I-TASSER results

I-TASSER results for job id Rv2308

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (238 residues)
MRADMSVTSMLDREVYVYAEVDKLIGLPAGTAKRWINGYERGGKDHPPILRVTPGATPWV
TWGEFVETRMLAEYRDRRKVPIVRQRAAIEELRARFNLRYPLAHLRPFLSTHERDLTMGG
EEIGLPDAEVTIRTGQALLGDARWLASIATPGRDEVGEAVIVELPVDKAFPEIVINPSRY
SGQPTFVGRRVSPVTIAQMVDGGEEREDLAADYGLSLKQIQDAIDYTKKYRLARLVAA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MRADMSVTSMLDREVYVYAEVDKLIGLPAGTAKRWINGYERGGKDHPPILRVTPGATPWVTWGEFVETRMLAEYRDRRKVPIVRQRAAIEELRARFNLRYPLAHLRPFLSTHERDLTMGGEEIGLPDAEVTIRTGQALLGDARWLASIATPGRDEVGEAVIVELPVDKAFPEIVINPSRYSGQPTFVGRRVSPVTIAQMVDGGEEREDLAADYGLSLKQIQDAIDYTKKYRLARLVAA
Prediction	CCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCEEEHCCCCCCCHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEHCCCEEEEEHCCCCCCCCCEEEHCCCCEEEHCEEHCCEEEHCCCCCCCCCCEHCCCCCCCCCCEEHCCCCCCCEEEHCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCC
Conf.Score	9877665555568888999999998999999998756655688878865886789987556889999999999999979999999999999999989888754445455468679998544456665444544564444344444444544567778654333578888886898576568856875788779999999998999999999989999999999999999999887759
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MRADMSVTSMLDREVYVYAEVDKLIGLPAGTAKRWINGYERGGKDHPPILRVTPGATPWVTWGEFVETRMLAEYRDRRKVPIVRQRAAIEELRARFNLRYPLAHLRPFLSTHERDLTMGGEEIGLPDAEVTIRTGQALLGDARWLASIATPGRDEVGEAVIVELPVDKAFPEIVINPSRYSGQPTFVGRRVSPVTIAQMVDGGEEREDLAADYGLSLKQIQDAIDYTKKYRLARLVAA
Prediction	7555343442172330325202321704372032003225436642421042456644201011000010031015547041630250053037316462110344132404422021335435355433323534421343412431333334555233224134556443010003223030104544030320141044654163006417043720330041034144154358
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCEEEHCCCCCCCHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEHCCCEEEEEHCCCCCCCCCEEEHCCCCEEEHCEEHCCEEEHCCCCCCCCCCEHCCCCCCCCCCEEHCCCCCCCEEEHCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCC
MRADMSVTSMLDREVYVYAEVDKLIGLPAGTAKRWINGYERGGKDHPPILRVTPGATPWVTWGEFVETRMLAEYRDRRKVPIVRQRAAIEELRARFNLRYPLAHLRPFLSTHERDLTMGGEEIGLPDAEVTIRTGQALLGDARWLASIATPGRDEVGEAVIVELPVDKAFPEIVINPSRYSGQPTFVGRRVSPVTIAQMVDGGEEREDLAADYGLSLKQIQDAIDYTKKYRLARLVAA

5af3A

0.21

0.18

0.87

2.16

MUSTER

--------LRFDVPLYTLAEASRYLVVPRATLATWADQP------IITALPHPTGSHARLPFVGIAEAYVLNAFRRAG-VPMQRIRPSLDWLIKNVG-PHALASQDLCTDGAEVLWRFAERSGEGSRGLIVPRSGQYVFKEI-VEHYLQQISFADDNLASMIRLPQYGD-ANVVLDPRRGYGQPVFDGSGVRVADVLGPLRAGATFQAVADDYGVTPDQLRDALDA------------

5af3A

0.21

0.18

0.87

2.66

dPPAS

--------LRFDVPLYTLAEASRYLVVPRATLATWADQPIITALPH------PTGSHARLPFVGIAEAYVLNAFRRAG-VPMQRIRPSLDWLIKNVG-PHALASQDLCTDGAEVLWRFAERSGEGSRGLIVPRSGQYVFKEI-VEHYLQQISFADDNLASMIRLPQY-GDANVVLDPRRGYGQPVFDGSGVRVADVLGPLRAGATFQAVADDYGVTPDQLRDALDA------------

