAKALEQHNAYIRALQTCDVDITLLPPDERFPDSVFVEDPVLCTSRCAIITRPGAESRRGETEIIEETVQRFKVERIEAPGTVEAG-DIMMVGDHFYIGESARTNAEGARQMIAILEKHGLSGSVVREKVLGLKTGLAYLEHNNLLAAGEFVSKPEFQ-----DFNIIEIP--EEESYAANCIWVNERVIMPAGYPRTREKIARLGYRVIEVDTSEYRKIDGGVSCMSLRF--

3bpbA

0.19

0.16

0.83

4.48

wPPAS

---------------------------------------MFKHIIARTPARSLVDGLTSSHL---GKPDYAKALEQHNAYIRALQTCDVDITLLPPDERFPDSVFVEDPVLCTSRCAIITRPGAESRRGETEIIEETVQRFYPERIEAPGTVEAG-DIMMVGDHFYIGESARTNAEGARQMIAILEKHGLSGSVVREKVLGLKTGLAYLEHNNLLAAGEFVSKPEFQ-----DFNIIEIP--EEESYAANCIWVNERVIMPAGYPRTREKIARLGYRVIEVDTSEYRKIDGGVSCMSLRF--

3bpbA

0.20

0.16

0.83

10.02

dPPAS2

---------------------------------------MFKHIIARTPARSLVDGLT---SSHLGKPDYAKALEQHNAYIRALQTCDVDITLLPPDERFPDSVFVEDPVLCTSRCAIITRPGAESRRGETEIIEETVQRFGKVERIEAPGTVEAGDIMMVGDHFYIGESARTNAEGARQMIAILEKHGLSGSVVLEKVLGLKTGLAYLEHNNLLAAGEFVSKPEFQ-----DFNIIEIP--EEESYAANCIWVNERVIMPAGYPRTREKIARLGYRVIEVDTSEYRKIDGGVSCMSLRF--

3bpbA

0.19

0.16

0.83

3.87

PPAS

---------------------------------------MFKHIIARTPARSLVDGLTS---SHLGKPDYAKALEQHNAYIRALQTCDVDITLLPPDERFPDSVFVEDPVLCTSRCAIITRPGAESRRGETEIIEETVQRFYPVERIEAPGTVEAGDIMMVGDHFYIGESARTNAEGARQMIAILEKHGLSGSVVREKVLGLKTGLAYLEHNNLLAAGEFVSKPEFQ-----DFNIIEIP--EEESYAANCIWVNERVIMPAGYPRTREKIARLGYRVIEVDTSEYRKIDGGVSCMSLRF--

3bpbA

0.19

0.16

0.83

5.55

Env-PPAS

---------------------------------------MFKHIIARTPARSLVDGLTSSHL---GKPDYAKALEQHNAYIRALQTCDVDITLLPPDERFPDSVFVEDPVLCTSRCAIITRPGAESRRGETEIIEETVQRFYPVERIEAPGTVEAGDIMMVGDHFYIGESARTNAEGARQMIAILEKHGLSGSVVREKVLGLKTGLAYLEHNNLLAAGEFVSK-----PEFQDFNIIEIP--EEESYAANCIWVNERVIMPAGYPRTREKIARLGYRVIEVDTSEYRKIDGGVSCMSLRF--

2jajB

0.18

0.16

0.89

2.21

MUSTER

------------------------GPLGMAGLGHPAAFGRATHAVVRAL----PESLGQHALRSAKEVDVARAERQHQLYVGVLGSLGLQVVELPADESLPDCVFVEDVAVVCEETALITRPGAPSRRKEVDMMKEALEKLQLNIVEDENATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFKDYAVSTV----PVLHLKSFCSMAGPNLIAIGSSESAQKALKIMQQMDHRYDKLTVPDDIAANCIYLNIPNKVLLHEEYPESAKVYEKKDHMLIPVSMSELEKVDGLLTCCSVLINK

2jajB

0.18

0.16

0.89

4.33

dPPAS

------------------------GPLGMAGLGHPAAFGRATHAVVRALPE----SLGQHALRSAKEVDVARAERQHQLYVGVLGSLGLQVVELPADESLPDCVFVEDVAVVCEETALITRPGAPSRRKEVDMMKEALEKLQLNIVEDENATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFKDYAVSTV----PVLHLKSFCSMAGPNLIAIGSSESAQKALKIMQQMSDHYDKLTVPDDIAANCIYLNIPNKHRTPEEYPESAKVYEKKDHMLIPVSMSELEKVDGLLTCCSVLINK