5af3A

0.21

0.18

0.87

3.84

wdPPAS

--------LRFDVPLYTLAEASRYLVVPRATLATWAD-----QPIITAL-PHPTGSHARLPFVGIAEAYVLNAFRRAG-VPMQRIRPSLDWLIKNVG-PHALASQDLC--TDGAEVLWRFAERSGEGSLIVPRSGQYVFKEIV-EHYLQQISFADDNLASMIRLPQ-YGDANVVLDPRRGYGQPVFDGSGVRVADVLGPLRAGATFQAVADDYGVTPDQLRDALDA------------

5af3A

0.21

0.18

0.87

2.62

wMUSTER

---------RFDVPLYTLAEASRYLVVPRATLATWADQP------IITALPHPTGSHARLPFVGIAEAYVLNAFRRAG-VPMQRIRPSLDWLIKNVG-PHALASQDLCTDGAEVLWRFAERSGEGSRGLIVPRSGQYVFKEI-VEHYLQQISFADDNLASMIRLPQYGD-ANVVLDPRRGYGQPVFDGSGVRVADVLGPLRAGATFQAVADDYGVTPDQLRDALDA------------

5af3A

0.21

0.18

0.87

4.33

wPPAS

--------LRFDVPLYTLAEASRYLVVPRATLATWADQP-----IITAL-PHPTGSHARLPFVGIAEAYVLNAFRRAG-VPMQRIRPSLDWLIKNVG-PHALASQDLC--TDGAEVLWRFAERSGEGSLIVPRSGQYVFKEIV-EHYLQQISFADDNLASMIRLPQ-YGDANVVLDPRRGYGQPVFDGSGVRVADVLGPLRAGATFQAVADDYGVTPDQLRDALDA------------

5af3A

0.21

0.18

0.87

6.70

dPPAS2

--------LRFDVPLYTLAEASRYLVVPRATLATWADQP------IITALPHPTGSHARLPFVGIAEAYVLNAFRRAG-VPMQRIRPSLDWLIKNVG-PHALASQDLCTDGAEVLWRFAERSGEGSRGLIVPRSGQYVFKEI-VEHYLQQISFADDNLASMIRLPQY-GDANVVLDPRRGYGQPVFDGSGVRVADVLGPLRAGATFQAVADDYGVTPDQLRDALDA------------

5af3A

0.21

0.18

0.87

3.60

PPAS

--------LRFDVPLYTLAEASRYLVVPRATLATWADQP------IITALPHPTGSHARLPFVGIAEAYVLNAFRRAG-VPMQRIRPSLDWLIKNVG-PHALASQDLCTDGAEVLWRFAERSGEGSRGLIVPRSGQYVFKEI-VEHYLQQISFADDNLASMIRLPQ-YGDANVVLDPRRGYGQPVFDGSGVRVADVLGPLRAGATFQAVADDYGVTPDQLRDALDA------------

5af3A

0.21

0.18

0.87

4.36

Env-PPAS

--------LRFDVPLYTLAEASRYLVVPRATLATWADQP------IITALPHPTGSHARLPFVGIAEAYVLNAFRRAG-VPMQRIRPSLDWLIKNVG-PHALASQDLCTDGAEVLWRFAERSGEGSRGLIVPRSGQYVFKEI-VEHYLQQISFADDNLASMIRLPQ-YGDANVVLDPRRGYGQPVFDGSGVRVADVLGPLRAGATFQAVADDYGVTPDQLRDALDA------------

5af3A1

0.17

0.10

0.61

1.14

MUSTER

--------LRFDVPLYTLAEASRYLVVPRATLATWADQP------IITALPHPTGSHARLPFVGIAEAYVLNAFRRAG-VPMQRIRPSLDWLIKNVG-PHALASQDLCTDGAEVLWRFAERSGEGSRGLIVPRSGQYVFKEI-VEHYLQQISFADDNLASM-----------------------------------------------------------------------------

5af3A1

0.17

0.10

0.61

1.55

dPPAS

--------LRFDVPLYTLAEASRYLVVPRATLATWADQP------IITALPHPTGSHARLPFVGIAEAYVLNAFRRAG-VPMQRIRPSLDWLIKNVG-PHALASQDLCTDGAEVLWRFAERSGEGSRGLIVPRSGQYVFKEI-VEHYLQQISFADDNLASM-----------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.64

Estimated TM-score = 0.80±0.09

Estimated RMSD = 4.4±2.9Å

Download Model 2

C-score=-2.07

Download Model 3

C-score=-1.56

Download Model 4

C-score=-1.79

Download Model 5

C-score=-4.33

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5af3A	0.848	1.03	0.212	0.874
2	1e9xA	0.464	5.27	0.071	0.719
3	4ii2A	0.454	5.83	0.053	0.760
4	3cmmC	0.450	5.66	0.053	0.744
5	2cse1	0.449	5.64	0.036	0.756
6	1m56A	0.445	5.38	0.060	0.706
7	1ocrN	0.444	5.44	0.055	0.706
8	3b98A	0.443	5.55	0.039	0.719
9	2yevA	0.443	5.56	0.049	0.723
10	5ifiA	0.442	5.69	0.060	0.740

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	3	2wxdM	NAG	Rep, Mult	16,20,182
2	0.06	3	4bntD	36E	Rep, Mult	220,224
3	0.04	2	3fyeA	DMU	Rep, Mult	28,30,66,67,70,71,74
4	0.04	2	2v50D	LMT	Rep, Mult	232,235
5	0.04	2	3v8eA	MG	Rep, Mult	177,182,185
6	0.04	2	1ku7A	NUC	Rep, Mult	192,215,216,218,219,222
7	0.02	1	1n38A	CH1	Rep, Mult	192,193,198,199,209
8	0.02	1	3zvwC	MG	Rep, Mult	165,166
9	0.02	1	2zalB	ASP	Rep, Mult	214,215,216
10	0.02	1	1l5yA	BF2	Rep, Mult	228,231
11	0.02	1	4d26A	MG	Rep, Mult	23,183
12	0.02	1	3svlB	FMN	Rep, Mult	16,41
13	0.02	1	3uomD	CA	Rep, Mult	20,21
14	0.02	1	4ryqA	MPG	Rep, Mult	70,74,140
15	0.02	1	2wse4	CLA	Rep, Mult	82,86
16	0.02	1	2o01L	CLA	Rep, Mult	209,213
17	0.02	1	3dtuC	DXC	Rep, Mult	71,74,75,78,81,85