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.16

Estimated TM-score = 0.69±0.12

Estimated RMSD = 6.5±3.9Å

Download Model 2

C-score=-1.12

Download Model 3

C-score=-0.42

Download Model 4

C-score=-0.80

Download Model 5

C-score=-4.11

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2jajB	0.816	1.91	0.195	0.881
2	3bpbA	0.812	1.02	0.191	0.831
3	1s9rA	0.772	2.80	0.162	0.884
4	4bofA	0.761	3.02	0.169	0.884
5	4jdwA	0.756	2.96	0.112	0.874
6	4e4jA	0.751	3.16	0.189	0.884
7	1bwdA	0.749	3.03	0.123	0.868
8	1rxxC	0.749	3.08	0.184	0.868
9	1ynhB	0.745	2.90	0.155	0.874
10	2jerD	0.713	3.36	0.120	0.848

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.77	35	1lxyA	CIR	Rep, Mult	57,102,105,107,108,127,156,172,201,203,204,289,290,295
2	0.09	4	2ci7A	GLY	Rep, Mult	57,102,105,127,172,289
3	0.05	4	6jdwA	ABU	Rep, Mult	198,201,203,204,220,243,244,247,290,295
4	0.02	2	3jdwA	ORN	Rep, Mult	200,201,203,204,290,295

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.177	2a9gD	0.769	2.99	0.185	0.884	3.5.3.6	197,204,291
2	0.073	2jerD	0.713	3.36	0.120	0.848	3.5.3.12	151,291
3	0.069	2ewoH	0.704	3.70	0.146	0.858	3.5.3.12	154,249,291
4	0.060	1simA	0.440	6.26	0.071	0.742	3.2.1.18	159,292
5	0.060	2q3uA	0.698	3.68	0.099	0.851	3.5.3.12	122,154,295
6	0.060	1bwdA	0.749	3.03	0.123	0.868	2.1.4.2	201,203,295
7	0.060	1s9rA	0.772	2.80	0.162	0.884	3.5.3.6	NA
8	0.060	3elqB	0.439	6.39	0.045	0.755	2.8.2.22	39
9	0.060	1gjqA	0.435	6.26	0.048	0.725	1.7.99.1,1.7.2.1	NA
10	0.060	1yniB	0.745	2.89	0.152	0.874	3.5.3.23	290
11	0.060	1yiqA	0.469	6.12	0.058	0.765	1.1.99.-	102
12	0.060	2cmlC	0.432	6.20	0.073	0.735	3.2.1.18	243
13	0.060	1v0zA	0.432	6.24	0.068	0.725	3.2.1.18	NA
14	0.060	1kv9A	0.465	6.07	0.082	0.775	1.1.99.-	NA
15	0.060	1aomB	0.456	6.27	0.062	0.765	1.7.99.1,1.7.2.1	NA
16	0.060	1usrA	0.424	6.22	0.070	0.715	3.2.1.18	134,298
17	0.060	1jdwA	0.758	2.94	0.116	0.874	2.1.4.1	127,201,203,295
18	0.060	1kb0A	0.427	6.54	0.050	0.742	1.1.99.-	102
19	0.060	2jajB	0.816	1.91	0.195	0.881	3.5.3.18	201,295
20	0.060	2bixA	0.436	6.40	0.030	0.732	1.14.99.-	NA
21	0.060	1z4zA	0.430	6.23	0.040	0.725	3.2.1.18	NA
22	0.060	1wd8A	0.553	3.34	0.095	0.666	3.5.3.15	296