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1aupA	0.406	5.78	0.049	0.698	1.4.1.2	154
2	0.060	3k9vA	0.419	5.66	0.063	0.685	1.14.13.-	195
3	0.060	1sj2A	0.429	6.36	0.069	0.798	1.11.1.6,1.11.1.7	212
4	0.060	1occA	0.443	5.46	0.060	0.710	1.9.3.1	20,186
5	0.060	1ry2A	0.427	5.44	0.057	0.681	6.2.1.1	36
6	0.060	2d1rA	0.427	5.64	0.056	0.693	1.13.12.7	NA
7	0.060	2f9qA	0.420	5.55	0.058	0.681	1.14.14.1	194,195
8	0.060	1e9xA	0.464	5.27	0.071	0.719	1.14.13.70	192
9	0.060	3cmmC	0.450	5.66	0.053	0.744	6.3.2.19	71
10	0.060	3k92A	0.437	5.83	0.044	0.744	1.4.1.2	15
11	0.060	2cvtA	0.436	5.68	0.080	0.731	1.17.4.1	NA
12	0.060	2wghB	0.436	5.52	0.059	0.719	1.17.4.1	NA
13	0.060	1n1hA	0.446	5.61	0.048	0.748	2.7.7.48	19,23,25
14	0.060	3b98A	0.443	5.55	0.039	0.719	5.3.99.4	140
15	0.060	1hrdA	0.405	5.81	0.043	0.668	1.4.1.2	NA
16	0.060	1bgvA	0.419	6.02	0.052	0.731	1.4.1.2	154
17	0.060	1ofdA	0.428	5.76	0.079	0.735	1.4.7.1	NA
18	0.060	1fftA	0.427	5.76	0.039	0.710	1.10.3.-	NA
19	0.060	1kqfA	0.364	6.50	0.045	0.693	1.2.1.2	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.39	0.848	1.03	0.21	0.87	5af3A	GO:0003677
1	0.07	0.464	5.27	0.07	0.72	1e9xA	GO:0004497 GO:0005506 GO:0005737 GO:0005829 GO:0006629 GO:0006694 GO:0008202 GO:0008398 GO:0016125 GO:0016126 GO:0016491 GO:0016705 GO:0020037 GO:0046872 GO:0055114 GO:0070988
2	0.07	0.437	5.57	0.06	0.71	2iagA	GO:0001516 GO:0004497 GO:0005506 GO:0005615 GO:0005634 GO:0005737 GO:0005783 GO:0005789 GO:0005901 GO:0006629 GO:0006631 GO:0006633 GO:0006690 GO:0006693 GO:0006769 GO:0007566 GO:0008116 GO:0016020 GO:0016021 GO:0016705 GO:0016853 GO:0019371 GO:0020037 GO:0032088 GO:0035360 GO:0045019 GO:0045766 GO:0046697 GO:0046872 GO:0050728 GO:0055114 GO:0071347 GO:0071354 GO:0071456 GO:0097190 GO:1900119
3	0.07	0.443	5.55	0.04	0.72	3b98A	GO:0004497 GO:0005506 GO:0005783 GO:0005789 GO:0008116 GO:0016020 GO:0016705 GO:0016853 GO:0020037 GO:0046872 GO:0055114
4	0.07	0.415	5.54	0.05	0.68	5e58C	GO:0004497 GO:0005506 GO:0016491 GO:0016705 GO:0016712 GO:0020037 GO:0046872 GO:0055114
5	0.06	0.429	5.57	0.06	0.71	3v8dA	GO:0004497 GO:0005506 GO:0005783 GO:0005789 GO:0006629 GO:0006699 GO:0006707 GO:0008123 GO:0008202 GO:0008203 GO:0016020 GO:0016125 GO:0016491 GO:0016705 GO:0020037 GO:0031090 GO:0042632 GO:0043231 GO:0046872 GO:0055114 GO:0070857 GO:0071333 GO:0071397
6	0.06	0.413	5.67	0.05	0.69	3kw4A	GO:0004497 GO:0005506 GO:0005783 GO:0005789 GO:0016020 GO:0016491 GO:0016705 GO:0016712 GO:0020037 GO:0031090 GO:0043231 GO:0046872 GO:0055114 GO:0070330
7	0.06	0.409	5.99	0.05	0.70	4j14A	GO:0004497 GO:0005506 GO:0005783 GO:0005789 GO:0006629 GO:0006699 GO:0006707 GO:0006805 GO:0007399 GO:0008202 GO:0008203 GO:0008395 GO:0016020 GO:0016021 GO:0016125 GO:0016491 GO:0016705 GO:0020037 GO:0031090 GO:0033781 GO:0043231 GO:0046872 GO:0055114
8	0.06	0.409	5.86	0.05	0.70	1tqnA	GO:0004497 GO:0005496 GO:0005506 GO:0005737 GO:0005783 GO:0005789 GO:0006629 GO:0006706 GO:0006805 GO:0008202 GO:0008209 GO:0008395 GO:0009822 GO:0016020 GO:0016021 GO:0016098 GO:0016491 GO:0016705 GO:0016712 GO:0017144 GO:0019825 GO:0019899 GO:0020037 GO:0030343 GO:0031090 GO:0033780 GO:0034875 GO:0036378 GO:0042359 GO:0042737 GO:0042738 GO:0043231 GO:0046483 GO:0046872 GO:0047638 GO:0050591 GO:0050649 GO:0055114 GO:0070330 GO:0070576 GO:0070989