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.42	0.812	1.11	0.19	0.83	1h70A	GO:0016403 GO:0016787 GO:0046872
1	0.39	0.816	1.91	0.20	0.88	2jajB	GO:0000052 GO:0003073 GO:0003824 GO:0005739 GO:0005829 GO:0006525 GO:0006527 GO:0007263 GO:0016403 GO:0016597 GO:0016787 GO:0045429 GO:0045766 GO:0046872 GO:0050999 GO:0070062
2	0.33	0.771	2.81	0.16	0.88	1lxyA	GO:0005737 GO:0006525 GO:0006527 GO:0016787 GO:0016990 GO:0018101 GO:0019547
3	0.33	0.766	3.00	0.18	0.88	1rxxC	GO:0005737 GO:0006525 GO:0006527 GO:0016787 GO:0016990 GO:0018101 GO:0019546 GO:0019547
4	0.27	0.751	3.16	0.19	0.88	4e4jA	GO:0005737 GO:0006525 GO:0006527 GO:0016787 GO:0016990 GO:0018101 GO:0019547
5	0.15	0.765	3.04	0.17	0.89	4bofB	GO:0005737 GO:0006525 GO:0006527 GO:0016787 GO:0016990 GO:0018101 GO:0019547
6	0.14	0.758	2.94	0.12	0.87	1jdwA	GO:0005737 GO:0005739 GO:0005743 GO:0005758 GO:0006600 GO:0006601 GO:0015067 GO:0015068 GO:0016020 GO:0016740 GO:0070062
7	0.14	0.749	3.03	0.12	0.87	1bwdA	GO:0015067 GO:0015069 GO:0016740 GO:0017000 GO:0019872
8	0.07	0.519	3.62	0.08	0.65	5an9I	GO:0000054 GO:0000460 GO:0000470 GO:0003743 GO:0005634 GO:0005730 GO:0005737 GO:0005829 GO:0006412 GO:0006413 GO:0030687 GO:0042254 GO:0042256 GO:0042273 GO:0043022 GO:0043023 GO:1902626
9	0.07	0.513	3.69	0.06	0.64	1g61A	GO:0000054 GO:0000460 GO:0000470 GO:0003743 GO:0005730 GO:0005829 GO:0006412 GO:0006413 GO:0030687 GO:0042256 GO:0043022 GO:0043023 GO:1902626
10	0.07	0.513	3.61	0.09	0.64	4adxI	GO:0003743 GO:0006412 GO:0006413 GO:0042256 GO:0043022
11	0.07	0.523	3.59	0.06	0.65	3jcty	GO:0000054 GO:0000463 GO:0000466 GO:0003743 GO:0005634 GO:0005730 GO:0005737 GO:0005829 GO:0006364 GO:0006412 GO:0006413 GO:0030687 GO:0042254 GO:0042256 GO:0042273 GO:0042802 GO:0043022 GO:0043023 GO:1902626
12	0.07	0.522	3.42	0.08	0.64	4v8pAJ	GO:0000054 GO:0000460 GO:0000470 GO:0003743 GO:0005634 GO:0005730 GO:0005737 GO:0005829 GO:0006412 GO:0006413 GO:0030687 GO:0042254 GO:0042256 GO:0042273 GO:0043022 GO:0043023 GO:1902626
13	0.06	0.341	6.32	0.01	0.56	2nwhA	GO:0016301 GO:0016310 GO:0016740 GO:0016773
14	0.06	0.352	7.02	0.04	0.64	3rmjB	GO:0003824 GO:0003852 GO:0008652 GO:0009082 GO:0009098 GO:0016740 GO:0019752 GO:0046912
15	0.06	0.346	6.21	0.06	0.57	4mduB	GO:0005509 GO:0005544 GO:0042802 GO:0046872
16	0.06	0.290	6.45	0.06	0.51	1oxyA	GO:0005344 GO:0005507 GO:0005576 GO:0005615 GO:0006810 GO:0008152 GO:0015671 GO:0016491 GO:0031404 GO:0046872 GO:0051259 GO:0055114
17	0.06	0.324	6.80	0.04	0.58	2w41B	GO:0000166 GO:0004370 GO:0005524 GO:0005739 GO:0005975 GO:0006071 GO:0006072 GO:0006641 GO:0016301 GO:0016310 GO:0016740 GO:0016773 GO:0046167
18	0.06	0.345	5.89	0.08	0.55	5ifyA	GO:0008879 GO:0009058 GO:0016740 GO:0016779 GO:0045226 GO:0046872
19	0.06	0.348	5.71	0.06	0.55	5idsA	GO:0008879 GO:0009058 GO:0016740 GO:0016779 GO:0045226 GO:0046872
20	0.06	0.280	6.89	0.04	0.51	5fhdB	GO:0000723 GO:0003678 GO:0004386 GO:0005524 GO:0006281 GO:0032508
21	0.06	0.280	7.08	0.04	0.53	5ftcA	GO:0000723 GO:0003678 GO:0004386 GO:0005524 GO:0006281 GO:0032508
22	0.06	0.278	6.48	0.04	0.48	2f9iB	GO:0000166 GO:0003989 GO:0005524 GO:0005737 GO:0006629 GO:0006631 GO:0006633 GO:0008270 GO:0009317 GO:0016874 GO:0046872 GO:2001295
23	0.06	0.274	6.77	0.09	0.48	4zj8A	GO:0004373 GO:0004871 GO:0004930 GO:0005886 GO:0005887 GO:0007165 GO:0007186 GO:0007218 GO:0007268 GO:0007631 GO:0008188 GO:0016020 GO:0016021 GO:0016499 GO:0017046 GO:0032870 GO:0042277 GO:0045187 GO:0051480 GO:1901652

Consensus prediction of GO terms

Molecular Function	GO:0016990	GO:0016403	GO:0046872	GO:0016597
GO-Score	0.67	0.64	0.64	0.39
Biological Processes	GO:0019547	GO:0018101	GO:0007263	GO:0003073	GO:0045766	GO:0050999	GO:0045429	GO:0019546
GO-Score	0.67	0.67	0.39	0.39	0.39	0.39	0.39	0.33
Cellular Component	GO:0005829	GO:0070062	GO:0005739
GO-Score	0.39	0.39	0.39

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.