9	0.06	0.414	5.69	0.06	0.68	4nz2A	GO:0001567 GO:0004497 GO:0005506 GO:0005783 GO:0005789 GO:0006629 GO:0006805 GO:0008144 GO:0008202 GO:0008392 GO:0008395 GO:0016020 GO:0016098 GO:0016491 GO:0016705 GO:0017144 GO:0018675 GO:0018676 GO:0019373 GO:0019627 GO:0019825 GO:0020037 GO:0031090 GO:0032787 GO:0034875 GO:0042737 GO:0042738 GO:0043231 GO:0043603 GO:0046872 GO:0052741 GO:0055114 GO:0070989 GO:0097267
10	0.06	0.414	5.60	0.06	0.69	4i91A	GO:0004497 GO:0005506 GO:0005783 GO:0005789 GO:0006805 GO:0008202 GO:0008392 GO:0008395 GO:0016020 GO:0016491 GO:0016705 GO:0016712 GO:0017144 GO:0019373 GO:0019825 GO:0020037 GO:0031090 GO:0042180 GO:0042738 GO:0043231 GO:0046872 GO:0055114
11	0.06	0.411	5.85	0.08	0.71	2hi4A	GO:0004497 GO:0005506 GO:0005783 GO:0005789 GO:0006629 GO:0006706 GO:0006725 GO:0006778 GO:0006805 GO:0008202 GO:0009055 GO:0009403 GO:0009404 GO:0009791 GO:0009820 GO:0010033 GO:0010468 GO:0014070 GO:0016020 GO:0016098 GO:0016491 GO:0016705 GO:0016712 GO:0017144 GO:0018894 GO:0019373 GO:0019825 GO:0019899 GO:0020037 GO:0030324 GO:0031090 GO:0032259 GO:0032355 GO:0032451 GO:0032496 GO:0032787 GO:0034875 GO:0035902 GO:0042493 GO:0042737 GO:0042738 GO:0043231 GO:0045333 GO:0046483 GO:0046872 GO:0050665 GO:0055114 GO:0070330 GO:0070989 GO:0071276 GO:0071615 GO:0097267
12	0.06	0.403	5.96	0.06	0.70	4bjkA	GO:0004497 GO:0005506 GO:0008168 GO:0008398 GO:0016125 GO:0016491 GO:0016705 GO:0020037 GO:0032259 GO:0046872 GO:0055114 GO:0070988
13	0.06	0.415	5.57	0.05	0.68	1z11A	GO:0004497 GO:0005506 GO:0005783 GO:0005789 GO:0005881 GO:0008202 GO:0008389 GO:0008392 GO:0008395 GO:0009804 GO:0016020 GO:0016491 GO:0016705 GO:0016712 GO:0017144 GO:0019373 GO:0019899 GO:0020037 GO:0031090 GO:0042738 GO:0043231 GO:0046226 GO:0046872 GO:0055114
14	0.06	0.415	5.44	0.07	0.66	3dbgA	GO:0004497 GO:0005506 GO:0005886 GO:0010333 GO:0016125 GO:0016491 GO:0016705 GO:0016829 GO:0020037 GO:0046872 GO:0055114
15	0.06	0.393	5.74	0.08	0.66	3awmA	GO:0005506 GO:0016705 GO:0020037 GO:0046872 GO:0055114
16	0.06	0.411	5.72	0.07	0.70	4i8vA	GO:0001666 GO:0001889 GO:0003824 GO:0004497 GO:0005506 GO:0005737 GO:0005739 GO:0005783 GO:0005789 GO:0006778 GO:0007568 GO:0008283 GO:0008395 GO:0009308 GO:0009404 GO:0009611 GO:0009615 GO:0009624 GO:0009635 GO:0009636 GO:0009692 GO:0009792 GO:0009804 GO:0009812 GO:0010033 GO:0010041 GO:0014070 GO:0016020 GO:0016491 GO:0016679 GO:0016705 GO:0016711 GO:0016712 GO:0017143 GO:0017144 GO:0018894 GO:0019341 GO:0019373 GO:0019825 GO:0019899 GO:0020037 GO:0031090 GO:0032094 GO:0032451 GO:0032496 GO:0032502 GO:0033189 GO:0035902 GO:0042359 GO:0042493 GO:0042904 GO:0043010 GO:0043231 GO:0046483 GO:0046677 GO:0046685 GO:0046872 GO:0048565 GO:0050665 GO:0055093 GO:0055114 GO:0060137 GO:0070330 GO:0070365 GO:0070576 GO:0070988 GO:0071407 GO:0097267 GO:1900087
17	0.06	0.415	5.98	0.06	0.70	3juvA	GO:0004497 GO:0005506 GO:0005783 GO:0005789 GO:0005886 GO:0006629 GO:0006694 GO:0006695 GO:0008202 GO:0008203 GO:0008398 GO:0016020 GO:0016021 GO:0016125 GO:0016126 GO:0016491 GO:0016705 GO:0020037 GO:0031090 GO:0033488 GO:0043231 GO:0046872 GO:0055114 GO:0070988
18	0.06	0.389	5.34	0.08	0.62	3nc6B	GO:0004497 GO:0005506 GO:0005886 GO:0016125 GO:0016491 GO:0016705 GO:0016713 GO:0020037 GO:0046148 GO:0046872 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0046914	GO:0016491	GO:0046906	GO:0003677
GO-Score	0.47	0.47	0.47	0.39
Biological Processes	GO:0044710
GO-Score	0.47
Cellular Component	GO:0005789	GO:0005634	GO:0016021	GO:0005615	GO:0005829	GO:0005901
GO-Score	0.13	0.07	0.07	0.07	0.07	0.07

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.